Melnick−Needles Syndrome Associated with Growth Hormone Deficiency: A Case Report

Melnick−Needles syndrome is an X−linked dominant bone dysplasia characterized by a typical facies (exophthalmos, full cheeks, micrognathia, and malalignment of teeth), flaring of the metaphyses of long bones, s−like curvature of the lower extremities, irregular constriction in the ribs, and sclerosis of base of the skull. The phenotype of affected individuals varies, even within families. About fifty cases of Melnick−Needles syndrome have been reported to date. Short stature is not a well−known component of the disorder. There is only one reported case of Melnick−Needles syndrome associated with growth hormone deficiency

Bone Mineral Density and Vitamin D Values in Behçet’s Disease

Objective:It was aim to compare the bone mineral density (BMD) and 25-hydroxy vitamin D (25-OH vitamin D) values of the patients with Behçet’s disease (BD) according to healthy population.Materials and Methods:A total of 34 patients diagnosed with BD which was 15 males and 19 females (mean age: 35.1±8.6 years; age range: 19 to 50 years), and 29 controls which was 12 males and 17 females (mean age: 36.9±9.2 years; age range: 21 to 51 years) were included in the study. The lumbar spine (L1-L4 total) measurements were made for the axial skeleton BMD values, and femur total and femur neck measurements were used for the appendicular skeleton BMD values.Results:The patients’ lumbar BMD values were significantly (p0.05). There was no significant correlation between the 25-OH vitamin D values and the BMD values of the groups (p>0.05).Conclusion:Even though the BD has a subclinical inflammatory course, it can cause a reduction of BMD by affecting the bone metabolism. Thus, the patients’ BMD values should be followed up, and when required vitamin D supplements should be administered to prevent the development of secondary osteoporosis

Comparison of some wood properties of juvenile black pines of different origin planted in the same habitat

Black pine (Pinus nigra) is a significant raw material source for the forest products industry in Turkey. The purpose of this research was to study some chemical, anatomical, physical, and mechanical properties of wood obtained from juvenile black pines planted in Kavaklıdere - Muğla, originating from five different locations: Muğla, Balıkesir, Denizli, Bursa, and Kütahya. Although pines originating from Muğla and Balıkesir were good in terms of wood properties, those from Denizli, Bursa, and Kütahya exhibited no remarkable features. Black pine of Muğla origin was recommended for planting in Kavaklıdere and similar habitats, whereas pines of Denizli, Bursa, and Kütahya origins were not recommended. However, pine of Balıkesir origin may be an alternative to that of Muğla origin for black pine plantations at Kavaklıdere and similar sites

Histopathological changes in uncomplicated sole ulcers in dairy cattle

This study aimed to investigate the histopathological changes that occurred in the wound of the sole ulcer located on the hooves of dairy cattle. A total of 12 Holstein-Frisian dairy cows suffering from sole ulcer were studied. Sole ulcers in the lateral hoof of the left or right foot of hind legs containing the corium and a part of the epidermis were collected and examined histopathologically. There were subacute inflammatory changes in the superficial dermal vessels. A slight perivascular lymphocyte infiltration and congestion and hyalinization of arterial walls were observed in the corium. Thickening was observed in the endothelium of dermal vessels, and revascularization areas were also noticed. Although epithelial proliferation (acanthosis), degeneration, and necrosis were found, the more obvious changes observed were eosinophilia and mineralization of the connective tissue. In addition, congestion and edema were also seen in the connective tissue.This study aimed to investigate the histopathological changes that occurred in the wound of the sole ulcer located on the hooves of dairy cattle. A total of 12 Holstein-Frisian dairy cows suffering from sole ulcer were studied. Sole ulcers in the lateral hoof of the left or right foot of hind legs containing the corium and a part of the epidermis were collected and examined histopathologically. There were subacute inflammatory changes in the superficial dermal vessels. A slight perivascular lymphocyte infiltration and congestion and hyalinization of arterial walls were observed in the corium. Thickening was observed in the endothelium of dermal vessels, and revascularization areas were also noticed. Although epithelial proliferation (acanthosis), degeneration, and necrosis were found, the more obvious changes observed were eosinophilia and mineralization of the connective tissue. In addition, congestion and edema were also seen in the connective tissue

Idiopathic Thrombocytopenic Purpura as Initial Manifestation of Systemic Lupus Erythematosus: A Case Report

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect almost any organ system. Its presentation and course are highly variable. The classic presentation of SLE in a woman of childbearing age is fever, arthritis, and malar rash triad. However, patients may present rare types of manifestations such as idiopathic thrombocytopenic purpura

A case of diabetes mellitus associated with Rett Syndrome

Rett syndrome (RS) is a neurodevelopmental disorder mainly affecting girls. It is characterized by a normal prenatal and perinatal period, apparently normal development for the first 6 months of life, and then a decelaration in head growth, loss of hand and communication skills, psycho motor retardation, as well as the development of sterotyped hand movement and truncal or gait apraxia. It has been shown to be related to mutations in the MECP2 gene located on Xq28. Diabetes mellitus (DM) type 1 may be associated with certain genetic disorders such as Down syndrome, Turner syndrome, and Klinefelter syndrome. In this work, we report the case of a 9-year-old girl with RS who developed DM at the age of 6. To our knowledge, our patient is the third case reported to date of DM associated with Rett syndrome

Sığır masseter kaslarında kuduz virüsünün anatomik lokalizasyonun Real-Time PCR ile belirlenmesi

Amaç: Bu çalışmada sığırlarda kuduz virüsünün masseter kaslarda izlediği patho-anatomik lokalizasyonun Real-Time PCR ile belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışma kuduz bir köpek tarafından yüz bölgesinden ısırılmış 1.5 yaşında erkek sığırda yapıldı. Kuduz şüphesiyle karantinada tutulduktan 15 gün sonra ölen sığırın ilgili bölgesinden doku örnekleri alındı. Standart diseksiyon yöntemleriyle ısırılan bölgede N. trigeminus sinirinin dalları incelendi. Sığır baş bölgesinin 32 farklı kısmı Tagman probe esasına dayalı RT-PCR ve FAT yöntemiyle incelendi. Bulgular: Kuduz virüsüne spesifik nükleik asitler masseter kasların motor sinirlerinde; N. trigeminus'un N. mandibularis dalında N. masticatorius, N. mandibularis, N. massetericus ve Nn. temporalis profunda unilaterally ganglion trigeminale ve ponsta Real Time-PCR ile belirlendi. Beynin diğer kısımlarında incelenen örneklerde tespit edilemedi. Öneri: Bu çalışmada sığırlarda nöronal bağlantıların ve sinaps geçişlerinin virüs nükleik asitlerinin RT-PCR yöntemi ile ortaya konulmasıyla anatomik olarak izlenebileceği belirlendi.Aim: In this case, the anatomical pathways on masticatory muscles of cattle infected rabies virüs have been determined by Real Time PCR (RT-PCR). Materials and Methods: A 1.5-year old male Brown Swiss cattle which was bitten in face by dog was used. The cattle was died 15 days post exposure to the dog rabies suspected. The areas where the tissue samples to taken. The origin, course and branches of the trigeminal nerve were exposed by standart dissection method. Rabies virus was investigated on 32 different parts of the cattle's head by means of TaqMan Probe-Based Real-Time PCR and FAT. Results: The rabies virus specific nucleic acid was detected in masseter muscles motor nerves; N. mandibularis branch of N. trigeminus, N. masticatorius, motor leaf of N. mandibularis, N. massetericus and Nn. temporalis profunda which are two extra branches of N. masticatorius, unilaterally ganglion trigeminale, and pons by Real Time-PCR. However, no rabies virus has been detected in the samples obtained from other different parts of the brain. Conclusion: Contrary to immunohistochemical methods, it is not possible to trace neuronal connections across synapses within the brain. RT-PCR method could be helpful to detect pathways of the neurotropic agents suspected cattle

A Rare Case of Osteonecrosis Caused by Arthroscopy: A Case Report

Avascular necrosis, which is caused by non-traumatic factors, is not a specific disease entity but the final common result of many conditions leading to death of bone cells by the impairment of blood supply. Although associated diseases and conditions (steroid administration, alcoholism, systemic lupus erythematosus, etc.) are well known, avascular necrosis is thought to arise from a multifactorial etiology of mechanical, hormonal and hematologic factors. The goals of treatment are to maintain range of motion, to stop the progression of disease, and to reduce symptoms. If conservative treatment fails, arthroscopic debridement, core decompression, grafting, and arthroplasty are surgical alternatives according to the stage of disease