Accident vasculaire cerebral ischemique post-chimiotherapie pour cancer du sein

IntroductionLa chimiothérapie anticancéreuse est pourvoyeuse d’un large spectre de complications neurologiques. Parmi ces complications les accidents vasculaires cérébraux ischémiques (AVCI) restent un évènement inhabituel dont l’incidence est de 0,14%.ObjectifRapporter et commenter l’observation d’une patiente ayant présenté un AVCI dans les suites d’une chimiothérapie pour cancer du sein.ObservationPatiente âgée de 46ans, traitée pour une épilepsie généralisée, et sans facteur de risque cardiovasculaire, est suivie pour un cancer du sein. Elle a présenté au décours de la chimiothérapie un accident vasculaire cérébral ischémique sylvien droit confirmé au scanner cérébral. Les explorations cardiaques sont normales, ainsi que le bilan biologique étiologique.DiscussionLe diagnostic d’AVC post-chimiothérapie a été retenu chez notre patiente sur la base de l’absence de facteur de risque vasculaire et la négativité du bilan étiologique, ainsi que l’usage du 5 Fluorouracile qui a été incriminé dans la survenue d’AVC ischémiques. La survenue de cette complication dépend du type de drogue utilisé, et de certaines associations thérapeutiques, et relèverait de plusieurs mécanismes pouvant être intriqués. Le bilan doit être le plus complet possible afin d’affirmer l’imputabilité de la chimiothérapie.ConclusionNotre observation souligne la sévérité des complications neurologiques de la chimiothérapie, ainsi que le dilemme thérapeutique posé, en l’absence de protocole de prise en charge codifié.Mots clés : Accident vasculaire cérébral, cancer du sein, chimiothérapie, toxicité, 5-Fluorouracil

Black Holes in Type IIA String on Calabi-Yau Threefolds with Affine ADE Geometries and q-Deformed 2d Quiver Gauge Theories

Motivated by studies on 4d black holes and q-deformed 2d Yang Mills theory, and borrowing ideas from compact geometry of the blowing up of affine ADE singularities, we build a class of local Calabi-Yau threefolds (CY^{3}) extending the local 2-torus model \mathcal{O}(m)\oplus \mathcal{O}(-m)\to T^{2\text{}} considered in hep-th/0406058 to test OSV conjecture. We first study toric realizations of T^{2} and then build a toric representation of X_{3} using intersections of local Calabi-Yau threefolds \mathcal{O}(m)\oplus \mathcal{O}(-m-2)\to \mathbb{P}^{1}. We develop the 2d \mathcal{N}=2 linear \sigma-model for this class of toric CY^{3}s. Then we use these local backgrounds to study partition function of 4d black holes in type IIA string theory and the underlying q-deformed 2d quiver gauge theories. We also make comments on 4d black holes obtained from D-branes wrapping cycles in \mathcal{O}(\mathbf{m}) \oplus \mathcal{O}(\mathbf{-m-2}%) \to \mathcal{B}_{k} with \mathbf{m=}(m_{1},...,m_{k}) a k-dim integer vector and \mathcal{B}_{k} a compact complex one dimension base consisting of the intersection of k 2-spheres S_{i}^{2} with generic intersection matrix I_{ij}. We give as well the explicit expression of the q-deformed path integral measure of the partition function of the 2d quiver gauge theory in terms of I_{ij}.Comment: 36 pages, latex, 9 figures. References adde

Generalized MacMahon G(q) as q-deformed CFT Correlation Function

Using $\Gamma_{\pm}(z)$ vertex operators of the $c=1$ two dimensional conformal field theory, we give a 2d-quantum field theoretical derivation of the conjectured d- dimensional MacMahon function G$_{d}(q)$. We interpret this function G$_{d}(q)$ as a $(d+1)$- point correlation function $\mathcal{G}_{d+1}(z_{0},...,z_{d})$ of some local vertex operators $\mathcal{O}$. We determine these operators and show that they are particular composites of q-deformed hierarchical vertex operators $_{\pm}^{(p)}$, with a positive integer p. In agreement with literature's results, we find that G$_{d}(q)$, $d\geq 4$, cannot be the generating functional of all \textit{d- dimensional} generalized Young diagrams .Comment: 35 pages, Appendix B shortened, references updated, To appear in NP

Topological String on Toric CY3s in Large Complex Structure Limit

We develop a non planar topological vertex formalism and we use it to study the A-model partition function $\mathcal{Z}_{top}$ of topological string on the class of toric Calabi-Yau threefolds (CY3) in large complex structure limit. To that purpose, we first consider the $T^{2}\times R$ special Lagrangian fibration of generic CY3-folds and we give the realization of the class of large $\mu$ toric CY3-folds in terms of supersymmetric gauged linear sigma model with \emph{non zero} gauge invariant superpotentials $)$. Then, we focus on a one complex parameter supersymmetric $U(1)$ gauged model involving six chiral superfields ${\Phi_{i}}$ with $\mathcal{W}=\mu (\prod\nolimits_{i=0}^{5}\Phi_{i})$ and we use it to compute the function $\mathcal{Z}_{top}$ for the case of the local elliptic curve in the limit $\mu \to \infty$.Comment: Latex, 38 pages, 12 figures. To appear in Nucl Phys

On Black Hole Effective Potential in 6D/7D N=2 Supergravity

Using the harmonic superspace method and the duality between real and complex representations of hypermultiplets, we compute the explicit scalar field expression of the quaternionic metric $G_{mn}$ of the moduli space SO(1,1)x[SO(4,k)/(SO(4)xSO(k))] of 6D N=2 supergravity with generic k Maxwell supermultiplets. The obtained metric includes the particular case k=20 associated with 10D type IIA superstring on K3. Uplifting to 7D N=2 supergravity is described and aspects of 6D/7D black attractor effective potentials are studied.Comment: 49 pages, To appear in NP

Deep Brain Stimulation in Moroccan Patients With Parkinson's Disease: The Experience of Neurology Department of Rabat

Introduction: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is known as a therapy of choice of advanced Parkinson's disease. The present study aimed to assess the beneficial and side effects of STN DBS in Moroccan Parkinsonian patients.Material and Methods: Thirty five patients underwent bilateral STN DBS from 2008 to 2016 in the Rabat University Hospital. Patients were assessed preoperatively and followed up for 6 to 12 months using the Unified Parkinson's Disease Rating Scale in four conditions (stimulation OFF and ON and medication OFF and ON), the levodopa-equivalent daily dose (LEDD), dyskinesia and fluctuation scores and PDQ39 scale for quality of life (QOL). Postoperative side effects were also recorded.Results: The mean age at disease onset was 42.31 ± 7.29 years [28–58] and the mean age at surgery was 54.66 ± 8.51 years [34–70]. The median disease duration was 11.95 ± 4.28 years [5–22]. Sixty-three percentage of patients were male. 11.4% of patients were tremor dominant while 45.71 showed akinetic-rigid form and 42.90 were classified as mixed phenotype. The LEDD before surgery was 1200 mg/day [800-1500]. All patients had motor fluctuations whereas non-motor fluctuations were present in 61.80% of cases. STN DBS decreased the LEDD by 51.72%, as the mean LEDD post-surgery was 450 [188-800]. The UPDRS-III was improved by 52.27%, dyskinesia score by 66.70% and motor fluctuations by 50%, whereas QOL improved by 27.12%. Post-operative side effects were hypophonia (2 cases), infection (3 cases), and pneumocephalus (2 cases).Conclusion: Our results showed that STN DBS is an effective treatment in Moroccan Parkinsonian patients leading to a major improvement of the most disabling symptoms (dyskinesia, motor fluctuation) and a better QOL