Knowledge Diffusion in R&D Groups: The Impact of Internet Technologies

判型：B5，昭和55年7月12

Knowledge Diffusion in R&D Groups: The Impact of Internet Technologies

Knowledge flows are the lifeblood of any R&D organisation. These firms are increasingly discovering that the knowledge they require is often located beyond their boundaries. In this paper, we investigate how R&D groups acquire and diffuse external knowledge and the role Internet technologies play in this process. The focus of our study is on the technological gatekeeper. Previous studies have found that gatekeepers are key nodes in the innovation process. These sporadic individuals have the skills to identify useful knowledge outside the firm and disseminate this among their local colleagues. However, much of the seminal gatekeeper research has been conducted over two decades ago. In the time since, there have been huge advances in ICT and especially Internet technologies. These technologies have dramatically altered how knowledge workers source and share their information. Our objective is to advance the gatekeeper theory into an era where the knowledge worker is saturated with information. Using case study methods, we examine knowledge flows in the R&D group of an Irish medical devices firm. Our results indicate that due to advances in Internet technology, the traditional gatekeeper no longer exists to any great extent. Instead, the modern R&D lab acquires and diffuses external knowledge through a combination of a ‘web gatekeeper’ and a ‘knowledge transformer.

Measurements and Variability of Arterial Blood Pressure and Heart Interval in Conscious and Anesthetized Dogs

No abstract availabl

Strong Coupling Corrections to the Ginzburg-Landau Theory of Superfluid ^{3}He

In the Ginzburg-Landau theory of superfluid $^{3}$He, the free energy is expressed as an expansion of invariants of a complex order parameter. Strong coupling effects, which increase with increasing pressure, are embodied in the set of coefficients of these order parameter invariants\cite{Leg75,Thu87}. Experiments can be used to determine four independent combinations of the coefficients of the five fourth order invariants. This leaves the phenomenological description of the thermodynamics near $T_{c}$ incomplete. Theoretical understanding of these coefficients is also quite limited. We analyze our measurements of the magnetic susceptibility and the NMR frequency shift in the $B$-phase which refine the four experimental inputs to the phenomenological theory. We propose a model based on existing experiments, combined with calculations by Sauls and Serene\cite{Sau81} of the pressure dependence of these coefficients, in order to determine all five fourth order terms. This model leads us to a better understanding of the thermodynamics of superfluid $^{3}$He in its various states. We discuss the surface tension of bulk superfluid $^{3}$He and predictions for novel states of the superfluid such as those that are stabilized by elastic scattering of quasiparticles from a highly porous silica aerogel.Comment: 9 pages, 7 figures, 2 table

AVEC 2011 – the first international Audio/Visual Emotion Challenge

Abstract. The Audio/Visual Emotion Challenge andWorkshop (AVEC 2011) is the first competition event aimed at comparison of multimedia processing and machine learning methods for automatic audio, visual and audiovisual emotion analysis, with all participants competing under strictly the same conditions. This paper first describes the challenge par-ticipation conditions. Next follows the data used – the SEMAINE corpus – and its partitioning into train, development, and test partitions for the challenge with labelling in four dimensions, namely activity, expectation, power, and valence. Further, audio and video baseline features are intro-duced as well as baseline results that use these features for the three sub-challenges of audio, video, and audiovisual emotion recognition

A Conscious Porcine Model for Sudden Cardiac Death

No abstract availabl

Concentration Dependence of the Effective Mass of He-3 Atoms in He-3/He-4 Mixtures

Recent measurements by Yorozu et al. (S. Yorozu, H. Fukuyama, and H. Ishimoto, Phys. Rev. B 48, 9660 (1993)) as well as by Simons and Mueller (R. Simons and R. M. Mueller, Czhechoslowak Journal of Physics Suppl. 46, 201 (1976)) have determined the effective mass of He-3 atoms in a He-3/He-4 mixture with great accuracy. We here report theoretical calculations for the dependence of that effective mass on the He-3 concentration. Using correlated basis functions perturbation theory to infinite order to compute effective interactions in the appropriate channels, we obtain good agreement between theory and experiment.Comment: 4 pages, 1 figur

Assessment of Canine \u3cem\u3eBEST1\u3c/em\u3e Variations Identifies New Mutations and Establishes an Independent Bestrophinopathy Model (\u3cem\u3ecmr3\u3c/em\u3e)

Purpose: Mutations in bestrophin 1 (BEST1) are associated with a group of retinal disorders known as bestrophinopathies in man and canine multifocal retinopathies (cmr) in the dog. To date, the dog is the only large animal model suitable for the complex characterization and in-depth studies of Best-related disorders. In the first report of cmr, the disease was described in a group of mastiff-related breeds (cmr1) and the Coton de Tulear (cmr2). Additional breeds, e.g., the Lapponian herder (LH) and others, subsequently were recognized with similar phenotypes, but linked loci are unknown. Analysis of the BEST1 gene aimed to identify mutations in these additional populations and extend our understanding of genotype–phenotype associations. Methods: Animals were subjected to routine eye exams, phenotypically characterized, and samples were collected for molecular studies. Known BEST1 mutations were assessed, and the canine BEST1 coding exons were amplified and sequenced in selected individuals that exhibited a cmr compatible phenotype but that did not carry known mutations. Resulting sequence changes were genotyped in several different breeds and evaluated in the context of the phenotype. Results: Seven novel coding variants were identified in exon 10 of cBEST1. Two linked mutations were associated with cmr exclusive to the LH breed (cmr3). Two individuals of Jämthund and Norfolk terrier breeds were heterozygous for two conservative changes, but these were unlikely to have disease-causing potential. Another three substitutions were found in the Bernese mountain dog that were predicted to have a deleterious effect on protein function. Previously reported mutations were excluded from segregation in these populations, but cmr1 was confirmed in another mastiff-related breed, the Italian cane corso. Conclusions: A third independent canine model for human bestrophinopathies has been established in the LH breed. While exhibiting a phenotype comparable to cmr1 and cmr2, the novel cmr3 mutation is predicted to be based on a distinctly different molecular mechanism. So far cmr2 and cmr3 are exclusive to a single dog breed each. In contrast, cmr1 is found in multiple related breeds. Additional sequence alterations identified in exon 10 of cBEST1 in other breeds exhibit potential disease-causing features. The inherent genetic and phenotypic variation observed with retinal disorders in canines is complicated further by cmr3 being one of four distinct genetic retinal traits found to segregate in LH. Thus, a combination of phenotypic, molecular, and population analysis is required to establish a strong phenotype–genotype association. These results indicate that cmr has a larger impact on the general dog population than was initially suspected. The complexity of these models further confirms the similarity to human bestrophinopathies. Moreover, analyses of multiple canine models will provide additional insight into the molecular basis underlying diseases caused by mutations in BEST1