SORVEGLIANZA DI UNA EPIDEMIA DA E. FAECIUMVANCOMICINA RESISTENTE (VRE) IN SETTE REPARTI DELL'OSPEDALE DI LEGNANO.

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Central hyperthermia, brain hyperthermia and low hypothalamus temperature

Introduction, Patients and Methods: We measured brain temperature in a case of central hyperthermia. Results Brain temperature was increased except for hypothalamus that was colder. Conclusion: We suppose that central hyperthermia is driven by cold hypothalamus

Early peripheral nerve abnormalities in impaired glucose tolerance

Increased prevalence of impaired glucose tolerance (IGT) has been recently detected in patients with painful sensory neuropathy. To determine whether nerve abnormalities are present in IGT, we investigated IGT subjects without clinical neuropathy. Nerve conduction studies (NCS) were performed in 12 subjects with IGT without symptoms and signs of neuropathy. The results were compared with those obtained from 12 patients with type 2 diabetes (DM) without clinical neuropathy and 12 healthy controls. Sensory NCS of the sural nerve were performed on different segments, the distal-leg (10 cm proximal to the lateral malleolus) and the proximal-leg segment (10 cm more proximal). The distal conduction velocity of the sural nerve was increased in IGT subjects, compared both to healthy controls and DM patients. No difference was found among the groups with respect to the sensory conduction velocity of the sural nerve fibers in the proximal-leg segment. A reduction of both distal and proximal amplitudes of the sural nerve action potentials was detected in DM patients compared with IGT subjects and controls. The abnormal conduction velocity in the distal segment of the sural nerve, observed in IGT subjects without clinical neuropathy, suggests that the myelin dysfunction of the distal sensory fibers represents the earliest detectable nerve response to the hYperglycemia. The reduced amplitude of the sural nerve action potential in asymptomatic patients with DM arises ftom the axonal degeneration and represents a more advanced stage of nerve disease

3-Oxo-hexahydro-1H-isoindole-4-carboxylic acid as a drug chiral bicyclic scaffold and its application to the preparation of conformationally constrained covalent and non-covalent prolyl oligopeptidase inhibitors.

Bicyclic chiral scaffolds are privileged motifs in medicinal chemistry. Over the years, we have reported covalent bicyclic prolyl oligopeptidase inhibitors that were highly selective for POP over a number of homologous proteins. Herein, we wish to report the structure-based design and synthesis of a novel class of POP inhibitors based on hexahydroisoindoles. A docking study guided the selection of structures for synthesis. The stereochemistry, decoration, and position within the molecule of the bicyclic scaffolds were assessed virtually. Following the synthesis of the best candidates, in vitro assays revealed that one member of this chemical series was more active than any of our previous inhibitors with a Ki of 1.0 nM. Additional assays also showed that the scaffold of this potent inhibitor, in contrast to one of our previously reported chemical series, is highly metabolically stable, despite the foreseen potential sites of metabolism. Interestingly, computer docking calculations accurately predicted the optimal features of the inhibitors

Shortening of the axial zone, pyrenees: Shortening sequence, upper crustal mylonites and crustal strength

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