Vulnerability to Climate Change: Adaptation Strategies and Layers of Resilience - Quantifying Vulnerability to Climate Change in Bangladesh. Research Report No. 16

Bangladesh is considered to be one of the countries highly vulnerable to climate change. As part of the ADB funded project, “Vulnerability to Climate Change, Adaptation Strategies and Layers of Resilience”, analysis of climate change vulnerability using two popular methods was carried out for Bangladesh. A set of indicators defining the three components of vulnerability, ie, exposure, sensitivity and adaptive capacity were selected considering their functional relationship and their contribution to the vulnerability. The aim of the exercise is to characterize different regions and ecological zones (EZ) of the country in terms of vulnerability related to climate change. From the analysis, we conclude that the majority of the regions are very highly vulnerable to climate change. These regions should receive high priority for channelizing resources such as technologies, finances and developmental programs to enhance their ability to cope with the impacts. Appropriate action should be planned and carried out in advance so as to foresee the anticipated impacts of climate change and the expected vulnerability of the regions and the population

Intertwining the arts and sciences to stimulate a creative mind

From the basic motion of a simple pendulum, which acts as a tool that turns a blank canvas into pure abstract art, this particular concept has been applied to science-related art to showcase its tremendous impact on scientific, psychological and educational fields. The Art and Science Program is a collaborative artistic program between the committees from the Chemical and Energy School of Engineering, UTM, and Sekolah Tun Fatimah (STF), with the aim of examining the impacts of the rotational motion of the pendulum which can generate mesmerizing art on blank mahjong papers. The outcome of the art has been influenced by various factors, such as the viscosity of the paint used, the flowrate of the paint drip, the velocity of the paint-pendulum-modelled dripper, the position of the release point, and the motion of the dripper arising from the resultant force of multiple interacting forces. By showing the interconnections between pendulum motion, gravitational force, potential and kinetic energies, and the fundamentals of fluid dynamics, artistic abstract paintings can be created from the science of mechanics. Intertwining the arts and sciences that has been the main focus of this program can garner greater appreciation, even embraced, as it results in a significant effect on the development of both creative and critical thinking among the participants and committees

Impact of financial inclusion in low- and middle-income countries: a systematic review of reviews

Financial inclusion programmes seek to increase access to financial services such as credit, savings, insurance and money transfers and so allow poor and low-income households in low- and middle-income countries to enhance their welfare, grasp opportunities, mitigate shocks, and ultimately escape poverty. This systematic review of reviews assesses the evidence on economic, social, behavioural and gender-related outcomes from financial inclusion. It collects and appraises all of the existing meta-studies - that is systematic reviews and meta-analyses - of the impact of financial inclusion. The authors first analyse the strength of the methods used in those meta-studies, then synthesise the findings from those that are of a sufficient quality, and finally, report the implications for policy, programming, practice and further research arising from the evidence. Eleven studies are included in the analysis

Can We Monitor All Multithreaded Programs?

International audienceRuntime Verification (RV) is a lightweight formal method which consists in verifying that an execution of a program is correct wrt a specification. The specification formalizes with properties the expected correct behavior of the system. Programs are instrumented to extract necessary information from the execution and feed it to monitors tasked with checking the properties. From the perspective of a monitor, the system is a black box; the trace is the only system information provided. Parallel programs generally introduce an added level of complexity on the program execution due to concurrency. A concurrent execution of a parallel program is best represented as a partial order. A large number of RV approaches generate monitors using formalisms that rely on total order, while more recent approaches utilize formalisms that consider multiple traces. In this tutorial, we review some of the main RV approaches and tools that handle multithreaded Java programs. We discuss their assumptions, limitations, ex-pressiveness, and suitability when tackling parallel programs such as producer-consumer and readers-writers. By analyzing the interplay between specification formalisms and concurrent executions of programs, we identify four questions RV practitioners may ask themselves to classify and determine the situations in which it is sound to use the existing tools and approaches

What information and the extent of information research participants need in informed consent forms: a multi-country survey

Background: The use of lengthy, detailed, and complex informed consent forms (ICFs) is of paramount concern in biomedical research as it may not truly promote the rights and interests of research participants. The extent of information in ICFs has been the subject of debates for decades; however, no clear guidance is given. Thus, the objective of this study was to determine the perspectives of research participants about the type and extent of information they need when they are invited to participate in biomedical research. Methods: This multi-center, cross-sectional, descriptive survey was conducted at 54 study sites in seven Asia-Pacific countries. A modified Likert-scale questionnaire was used to determine the importance of each element in the ICF among research participants of a biomedical study, with an anchored rating scale from 1 (not important) to 5 (very important). Results: Of the 2484 questionnaires distributed, 2113 (85.1%) were returned. The majority of respondents considered most elements required in the ICF to be \u27moderately important\u27 to \u27very important\u27 for their decision making (mean score, ranging from 3.58 to 4.47). Major foreseeable risk, direct benefit, and common adverse effects of the intervention were considered to be of most concerned elements in the ICF (mean score = 4.47, 4.47, and 4.45, respectively). Conclusions: Research participants would like to be informed of the ICF elements required by ethical guidelines and regulations; however, the importance of each element varied, e.g., risk and benefit associated with research participants were considered to be more important than the general nature or technical details of research. Using a participant-oriented approach by providing more details of the participant-interested elements while avoiding unnecessarily lengthy details of other less important elements would enhance the quality of the ICF

Stroke genetics informs drug discovery and risk prediction across ancestries

Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries

GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder affecting 0.5–2% of pregnancies. The majority of cases present in the third trimester with pruritus, elevated serum bile acids and abnormal serum liver tests. ICP is associated with an increased risk of adverse outcomes, including spontaneous preterm birth and stillbirth. Whilst rare mutations affecting hepatobiliary transporters contribute to the aetiology of ICP, the role of common genetic variation in ICP has not been systematically characterised to date. Here, we perform genome-wide association studies (GWAS) and meta-analyses for ICP across three studies including 1138 cases and 153,642 controls. Eleven loci achieve genome-wide significance and have been further investigated and fine-mapped using functional genomics approaches. Our results pinpoint common sequence variation in liver-enriched genes and liver-specific cis-regulatory elements as contributing mechanisms to ICP susceptibility