Stability Parameters in Lentil Genotypes

Total 20 lentil genotypes were examined for assessment stability in different environments for grain yield in Southeastern Anatolia of Turkey. Genotypes and genotypes x environments interactions were significant for grain yield. The regression coefficient, deviations of the regression coefficients, coefficient of variation, ecovalence and stability variance were computed for genotypes. Genotypes FLIP2011-26L, ILL10975 and Firat 87 with a high stability (b) and high grain yield would be adapted to a wide range of growing conditions in a given production area with above average yield. The stability variance (σ2i) revealed that the lentil genotypes Kafkas, Cagil and FLIP2009-55L had the smallest variance across the environments, while the genotype Firat 87 had the largest stability variance (σ2i)

Bazı Arpa Genotiplerinin Diyarbakır ve Şanlıurfa Koşullarında Verim ve Kalite Özellikleri Açısından İncelenmesi

Bu çalışmada, Dicle Üniversitesi Ziraat Fakültesi tarafından geliştirilen arpa genotiplerinin standart çeşitlerkarşısında verim ve kalite özellikleri bakımından farklılıklarının araştırılması amaçlanmıştır. Araştırma, tesadüfblokları deneme desenine göre, 2013-2014 yetiştirme sezonunda, Dicle Üniversitesi Ziraat Fakültesi denemealanı ve Siverek lokasyonlarında 4 tekrarlamalı olarak yürütülmüştür. Materyal olarak Dicle Üniversitesi ZiraatFakültesi tarafından geliştirilen 3 arpa genotipi ve kontrol amaçlı olarak GAPUTAEM tarafından tescil edilmiş2 arpa çeşidi (Samyeli ve Altıkat) kullanılmıştır. Çalışmada; SPAD değeri, tane verimi, 1000 tane ağırlığı,protein oranı, tanede nişasta oranı ve hektolitre ağırlığı özellikleri incelenmiştir. İncelenen tüm özelliklerüzerine lokasyon etkisinin önemli olduğu belirlenmiştir. Genotipler arasındaki farklılıklar incelendiğinde SPADdeğeri hariç incelenen özelliklerin tümünde genotipin etkili olduğu görülmüştür. İnteraksiyon etkisi iseincelenen tüm özelliklerde önemsiz çıkmıştır. Arpa genotiplerinde tane verimi 324.3 kg/da ile 445.8 kg/daarasında değişmiştir. En yüksek tane verimi ve bin tane ağırlığı (46.84 g) Samyeli çeşidinden elde edilmiştir.En yüksek protein oranı ise DZ12-2 genotipinden (%16.21) elde edilmiştir. İleri hatlardan DZ7-07 genotipiçeşit adayı olarak değerlendirilebileceği ön görülmüştür

Evaluation of patients with fibrotic interstitial lung disease: Preliminary results from the Turk-UIP study

OBJECTIVE: Differential diagnosis of idiopathic pulmonary fibrosis (IPF) is important among fibrotic interstitial lung diseases (ILD). This study aimed to evaluate the rate of IPF in patients with fibrotic ILD and to determine the clinical-laboratory features of patients with and without IPF that would provide the differential diagnosis of IPF. MATERIAL AND METHODS: The study included the patients with the usual interstitial pneumonia (UIP) pattern or possible UIP pattern on thorax high-resolution computed tomography, and/or UIP pattern, probable UIP or possible UIP pattern at lung biopsy according to the 2011 ATS/ERSARS/ALAT guidelines. Demographics and clinical and radiological data of the patients were recorded. All data recorded by researchers was evaluated by radiology and the clinical decision board. RESULTS: A total of 336 patients (253 men, 83 women, age 65.8 +/- 9.0 years) were evaluated. Of the patients with sufficient data for diag-nosis (n=300), the diagnosis was IPF in 121 (40.3%), unclassified idiopathic interstitial pneumonia in 50 (16.7%), combined pulmonary fibrosis and emphysema (CPFE) in 40 (13.3%), and lung involvement of connective tissue disease (CTD) in 16 (5.3%). When 29 patients with definite IPF features were added to the patients with CPFE, the total number of IPF patients reached 150 (50%). Rate of male sex (p<0.001), smoking history (p<0.001), and the presence of clubbing (p=0.001) were significantly high in patients with IPE None of the women <50 years and none of the men <50 years of age without a smoking history were diagnosed with IPE Presence of at least 1 of the symptoms suggestive of CTD, erythrocyte sedimentation rate (ESR), and antinuclear antibody (FANA) positivity rates were significantly higher in the non-IPF group (p<0.001, p=0.029, p=0.009, respectively). CONCLUSION: The rate of IPF among patients with fibrotic ILD was 50%. In the differential diagnosis of IPF, sex, smoking habits, and the presence of clubbing are important. The presence of symptoms related to CTD, ESR elevation, and EANA positivity reduce the likelihood of IPF

Efficacy and tolerability of the first antiepileptic drug in children with newly diagnosed idiopathic epilepsy

AbstractPurposeLimited data are available for the effectiveness of the antiepileptic drugs in children in daily clinical practice. The aim of this study was to investigate the efficacy and tolerability of the first prescribed old and new antiepileptic drugs in children with newly diagnosed idiopathic epilepsy during a 12-month period.MethodA total of 289 children (141 females and 148 males) who received phenobarbital (n=33), valproate (n=142), carbamazepine (n=42), oxcarbazepine (n=38), or levetiracetam (n=34) as the first-line treatment, were enrolled in the study. Seizure control and the occurrence of adverse events were assessed during a treatment period of 12 months.ResultsOverall, 245 (84.8%) patients remained seizure-free during the study period. The rate of seizure control did not differ significantly between the drug groups (p=0.099). Forty-four (15.2%) patients including 1 (3.0%) treated with phenobarbital, 22 (15.5%) with valproate, 7 (16.7%) with carbamazepine, 10 (26.3%) with oxcarbazepine, and 4 (11.8%) with levetiracetam had treatment failure. There was no significant difference between seizure-free and failure groups in terms of age, gender, seizure type, and drugs used. Overall, 80 (27.7%) patients had adverse events, of those the most common ones were behavioral problems, nausea and/or vomiting, weight gain, and learning difficulties. The reasons for treatment failures were lack of seizure control in 29 (10.0%) patients and intolerable adverse events in 15 (5.2%) patients.ConclusionIt appears that old (phenobarbital, valproate and carbamazepine) and new antiepileptic drugs (oxcarbazepine and levetiracetam) have similar efficacy and tolerability profiles.Institutional ethic number is 28.3.2013/14

The effect of sleep disorders on quality of life in patients with epilepsy: A multicenter study from Turkey

Objective: We aimed to investigate sleep disorders in patients with epilepsy (PWE) and to investigate the effects of sleep disorders on quality of life. Methods: In our multicenter study conducted in Turkey, 1358 PWE were evaluated. The demographic and clinical data of the patients were recorded. The Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory (BDI), and Quality of Life in Epilepsy Inventory-10 (QOLIE-10) were administered. Results: The mean age of 1358 patients was 35.92 ± 14.11 (range, 18–89) years. Seven hundred fifty-one (55.30 %) were women. Some 12.7 % of the patients had insomnia (ISI > 14), 9.6 % had excessive daytime sleepiness (ESS > 10), 46.5 % had poor sleep quality (PSQI > 5), and 354 patients (26.1 %) had depressive symptoms (BDI > 16). The mean QOLIE-10 score was 22.82 ± 8.14 (10–48). Resistant epilepsy was evaluated as the parameter with the highest risk affecting quality of life Adjusted odds ratio (AOR = 3.714; 95 % confidence interval (CI): [2.440–5.652] < 0.001)). ISI (AOR = 1.184; 95 % CI: [1.128–1.243]; p < 0.001), ESS (AOR = 1.081; 95 % CI: [1.034–1.130]; p < 0.001), PSQI (AOR = 0.928; 95 % CI: [0.867 – 0.994]; p = 0.034), BDI (AOR = 1.106; 95 % CI: [1.084–1.129]; p < 0.001), epilepsy duration (AOR = 1.023; 95 % CI: [1.004–1.041]; p = 0.014), were determined as factors affecting quality of life. Significance: Sleep disorders are common in PWE and impair their quality of life. Quality of life can be improved by controlling the factors that may cause sleep disorders such as good seizure control, avoiding polypharmacy, and correcting the underlying mood disorders in patients with epilepsy