Crystal structure of 3-(morpholin-4-yl)-1-phenyl-3-(pyridin-2-yl)propan-1-one

Acknowledgements FMMA acknowledges the PG and Research Department of Chemistry and the Management of Jamal Mohamed College (Autonomous) for their kind support.Peer reviewedPublisher PD

SmartHeLP: Smartphone-based Hemoglobin Level Prediction Using an Artificial Neural Network

Blood hemoglobin level (Hgb) measurement has a vital role in the diagnosis, evaluation, and management of numerous diseases. We describe the use of smartphone video imaging and an artificial neural network (ANN) system to estimate Hgb levels non-invasively. We recorded 10 second-300 frame fingertip videos using a smartphone in 75 adults. Red, green, and blue pixel intensities were estimated for each of 100 area blocks in each frame and the patterns across the 300 frames were described. ANN was then used to develop a model using the extracted video features to predict hemoglobin levels. In our study sample, with patients 20-56 years of age, and gold standard hemoglobin levels of 7.6 to 13.5 g/dL., we observed a 0.93 rank order of correlation between model and gold standard hemoglobin levels. Moreover, we identified specific regions of interest in the video images which reduced the required feature space

Fuzzy Logic Controller Design for Intelligent Air-Conditioning System

Inefficient air cooling systems may cause of wasting energy in a great amount specially in the urban area. Being the most popular cooling system, air-conditioners have been used in domestic usage as well as in industrial applications. However, the unintelligent nature of such cooling system gives rise to excess energy consumption which causes a huge problem in the current energy hungry world. In this paper, we present design of a fuzzy logic controller for the intelligent air-conditioning system. The performance of the controller is also simulated. The proposed controller has the adaptive nature to control fan and compressor speed which leads to reducing power consumption. Also, the system controls the operation mode to retain the healthy oxygen level and humid condition of the indoor environment

Elemental Study of Bangladeshi Fish Samples Using PIGE Technique

Proton induced gamma emission (PIGE) method has been developed at the Accelerator Laboratory of Atomic Energy Center, Dhaka (AECD) for the investigation of various human health related specimens. In the present study PIGE analytical technique has been used for the determination of numerous trace elements in some commonly used fish samples which were collected from Islampur area at Savar. During the experimental work the γrays emitted from the prepared fish samples were measured using a Highpurity Germenium (HPGe) detector. The detected 18 elements were Iron, Calcium, Sodium, Magnesium, Aluminum, Potassium, Vanadium, Chromium, Manganese, Copper, Zinc, Selenium, Bromine, Rubidium, Strontium, Cadmium, Iodine, Lead etc. The objective of this study was to measure the concentrations of these trace elements in the collected fish samples and to investigate whether their concentrations are harmful for human health by comparison with limits set by WHO/FAO. The results obtained indicate that Fe, K and Ca concentrations were relatively high in all samples as compared with the other elements. The measured elemental concentration of Fe, Mn, Zn, Cu, Cr and V in all fish samples were found to be above the WHO/FAO recommended limits

Fabrication of an autonomously self-healing flexible thin-film capacitor by slot-die coating

Flexible pressure sensors with self-healing abilities for wearable electronics are being developed, but generally either lack autonomous self-healing properties or require sophisticated material processing methods. To address this challenge, we developed flexible, low-cost and autonomously self-healing capacitive sensors using a crosslinked poly(dimethylsiloxane) through metal-ligand interactions processed into thin films via slot-die coating. These films have excellent self-healing properties, approximately 1.34 × 105 μm3 per hour at room temperature and 2.87 × 105 μm3 per hour at body temperature (37 °C). Similarly, no significant change in capacitance under bending strain was observed on these flexible thin-films when assembled on poly(ethyleneterephthalate) (PET) substrates; capacitors showed good sensitivity at low pressure regimes. More importantly, the devices fully recovered their sensitivity after being damaged and healed, which is directly attributed to the rapid and autonomous self-healing of the dielectric materials

Fuzzy Logic Controller Design for Intelligent Drilling System

An intelligent drilling system can be commercially very profitable in terms of reduction in crude material and labor involvement. The use of fuzzy logic based controller in the intelligent cutting and drilling operations has become a popular practice in the ever growing manufacturing industry. In this paper, a fuzzy logic controller has been designed to select the cutting parameter more precisely for the drilling operation. Specifically, different input criterion of machining parameters are considered such as the tool and material hardness, the diameter of drilling hole and the flow rate of cutting fluid. Unlikethe existing fuzzy logic based methods, which use only two input parameters, the proposed system utilizes more input parameters to provide spindle speed and feed rate information more precisely for the intelligent drilling operation

Pharmacokinetics and antiangiogenic studies of potassium koetjapate in rats

© 2020 Purpose: Koetjapic acid is an active compound of a traditional medicinal plant, Sandoricum koetjape. Although koetjapic acid has a promising anticancer potential, yet it is highly insoluble in aqueous solutions. To increase aqueous solubility of koetjapic acid, we have previously reported a chemical modification of koetjapic acid to potassium koetjapate (KKA). However, pharmacokinetics of KKA has not been studied. In this study, pharmacokinetics and antiangiogenic efficacy of KKA are investigated. Methods: Pharmacokinetics of KKA was studied after intravenous and oral administration in SD rats using HPLC. Anti-angiogenic efficacy of KKA was investigated in rat aorta, human endothelial cells (EA.hy926) and nude mice implanted with matrigel. Results: Pharmacokinetic study revealed that KKA was readily absorbed into blood and stayed for a long time in the body with Tmax 2.89 ± 0.12 h, Cmax 7.24 ± 0.36 μg/mL and T1/2 1.46 ± 0.03 h. The pharmacological results showed that KKA significantly suppressed sprouting of microvessels in rat aorta with IC50 18.4 ± 4.2 μM and demonstrated remarkable inhibition of major endothelial functions such as migration, differentiation and VEGF expression in endothelial cells. Further, KKA significantly inhibited vascularization in matrigel plugs implanted in nude mice. Conclusions: The results indicate that bioabsorption of KKA from oral route was considerably efficient with longer retention in body than compared to that of the intravenous route. Further, improved antiangiogenic activity of KKA was recorded which could probably be due to its increased solubility and bioavailability. The results revealed that KKA inhibits angiogenesis by suppressing endothelial functions and expression of VEGF

Optimization of cat's whiskers tea (orthosiphon stamineus) using supercritical carbon dioxide and selective chemotherapeutic potential against prostate cancer cells

Cat's whiskers (Orthosiphon stamineus) leaves extracts were prepared using supercritical CO₂ (SC-CO₂) with full factorial design to determine the optimum extraction parameters. Nine extracts were obtained by varying pressure, temperature, and time. The extracts were analysed using FTIR, UV-Vis, and GC-MS. Cytotoxicity of the extracts was evaluated on human (colorectal, breast, and prostate) cancer and normal fibroblast cells. Moderate pressure (31.1 MPa) and temperature (60°C) were recorded as optimum extraction conditions with high yield (1.74%) of the extract (B2) at 60 min extraction time. The optimized extract (B2) displayed selective cytotoxicity against prostate cancer (PC3) cells (IC₅₀ 28 µg/mL) and significant antioxidant activity (IC₅₀ 42.8 µg/mL). Elevated levels of caspases 3/7 and 9 in B2-treated PC3 cells suggest the induction of apoptosis through nuclear and mitochondrial pathways. Hoechst and rhodamine assays confirmed the nuclear condensation and disruption of mitochondrial membrane potential in the cells. B2 also demonstrated inhibitory effects on motility and colonies of PC3 cells at its subcytotoxic concentrations. It is noteworthy that B2 displayed negligible toxicity against the normal cells. Chemometric analysis revealed high content of essential oils, hydrocarbon, fatty acids, esters, and aromatic sesquiterpenes in B2. This study highlights the therapeutic potentials of SC-CO₂ extract of cat's whiskers in targeting prostate carcinoma.Fouad Saleih R. Al-Suede, Mohamed B. Khadeer Ahamed, Aman S. Abdul-Majid, Hussin M. Baharetha, Loiy E.A. Hassan, Mohd Omar A. Kadir, Zeyad D. Nassar and Amin M.S. Abdul Maji

Proapoptotic and antimetastatic properties of supercritical CO2 extract of Nigella sativa Linn. Against breast cancer cells

Nigella sativa, commonly referred as black cumin, is a popular spice that has been used since the ancient Egyptians. It has traditionally been used for treatment of various human ailments ranging from fever to intestinal disturbances to cancer. This study investigated the apoptotic, antimetastatic, and anticancer activities of supercritical carbon dioxide (SC-CO) extracts of the seeds of N. sativa Linn. against estrogen-dependent human breast cancer cells (MCF-7). Twelve extracts were prepared from N. sativa seeds using the SC-CO extraction method by varying pressure and temperature. Extracts were analyzed using FTIR and UV-Vis spectrometry. Cytotoxicity of the extracts was evaluated on various human cancer and normal cell lines. Of the 12 extracts, 1 extract (A3) that was prepared at 60 C and 2500 psi (∼17.24 MPa) showed selective antiproliferative activity against MCF-7 cells with an IC of 53.34±2.15 μg/mL. Induction of apoptosis was confirmed by evaluating caspases activities and observing the cells under a scanning electron microscope. In vitro antimetastatic properties of A3 were investigated by colony formation, cell migration, and cell invasion assays. The elevated levels of caspases in A3 treated MCF-7 cells suggest that A3 is proapoptotic. Further nuclear condensation and fragmentation studies confirmed that A3 induces cytotoxicity through the apoptosis pathway. A3 also demonstrated remarkable inhibition in migration and invasion assays of MCF-7 cells at subcytotoxic concentrations. Thus, this study highlights the therapeutic potentials of SC-CO extract of N. sativa in targeting breast cancer