Association of characteristics of delivery and medical conditions during the first month of life with developmental defects of enamel.

BACKGROUND: Developmental defects of enamel (DDE) may be influenced by health problems and illness in children. The aim of the study was to identify the main characteristics of birth (delivery) and adverse medical conditions during the first month of life that may be related to DDE in permanent teeth. METHODS: 1000 schoolchildren between the ages of 9 and 11 years were selected for this cross-sectional study by multistage randomization from four educational zones in Shiraz in 2013. Intraoral examination was used to diagnose DDE according to World Health Organization screening guidelines and the Modified DDE Index. The data on seven birth factors as well as health and nutritional conditions during the first month of life were collected by a questionnaire completed by the parents, and were analyzed with the chi-squared test, Spearman's correlation and binary logistic regression. RESULTS: 469 (48.2%) out of 974 schoolchildren had at least one permanent tooth with DDE. The defects were significantly related with Apgar score at birth <7 (p = 0.003) and illness during the first month (p = 0.035). The frequency of DDE was significantly lower in the third child in families compared to the first and second child (p = 0.005). However, DDE showed no significant relationship with gestational age, delivery type, birth weight, gender or type of feeding during early infancy. CONCLUSIONS: Three associated factors were identified (birth Apgar score, illness during the first month of life, birth order) for DDE in permanent teeth. No specific illness was found to be significantly associated with DDE

Acoustic phonon scattering in a low density, high mobility AlGaN/GaN field effect transistor

We report on the temperature dependence of the mobility, $\mu$, of the two-dimensional electron gas in a variable density AlGaN/GaN field effect transistor, with carrier densities ranging from 0.4$\times10^{12}$ cm$^{-2}$ to 3.0$\times10^{12}$ cm$^{-2}$ and a peak mobility of 80,000 cm$^{2}$/Vs. Between 20 K and 50 K we observe a linear dependence $\mu_{ac}^{-1} = \alpha$T indicating that acoustic phonon scattering dominates the temperature dependence of the mobility, with $\alpha$ being a monotonically increasing function of decreasing 2D electron density. This behavior is contrary to predictions of scattering in a degenerate electron gas, but consistent with calculations which account for thermal broadening and the temperature dependence of the electron screening. Our data imply a deformation potential D = 12-15 eV.Comment: 3 pages, 2 figures, RevTeX. Submitted to Appl Phys Let

An eigenvalue-eigenvector method for solving a system of fractional differential equations with uncertainty

A new method is proposed for solving systems of fuzzy fractional differential equations (SFFDEs) with fuzzy initial conditions involving fuzzy Caputo differentiability. For this purpose, three cases are introduced based on the eigenvalue-eigenvector approach; then it is shown that the solution of system of fuzzy fractional differential equations is vector of fuzzy-valued functions. Then the method is validated by solving several examples

The effects of a Severn Barrage on wave conditions in the Bristol Channel

The study investigates the impact that construction of a Severn Barrage in the Severn Estuary, on the west coast of the UK, might have on local wave conditions. Implementation of a barrage will impact on tidal currents and water elevations in the wider region. There is strong tidal modulation of wave conditions under the natural regime and therefore barrage-induced changes to tidal conditions could affect wave modulation in the region. This paper uses Swan, an open source 3rd generation spectral wave model, to investigate the possible impacts of construction of a barrage on tidal modulation of the wave conditions. It is found that current variations, rather than water level variations, are the dominant factor in tidal modulation of wave conditions. Barrage implementation does not substantially change the modulation of the wave period or direction. However, barrage implementation does affect the tidal modulation of wave heights in the area of interest. The tidal modulation of the wave heights is generally reduced compared to the natural case; the peaks in the wave heights on an incoming tide are slightly lowered and there is lesser attenuation in wave heights on the outgoing tide. This modulation leads to net changes in the wave heights over one tidal cycle. For all of the tested wave conditions, this net change is small for the majority of the tested domain, namely to within ±5% of the no barrage case. There are some areas of greater change, most notably larger net increases in the wave heights near the North Somerset coast where the post-construction net wave height increase over a tidal cycle approach 20% of the pre-construction conditions. These changes do not impact coastal flooding because the wave height increase is not co-incident with high tide. Importantly, the maximum wave height is not increased and thus the likelihood of extreme events is not increased. The area of greatest reduction is between Swansea and Porthcawl. Changes over a neap tidal cycle show similar patterns of net change, but the modulation over the tidal cycle is different; primarily the magnitude of modulation is half that for the spring tide case and the shape is altered in some locations

Prioritizing barriers to successful implementation of hospital information systems.

Hospital information systems (HIS) are often implemented to enhance the quality of care, as well as to improve the efficiency and safety of health care services. However, there are various barriers for their successful implementation. The aim of this paper is to prioritize these barriers. This research is a cross sectional analytic-descriptive study. The study populations were hospital managers, IT department administrators, and clinical supervisors at the academic and non-academic hospitals of two cities in Iran. The data was collected by a questionnaire that its content validity was confirmed by three specialists. Its reliability was confirmed using Cronbach's alpha (α = 0.78). Questionnaire contained five dimensions and 39 implementation barriers. The collected data was analyzed by descriptive and analytical statistics using the Kendall Rank Correlation Coefficient and Chi2 tests. The findings of the study revealed that lack of powerful information networks, error in data entry, technical problems related to system design, lack of organizational training, lack of users' knowledge about system and working with it, and negative attitudes of providers and patients toward systems are the most important barriers of HIS implementation. Prioritizing of these barriers helps policy makers to decide what to do when planning for HIS utilization

A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis.

The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute inhibition of IKK-ε and TBK1 with amlexanox treatment increases cAMP levels in subcutaneous adipose depots of obese mice, promoting the synthesis and secretion of the cytokine IL-6 from adipocytes and preadipocytes, but not from macrophages. IL-6, in turn, stimulates the phosphorylation of hepatic Stat3 to suppress expression of genes involved in gluconeogenesis, in the process improving glucose handling in obese mice. Preliminary data in a small cohort of obese patients show a similar association. These data support an important role for a subcutaneous adipose tissue-liver axis in mediating the acute metabolic benefits of amlexanox on glucose metabolism, and point to a new therapeutic pathway for type 2 diabetes

An Investigation on the Nonlinear Free Vibration Analysis of Beams with Simply Supported Boundary Conditions Using Four Engineering Theories

The objective of this study is to present a brief survey on the geometrically nonlinear free vibrations of the Bernoulli-Euler, the Rayleigh, shear, and the Timoshenko beams with simple end conditions using the Homotopy Analysis Method (HAM). Expressions for the natural frequencies, the transverse deflection, postbuckling load-deflection relation to, and critical buckling load are presented. The results of nonlinear analysis are validated with the published results, and excellent agreement is observed. The effects of some parameters, such as slender ratio, the rotary inertia, and the shear deformation, are examined as other parameters are fixed

The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration

Chemotherapy is one of the pillars of anti-cancer therapy. Although chemotherapeutics cause regression of the primary tumor, many chemotherapeutics are often shown to induce or accelerate metastasis formation. Moreover, metastatic tumors are largely resistant against chemotherapy. As more than 90% of cancer patients die due to metastases and not due to primary tumor formation, novel drugs are needed to overcome these shortcomings. In this study, we identified the anticancer phytochemical Rocaglamide (Roc-A) to be an inhibitor of cancer cell migration, a crucial event in metastasis formation. We show that Roc-A inhibits cellular migration and invasion independently of its anti-proliferative and cytotoxic effects in different types of human cancer cells. Mechanistically, Roc-A treatment induces F-actin-based morphological changes in membrane protrusions. Further investigation of the molecular mechanisms revealed that Roc-A inhibits the activities of the small GTPases RhoA, Rac1 and Cdc42, the master regulators of cellular migration. Taken together, our results provide evidence that Roc-A may be a lead candidate for a new class of anticancer drugs that inhibit metastasis formation