317 research outputs found
Wpływ Design Thinking na rozwój przedsiębiorczości
Celem artykułu jest przedstawienie innowacyjnego podejścia do rozwijania przedsiębior‑ czości poprzez zastosowanie umiejętności myślenia projektowego stosowanego w meto‑ dologii Design Thinking. Badania prowadzone od kilku lat przez firmę MasConsulting potwierdzają, że Design Thinking pozwala na skuteczne rozwiązywanie skomplikowanych problemów oraz tworzenie innowacyjnych rozwiązań. Skłania do przedsiębiorczości i współpracy interdyscyplinarnych zespołów nastawionych na diagnozowanie problemów, generowanie pomysłów oraz testowanie najlepszych rozwiązań. Celem procesu Design Thinking jest opracowanie rozwiązań, które są jednocześnie opłacalne biznesowo, wyko‑ nalne technicznie i pożądane przez klientów oraz odpowiadają na ich realne potrzeby
The sustained increase of plasma fibrinogen during ischemic stroke predicts worse outcome independently of baseline fibrinogen level
Hyperfibrinogenemia at the beginning of ischemic stroke is associated with poor outcome.
We hypothesized that the sustained increase of plasma fibrinogen during stroke predicts outcome independently
of baseline fibrinogen concentration. We included 266 patients with first-ever ischemic stroke
in whom plasma fibrinogen level was measured on days 1, 7, and 14. The sustained fibrinogen's
increase was defined as the persistent elevation of fibrinogen's concentration on days 7 and 14 by at least
20 % compared to the level on day 1. The functional outcome on day 30 was assessed using modified
Rankin Scale (mRS). Favorable outcome was defined as mRS 0-1. The sustained increase of fibrinogen
was found in 17 % of patients. On multivariate logistic regression analysis adjusted for age, NIHSS
score, baseline fibrinogen >2.66 mmol/L, presence of infection, and hyperglycemia, the sustained fibrinogen's
level was associated with reduced chance of favorable outcome (OR: 0.17, 95 % CI: 0.06-0.48, P<0.01)
Improvement of survival in Polish stroke patients is related to reduced stroke severity and better control of risk factors : the Krakow Stroke Database
Introduction: In the last decade, the stroke mortality rate in Poland significantly decreased. We hypothesised that stroke severity, the major determinant of outcome, is lowered in Polish stroke patients.
Material and methods: We compared the stroke severity in two cohorts of
first-ever ischaemic stroke patients admitted within 24 h after stroke onset
to the Department of Neurology, Jagiellonian University, Krakow in the years
1994-2000 and 2008-2012. To assess stroke severity we used the National
Institute of Health Stroke Scale (NIHSS). We defined mild stroke as an NIHSS
score ≤ 4.
Results: We included 816 patients hospitalised in the years 1994-2000 and
569 patients hospitalised in the years 2008-2012. NIHSS score on admission was higher in the former (mean: 12.0 ±7.0 vs. 8.0 ±6.0, p < 0.01), and
the frequency of mild stroke was higher in the latter (12.7% vs. 41.8%, p <
0.01). Although the frequency of hypertension (67.3% vs. 81.2%, p < 0.01),
diabetes mellitus (20.8% vs. 26.4%, p = 0.02) and atrial fibrillation (20.7%
vs. 26.2%, p = 0.02) was higher in patients hospitalised in the years 2008-
2012, the systolic and diastolic blood pressure values and the frequency
of fasting hyperglycaemia were lower in this cohort. This cohort also less
frequently suffered from hypercholesterolaemia (25.4% vs. 16.3%, p < 0.01).
Conclusions: Reduced stroke severity is associated with better recognition
and control of risk factors and explains the improvement of survival in Polish
stroke patients
EPAS1 gene variants are associated with sprint/power athletic performance in two cohorts of European athletes
BACKGROUND: The endothelial PAS domain protein 1 (EPAS1) activates genes that are involved in erythropoiesis and angiogenesis, thus favoring a better delivery of oxygen to the tissues and is a plausible candidate to influence athletic performance. Using innovative statistical methods we compared genotype distributions and interactions of EPAS1 SNPs rs1867785, rs11689011, rs895436, rs4035887 and rs1867782 between sprint/power athletes (n = 338), endurance athletes (n = 254), and controls (603) in Polish and Russian samples. We also examined the association between these SNPs and the athletes’ competition level (‘elite’ and ‘sub-elite’ level). Genotyping was performed by either Real-Time PCR or by Single-Base Extension (SBE) method. RESULTS: In the pooled cohort of Polish and Russian athletes, 1) rs1867785 was associated with sprint/power athletic status; the AA genotype in rs1867785 was underrepresented in the sprint/power athletes, 2) rs11689011 was also associated with sprint/power athletic status; the TT genotype in rs11689011 was underrepresented sprint/power athletes, and 3) the interaction between rs1867785, rs11689011, and rs4035887 was associated with sprint/power athletic performance; the combinations of the AA genotype in rs4035887 with either the AG or GG genotypes in rs1867785, or with the CT or CC genotypes in rs11689011, were underrepresented in two cohorts of sprint/power athletes. CONCLUSIONS: Based on the unique statistical model rs1867785/rs11689011 are strong predictors of sprint/power athletic status, and the interaction between rs1867785, rs11689011, and rs4035887 might contribute to success in sprint/power athletic performance. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2164-15-382) contains supplementary material, which is available to authorized users
4C Mortality Score correlates with in-hospital functional outcome after COVID-19-associated ischaemic stroke
Aim of the study. The 4C Mortality Score was created to predict mortality in hospitalised patients with COVID-19 and has to date been evaluated only in respiratory system disorders. The aim of this study was to investigate its application in patients with COVID-19-associated acute ischaemic stroke (AIS).Clinical rationale for study. COVID-19 is a risk factor for AIS. COVID-19-associated AIS results in higher mortality and worse functional outcome. Predictors of functional outcome in COVID-19-associated AIS are required.Materials and methods. This was a retrospective observational study of patients with AIS hospitalised in seven neurological wards in Małopolska Voivodship (Poland) between August and December 2020. We gathered data concerning the patients’ age, sex, presence of cardiovascular risk factors, type of treatment received, and the presence of stroke-associated infections (including pneumonia, urinary tract infection and infection of unknown source). We calculated 4C Mortality Score at stroke onset, and investigated whether there was a correlation with neurological deficit measured using the National Health Institute Stroke Scale (NIHSS) and functional outcome assessed using the modified Rankin Scale (mRS) at discharge.Results. The study included 52 patients with COVID-19-associated AIS. The 4C Mortality Score at stroke onset correlated with mRS (rs = 0.565, p < 0.01) at discharge. There was also a statistically significant difference in the mean 4C Mortality Score between patients who died and patients who survived the stroke (13.08 ± 2.71 vs. 9.85 ± 3.47, p = 0.04).Conclusions and clinical implications. 4C Mortality Score predicts functional outcome at discharge in COVID-19-associated AIS patients
Multidifferential study of identified charged hadron distributions in -tagged jets in proton-proton collisions at 13 TeV
Jet fragmentation functions are measured for the first time in proton-proton
collisions for charged pions, kaons, and protons within jets recoiling against
a boson. The charged-hadron distributions are studied longitudinally and
transversely to the jet direction for jets with transverse momentum 20 GeV and in the pseudorapidity range . The
data sample was collected with the LHCb experiment at a center-of-mass energy
of 13 TeV, corresponding to an integrated luminosity of 1.64 fb. Triple
differential distributions as a function of the hadron longitudinal momentum
fraction, hadron transverse momentum, and jet transverse momentum are also
measured for the first time. This helps constrain transverse-momentum-dependent
fragmentation functions. Differences in the shapes and magnitudes of the
measured distributions for the different hadron species provide insights into
the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb
public pages
Study of the decay
The decay is studied
in proton-proton collisions at a center-of-mass energy of TeV
using data corresponding to an integrated luminosity of 5
collected by the LHCb experiment. In the system, the
state observed at the BaBar and Belle experiments is
resolved into two narrower states, and ,
whose masses and widths are measured to be where the first uncertainties are statistical and the second
systematic. The results are consistent with a previous LHCb measurement using a
prompt sample. Evidence of a new
state is found with a local significance of , whose mass and width
are measured to be and , respectively. In addition, evidence of a new decay mode
is found with a significance of
. The relative branching fraction of with respect to the
decay is measured to be , where the first
uncertainty is statistical, the second systematic and the third originates from
the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb
public pages
Measurement of the ratios of branching fractions and
The ratios of branching fractions
and are measured, assuming isospin symmetry, using a
sample of proton-proton collision data corresponding to 3.0 fb of
integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The
tau lepton is identified in the decay mode
. The measured values are
and
, where the first uncertainty is
statistical and the second is systematic. The correlation between these
measurements is . Results are consistent with the current average
of these quantities and are at a combined 1.9 standard deviations from the
predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb
public pages
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