Developing Primary Liaison Psychiatric Services for HIV/AIDS Patients in Community

In Indonesia, the number of HIV/AIDS patients has grown at significant level. HIV can be a source of major stress which can lead to changes in mental health, such as persistent sadness, feeling empty and anxiety. The ability of liaison officer could help patients reduce their psychiatric problems and at the same time it can greatly affect patients' risks for transmission of HIV to others. This study aimed to analyze the effect of developing primary liaison psychiatric services for HIV/AIDS patients on the abilities of health care workers to provide treatments. This study used a quasi experimental design with one group pretest-posttest which included 64 health care workers aged between 20 and 50 years from the Community-Integrated Health Care in East Java. The inclusion criteria were nurses and physician in Community-Integrated Health Care. The respondents were assessed using the Abilities of Health Care Workers Checklist pre-treatment and post-treatment. The outcomes were analyzed using the Wilcoxon signed rank test. There was a significant increased in the abilities of health care workers to provide psychiatric services after treatment (p<0.05). The liaison psychiatric services were considered to be effective in increasing the abilities of health care workers in improving the treatment of HIV/AIDS

Pengaruh Terapi Sleep Hygiene Terhadap Gangguan Tidur Pada Anak Usia Sekolah Yang Menjalani Hospitalisasi

Gangguan tidur merupakan masalah yang sering muncul pada populasi anak usia sekolah yang menjalani hospitalisasi. Pemenuhan kebutuhan istirahat dan tidur penting untuk mendapatkan energi demi memulihkan status kesehatan. Terapi sleep hygiene sebagai salah satu terapi non-farmakologis gangguan tidur mempromosikan pembentukan rutinitas tidur, pola tidur yang baik dan tidur berkualitas. Penelitian ini bertujuan untuk mengetahui pengaruh terapi sleep hygiene terhadap gangguan tidur pada anak usia sekolah yang menjalani hospitalisasi. Penelitian semu dengan desain non-equivalent control pre test-post test dilakukan pada 16 responden kelompok kontrol dan intervensi dengan memberikan intervensi sleep hygiene pada kelompok intervensi. Analisis uji T dependen menunjukkan hasil signifikan (p=0,002) pada kelompok intervensi dan uji T independen menunjukkan nilai signifikan pada post test (p=0,002). Kesimpulan penelitian ini adalah terdapat pengaruh terapi sleep hygiene terhadap gangguan tidur pada anak usia sekolah yang menjalani hospitalisasi secara nyata

Modelling of 4WD vehicle driveability during tip-in/tip-out events

This paper describes a modelling method to investigate the dynamic behaviour of 4WD vehicle under a severe driving condition, where the driver applies a rapid tip-in on the accelerator pedal in 2nd gear to achieve maximum engine torque. This is followed by a tip-out event by releasing the accelerator quickly. The Tip-In/Tip-Out events are one of important elements to assess the vehicle driveability. During these test events, the vehicle is expected to generate low frequency vibration between 2 Hz and 10 Hz and gives discomfort feelings induced by resonance effects on sensitive human organs. The aim of this paper is to develop a 4WD vehicle model in a modern object-oriented multi-body simulation tool and study its driveability

Initial B Cell Activation Induces Metabolic Reprogramming and Mitochondrial Remodeling.

B lymphocytes provide adaptive immunity by generating antigen-specific antibodies and supporting the activation of T cells. Little is known about how global metabolism supports naive B cell activation to enable an effective immune response. By coupling RNA sequencing (RNA-seq) data with glucose isotopomer tracing, we show that stimulated B cells increase programs for oxidative phosphorylation (OXPHOS), the tricarboxylic acid (TCA) cycle, and nucleotide biosynthesis, but not glycolysis. Isotopomer tracing uncovered increases in TCA cycle intermediates with almost no contribution from glucose. Instead, glucose mainly supported the biosynthesis of ribonucleotides. Glucose restriction did not affect B cell functions, yet the inhibition of OXPHOS or glutamine restriction markedly impaired B cell growth and differentiation. Increased OXPHOS prompted studies of mitochondrial dynamics, which revealed extensive mitochondria remodeling during activation. Our results show how B cell metabolism adapts with stimulation and reveals unexpected details for carbon utilization and mitochondrial dynamics at the start of a humoral immune response

Electronic structure of spin 1/2 Heisenberg antiferromagnetic systems: Ba_2Cu(PO_4)_2 and Sr_2Cu(PO_4)_2

We have employed first principles calculations to study the electronic structure and magnetic properties of the low-dimensional phosphates, Ba2Cu(PO4)2 and Sr2Cu(PO4)2. Using the self-consistent tight-binding lin- earized muffin-tin orbital method and the Nth order muffin-tin orbital method, we have calculated the various intrachain as well as the interchain hopping parameters between the magnetic ions Cu2+ for both the com- pounds. We find that the nearest-neighbor intrachain hopping t is the dominant interaction suggesting the compounds to be indeed one dimensional. Our analysis of the band dispersion, orbital projected band struc- tures, and the hopping parameters confirms that the Cu2+-Cu2+ super-super exchange interaction takes place along the crystallographic b direction mediated by O-P-O. We have also analyzed in detail the origin of short-range exchange interaction for these systems. Our ab initio estimate of the ratio of the exchange inter- action of Sr2Cu(PO4)2 to that of Ba2Cu(PO4)2 compares excellently with available experimental results.Comment: 6 pages, 4 figure

Shuffle frequency migration of 4WD vehicle

This paper explains the method to examine the driveability of Four Wheels Drive vehicle. One of key elements to assess the vehicle driveability is to expose the vehicle under harsh driving conditions such as feeding the crankshaft with wide open throttle torque within a short period of time. As a result of this abrupt torque excitation, the vehicle is expected to generate low frequency responses and deliver discomfort feelings induced by resonance effects on sensitive human organs. Understanding the interaction across vehicle component levels is imperative to address the root cause of driveability issues. Frequency migration analysis was carried out to determine the prevailing factors and sub-system components that control this occurrence. Matrices consisting of a range of frequencies have been structured and analysed to precisely pinpoint the sensitivity of vehicle shuffle frequency migration based on different operating mode

Dissipation enhanced vibrational sensing in an olfactory molecular switch

Motivated by a proposed olfactory mechanism based on a vibrationally-activated molecular switch, we study electron transport within a donor-acceptor pair that is coupled to a vibrational mode and embedded in a surrounding environment. We derive a polaron master equation with which we study the dynamics of both the electronic and vibrational degrees of freedom beyond previously employed semiclassical (Marcus-Jortner) rate analyses. We show: (i) that in the absence of explicit dissipation of the vibrational mode, the semiclassical approach is generally unable to capture the dynamics predicted by our master equation due to both its assumption of one-way (exponential) electron transfer from donor to acceptor and its neglect of the spectral details of the environment; (ii) that by additionally allowing strong dissipation to act on the odorant vibrational mode we can recover exponential electron transfer, though typically at a rate that differs from that given by the Marcus-Jortner expression; (iii) that the ability of the molecular switch to discriminate between the presence and absence of the odorant, and its sensitivity to the odorant vibrational frequency, are enhanced significantly in this strong dissipation regime, when compared to the case without mode dissipation; and (iv) that details of the environment absent from previous Marcus-Jortner analyses can also dramatically alter the sensitivity of the molecular switch, in particular allowing its frequency resolution to be improved. Our results thus demonstrate the constructive role dissipation can play in facilitating sensitive and selective operation in molecular switch devices, as well as the inadequacy of semiclassical rate equations in analysing such behaviour over a wide range of parameters.Comment: 12 pages, 6 figures, close to published version, comments welcom

Assessment of Menopausal Symptoms During Perimenopause and Postmenopause in Tertiary Care Hospital

Background: Issues related to menopausal symptoms are very complicated in terms of experience, severity, and dynamics of the symptoms. Studies have shown that these symptoms vary among individuals depending on the menopausal stage, ethnicity, geographical location, and other factors. Menopause Rating Scale (MRS) is an effective tool to assess the severity of these symptoms. Aim: This study was done to compare the frequency and severity of menopausal symptoms during peri‑ and postmenopause using the MRS. Subjects and Methods: Ninety‑two perimenopausal women and 95 postmenopausal women who attended Gynecology out patient department ( OPD) for treatment of menopausal complaints were assessed using the MRS questionnaire before starting therapy. Informed consent and ethics committee clearance was obtained prior to the study. Response was recorded and statistical analysis was done using Statistical Package for Social Sciences (SPSS) software version 17.0 (SPSS Inc, Chicago, IL, USA). Result: The mean total MRS score was comparable in both the groups. The mean psychological score was significantly higher in perimenopausal group in comparison to postmenopausal group (P<0.01). The mean urogenital score was higher in postmenopausal women (P < 0.001). Conclusion: Fatigue, depression, anxiety, hot flashes, and sexual disturbances were the common symptoms that appeared first during the perimenopausal phase. As the age advanced and women progressed in the postmenopausal stage, the psychological symptoms of depression, irritability, and sleep disturbances decreased; while the urogenital symptoms, fatigue, and generalized body ache became more prominent.Keywords: Africa, menopause, menopause rating scale, perimenopause, postmenopause, severity of menopausal symptom

Interactive time series analytics powered by ONEX

Modern applications in this digital age collect a staggering amount of time series data from economic growth rates to electrical household consumption habits. To make sense of it, domain analysts interactively sift through these time series collections in search of critical relationships between and recurring patterns within these time series. The ONEX (Online Exploration of Time Series) system supports effective exploratory analysis of time series collections composed of heterogeneous, variable-length and misaligned time series using robust alignment dynamic time warping (DTW) methods. To assure real-time responsiveness even for these complex and compute-intensive analytics, ONEX precomputes and then encodes time series relationships based on the inexpensive-to-compute Euclidean distance into the ONEX base. Thereafter, based on a solid formal foundation, ONEX uses DTW-enhanced analytics to correctly extract relevant time series matches on this Euclidean-prepared ONEX base. Our live interactive demonstration shows how our ONEX exploratory tool, supported by a rich array of visual interactions and expressive visualizations, enables efficient mining and interpretation of the MATTERS real data collection composed of economic, social, and education data trends across the fifty American states. © 2017 ACM