A field-based computing approach to sensing-driven clustering in robot swarms

Swarm intelligence leverages collective behaviours emerging from interaction and activity of several “simple” agents to solve problems in various environments. One problem of interest in large swarms featuring a variety of sub-goals is swarm clustering, where the individuals of a swarm are assigned or choose to belong to zero or more groups, also called clusters. In this work, we address the sensing-based swarm clustering problem, where clusters are defined based on both the values sensed from the environment and the spatial distribution of the values and the agents. Moreover, we address it in a setting characterised by decentralisation of computation and interaction, and dynamicity of values and mobility of agents. For the solution, we propose to use the field-based computing paradigm, where computation and interaction are expressed in terms of a functional manipulation of fields, distributed and evolving data structures mapping each individual of the system to values over time. We devise a solution to sensing-based swarm clustering leveraging multiple concurrent field computations with limited domain and evaluate the approach experimentally by means of simulations, showing that the programmed swarms form clusters that well reflect the underlying environmental phenomena dynamics

Evaluation of anti-inflammatory and immunoregulatory activities of Stimunex® and Stimunex D3® in human monocytes/macrophages stimulated with LPS or IL-4/IL-13

Macrophages exert an important role in maintaining and/or ameliorating the inflammatory response. They are involved in the activation of an immune response to pathogens, with a balance between the immunomodulatory role and tissue integrity maintenance, however, excessive macrophage activity promotes tissue injury and chronic disease pathogenesis. There is a high interest in evaluating the anti-inflammatory properties of new botanical preparations. Stimunex® and Stimunex D3® are two food supplements formulated as syrups, containing the extract of elderflower (Sambucus nigra, Caprifoliaceae), standardized in polyphenol (6%) and anthocyanins (4%), associated with wellmune WGP® β-glucan, with the addiction of vitamin D3 (in Stimunex D3® formulation). The aim of the work was the evaluation of Stimunex® and Stimunex D3® activity in human polarized-macrophages, in order to support their use as supplement for preventing and reducing the inflammatory processes. In primary human stimulated macrophages, both syrups were able to revert LPS- and IL-4/IL-13-mediated response, reducing the release of several pro-inflammatory cytokines. Results support that these standardized botanical preparations fortified with β-glucan, may have a potential use in the prevention and coadjuvant management of inflammatory process as respiratory recurrent infections and other similar conditions. Moreover, the addition of vitamin D3 revealed to be an advantage in Stimunex D3® for its important role in maintaining and enhancing the innate immune response

The prion gene is associated with human long-term memory

Human cognitive processes are highly variable across individuals and are influenced by both genetic and environmental factors. Although genetic variations affect short-term memory in humans, it is unknown whether genetic variability has also an impact on long-term memory. Because prion-like conformational changes may be involved in the induction of long-lasting synaptic plasticity, we examined the impact of single-nucleotide polymorphisms (SNPs) of the prion protein gene (PRNP) on long-term memory in healthy young humans. SNPs in the genomic region of PRNP were associated with better long-term memory performance in two independent populations with different educational background. Among the examined PRNP SNPs, the common Met129Val polymorphism yielded the highest effect size. Twenty-four hours after a word list-learning task, carriers of either the 129MM or the 129MV genotype recalled 17% more information than 129VV carriers, but short-term memory was unaffected. These results suggest a role for the prion protein in the formation of long-term memory in human

Transient receptor potential (Trp) channels in haematological malignancies: An update

Transient receptor potential (TRP) channels are improving their importance in different cancers, becoming suitable as promising candidates for precision medicine. Their important contribution in calcium trafficking inside and outside cells is coming to light from many papers published so far. Encouraging results on the correlation between TRP and overall survival (OS) and progression-free survival (PFS) in cancer patients are available, and there are as many promising data from in vitro studies. For what concerns haematological malignancy, the role of TRPs is still not elucidated, and data regarding TRP channel expression have demonstrated great variability throughout blood cancer so far. Thus, the aim of this review is to highlight the most recent findings on TRP channels in leukaemia and lymphoma, demonstrating their important contribution in the perspective of personalised therapies

Beach monitoring and morphological response in the presence of coastal defense strategies at riccione (Italy)

The coastal area at Riccione, in the southern Emilia-Romagna littoral region, is exposed to erosive processes, which are expected to be enhanced by climate change. The beach, mostly composed of fine sand, is maintained through various defense strategies, including frequent nourishment interventions for balancing the sediment deficit and other experimental solutions for reducing coastal erosion. Artificial reshaping of the beach and \u201ccommon practices\u201d in the sediment management redefine the beach morphology and the sediment redistribution almost continuously. These activities overlap each other and with the coastal dynamics, and this makes it very difficult to evaluate their effectiveness, as well as the role of natural processes on the beach morphological evolution. Topo-bathymetric and sedimentological monitoring of the beach has been carried out on a regular basis since 2000 by the Regional Agency for Prevention, Environment and Energy of Emilia-Romagna (Arpae). Further monitoring of the emerged and submerged beach has been carried out in 2019\u20132021 in the framework of the research project STIMARE, focusing on innovative strategies for coastal monitoring in relation with erosion risk. The aim of this study is to assess the coastal behavior at the interannual/seasonal scale in the southern coastal stretch of Riccione, where the adopted coastal defense strategies and management actions mostly control the morphological variations in the emerged and submerged beach besides the wave and current regime. The topo-bathymetric variations and erosion/accretion patterns provided by multitemporal monitoring have been related to natural processes and to anthropogenic activities. The morphological variations have been also assessed in volumetric terms in the different subzones of the beach, with the aim of better understanding the onshore/offshore sediment exchange in relation with nourishments and in the presence of protection structures. The effectiveness of the adopted interventions to combat erosion, and to cope with future climate change-related impacts, appears not fully successful in the presence of an overall sediment deficit at the coast. This demonstrates the need for repeated monitoring of the emerged and submerged beach in such a critical setting

Integrity of H1 helix in prion protein revealed by molecular dynamic simulations to be especially vulnerable to changes in the relative orientation of H1 and its S1 flank

In the template-assistance model, normal prion protein (PrPC), the pathogenic cause of prion diseases such as Creutzfeldt-Jakob (CJD) in human, Bovine Spongiform Encephalopathy (BSE) in cow, and scrapie in sheep, converts to infectious prion (PrPSc) through an autocatalytic process triggered by a transient interaction between PrPC and PrPSc. Conventional studies suggest the S1-H1-S2 region in PrPC to be the template of S1-S2 $\beta$-sheet in PrPSc, and the conformational conversion of PrPC into PrPSc may involve an unfolding of H1 in PrPC and its refolding into the $\beta$-sheet in PrPSc. Here we conduct a series of simulation experiments to test the idea of transient interaction of the template-assistance model. We find that the integrity of H1 in PrPC is vulnerable to a transient interaction that alters the native dihedral angles at residue Asn$^{143}$, which connects the S1 flank to H1, but not to interactions that alter the internal structure of the S1 flank, nor to those that alter the relative orientation between H1 and the S2 flank.Comment: A major revision on statistical analysis method has been made. The paper now has 23 pages, 11 figures. This work was presented at 2006 APS March meeting session K29.0004 at Baltimore, MD, USA 3/13-17, 2006. This paper has been accepted for pubcliation in European Biophysical Journal on Feb 2, 200

The effects of cannabidiol and prognostic role of TRPV2 in human endometrial cancer

Several studies support, both in vitro and in vivo, the anti-cancer effects of cannabidiol (CBD), a transient receptor potential vanilloid 2 (TRPV2) ligand. TRPV2, often dysregulated in tumors, is associated with altered cell proliferation and aggressiveness. Endometrial cancer (EC) is historically divided in type I endometrioid EC and type II non-endometrioid EC, associated with poor prognosis. Treatment options with chemotherapy and combinations with radiation showed only limited efficacy. Since no data are reported concerning TRPV2 expression as well as CBD potential effects in EC, the aim of this study was to evaluate the expression of TRPV2 in biopsies and cell lines as well as the effects of CBD in in vitro models. Overall survival (OS), progression-free survival (PFS), cell viability, migration, and chemo-resistance have been evaluated. Results show that TRPV2 expression increased with the malignancy of the cancer tissue and correlated with shorter PFS (p = 0.0224). Moreover, in vitro TRPV2 over-expression in Ishikawa cell line increased migratory ability and response to cisplatin. CBD reduced cell viability, activating predominantly apoptosis in type I cells and autophagy in mixed type EC cells. The CBD improved chemotherapeutic drugs cytotoxic effects, enhanced by TRPV2 over-expression. Hence, TRPV2 could be considered as a marker for optimizing the therapy and CBD might be a useful therapeutic option as adjuvant therapy