13,480 research outputs found

    Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models

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    Melanomas are highly lethal skin tumours that are frequently treated by surgical resection. However, the efficacy of such procedures is often limited by tumour recurrence and metastasis. Caveolin-1 (CAV1) has been attributed roles as a tumour suppressor, although in late-stage tumours, its presence is associated with enhanced metastasis. The expression of this protein in human melanoma development and particularly how the presence of CAV1 affects metastasis after surgery has not been defined. CAV1 expression in human melanocytes and melanomas increases with disease progression and is highest in metastatic melanomas. The effect of increased CAV1 expression can then be evaluated using B16F10 murine melanoma cells injected into syngenic immunocompetent C57BL/6 mice or human A375 melanoma cells injected into immunodeficient B6Rag1−/− mice. Augmented CAV1 expression suppresses tumour formation upon a subcutaneous injection, but enhances lung metastasis of cells injected into the tail vein in both models. A procedure was initially developed using B16F10 melanoma cells in C57BL/6 mice to mimic better the situation in patients undergoing surgery. Subcutaneous tumours of a defined size were removed surgically and local tumour recurrence and lung metastasis were evaluated after another 14 days. In this postsurgery setting, CAV1 presence in B16F10 melanomas favoured metastasis to the lung, although tumour suppression at the initial site was still evident. Similar results were obtained when evaluating A375 cells in B6Rag1−/− mice. These results implicate CAV1 expression in melanomas as a marker of poor prognosis for patients undergoing surgery as CAV1 expression promotes experimental lung metastasis in two different preclinical models

    Neutrinoless Double Beta Decay in Light of SNO Salt Data

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    In the SNO data from its salt run, probably the most significant result is the consistency with the previous results without assuming the 8B energy spectrum. In addition, they have excluded the maximal mixing at a very high confidence level. This has an important implication on the double beta decay experiments. For the inverted or degenerate mass spectrum, we find |_{ee}| > 0.013 eV at 95% CL, and the next generation experiments can discriminate Majorana and Dirac neutrinos if the inverted or degenerate mass spectrum will be confirmed by the improvements in cosmology, tritium data beta decay, or long-baseline oscillation experiments.Comment: REVTEX4, three figures. Now uses the updated SK atmospheric data rather than naive rescaling. Conclusion unchanged. References adde

    Phenomenology of Quantum Gravity and its Possible Role in Neutrino Anomalies

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    New phenomenological models of Quantum Gravity have suggested that a Lorentz-Invariant discrete spacetime structure may become manifest through a nonstandard coupling of matter fields and spacetime curvature. On the other hand, there is strong experimental evidence suggesting that neutrino oscillations cannot be described by simply considering neutrinos as massive particles. In this manuscript we motivate and construct one particular phenomenological model of Quantum Gravity that could account for the so-called neutrino anomalies.Comment: For the proceedings of "Relativity and Gravitation: 100 Years after Einstein in Prague" (June 2012, Prague

    MiniBooNE and LSND data: non-standard neutrino interactions in a (3+1) scheme versus (3+2) oscillations

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    The recently observed event excess in MiniBooNE anti-neutrino data is in agreement with the LSND evidence for electron anti-neutrino appearance. We propose an explanation of these data in terms of a (3+1) scheme with a sterile neutrino including non-standard neutrino interactions (NSI) at neutrino production and detection. The interference between oscillations and NSI provides a source for CP violation which we use to reconcile different results from neutrino and anti-neutrino data. Our best fit results imply NSI at the level of a few percent relative to the standard weak interaction, in agreement with current bounds. We compare the quality of the NSI fit to the one obtained within the (3+1) and (3+2) pure oscillation frameworks. We also briefly comment on using NSI (in an effective two-flavour framework) to address a possible difference in neutrino and anti-neutrino results from the MINOS experiment.Comment: 28 pages, 9 figures, discussion improved, new appendix added, conclusions unchange

    Standard and Non-Standard Physics in Neutrino Oscillations

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    We analyze the impact of recent solar and atmospheric data in the determination of the neutrino oscillation parameters, taking into account that both the solar nu_e and the atmospheric nu_mu may convert to a mixture of active and sterile neutrinos. Furthermore, in the context of the atmospheric neutrino problem we discuss an extended mechanism of neutrino propagation which combines both oscillations and non-standard neutrino-matter interactions. We use the most recent neutrino data, including the 1496-day Super-K solar and atmospheric data samples, the latest SNO spectral and day/night solar data, and the final MACRO atmospheric results. We confirm the clear preference of all the data for pure-active oscillation solutions, bounding the fraction of sterile neutrino involved in oscillations to be less than 52% in the solar sector and less than 40% in the atmospheric sector, at 3 sigma. For the atmospheric case we also derive a bound on the total amount of non-standard neutrino-matter interactions, bounding the flavor-changing component to -0.03 <= epsilon <= 0.02 and the non-universal component to |epsilon'| <= 0.05.Comment: 6 pages, LaTeX file using espcrc2.sty, 1 table and 3 figures included. Talk given at the XXX International Meeting on Fundamental Physics (Jaca, Spain, 28/01-1/02/2002

    Constraining neutrino oscillation parameters with current solar and atmospheric data

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    We analyze the impact of recent solar, atmospheric and reactor data in the determination of the neutrino oscillation parameters, taking into account that both the solar nu_e and the atmospheric nu_mu may convert to a mixture of active and sterile neutrinos. We use the most recent global solar neutrino data, including the 1496-day Super-K neutrino data sample, and we investigate in detail the impact of the SNO neutral current, spectral and day/night data by performing also an analysis using only the charged current rate from SNO. The implications of the first 145.1 days of KamLAND data on the determination of the solar neutrino parameters are also discussed in detail. We confirm the clear preference of solar+reactor data for the pure active LMA-MSW solution of the solar neutrino problem, and obtain that the LOW, VAC, SMA and Just-So^2 solutions are disfavored with a Delta_chi^2 = 22, 22, 36, 44, respectively. Furthermore, we find that the global solar data constrains the admixture of a sterile neutrino to be less than 43% at 99% CL. By performing an improved fit of the atmospheric data, we also update the corresponding regions of oscillation parameters. We find that the recent atmospheric Super-K (1489-day) and MACRO data have a strong impact on constraining a sterile component in atmospheric oscillations: if the nu_mu is restricted to the atmospheric mass states only a sterile admixture of 16% is allowed at 99% CL, while a bound of 35% is obtained in the unconstrained case. Pure sterile oscillations are disfavored with a Delta_chi^2 = 34.6 compared to the pure active case.Comment: 28 pages, LaTeX file using RevTEX4, 12 figures and 3 tables included. Improved version including the new KamLAND dat

    Two experiments for the price of one? -- The role of the second oscillation maximum in long baseline neutrino experiments

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    We investigate the quantitative impact that data from the second oscillation maximum has on the performance of wide band beam neutrino oscillation experiments. We present results for the physics sensitivities to standard three flavor oscillation, as well as results for the sensitivity to non-standard interactions. The quantitative study is performed using an experimental setup similar to the Fermilab to DUSEL Long Baseline Neutrino Experiment (LBNE). We find that, with the single exception of sensitivity to the mass hierarchy, the second maximum plays only a marginal role due to the experimental difficulties to obtain a statistically significant and sufficiently background-free event sample at low energies. This conclusion is valid for both water Cherenkov and liquid argon detectors. Moreover, we confirm that non-standard neutrino interactions are very hard to distinguish experimentally from standard three-flavor effects and can lead to a considerable loss of sensitivity to \theta_{13}, the mass hierarchy and CP violation.Comment: RevTex 4.1, 23 pages, 10 figures; v2: Typos corrected, very minor clarifications; matches published version; v3: Fixed a typo in the first equation in sec. III

    Confusing non-standard neutrino interactions with oscillations at a neutrino factory

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    Most neutrino mass theories contain non-standard interactions (NSI) of neutrinos which can be either non-universal (NU) or flavor-changing (FC). We study the impact of such interactions on the determination of neutrino mixing parameters at a neutrino factory using the so-called ``golden channels'' \pnu{e}\to\pnu{\mu} for the measurement of \theta_{13}. We show that a certain combination of FC interactions in neutrino source and earth matter can give exactly the same signal as oscillations arising due to \theta_{13}. This implies that information about \theta_{13} can only be obtained if bounds on NSI are available. Taking into account the existing bounds on FC interactions, this leads to a drastic loss in sensitivity in \theta_{13}, at least two orders of magnitude. A near detector at a neutrino factory offers the possibility to obtain stringent bounds on some NSI parameters. Such near site detector constitutes an essential ingredient of a neutrino factory and a necessary step towards the determination of \theta_{13} and subsequent study of leptonic CP violation.Comment: 23 pages, 5 figures, improved version, accepted for publication in Phs. Rev. D, references adde
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