Forensic applications of analog memory: the digital evidence bag

Digital evidence is electronic data that \has the potential to make the factual account of either party more probable or less probable than it would be without the evidence" [1]. We consider digital evidence stored on a physical memory device, collected in the fi eld and transported to a lab where the digital content is stored and analyzed. Digital Forensics is the area of study that deals with the science behind this process, as well as establishing best practices and legal requirements. The core aspects of digital forensics are preserving evidence integrity and the chain of custody during the handling and storage of the evidence [2]. In this thesis, we look specifi cally at digital evidence where only digital data is collected (such as forensic photography), as opposed to digital evidence that also includes the storage medium (such as seized mobile phones). We review the existing procedures used for collecting and transporting evidence and explore how these processes could be improved to better suit this kind of digital evidence. The fi eld of Information Security deals with providing con fidentiality and integrity of data, along with authentication and non-repudiation of both data and entities [3]. This is a widely researched and well developed area with many commercial applications, the most well known being internet security. We review and categorize the existing technologies used in information security into four avenues of approach based upon the fundamental security concepts of each: cryptography, widely witnessed, hardware security and exploitation of manufacturing defects. Many information security systems incorporate several of these approaches which leads to the overall security of the system being improved. The aims of Digital Forensics and Information Security are similar, however the processes and systems used are very different. This partly reflects that digital forensics is usually subject to a greater level of legal scrutiny, but it also highlights that there are potentially opportunities to improve the processes and systems used. Hence we develop the concept of a \digital evidence bag" (DEB), a device for the secure transport of digital evidence that has the same requirements as physical evidence bags: tamper-evident, unforgeable and clean. To achieve these requirements through technological solutions, we look at technology used in Information Security along with traditional forensic processes and explore how they can be adapted to create a DEB. Given the nature of digital data, it is easy to produce exact copies and edit the data with- out loss of quality. From a forensics point of view, this strips out a lot of the imperfections that are usually exploited in the traditional forensic processes. However the technology used to build digital memory is still inherently analog and has non-ideal characteristics, which are usually obfuscated in the digital application space. We show how these characteristics can be exploited to achieve the DEB requirements. We explore how a digital fi ngerprint for conventional digital memory could be used to meet the requirements of the DEB. We also propose a DEB based on analog memory cells which offers a novel method to meet the requirements.Thesis (MPhil) -- University of Adelaide, School of Electrical and Electronic Engineering, 202

Commitment readiness and relationship formation

The concept of being ready for a relationship is pervasive in popular culture, but theoretical and empirical research on readiness is lacking. We offer a conceptualization of commitment readiness and provide some of the first empirical work examining readiness among single individuals—specifically how this construct shapes various aspects of relationship formation. Using data from five independent samples of individuals not involved in romantic relationships, we first establish that commitment readiness is associated with more interest in developing a close romantic relationship (Studies 1a, 1b, 2) and with active pursuit of relationship initiation (Study 2). We then test whether readiness among single individuals longitudinally predicts both the likelihood of later entering a relationship and, ultimately, how committed individuals are to a future relationship (Studies 3a, 3b, 3c). Implications of commitment readiness specifically, and perceived personal timing more generally, for the social psychology of relationships are discussed. </jats:p

Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms:A gene–environment correlation study

BACKGROUND: Chaotic home environments may contribute to children's attention‐deficit hyperactivity disorder (ADHD) symptoms. However, ADHD genetic risk may also influence household chaos. This study investigated whether children in chaotic households had more ADHD symptoms, if mothers and children with higher ADHD genetic risk lived in more chaotic households, and the joint association of genetic risk and household chaos on the longitudinal course of ADHD symptoms across childhood. METHODS: Participants were mothers and children from the Environmental Risk (E‐Risk) Longitudinal Twin Study, a UK population‐representative birth cohort of 2,232 twins. Children's ADHD symptoms were assessed at ages 5, 7, 10 and 12 years. Household chaos was rated by research workers at ages 7, 10 and 12, and by mother's and twin's self‐report at age 12. Genome‐wide ADHD polygenic risk scores (PRS) were calculated for mothers (n = 880) and twins (n = 1,999); of these, n = 871 mothers and n = 1,925 children had information on children's ADHD and household chaos. RESULTS: Children in more chaotic households had higher ADHD symptoms. Mothers and children with higher ADHD PRS lived in more chaotic households. Children's ADHD PRS was associated with household chaos over and above mother's PRS, suggesting evocative gene–environment correlation. Children in more chaotic households had higher baseline ADHD symptoms and a slower rate of decline in symptoms. However, sensitivity analyses estimated that gene–environment correlation accounted for a large proportion of the association of household chaos on ADHD symptoms. CONCLUSIONS: Children's ADHD genetic risk was independently associated with higher levels of household chaos, emphasising the active role of children in shaping their home environment. Our findings suggest that household chaos partly reflects children's genetic risk for ADHD, calling into question whether household chaos directly influences children's core ADHD symptoms. Our findings highlight the importance of considering parent and child genetic risk in relation to apparent environmental exposures

Polygenic risk and the course of Attention-Deficit/Hyperactivity Disorder from childhood to young adulthood:Findings from a nationally representative cohort

OBJECTIVE: To understand whether genetic risk for attention-deficit/hyperactivity disorder (ADHD) is associated with the course of the disorder across childhood and into young adulthood. METHOD: Participants were from the Environmental Risk (E-Risk) Longitudinal Twin Study, a population-based birth cohort of 2,232 twins. ADHD was assessed at ages 5, 7, 10, and 12 with mother- and teacher-reports and at age 18 with self-report. Polygenic risk scores (PRSs) were created using a genome-wide association study of ADHD case status. Associations with PRS were examined at multiple points in childhood and longitudinally from early childhood to adolescence. We investigated ADHD PRS and course to young adulthood, as reflected by ADHD remission, persistence, and late onset. RESULTS: Participants with higher ADHD PRSs had increased risk for meeting ADHD diagnostic criteria (odds ratios ranging from 1.17 at age 10 to 1.54 at age 12) and for elevated symptoms at ages 5, 7, 10, and 12. Higher PRS was longitudinally associated with more hyperactivity/impulsivity (incidence rate ratio = 1.18) and inattention (incidence rate ratio = 1.14) from age 5 to age 12. In young adulthood, participants with persistent ADHD exhibited the highest PRS (mean PRS = 0.37), followed by participants with remission (mean PRS = 0.21); both groups had higher PRS than controls (mean PRS = −0.03), but did not significantly differ from one another. Participants with late-onset ADHD did not show elevated PRS for ADHD, depression, alcohol dependence, or marijuana use disorder. CONCLUSION: Genetic risk scores derived from case-control genome-wide association studies may have relevance not only for incidence of mental health disorders, but also for understanding the longitudinal course of mental health disorders

A systematic review of the effect of therapists’ internalised models of relationships on the quality of the therapeutic relationship

The quality of the therapeutic relationship has been identified as a key factor in predicting client outcomes, accounting for around 8% of variation (Horvath, Del Re, Flückiger, & Symonds, 2011; Martin, Garske, & Davis, 2000; Wampold, 2001). Although therapist factors have been seen as less relevant to therapeutic relationship quality than client factors, focus on therapist factors has steadily increased in line with the view that the therapist responds differently to different clients, due to their own personal characteristics and unconscious processes. Relational theory suggests that the therapist’s particular qualities combine with the client’s particular qualities to form a unique interpersonal context (e.g. Wachtel, 2008). Safran and Muran (2000) suggest that the interpersonal context is heavily influenced by client and therapist internalised patterns of relating formed in early childhood. Evidence shows that certain therapist factors do affect therapeutic relationship quality; the qualities of dependability, warmth and responsiveness in therapists have all been found to create stronger alliances (Ackerman & Hilsenroth, 2003). The importance of these mostly interpersonal characteristics imply that the internalised relational models of therapists may also be important in determining the type of relationship that is built and the therapeutic processes occurring within

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts