MEDIA PASINAON VIDEO TUTORIAL LANCARAN MAYAR SEWU LAN GUGUR GUNUNG BERBASIS WEB KANGGE MAHASISWA PENDIDIKAN BAHASA DAERAH FAKULTAS BAHASA DAN SENI UNIVERSITAS NEGERI YOGYAKARTA

Ancasing panaliten menika, inggih menika: (1) ngandharaken tahap-tahap damel media pasinaon Video Tutorial Lancaran Manyar Sewu Lan Lancaran Gugur Gunung Berbasis Web Kangge Mahasiswa Pendidikan Bahasa Daerah Fakultas Bahasa Dan Seni Universitas Negeri Yogyakarta; (2) ngandharaken kualitas media pasinaon Video Tutorial Lancaran Manyar Sewu Lan Lancaran Gugur Gunung Berbasis Web Kangge Mahasiswa Pendidikan Bahasa Daerah Fakultas Bahasa Dan Seni Universitas Negeri Yogyakarta dening dosen ahli materi saha dosen ahli media; (3) ngandharaken pamanggihipun Dosen Basa Jawi sarta Mahasiswa babagan media pasinaon Video Tutorial Lancaran Manyar Sewu Lan Lancaran Gugur Gunung Berbasis Web babagan penyajian materi saha tampilan produk. Panaliten menika kalebet jinis panaliten Research and Development (R&D). Kanthi tahap analysis, design, development, implementation, sarta evaluation. Produk media menika dipunevaluasi dening dosen ahli materi saha dosen ahli media mawi validasi dumugi pikantuk kualitas media ingkang sae saha layak dipunuji coba wonten ing sekolah. Asiling panaliten nedahaken bilih cak-cakanipun damel media pasinaon kaperang dados gangsal tataran. Tataran ingkang sepisan inggih menika analisis kurikulum, kabetahan Mahasiswa, saha wawancara Dosen. Tataran kaping kalih inggih menika damel design media pasinaon kanthi ngempalaken referensi saha damel Bagan saha Planning Materi. Tataran kaping tiga inggih menika nyuwun validasi dening dosen ahli materi saha dosen ahli media dumugi pikantuk pasarujukan kangge uji coba. Tataran kaping sekawan inggih menika uji coba media pasinaon dhateng sekolah. Tataran kaping gangsal evaluasi media pasinaon. Wondene kualitas media saking dosen ahli materi pikantuk rata-rata presentase biji 82% ingkang kagolong sae sanget. Pambiji kualitas media dening dosen ahlli media pikantuk rata-rata presentase biji 88% ingkang kagolong sae sanget. Wondene pamanggih Dosen Basa Jawi ngengingi leresipun konsep saha kompetensi saha kualitas tampilan media menika pikantuk rata-rata presentase 96% ingkang kagolong sae sanget. Asiling angket pamanggih Mahasiswa tumrap panganggenipun media pasinaon menika saged narik kawigatosan Mahasiswa

Analisis Tata Kelola Seni Pertunjukan di Taman Budaya Yogyakarta

Pandemik covid-19 berdampak besar terhadap penyelenggaraan seni pertunjukan di Taman Budaya Yogyakarta. Penelitian ini bertujuan untuk mendeskripsikan tata kelola seni pertunjukan di Taman Budaya Yogyakarta pada masa pandemik covid-19. Penelitian ini merupakan penelitian deskriptif kualitatif fenomenologi. Sasaran penelitian adalah UPT Taman Budaya Yogyakarta. Informan terdiri dari enam orang yaitu Kepala UPT, Seksi Penyajian dan Pengembangan Seni Budaya, Seksi Dokumentasi dan Informasi Seni Budaya, serta tiga seniman. Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Analisis data menggunakan analisis deskriptif dengan cara reduksi data, penyajian data, penarikan kesimpulan/verifikasi. Hasil penelitian pada Perencanaan mengacu program dari pemerintah daerah sebagai kegiatan rutin, ditambah dengan pertunjukan melalui seleksi proposal dari masyarakat, penyusunan program dengan adaptasi kebutuhan media pada masa pandemik covid-19. Pengorganisasian dan Pengawasan dilaksanakan sesuai dengan perencanaan, pola hubungan dilaksanakan secara kerja sama lintas seksi sesuai dengan tugas dan fungsi. Pengawasan di bawah seksi bidang penyajian dan pengembangan seni budaya serta seksi bidang dokumentasi dan publikasi. Beberapa hambatan ditemukan mulai dari peralatan, serta keterbatasan SDM. Evaluasi dilakukan setiap program berjalan, laporan langsung kepada Kepala Taman Budaya Yogyakarta dalam bentuk LPJ. Tindak lanjut berupa pengembangan inovasi program seperti peralatan daring bekerja sama dengan pihak luar dan inovasi program kepada kalangan disabilitas walaupun masih banyak keterbatasan. Analysis of Governance in the Performing Arts Culture Yogyakarta ABSTRACT The covid-19 pandemic has significantly impacted the implementation of performing arts at Taman Budaya Yogyakarta. This study aims to describe the governance of performing arts in Taman Budaya Yogyakarta during the covid-19 pandemic. This research is a qualitative descriptive research of phenomenology. The target of the study was UPT Taman Budaya Yogyakarta. The informants comprised six: the Head of UPT, the Cultural Arts Presentation and Development Section, the Cultural Arts Documentation and Information Section, and three artists. Data collection techniques use observation, interview, and documentation techniques. Data analysis uses descriptive data reduction, presentation, and concluding/verification. The results of this research are on Planning to refer to programs from local governments as routine activities, coupled with performances through the selection of proposals from the community and preparation of programs adapting to media needs during the covid-19 pandemic. Organizing and supervision are carried out by planning, and the pattern of relationships is carried out in cross-sectional cooperation following duties and functions, supervised under the section in the field of presentation and development of cultural arts and the section in the field of documentation and publications. Several obstacles were found, ranging from equipment to limited human resources. Evaluation is carried out every running program, a direct report to the head of Taman Budaya Yogyakarta in the form of LPJ. Follow-up is in the form of developing program innovations such as online equipment in collaboration with outside parties and program innovations for people with disabilities, although there are still many limitations

Mobility-shift-Affinitätskapillarelektrophorese zur Untersuchung von Protein-Metallionen-Wechselwirkungen: Aspekte der Methodenentwicklung, -validierung und des High-Throughput-Screenings

Approximately one third of all proteins are metalloproteins, which means the metal ions are important for their biological functions. Therefore, investigation and characterization of interactions between proteins and metal ions are interesting. Several techniques can be used for these purposes. Mobility shift-affinity capillary electrophoresis has been selected over the other techniques due to its rapid analysis, small injection volume (nano-level), high separation efficiency, direct injection of impure samples and the ability to perform under physiological-like conditions. In order to facilitate the implementation of a mobility shift-affinity capillary electrophoresis method into routine binding studies, method acceleration, transfer and precision improvement were investigated. The mobility shift-affinity capillary electrophoresis method was successfully accelerated by using shorter capillaries, lower sample concentrations and smaller injection volumes. Fast run time of 4 min has been achieved. The precision of results was enhanced by slightly pushing the sample into the capillary, refreshing the buffer vials after each 30 runs and employing extra flushing after each 60 subsequent runs and using 0.1 M EDTA within the rinsing protocols. The accelerated mobility shift-affinity capillary electrophoresis method has been successfully applied for the interaction study of Li+, Na+, Mg2+, Ca2+, Ba2+, Al3+, Ga3+, La3+, Pd2+, Ir3+, Ru3+, Rh3+, Pt2+, Pt4+, Os3+, Au3+, Au+, Ag+, Cu+, Cu2+, Fe2+, Fe3+, Co2+, Ni2+, Cr3+, V3+, MoO42- and SeO32- with bovine serum albumin, β-lactoglobulin, human serum albumin, myoglobin and ovalbumin. Excellent precision for mobility ratios was achieved for all protein-metal ion interactions (RSD% of 0.05-1.0%, n > 324). The calculated normalized difference of mobility ratio and its sign (positive and negative) for each protein-metal ion interaction have been successfully used to detect the interaction and estimate further coordination of the bound metal ion, respectively. Furthermore, the results were successfully discussed in view of the properties of the metal ions and proteins, and the HSAB concept as well. The comprehensive platform summarizes all the obtained interaction results, and is valuable for any future protein-metal ion investigation.Schätzungsweise ein Drittel aller Proteine sind Metalloproteine, dies bedeutet, dass Metallionen für ihre biologische Funktion von Bedeutung sind. Somit ist die Untersuchung und Charakterisierung der Wechselwirkungen zwischen Proteinen und Metallionen von Interesse. Einige Techniken können für diesen Zweck verwendet werden. Der Mobility-shift-Affinitätskapillarelektrophorese wurde gegenüber anderen Techniken der Vorzug gegeben, da sie kurze Analysenzeiten, Injektionen von geringen Probenvolumina (im Nanoliterbereich), hohe Trennungseffizienz, direkte Injektion von nicht aufgearbeitet Proben und die Möglichkeit unter physiologischen Bedingungen zu arbeiten vereint. Um das Einbinden einer Mobility-shift-Affinitätskapillarelektrophoresemethode in Routinebindungsstudien zu erleichtern, wurden eine Verkürzung der Analysendauer, der Methodentransfer und die Verbesserung der Präzision untersucht. Die Mobility-shift-Affinitätskapillarelektrophoresemethode wurde erfolgreich beschleunigt durch Verkürzen der Kapillare, Verwenden geringerer Probenkonzentrationen und geringerer Probenvolumina. Hierbei wurden kurze Analysezeiten von 4 Minuten erreicht. Die Präzision der Ergebnisse wurden durch ein leichtes Drücken der Probe in die Kapillare nach der Injektion, das Tauschen der Puffergefäße nach 30 Läufen, Einführen eines weiteren Spülschrittes nach 60 aufeinanderfolgenden Läufen und Verwendung von 0.1 M EDTA-Lösungen im Spülprotokoll verbessert. Diese verbesserte Mobility-shift-Affinitätskapillarelektrophoresemethode wurde erfolgreich verwendet um Interaktionsstudien zwischen Li+, Na+, Mg2+, Ca2+, Ba2+, Al3+, Ga3+, La3+, Pd2+, Ir3+, Ru3+, Rh3+, Pt2+, Pt4+, Os3+, Au3+, Au+, Ag+, Cu+, Cu2+, Fe2+, Fe3+, Co2+, Ni2+, Cr3+, V3+, MoO42- und SeO32- mit bovinem Serumalbumin, β-Lactoglobulin, humanem Serumalbumin, Myoglobin und Ovalbumin. Ausgezeichnete Präzision wurde für den Mobilitätsquotienten jeder Protein-Metallionen-Interaktion (RSD% von 0,05-1,0%, n > 324). Die berechnete, normalisierte Differenz der Mobilitätsquotienten und deren Vorzeichen (positiv und negativ) jeder Protein-Metalionen-Interaktion konnten erfolgreich verwendet werden um Interaktionen zu erkennen und die weitere Koordination der Metallionen abzuschätzen. Des Weiteren konnten die Ergebnisse in Hinblick auf die Eigenschaften der Metallionen und Proteine sowie des HSAB-Konzepts erfolgreich diskutiert werden. Die Gesamtübersicht fasst alle erhaltenen Interaktionsergebnisse zusammen und ist wertvoll für zukünftige Protein-Metallionenuntersuchungen

Synthesis of some novel pyrimidine, thiophene, coumarin, pyridine and pyrrole derivatives and their biological evaluation as analgesic, antipyretic and anti-inflammatory agents

Pyrimidine derivative 3 was afforded through the reaction of compound (1) with 5-ureidohydantion (2). Product 3 underwent a cyclization to produce fused pyrimidine derivative 7, although the latter product 7 was synthesized through one step via the reaction of compound (1) with 5-ureidohydantion (2) using another catalyst. Compound 3 was oriented to react with cyclic ketones 8a,b in the presence of elemental sulfur, salicylaldehyde (10), aryldiazonium chlorides 12a,b and ω-bromo-4-methoxy- acetophenone (14), which afforded, fused thiophene derivatives 9a,b, coumarin derivative 11, arylhdrazono derivatives 13a,b and 4-methoxyphenyl butenyl derivative 15, respectively. The latter product 15 was reacted with either potassium cyanide (16a) or potassium thiocyanide (16b) to form cyano and thiocyano derivatives 17a,b, respectively. Compound 17a underwent further cyclization to afford pyridopyrimidine derivative 19. Compound 15 was reacted with either hydrazine (20a) or phenylhydrazine (20b) to produce hydrazo derivatives 21a,b and these products were cyclize to produce pyrrole derivatives 23a,b. Finally, 5-ureidohydantion (2) was reacted with compounds 24a,b,c to afford pyrimidine derivatives 25a,b,c. The structures of the synthesized compounds were confirmed using IR, 1 H NMR, 13C NMR and mass spectrometry techniques. Compounds 11 and 19 have promising as analgesic and antipyretic activities

Barriers and facilitators of weight bearing after hip fracture surgery among older adults. A scoping review

PURPOSE: This scoping review aimed to synthesise the available evidence on barriers and facilitators of weight bearing after hip fracture surgery in older adults. METHODS: Published (Cochrane Central, MEDLINE, EMBASE, CINAHL, and PEDro) and unpublished (Global Health, EThOS, WorldCat dissertation and thesis, ClinicalTrials.gov , OpenAIRE, DART-Europe) evidence was electronically searched from database inception to 29 March 2022. Barriers and facilitators of weight bearing were extracted and synthesised into patient, process (non-surgical), process (surgical), and structure-related barriers/facilitators using a narrative review approach. RESULTS: In total, 5594 were identified from the primary search strategy, 1314 duplicates were removed, 3769 were excluded on title and abstract screening, and 442 were excluded on full-text screening. In total, 69 studies (all from published literature sources) detailing 47 barriers and/or facilitators of weight bearing were included. Of barriers/facilitators identified, 27 were patient-, 8 non-surgical process-, 8 surgical process-, and 4 structure-related. Patient facilitators included anticoagulant, home discharge, and aid at discharge. Barriers included preoperative dementia and delirium, postoperative delirium, pressure sores, indoor falls, ventilator dependence, haematocrit < 36%, systemic sepsis, and acute renal failure. Non-surgical process facilitators included early surgery, early mobilisation, complete medical co-management, in-hospital rehabilitation, and patient-recorded nurses' notes. Barriers included increased operative time and standardised hip fracture care. Surgical process facilitators favoured intramedullary fixations and arthroplasty over extramedullary fixation. Structure facilitators favoured more recent years and different healthcare systems. Barriers included pre-holiday surgery and admissions in the first quarter of the year. CONCLUSION: Most patient/surgery-related barriers/facilitators may inform future risk stratification. Future research should examine additional process/structure barriers and facilitators amenable to intervention. Furthermore, patient barriers/facilitators need to be investigated by replicating the studies identified and augmenting them with more specific details on weight bearing outcomes

Osteopontin as a marker for response to pegylated interferon Alpha-2b treatment in Chronic HCV Saudi patients

Background: Many recent studies support the idea that osteopontin (OPN) can be used to predict the success of pegylated interferon (PEG IFN) alpha-2b/ribavirin therapy in chronic HCV patients.Objective: Our aim was to investigate the role of plasma OPN and its gene polymorphism at nt – 443 in response to PEG IFN in Saudi patients with chronic HCV.Methods: Blood was collected from 87 patients with chronic hepatitis C before treatment, then patients received PEG IFN α2b plus ribavirin combination therapy. Another 25 healthy subjects, matched for age and sex to patients, were enrolled as controls. Single nucleotide polymorphism (SNP) in OPN at nt – 443 and its blood level were analyzed.Results: The frequency of patients who reached sustained virological response (SVR) was increased in patients with T/T at nt – 443 than in those with C/C or C/T. Also the frequency of T allele was increased in responders than in non-responders. However, this increase was not statistically significant. The blood level of OPN was significantly increased in non-responders (Mean±SD=37.21±3.9) in comparison to responders (Mean±SD=33.22±4.1).Conclusion: Osteopontin blood level can be considered as a reliable predictor to PEG IFN α2b plus ribavirin therapy in chronic HCV Saudi Patients.Keywords: OPN, PEG IFN, HCV, SVR, SNP, RT-PC

A novel superframe structure and optimal time slot allocation algorithm for IEEE 802.15.4–based Internet of things

IEEE 802.15.4 standard is specifically designed for a low-rate and low-processing Internet of things (IoT) applications and offers guaranteed time slots. A beacon-enabled IEEE 802.15.4 consists of a superframe structure that comprises of the contention access period and contention-free period. During contention-free period, nodes transfer their data using guaranteed time slots without any collision. The coordinator node receives data transmission requests in one cycle and allocates guaranteed time slots to the nodes in the next cycle. This allocation process may cause large delay that may not be acceptable for few applications. In this work, a novel superframe structure is proposed that significantly reduces guaranteed time slots allocation delay for the nodes with data requests. The proposed superframe structure comprises of two contention access periods and one contention-free period, where contention-free period precedes both contention access periods with reduced slot size. In addition, the knapsack algorithm is modified for better guaranteed time slots allocation by allowing more guaranteed time slots requesting nodes to send their data as compared to the IEEE 802.15.4 standard. The simulation and analytical results show that the proposed superframe structure reduces the network delay by up to 80%, increases contention-free period utilization up to 50%, and allocates guaranteed time slots up to 16 nodes in a single superframe duration. © The Author(s) 2020.1

The Benign Prostatic Hyperplasia and Its Aetiologies

This study aimed at investigating the Benign Prostatic Hyperplasia and Its Aetiologies, therefore th prostatic hyperplasia predominantly involves the stromal compartment of the gland and affects more than 70% of men of 70 years or older with or without obstructive symptoms of benign prostatic hyperplasia. A consensus view is emerging concerning the factors and control systems that modulate cell proliferation and connective tissue biology in the prostate. The purpose of this review is to discuss some of the recent work contributing to the latter in the context of the aetiology of benign prostatic hyperplasia. The current study also reviews the most important findings regarding the key mechanisms involved in the pathophysiology of BPH. The study concluded that although the pathogenesis of BPH is not yet fully understood, several mechanisms seem to be involved in the development and progression of the disease. These mainly include systemic and local hormonal and vascular alterations as well as prostatic inflammation that would stimulate cellular proliferation

Osteopontin as a marker for response to pegylated interferon Alpha-2b treatment in Chronic HCV Saudi patients.

Background: Many recent studies support the idea that osteopontin (OPN) can be used to predict the success of pegylated interferon (PEG IFN) alpha-2b/ribavirin therapy in chronic HCV patients. Objective: Our aim was to investigate the role of plasma OPN and its gene polymorphism at nt \u2013 443 in response to PEG IFN in Saudi patients with chronic HCV. Methods: Blood was collected from 87 patients with chronic hepatitis C before treatment, then patients received PEG IFN \u3b12b plus ribavirin combination therapy. Another 25 healthy subjects, matched for age and sex to patients, were enrolled as controls. Single nucleotide polymorphism (SNP) in OPN at nt \u2013 443 and its blood level were analyzed. Results: The frequency of patients who reached sustained virological response (SVR) was increased in patients with T/T at nt \u2013 443 than in those with C/C or C/T. Also the frequency of T allele was increased in responders than in non-responders. However, this increase was not statistically significant. The blood level of OPN was significantly increased in non-responders (Mean\ub1SD=37.21\ub13.9) in comparison to responders (Mean\ub1SD=33.22\ub14.1). Conclusion: Osteopontin blood level can be considered as a reliable predictor to PEG IFN \u3b12b plus ribavirin therapy in chronic HCV Saudi Patients