Risultati audiologici e rate di attecchimento dell'innesto di cartilagine con pericondrio nella timpanoplastica: PACIT

La cartilagine rappresenta una delle opzioni più interessanti per il confezionamento dell'innesto nella timpanoplastica (TPL). Col presente studio presentiamo i nostri risultati audiologici e il rate di attecchimento nei casi di TPL trattati con innesto di cartilagine con pericondrio (PACIT). Sono stati analizzati, in termini di tipo di chirurgia effettuata, attecchimento dell'innesto e risultati audiologici, 194 orecchi di 191 pazienti (108 maschi, 83 donne). Sono state effettuate 127 (65,46%) TPL tipo I, 45 (23,20%) tipo II e 22 (11,34%) tipo III. Il gap medio fra via aerea e via ossea all'audiometria tonale preoperatoria è stato rispettivamente 33,74 ± 9,60, 52,58 ± 9,07, e 56,58 ± 10,27 dB HL; i valori nel postoperatorio sono stai invece 18,55 ± 9,25, 31,21 ± 4,36, and 44,84 ± 12,45 dB HL. Nel postoperatorio di è registrato un miglioramento della soglia (≥ 10dB) nel 76,81% degli orecchi valutati, con un recupero medio di 20 dB HL (range 10-40 dB). Tuttavia il 19,07% degli orecchi valutati non ha mostrato un miglioramento della soglia uditiva, e il 4,12% ha manifestato un peggioramento della soglia. L'innesto ha attecchito correttamente nel 91,24% dei casi con follow-up di almeno 13 mesi con una media di 68,64 mesi, mentre si è registrato un fallimento nel 8,76% dei casi. In considerazione dei livelli postoperatori della soglia uditiva e dell'elevato rate di attecchimenti registrato, il presente studio ha evidenziato l'efficacia a lungo termine dell'innesto di cartilagine con pericondrio

The Glasgow Benefit Inventory: a systematic review of the use and value of an otorhinolaryngological generic patient-recorded outcome measure

The Glasgow Benefit Inventory (GBI) is a validated, generic patient-recorded outcome measure widely used in otolaryngology to report change in quality of life post-intervention.To date, no systematic review has made (i) a quality assessment of reporting of Glasgow Benefit Inventory outcomes; (ii) a comparison between Glasgow Benefit Inventory outcomes for different interventions and objectives; (iii) an evaluation of subscales in describing the area of benefit; (iv) commented on its value in clinical practice and research.Systematic review.'Glasgow Benefit Inventory' and 'GBI' were used as keywords to search for published, unpublished and ongoing trials in PubMed, EMBASE, CINAHL and Google in addition to an ISI citation search for the original validating Glasgow Benefit Inventory paper between 1996 and January 2015.Papers were assessed for study type and quality graded by a predesigned scale, by two authors independently. Papers with sufficient quality Glasgow Benefit Inventory data were identified for statistical comparisons. Papers with 50% and gave sufficient Glasgow Benefit Inventory total and subscales for meta-analysis. For five of the 11 operation categories (vestibular schwannoma, tonsillectomy, cochlear implant, middle ear implant and stapes surgery) that were most likely to have a single clear clinical objective, score data had low-to-moderate heterogeneity. The value in the Glasgow Benefit Inventory having both positive and negative scores was shown by an overall negative score for the management of vestibular schwannoma. The other six operations gave considerable heterogeneity with rhinoplasty and septoplasty giving the greatest percentages (98% and 99%) most likely because of the considerable variations in patient selection. The data from these operations should not be used for comparative purposes. Five papers also reported the number of patients that had no or negative benefit, a potentially a more clinically useful outcome to report. Glasgow Benefit Inventory subscores for tonsillectomy were significantly different from ear surgery suggesting different areas of benefitThe Glasgow Benefit Inventory has been shown to differentiate the benefit between surgical and medical otolaryngology interventions as well as 'reassurance'. Reporting benefit as percentages with negative, no and positive benefit would enable better comparisons between different interventions with varying objectives and pathology. This could also allow easier evaluation of factors that predict benefit. Meta-analysis data are now available for comparison purposes for vestibular schwannoma, tonsillectomy, cochlear implant, middle ear implant and stapes surgery. Fuller report of the Glasgow Benefit Inventory outcomes for non-surgical otolaryngology interventions is encouraged

Intravitreal vs. subtenon triamcinolone acetonide for the treatment of diabetic cystoid macular edema

<p>Abstract</p> <p>Background</p> <p>To assess the efficacy of the intravitreal (IVT) injection of Triamcinolone Acetonide (TA) as compared to posterior subtenon (SBT) capsule injection for the treatment of cystoid diabetic macular edema.</p> <p>Methods</p> <p>Fourteen patients with type II diabetes mellitus and on insulin treatment, presenting diffuse cystoid macular edema were recruited. Before TA injection all focal lakes were treated by laser photocoagulation. In the same patients one eye was assigned to 4 mg IVT injection of TA and the fellow eye was then treated with 40 mg SBT injection of TA. Before and one, three and six months after treatment we measured visual acuity with ETDRS chart as well as thickness of the macula with optical coherence tomography (OCT) and intraocular pressure (IOP).</p> <p>Results</p> <p>The eyes treated with an IVT injection displayed significant improvement in visual acuity, both after one (0.491 ± 0.070; p < 0.001) and three months (0.500 ± 0.089; p < 0.001) of treatment. Significant improvement was displayed also in eyes treated with an SBT injection, again after one (0.455 ± 0.069; p < 0.001) and three months (0.427 ± 0.065; p < 0.001). The difference between an IVT injection (0.809 ± 0.083) and SBT injection (0.460 ± 0.072) becomes significant six months after the treatment (p < 0.001).</p> <p>Macular thickness of the eyes treated with IVT injection was significantly reduced both after one (222.7 ± 13.4 μm; p < 0.001) and after three months (228.1 ± 10.6 μm; p < 0.001) of treatment. The eyes treated with SBT injection displayed significant improvement after one (220.1 ± 15.1 μm; p < 0.001) and after three months (231.3 ± 10.9 μm; p < 0.001). The difference between the eyes treated with IVT injection (385.2 ± 11.3 μm) and those treated with SBT injection (235.4 ± 8.7 μm) becomes significant six months after the treatment (p < 0.001).</p> <p>Intraocular pressure of the eyes treated with IVT injection significantly increased after one month (17.7 ± 1.1 mm/Hg; p < 0.020), three (18.2 ± 1.2 mm/Hg; p < 0.003) and six month (18.1 ± 1.3 mm/Hg; p < 0.007) when compared to baseline value (16.1 ± 1.402 mm/Hg). In the SBT injection eyes we didn't display a significant increase of intraocular pressure after one (16.4 ± 1.2 mm/Hg; p < 0.450), three (16.3 ± 1.1 mm/Hg; p < 0.630) and six months (16.2 ± 1.1 mm/Hg; p < 0.720) when compared to baseline value (16.2 ± 1.3 mm/Hg).</p> <p>Conclusion</p> <p>The parabulbar subtenon approach can be considered a valid alternative to the intravitreal injection.</p> <p>Trial registration</p> <p>Current Controlled Trials <b>ISRCTN67086909</b></p

A comprehensive overview of radioguided surgery using gamma detection probe technology

The concept of radioguided surgery, which was first developed some 60 years ago, involves the use of a radiation detection probe system for the intraoperative detection of radionuclides. The use of gamma detection probe technology in radioguided surgery has tremendously expanded and has evolved into what is now considered an established discipline within the practice of surgery, revolutionizing the surgical management of many malignancies, including breast cancer, melanoma, and colorectal cancer, as well as the surgical management of parathyroid disease. The impact of radioguided surgery on the surgical management of cancer patients includes providing vital and real-time information to the surgeon regarding the location and extent of disease, as well as regarding the assessment of surgical resection margins. Additionally, it has allowed the surgeon to minimize the surgical invasiveness of many diagnostic and therapeutic procedures, while still maintaining maximum benefit to the cancer patient. In the current review, we have attempted to comprehensively evaluate the history, technical aspects, and clinical applications of radioguided surgery using gamma detection probe technology

Akciǧer Kanserinde 7. Tnm Evrelemesinden 8.'Ye Doǧru

Scopu

Evaluation of healthcare workers' and students' knowledge levels about infections transmitted by blood and body fluids, infection control measures, exposure frequencies and serological and hepatitis B vaccination status [Saglik Çalışanları ve ögrencilerin kan ve vücut sıvılarıyla bulşan enfeksiyonlar, enfeksiyon kontrol önlemleri hakkındaki bilgi düzeyleri, temas sıklıkları, serolojik durumları ve hepatit B aşilanma durumlarnin degerlendirilmesi]

Objective: Evaluation of healthcare workers', medical and nursing students' knowledge levels about infections transmitted by blood and body fluids, infection control measures, exposure frequencies and serological and hepatitis B vaccination status. Material and Methods: The study was cross-sectional and conducted in Karaelmas University Teaching and Research Hospital Zonguldak, Turkey. Data were collected by questionnaires. The study included 445 subjects (131 medical students [MS], 34 nursing students [NS], 280 healthcare workers). Results: Mean age was 25.5+5.4. Mean knowledge level scores (MKLS) increased with age and education level (p=0.001). Doctors had highest MKLS. MKLS of medical students working in clinics was higher than NS (p=0.001) and NS had higher MKLS than preclinical MS (p=0.001). Subjects who received in-service training on bloodborne infections and infection control precautions had higher MKLS than persons who did not (p=0.001). Blood and body fluid exposure frequency was 54%. Exposed subjects had higher MKLS than unexposed ones (p=0.001). Exposure frequency was higher in subjects who wanted to get training on bloodborne infections and infection control measures than subjects who did not (Chi square: 14.92 p=0.0001). Needle-stick injury was declared to be the most common exposure cause. Post-exposure reporting rate to the infectious diseases clinic was 27.3% and mean postexposure follow up duration was 2.9+2.3 months. The highest exposure rate was detected in the emergency department (76.3%), and the lowest rate was detected in dialysis unit (37.1%). Hepatitis B vaccination rate was 71.9%. The most frequent reason for nonvaccination was not having time. Anti HCV positivity was detected in 1.2% and inactive HBsAg carrier state was detected in 1.5% of healthcare workers. Conclusion: Exposure to blood and body secretions can be reduced by educating healthcare workers, increasing adherence to infection control measures, administrative support, and reporting exposures. Knowledge levels of workers should be tested to evaluate current policies. Seronegative workers should get hepatitis B vaccination. © 2010 by Türkiye Klinikleri