Iridoids and Anthraquinones from the Malaysian Medicinal Plant, Saprosma scortechinii (Rubiaceae)

A further investigation of the leaves and stems of Saprosma scortechinii afforded 13 compounds, of which 10 are new compounds. These were elucidated as the bis-iridoid glucosides, saprosmosides G (1) and H (2), the iridoid glucoside, 6-O-epi-acetylscandoside (3), and the anthraquinones, 1-methoxy-3-hydroxy-2-carbomethoxy-9,10-anthraquinone (4), 1-methoxy-3-hydroxy-2-carbomethoxy-9,10-anthraquinone 3-O-β-primeveroside (5), 1,3-dihydroxy-2-carbomethoxy-9,10-anthraquinone 3-O-β-primeveroside (6), 1,3,6-trihydroxy-2-methoxymethyl-9,10-anthraquinone (7), 1-methoxy-3,6-dihydroxy-2-hydroxymethyl-9,10-anthraquinone (8), 1,3,6-trihydroxy-2-hydroxymethyl-9,10-anthraquinone 3-O-β-primeveroside (9), and 3,6-dihydroxy-2-hydroxymethyl-9,10-anthraquinone (10). Structure assignments for all compounds were established by means of mass and NMR spectroscopies, chemical methods, and comparison with published data. The new anthraquinones were derivatives of munjistin and lucidin

L'Auto-vélo : automobilisme, cyclisme, athlétisme, yachting, aérostation, escrime, hippisme / dir. Henri Desgranges

27 mai 19281928/05/27 (A29,N0)

Additional file 7: Figure S4. of The gene–treatment interaction of paraoxonase-1 gene polymorphism and statin therapy on insulin secretion in Japanese patients with type 2 diabetes: Fukuoka diabetes registry

Association of PON1 Q192R polymorphism with FPG, HbA1c, C peptide, and HOMA2-%β after stratified analysis by statin therapy (IPTW). Data are expressed as adjusted mean (95% CI) referring to ANCOVA; P value refers to multiple regression analysis. * P < 0.05 for trend. (DOCX 68 kb

Additional file 6: Figure S3. of The gene–treatment interaction of paraoxonase-1 gene polymorphism and statin therapy on insulin secretion in Japanese patients with type 2 diabetes: Fukuoka diabetes registry

Association of PON1 Q192R polymorphism with FPG, HbA1c, C peptide, and HOMA2-%β after stratified analysis by statin therapy (after 1:1 matching). Data are expressed as mean (SD) referring to ANCOVA; P value refers to multiple regression analysis. * P < 0.05 for trend. (DOCX 72 kb

Additional file 4: Table S3. of The gene–treatment interaction of paraoxonase-1 gene polymorphism and statin therapy on insulin secretion in Japanese patients with type 2 diabetes: Fukuoka diabetes registry

Clinical characteristics according to statin therapy (after 1:1 matching). Data are expressed as mean ± SD, median (interquartile), and n (percentage). CVD: cardiovascular disease, OHA: oral hypoglycemic agents, α-GI: alpha-glucosidase inhibitor, DPP4-I: inhibitors of type 4 dipeptidyl peptidase.* log-transformed for the statistical analysis. (DOCX 14 kb