Editorial: Rising stars in exercise physiology

[Extract] Physical exercise has been recognized as essential for human health and evolution for thousands of years, beginning with the ancient cultures. Hippocrates, Plato, Aristotle, and the Roman physician Galen were the earliest recorded and most well-known promoters of the beneficial effects of physical exercise. Since these times, several dedicated laboratories worldwide have been established, with many researchers conducting numerous investigations related to exercise physiology; nevertheless, a cornerstone of all laboratories is the development of new and novel researchers. These talented and emerging researchers have been necessary for our understanding of exercise physiology to have reached where we are today (and where we will be in the future). Given the evolution of exercise physiology, the field has incorporated a range of basic to applied scientific investigations and a range of end-users (e.g., researchers, athletes, coaches, physiologists, and clinical/public health professionals) who will benefit from these new advances in exercise physiology

Simulation of cellular irradiation with the CENBG microbeam line using GEANT4

Light-ion microbeams provide a unique opportunity to irradiate biological samples at the cellular level and to investigate radiobiological effects at low doses of high LET ionising radiation. Since 1998 a single-ion irradiation facility has been developed on the focused horizontal microbeam line of the CENBG 3.5 MV Van de Graaff accelerator. This setup delivers in air single protons and alpha particles of a few MeV onto cultured cells, with a spatial resolution of a few microns, allowing subcellular targeting. In this paper, we present results from the use of the GEANT4 toolkit to simulate cellular irradiation with the CENBG microbeam line, from the entrance to the microprobe up to the cellular medium.Comment: 6 pages, 8 figures, presented at the 2003 IEEE-NSS conference, Portland, OR, USA, October 20-24, 200

Aplicación de índices de calidad de agua en un arroyo pampeano utilizando macroinvertebrados bentónicos como bioindicadores (Gualeguaychú, Entre Ríos, Argentina)

Water quality can be evaluated through a set of physical, chemical and environmental variables that characterize the water body under study. These variables, along with the climate impact,hydrological regime and land use, determine the diversity of organisms. Santa Barbara Stream is a loworder stream and is located in the Gualeguaychú Departament, Entre Ríos, in the Pampean Ecorregion. In order to study the water quality, benthonic macroinvertebrates and physical chemical variables were studied, between March and October 2012. Sixteen orders, 1 suborder and 27 invertebrates families were found. The most abundant families were Cochliopidae, Paleomonidae, Caenidae, and Sphaeriidae. BMWP, IBF, IMRP and IBPamp biotic indices and diversity index of Shannon-Weaver were applied. These showed different results suggesting the need for further studies of water bodies of the Pampas Ecorregion and adjustment of indices for the region. The combined application of different rates indicates that the stream shows signs of seasonal organic pollution associated with land use in the basin.Facultad de Ciencias Naturales y Muse

Aplicación de índices de calidad de agua en un arroyo pampeano utilizando macroinvertebrados bentónicos como bioindicadores (Gualeguaychú, Entre Ríos, Argentina)

Water quality can be evaluated through a set of physical, chemical and environmental variables that characterize the water body under study. These variables, along with the climate impact,hydrological regime and land use, determine the diversity of organisms. Santa Barbara Stream is a loworder stream and is located in the Gualeguaychú Departament, Entre Ríos, in the Pampean Ecorregion. In order to study the water quality, benthonic macroinvertebrates and physical chemical variables were studied, between March and October 2012. Sixteen orders, 1 suborder and 27 invertebrates families were found. The most abundant families were Cochliopidae, Paleomonidae, Caenidae, and Sphaeriidae. BMWP, IBF, IMRP and IBPamp biotic indices and diversity index of Shannon-Weaver were applied. These showed different results suggesting the need for further studies of water bodies of the Pampas Ecorregion and adjustment of indices for the region. The combined application of different rates indicates that the stream shows signs of seasonal organic pollution associated with land use in the basin.Facultad de Ciencias Naturales y Muse

Aplicación de índices de calidad de agua en un arroyo pampeano utilizando macroinvertebrados bentónicos como bioindicadores (Gualeguaychú, Entre Ríos, Argentina)

Water quality can be evaluated through a set of physical, chemical and environmental variables that characterize the water body under study. These variables, along with the climate impact,hydrological regime and land use, determine the diversity of organisms. Santa Barbara Stream is a loworder stream and is located in the Gualeguaychú Departament, Entre Ríos, in the Pampean Ecorregion. In order to study the water quality, benthonic macroinvertebrates and physical chemical variables were studied, between March and October 2012. Sixteen orders, 1 suborder and 27 invertebrates families were found. The most abundant families were Cochliopidae, Paleomonidae, Caenidae, and Sphaeriidae. BMWP, IBF, IMRP and IBPamp biotic indices and diversity index of Shannon-Weaver were applied. These showed different results suggesting the need for further studies of water bodies of the Pampas Ecorregion and adjustment of indices for the region. The combined application of different rates indicates that the stream shows signs of seasonal organic pollution associated with land use in the basin.Facultad de Ciencias Naturales y Muse

Low energy measurement of the 7Be(p,gamma)8B cross section

We have measured the cross section of the 7Be(p,gamma)8B reaction for E_cm = 185.8 keV, 134.7 keV and 111.7 keV using a radioactive 7Be target (132 mCi). Single and coincidence spectra of beta^+ and alpha particles from 8B and 8Be^* decay, respectively, were measured using a large acceptance spectrometer. The zero energy S factor inferred from these data is 18.5 +/- 2.4 eV b and a weighted mean value of 18.8 +/- 1.7 eV b (theoretical uncertainty included) is deduced when combining this value with our previous results at higher energies.Comment: Accepted for publication in Phys. Rev. Let

Increased FAT/CD36 Cycling and Lipid Accumulation in Myotubes Derived from Obese Type 2 Diabetic Patients

BACKGROUND: Permanent fatty acid translocase (FAT/)CD36 relocation has previously been shown to be related to abnormal lipid accumulation in the skeletal muscle of type 2 diabetic patients, however mechanisms responsible for the regulation of FAT/CD36 expression and localization are not well characterized in human skeletal muscle. METHODOLOGY/PRINCIPAL FINDINGS: Primary muscle cells derived from obese type 2 diabetic patients (OBT2D) and from healthy subjects (Control) were used to examine the regulation of FAT/CD36. We showed that compared to Control myotubes, FAT/CD36 was continuously cycling between intracellular compartments and the cell surface in OBT2D myotubes, independently of lipid raft association, leading to increased cell surface FAT/CD36 localization and lipid accumulation. Moreover, we showed that FAT/CD36 cycling and lipid accumulation were specific to myotubes and were not observed in reserve cells. However, in Control myotubes, the induction of FAT/CD36 membrane translocation by the activation of (AMP)-activated protein kinase (AMPK) pathway did not increase lipid accumulation. This result can be explained by the fact that pharmacological activation of AMPK leads to increased mitochondrial beta-oxidation in Control cells. CONCLUSION/SIGNIFICANCE: Lipid accumulation in myotubes derived from obese type 2 diabetic patients arises from abnormal FAT/CD36 cycling while lipid accumulation in Control cells results from an equilibrium between lipid uptake and oxidation. As such, inhibiting FAT/CD36 cycling in the skeletal muscle of obese type 2 diabetic patients should be sufficient to diminish lipid accumulation

A compilation of charged-particle induced thermonuclear reaction rates

Low-energy cross section data for 86 charged-particle induced reactions involving light (1 less than or equal to Z less than or equal to 14), mostly stable, nuclei are compiled. The corresponding Maxwellian-averaged thermonuclear reaction rates of relevance in astrophysical plasmas at temperatures in the range from 10(6) K to 10(10) K are calculated. These evaluations assume either that the target nuclei are in their ground state, or that the target states are thermally populated following a Maxwell-Boltzmann distribution, except in some cases involving isomeric states. Adopted values complemented with lower and upper limits of the rates are presented in tabular form. Analytical approximations to the adopted rates, as well as to the inverse/direct rate ratios, are provided. (C) 1999 Elsevier Science B.V. All rights reserved

Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues

Funding Information: This study was supported by the Latvian National Research Program BIOMEDICINE. E. Liepinsh was supported by the FP7 project InnovaBalt [grant Nr. 316149]. We would like to thank Dr. Reinis Vilskersts and Gita Dambrova for help with the isolated skeletal muscle experiments. Publisher Copyright: © 2017 The Author(s).Increased plasma concentrations of acylcarnitines (ACs) are suggested as a marker of metabolism disorders. The aim of the present study was to clarify which tissues are responsible for changes in the AC pool in plasma. The concentrations of medium- and long-chain ACs were changing during the fed-fast cycle in rat heart, muscles and liver. After 60 min running exercise, AC content was increased in fasted mice muscles, but not in plasma or heart. After glucose bolus administration in fasted rats, the AC concentrations in plasma decreased after 30 min but then began to increase, while in the muscles and liver, the contents of medium- and long-chain ACs were unchanged or even increased. Only the heart showed a decrease in medium- and long-chain AC contents that was similar to that observed in plasma. In isolated rat heart, but not isolated-contracting mice muscles, the significant efflux of medium- and long-chain ACs was observed. The efflux was reduced by 40% after the addition of glucose and insulin to the perfusion solution. Overall, these results indicate that during fed-fast cycle shifting the heart determines the medium- and long-chain AC profile in plasma, due to a rapid response to the availability of circulating energy substrates.publishersversionPeer reviewe

The relationship between job satisfaction, burnout, and turnover intention among physicians from urban state-owned medical institutions in Hubei, China: a cross-sectional study

<p>Abstract</p> <p>Background</p> <p>Throughout China, a growing number of physicians are leaving or intending to depart from their organizations owing to job dissatisfaction. Little information is available about the role of occupational burnout in this association. We set out to analyze the relationship between job satisfaction, burnout, and turnover intention, and further to determine whether occupational burnout can serve as a mediator among Chinese physicians from urban state-owned medical institutions.</p> <p>Methods</p> <p>A cross-sectional survey was carried out in March 2010 in Hubei Province, central China. The questionnaires assessed sociodemographic characteristics, job satisfaction, burnout, and turnover intention. The job satisfaction and occupational burnout instruments were obtained by modifying the Chinese Physicians' Job Satisfaction Questionnaire (CPJSQ) and the Chinese Maslach Burnout Inventory (CMBI), respectively. Such statistical methods as one-way ANOVA, Pearson correlation, GLM-univariate and structural equation modeling were used.</p> <p>Results</p> <p>Of the 1600 physicians surveyed, 1451 provided valid responses. The respondents had medium scores (3.18 +/-0.73) on turnover intention, in which there was significant difference among the groups from three urban areas with different development levels. Turnover intention, which significantly and negatively related to all job-satisfaction subscales, positively related to each subscale of burnout syndrome. Work environment satisfaction (<it>b </it>= -0.074, <it>p < 0.01</it>), job rewards satisfaction (<it>b </it>= -0.073, <it>p < 0.01</it>), organizational management satisfaction (<it>b </it>= -0.146, <it>p < 0.01</it>), and emotional exhaustion (<it>b </it>= 0.135, <it>p < 0.01</it>) were identified as significant direct predictors of the turnover intention of physicians, with 41.2% of the variance explained unitedly, under the control of sociodemographic variables, among which gender, age, and years of service were always significant. However, job-itself satisfaction no longer became significant, with the estimated parameter on job rewards satisfaction smaller after burnout syndrome variables were included. As congregated latent concepts, job satisfaction had both significant direct effects (gamma₂₁= -0.32, <it>p < 0.01</it>) and indirect effects (gamma₁₁× beta₂₁= -0.13, <it>p < 0.01</it>) through occupational burnout (62% explained) as a mediator on turnover intention (47% explained).</p> <p>Conclusions</p> <p>Our study reveals that several, but not all dimensions of both job satisfaction and burnout syndrome are relevant factors affecting physicians' turnover intention, and there may be partial mediation effects of occupational burnout, mainly through emotional exhaustion, within the impact of job satisfaction on turnover intention. This suggests that enhancements in job satisfaction can be expected to reduce physicians' intentions to quit by the intermediary role of burnout as well as the direct path. It is hoped that these findings will offer some clues for health-sector managers to keep their physician resource motivated and stable.</p