66 research outputs found
Experimental investigation of non-linear wave to plasma interaction in a quasi-flat magnetostatic field
A characterization of wave-to-plasma interaction in a quasi-flat magnetostatic field at 3.75 GHz has been carried out by using a small-wire movable RF antenna, connected to a spectrum analyzer. The coupling between electromagnetic and electrostatic waves leads to a characteristic spectral emission in low frequency range and around the pumping wave frequency. The most relevant results consist in the broadening of the pumping wave spectrum above critical RF power thresholds and in the generation of sidebands of the pumping frequency, with corresponding components in low frequency domain. The non-linearities are accompanied by the generation of overdense plasmas and intense fluxes of X-rays
Correlated pairs from the reaction
Correlated pairs emitted after the absorption of negative kaons
at rest in light nuclei and are
studied. -hyperons and deuterons are found to be preferentially
emitted in opposite directions. The invariant mass spectrum of
shows a bump whose mass is 32516 MeV/c. The bump mass (binding
energy), width and yield are reported. The appearance of a bump is discussed in
the realm of the [] clustering process in nuclei. The experiment was
performed with the FINUDA spectrometer at DANE (LNF).Comment: 13 pages, 5 figures, accepted for publication in Phys. Lett.
Herbicidal Activity of Thymbra capitata (L.) Cav. Essential Oil
[EN] The bioherbicidal potential ofThymbra capitata(L.) Cav. essential oil (EO) and its main compound carvacrol was investigated. In in vitro assays, the EO blocked the germination and seedling growth ofErigeron canadensisL.,Sonchus oleraceus(L.) L., andChenopodium albumL. at 0.125 mu L/mL, ofSetaria verticillata(L.) P.Beauv.,Avena fatuaL., andSolanum nigrumL. at 0.5 mu L/mL, ofAmaranthus retroflexusL. at 1 mu L/mL and ofPortulaca oleraceaL., andEchinochloa crus-galli(L.) P.Beauv. at 2 mu L/mL. Under greenhouse conditions,T. capitataEO was tested towards the emergent weeds from a soil seedbank in pre and post emergence, showing strong herbicidal potential in both assays at 4 mu L/mL. In addition,T. capitataEO, applied by spraying, was tested againstP. oleracea,A. fatuaandE. crus-galli. The species showed different sensibility to the EO, beingE. crus-gallithe most resistant. Experiments were performed againstA. fatuatestingT. capitataEO and carvacrol applied by spraying or by irrigation. It was verified that the EO was more active at the same doses in monocotyledons applied by irrigation and in dicotyledons applied by spraying. Carvacrol effects onArabidopsisroot morphology were also studied.This research was supported by the Universitat Politècnica de València [project number: SP20120543],
by Generalitat Valenciana [project number GV/2014/039], and by the Spanish Ministry of Science, Innovation
and Universities [project number: RTI2018¿094716¿B¿I00].
Thanks to Jovano Erris Nugroho and Muhamad Iqbal who collaborate to carry out in vivo experiment 4 during their internship in the Plant Health in Sustainable Cropping Systems Erasmus+ Programme. This research work has been developed as a result of a mobility stay funded by the Erasmus+-KA1 Erasmus Mundus Joint Master Degrees Programme of the European Commission under the PLANT HEALTH Project. Thanks to Xeda Italia S.r.l. for providing us Fitoil always when we need it. Thanks to Vicente Estornell Campos and the Library staff from Polytechnic University of Valencia that assisted us to get some helpful references.Verdeguer Sancho, MM.; Torres-Pagan, N.; Muñoz, M.; Jouini, A.; García-Plasencia, S.; Chinchilla, P.; Berbegal Martinez, M.... (2020). Herbicidal Activity of Thymbra capitata (L.) Cav. Essential Oil. Molecules. 25(12):1-31. https://doi.org/10.3390/molecules25122832S1312512Barros, L., Heleno, S. A., Carvalho, A. M., & Ferreira, I. C. F. R. (2010). Lamiaceae often used in Portuguese folk medicine as a source of powerful antioxidants: Vitamins and phenolics. LWT - Food Science and Technology, 43(3), 544-550. doi:10.1016/j.lwt.2009.09.024Goudjil, M. B., Zighmi, S., Hamada, D., Mahcene, Z., Bencheikh, S. E., & Ladjel, S. (2020). Biological activities of essential oils extracted from Thymus capitatus (Lamiaceae). South African Journal of Botany, 128, 274-282. doi:10.1016/j.sajb.2019.11.020Gagliano Candela, R., Maggi, F., Lazzara, G., Rosselli, S., & Bruno, M. (2019). The Essential Oil of Thymbra capitata and its Application as A Biocide on Stone and Derived Surfaces. Plants, 8(9), 300. doi:10.3390/plants8090300Tohidi, B., Rahimmalek, M., Arzani, A., & Sabzalian, M. R. (2020). Thymol, carvacrol, and antioxidant accumulation in Thymus species in response to different light spectra emitted by light-emitting diodes. Food Chemistry, 307, 125521. doi:10.1016/j.foodchem.2019.125521Vladimir-Knežević, S., Blažeković, B., Kindl, M., Vladić, J., Lower-Nedza, A., & Brantner, A. (2014). Acetylcholinesterase Inhibitory, Antioxidant and Phytochemical Properties of Selected Medicinal Plants of the Lamiaceae Family. Molecules, 19(1), 767-782. doi:10.3390/molecules19010767BRÄUCHLER, C. (2018). Delimitation and revision of the genus Thymbra (Lamiaceae). Phytotaxa, 369(1), 15. doi:10.11646/phytotaxa.369.1.2Paton, A. J., Springate, D., Suddee, S., Otieno, D., Grayer, R. J., Harley, M. M., … Savolainen, V. (2004). Phylogeny and evolution of basils and allies (Ocimeae, Labiatae) based on three plastid DNA regions. Molecular Phylogenetics and Evolution, 31(1), 277-299. doi:10.1016/j.ympev.2003.08.002Pastore, J. F. B., Harley, R. M., Forest, F., Paton, A., & van den Berg, C. (2011). Phylogeny of the subtribe Hyptidinae (Lamiaceae tribe Ocimeae) as inferred from nuclear and plastid DNA. TAXON, 60(5), 1317-1329. doi:10.1002/tax.605008Salmaki, Y., Zarre, S., Ryding, O., Lindqvist, C., Bräuchler, C., Heubl, G., … Bendiksby, M. (2013). Molecular phylogeny of tribe Stachydeae (Lamiaceae subfamily Lamioideae). Molecular Phylogenetics and Evolution, 69(3), 535-551. doi:10.1016/j.ympev.2013.07.024Salmaki, Y., Kattari, S., Heubl, G., & Bräuchler, C. (2016). Phylogeny of non-monophyletic Teucrium (Lamiaceae: Ajugoideae): Implications for character evolution and taxonomy. Taxon, 65(4), 805-822. doi:10.12705/654.8LI, B., & OLMSTEAD, R. G. (2017). Two new subfamilies in Lamiaceae. Phytotaxa, 313(2), 222. doi:10.11646/phytotaxa.313.2.9Bräuchler, C., Meimberg, H., & Heubl, G. (2010). Molecular phylogeny of Menthinae (Lamiaceae, Nepetoideae, Mentheae) – Taxonomy, biogeography and conflicts. Molecular Phylogenetics and Evolution, 55(2), 501-523. doi:10.1016/j.ympev.2010.01.016World Checklist of Lamiaceae. Facilitated by the Royal Botanic Gardens, Kewhttp://wcsp.science.kew.orgHarley, R. M., Atkins, S., Budantsev, A. L., Cantino, P. D., Conn, B. J., Grayer, R., … Upson, T. (2004). Labiatae. Flowering Plants · Dicotyledons, 167-275. doi:10.1007/978-3-642-18617-2_11Miceli, A., Negro, C., & Tommasi, L. (2006). Essential oil variability in Thymbra capitata (L.) Cav. growing wild in Southern Apulia (Italy). Biochemical Systematics and Ecology, 34(6), 528-535. doi:10.1016/j.bse.2005.12.010Delgado-Adámez, J., Garrido, M., Bote, M. E., Fuentes-Pérez, M. C., Espino, J., & Martín-Vertedor, D. (2017). Chemical composition and bioactivity of essential oils from flower and fruit of Thymbra capitata and Thymus species. Journal of Food Science and Technology, 54(7), 1857-1865. doi:10.1007/s13197-017-2617-5Alves, T. M. de A., Silva, A. F., Brandão, M., Grandi, T. S. M., Smânia, E. de F. A., Smânia Júnior, A., & Zani, C. L. (2000). Biological screening of Brazilian medicinal plants. Memórias do Instituto Oswaldo Cruz, 95(3), 367-373. doi:10.1590/s0074-02762000000300012BOUNATIROU, S., SMITI, S., MIGUEL, M., FALEIRO, L., REJEB, M., NEFFATI, M., … PEDRO, L. (2007). Chemical composition, antioxidant and antibacterial activities of the essential oils isolated from Tunisian Thymus capitatus Hoff. et Link. Food Chemistry, 105(1), 146-155. doi:10.1016/j.foodchem.2007.03.059Nejad Ebrahimi, S., Hadian, J., Mirjalili, M. H., Sonboli, A., & Yousefzadi, M. (2008). Essential oil composition and antibacterial activity of Thymus caramanicus at different phenological stages. Food Chemistry, 110(4), 927-931. doi:10.1016/j.foodchem.2008.02.083Casiglia, S., Bruno, M., Scandolera, E., Senatore, F., & Senatore, F. (2019). Influence of harvesting time on composition of the essential oil of Thymus capitatus (L.) Hoffmanns. & Link. growing wild in northern Sicily and its activity on microorganisms affecting historical art crafts. Arabian Journal of Chemistry, 12(8), 2704-2712. doi:10.1016/j.arabjc.2015.05.017Grayer, R. J., & Harborne, J. B. (1994). A survey of antifungal compounds from higher plants, 1982–1993. Phytochemistry, 37(1), 19-42. doi:10.1016/0031-9422(94)85005-4Kalemba, D., & Kunicka, A. (2003). Antibacterial and Antifungal Properties of Essential Oils. Current Medicinal Chemistry, 10(10), 813-829. doi:10.2174/0929867033457719Ricci, D., Fraternale, D., Giamperi, L., Bucchini, A., Epifano, F., Burini, G., & Curini, M. (2005). Chemical composition, antimicrobial and antioxidant activity of the essential oil of Teucrium marum (Lamiaceae). Journal of Ethnopharmacology, 98(1-2), 195-200. doi:10.1016/j.jep.2005.01.022Al-Mustafa, A. H., & Al-Thuniba, O. Y. (2008). Antioxidant Activity of Some Jordanian Medicinal Plants Used Traditionally for Treatment of Diabetes. Pakistan Journal of Biological Sciences, 11(3), 351-358. doi:10.3923/pjbs.2008.351.358Dhifi, W., Bellili, S., Jazi, S., Bahloul, N., & Mnif, W. (2016). Essential Oils’ Chemical Characterization and Investigation of Some Biological Activities: A Critical Review. Medicines, 3(4), 25. doi:10.3390/medicines3040025Ruberto, G., Biondi, D., & Piattelli, M. (1992). The Essential Oil of SicilianThymus capitatus(L.) Hoffmanns, et Link. Journal of Essential Oil Research, 4(4), 417-418. doi:10.1080/10412905.1992.9698094Saija, A., Speciale, A., Trombetta, D., Leto, C., Tuttolomondo, T., La Bella, S., … Ruberto, G. (2016). Phytochemical, Ecological and Antioxidant Evaluation of Wild Sicilian Thyme: Thymbra capitata
(L.) Cav
. Chemistry & Biodiversity, 13(12), 1641-1655. doi:10.1002/cbdv.201600072Arras, G., & Grella, G. E. (1992). Wild thyme,Thymus capitatus, essential oil seasonal changes and antimycotic activity. Journal of Horticultural Science, 67(2), 197-202. doi:10.1080/00221589.1992.11516237Tommasi, L., Negro, C., Cerfeda, A., Nutricati, E., Zuccarello, V., De Bellis, L., & Miceli, A. (2007). Influence of Environmental Factors on Essential Oil Variability inThymbra capitata(L.) Cav. Growing Wild in Southern Puglia (Italy). Journal of Essential Oil Research, 19(6), 572-580. doi:10.1080/10412905.2007.9699335Salas, J. B., Téllez, T. R., Alonso, M. J. P., Pardo, F. M. V., de los Ángeles Cases Capdevila, M., & Rodríguez, C. G. (2010). Chemical composition and antioxidant activity of the essential oil ofThymbra capitata(L.) Cav. in Spain. Acta Botanica Gallica, 157(1), 55-63. doi:10.1080/12538078.2010.10516189Rodrigues, L. S., Monteiro, P., Maldoa-Martins, M., Monteiro, A., Povoa, O., & Teixeira, G. (2006). BIODIVERSITY STUDIES ON PORTUGUESE THYMBRA CAPITATA. Acta Horticulturae, (723), 127-132. doi:10.17660/actahortic.2006.723.13El Hadj Ali, I. B., Guetat, A., & Boussaid, M. (2012). Variation of Volatiles in Tunisian Populations of Thymbra capitata (L.) Cav. (Lamiaceae). Chemistry & Biodiversity, 9(7), 1272-1285. doi:10.1002/cbdv.201100344Katz, D. A., Sneh, B., & Friedman, J. (1987). The allelopathic potential ofCoridothymus capitatus L. (Labiatae). Preliminary studies on the roles of the shrub in the inhibition of annuals germination and/or to promote allelopathically active actinomycetes. Plant and Soil, 98(1), 53-66. doi:10.1007/bf02381727Dudai, N., Poljakoff-Mayber, A., Mayer, A. M., Putievsky, E., & Lerner, H. R. (1999). Journal of Chemical Ecology, 25(5), 1079-1089. doi:10.1023/a:1020881825669Saoud, I., Hamrouni, L., Gargouri, S., Amri, I., Hanana, M., Fezzani, T., … Jamoussi, B. (2013). Chemical composition, weed killer and antifungal activities of Tunisian thyme (Thymus capitatusHoff. et Link.) essential oils. Acta Alimentaria, 42(3), 417-427. doi:10.1556/aalim.42.2013.3.15Chaimovitsh, D., Shachter, A., Abu-Abied, M., Rubin, B., Sadot, E., & Dudai, N. (2016). Herbicidal Activity of Monoterpenes Is Associated with Disruption of Microtubule Functionality and Membrane Integrity. Weed Science, 65(1), 19-30. doi:10.1614/ws-d-16-00044.1Verdeguer, M., Castañeda, L. G., Torres-Pagan, N., Llorens-Molina, J. A., & Carrubba, A. (2020). Control of Erigeron bonariensis with Thymbra capitata, Mentha piperita, Eucalyptus camaldulensis, and Santolina chamaecyparissus Essential Oils. Molecules, 25(3), 562. doi:10.3390/molecules25030562Cordeau, S., Triolet, M., Wayman, S., Steinberg, C., & Guillemin, J.-P. (2016). Bioherbicides: Dead in the water? A review of the existing products for integrated weed management. Crop Protection, 87, 44-49. doi:10.1016/j.cropro.2016.04.016Mahmood, I., Imadi, S. R., Shazadi, K., Gul, A., & Hakeem, K. R. (2016). Effects of Pesticides on Environment. Plant, Soil and Microbes, 253-269. doi:10.1007/978-3-319-27455-3_13Harker, K. N., & O’Donovan, J. T. (2013). Recent Weed Control, Weed Management, and Integrated Weed Management. Weed Technology, 27(1), 1-11. doi:10.1614/wt-d-12-00109.1Olson, S. (2015). An Analysis of the Biopesticide Market Now and Where it is Going. Outlooks on Pest Management, 26(5), 203-206. doi:10.1564/v26_oct_04Santamarina, M., Ibáñez, M., Marqués, M., Roselló, J., Giménez, S., & Blázquez, M. (2017). Bioactivity of essential oils in phytopathogenic and post-harvest fungi control. Natural Product Research, 31(22), 2675-2679. doi:10.1080/14786419.2017.1286479Tuttolomondo, T., Dugo, G., Leto, C., Cicero, N., Tropea, A., Virga, G., … La Bella, S. (2015). Agronomical and chemical characterisation ofThymbra capitata(L.) Cav. biotypes from Sicily, Italy. Natural Product Research, 29(14), 1289-1299. doi:10.1080/14786419.2014.997726Miguel, M. G., Gago, C., Antunes, M. D., Megías, C., Cortés-Giraldo, I., Vioque, J., … Figueiredo, A. C. (2015). Antioxidant and Antiproliferative Activities of the Essential Oils fromThymbra capitataandThymusSpecies Grown in Portugal. Evidence-Based Complementary and Alternative Medicine, 2015, 1-8. doi:10.1155/2015/851721Karousou, R., Koureas, D. N., & Kokkini, S. (2005). Essential oil composition is related to the natural habitats: Coridothymus capitatus and Satureja thymbra in NATURA 2000 sites of Crete. Phytochemistry, 66(22), 2668-2673. doi:10.1016/j.phytochem.2005.09.020Vasilakoglou, I., Dhima, K., Paschalidis, K., & Ritzoulis, C. (2013). Herbicidal potential onLolium rigidumof nineteen major essential oil components and their synergy. Journal of Essential Oil Research, 25(1), 1-10. doi:10.1080/10412905.2012.751054Hazrati, H., Saharkhiz, M. J., Niakousari, M., & Moein, M. (2017). Natural herbicide activity of Satureja hortensis L. essential oil nanoemulsion on the seed germination and morphophysiological features of two important weed species. Ecotoxicology and Environmental Safety, 142, 423-430. doi:10.1016/j.ecoenv.2017.04.041Pinheiro, P. F., Costa, A. V., Alves, T. de A., Galter, I. N., Pinheiro, C. A., Pereira, A. F., … Fontes, M. M. P. (2015). Phytotoxicity and Cytotoxicity of Essential Oil from Leaves of Plectranthus amboinicus, Carvacrol, and Thymol in Plant Bioassays. Journal of Agricultural and Food Chemistry, 63(41), 8981-8990. doi:10.1021/acs.jafc.5b03049Tworkoski, T. (2002). Herbicide effects of essential oils. Weed Science, 50(4), 425-431. doi:10.1614/0043-1745(2002)050[0425:heoeo]2.0.co;2Benvenuti, S., Cioni, P. L., Flamini, G., & Pardossi, A. (2017). Weeds for weed control: Asteraceae essential oils as natural herbicides. Weed Research, 57(5), 342-353. doi:10.1111/wre.12266N. MALPASSI, R. (2006). Herbicide effects on cuticle ultrastructure in Eleusine indica and Portulaca oleracea. BIOCELL, 30(1), 51-56. doi:10.32604/biocell.2006.30.051Schreiber, L. (1995). A mechanistic approach towards surfactant/wax interactions: Effects of octaethyleneglycolmonododecylether on sorption and diffusion of organic chemicals in reconstituted cuticular wax of barley leaves. Pesticide Science, 45(1), 1-11. doi:10.1002/ps.2780450102Hull, H. M., Morton, H. L., & Wharrie, J. R. (1975). Environmental influences on cuticle development and resultant foliar penetration. The Botanical Review, 41(4), 421-452. doi:10.1007/bf02860832Kern, A. J., Jackson, L. L., & Dyer, W. E. (1997). Fatty acid and wax biosynthesis in susceptible and triallate-resistantAvena fatuaL. Pesticide Science, 51(1), 21-26. doi:10.1002/(sici)1096-9063(199709)51:13.0.co;2-9SANYAL, D., BHOWMIK, P. C., & REDDY, K. N. (2008). Effects of surfactants on primisulfuron activity in barnyardgrass (Echinochloa crus-galli [L.] Beauv.) and green foxtail (Setaria viridis [L.] Beauv.). Weed Biology and Management, 8(1), 46-53. doi:10.1111/j.1445-6664.2007.00273.xPrinciples of Soil and Plant Water Relations. (2014). doi:10.1016/c2013-0-12871-1Kim, H. K., Park, J., & Hwang, I. (2014). Investigating water transport through the xylem network in vascular plants. Journal of Experimental Botany, 65(7), 1895-1904. doi:10.1093/jxb/eru075Norris, R. F. (1974). PENETRATION OF 2,4-D IN RELATION TO CUTICLE THICKNESS. American Journal of Botany, 61(1), 74-79. doi:10.1002/j.1537-2197.1974.tb06029.xSchönherr, J., & Riederer, M. (1989). Foliar Penetration and Accumulation of Organic Chemicals in Plant Cuticles. Reviews of Environmental Contamination and Toxicology, 1-70. doi:10.1007/978-1-4613-8850-0_1GOURET, E., ROHR, R., & CHAMEL, A. (1993). Ultrastructure and chemical composition of some isolated plant cuticles in relation to their permeability to the herbicide, diuron. New Phytologist, 124(3), 423-431. doi:10.1111/j.1469-8137.1993.tb03832.xRiederer, M., & Schönherr, J. (1985). Accumulation and transport of (2,4-dichlorophenoxy)acetic acid in plant cuticles. Ecotoxicology and Environmental Safety, 9(2), 196-208. doi:10.1016/0147-6513(85)90022-3Melo, C. R., Picanço, M. C., Santos, A. A., Santos, I. B., Pimentel, M. F., Santos, A. C. C., … Bacci, L. (2018). Toxicity of essential oils of Lippia gracilis chemotypes and their major compounds on Diaphania hyalinata and non-target species. Crop Protection, 104, 47-51. doi:10.1016/j.cropro.2017.10.013Araniti, F., Graña, E., Krasuska, U., Bogatek, R., Reigosa, M. J., Abenavoli, M. R., & Sánchez-Moreiras, A. M. (2016). Loss of Gravitropism in Farnesene-Treated Arabidopsis Is Due to Microtubule Malformations Related to Hormonal and ROS Unbalance. PLOS ONE, 11(8), e0160202. doi:10.1371/journal.pone.0160202Smyth, D. R. (2016). Helical growth in plant organs: mechanisms and significance. Development, 143(18), 3272-3282. doi:10.1242/dev.134064Graña, E., Costas-Gil, A., Longueira, S., Celeiro, M., Teijeira, M., Reigosa, M. J., & Sánchez-Moreiras, A. M. (2017). Auxin-like effects of the natural coumarin scopoletin on Arabidopsis cell structure and morphology. Journal of Plant Physiology, 218, 45-55. doi:10.1016/j.jplph.2017.07.007Verbelen, J.-P., Le, J., Vissenberg, K., De Cnodder, T., Vandenbussche, F., Sugimoto, K., & Van Der Straeten, D. (2008). Microtubules And The Control Of Cell Elongation In Arabidopsis Roots. NATO Science for Peace and Security Series C: Environmental Security, 73-90. doi:10.1007/978-1-4020-8843-8_4Blume, Y. B., Krasylenko, Y. A., & Yemets, A. I. (2012). Effects of phytohormones on the cytoskeleton of the plant cell. Russian Journal of Plant Physiology, 59(4), 515-529. doi:10.1134/s1021443712040036López-González, D., Costas-Gil, A., Reigosa, M. J., Araniti, F., & Sánchez-Moreiras, A. M. (2020). A natural indole alkaloid, norharmane, affects PIN expression patterns and compromises root growth in Arabidopsis thaliana. Plant Physiology and Biochemistry, 151, 378-390. doi:10.1016/j.plaphy.2020.03.047The International Herbicide-Resistant Weed Databasewww.weedscience.orgAngelini, L. G., Carpanese, G., Cioni, P. L., Morelli, I., Macchia, M., & Flamini, G. (2003). Essential Oils from Mediterranean Lamiaceae as Weed Germination Inhibitors. Journal of Agricultural and Food Chemistry, 51(21), 6158-6164. doi:10.1021/jf0210728DÍAZ-TIELAS, C., GRAÑA, E., SOTELO, T., REIGOSA, M. J., & SÁNCHEZ-MOREIRAS, A. M. (2012). The natural compound trans-chalcone induces programmed cell death in Arabidopsis thaliana roots. Plant, Cell & Environment, 35(8), 1500-1517. doi:10.1111/j.1365-3040.2012.02506.
Production of H and H with the (K,) reaction
The production of neutron rich -hypernuclei via the
(,) reaction has been studied using data collected with the
FINUDA spectrometer at the DANE -factory (LNF). The analysis of the
inclusive momentum spectra is presented and an upper limit for the
production of H and H from Li and Li, is
assessed for the first time.Comment: 11 pages, 3 figures. Accepted for publication in PL
A study of the proton spectra following the capture of in Li and C with FINUDA
Momenta spectra of protons emitted following the capture of in Li
and C have been measured with 1% resolution. The C spectrum is
smooth whereas for Li a well defined peak appears at about 500 MeV/. The
first observation of a structure in this region was identified as a strange
tribaryon or, possibly, a -nuclear state. The peak is correlated with a
coming from decay in flight, selected by setting momenta
larger than 275 MeV/. The could be produced, together with a 500
MeV/ proton, by the capture of a in a deuteron-cluster substructure of
the Li nucleus. The capture rate for such a reaction is (1.62\pm
0.23_{stat} ^{+0.71}_{-0.44}(sys))%/K^-_{stop}, in agreement with the existing
observations on He targets and with the hypothesis that the Li nucleus
can be interpreted as a cluster.Comment: 21 pages, 10 figures. Accepted for publication in NP
First Results on 12Lambda-C production at DAPHNE
Lambda-hypernuclei are produced and studied, with the FINUDA spectrometer,
for the first time at an e+e- collider: DAPHNE, the Frascati phi-factory. The
slow negative kaons from phi(1020) decay are stopped in thin (0.2 g/cm^2)
nuclear targets, and Lambda-hypernuclei formation is detected by measuring the
momentum of the outgoing pi^-. A preliminary analysis on 12Lambda-C shows an
energy resolution of 1.29 MeV FWHM on the hypernuclear levels, the best
obtained so far with magnetic spectrometers at hadron facilities. Capture rates
for the ground state and the excited ones are reported, and compared with
previous experiments.Comment: 15 pages, 5 figures. v2: one reference updated. Accepted for
publication in Phys. Lett.
Experimental study of the (K+,K0) interactions on 7Li close to threshold
Abstract The inelastic charge exchange reaction ( K + , K 0 ) on 7Li has been experimentally investigated close to threshold with the FINUDA spectrometer at the e + e − collider DAΦNE by searching for K S 0 decays. It is the first time that this process has been studied at such low momentum. An upper limit of 2.0 mb (at 95% confidence level) has been measured for the total cross section
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Peripheral effects of centrally administered interleukin-1beta in mice in relation to its clearance from the brain into the blood and tissue distribution
: Administration of interleukin IL-1 induces acute-phase response and inhibition of gastric secretion more efficiently when administered intracerebroventricularly (i.c.v.) than when the same dose of IL-1 is administered systemically. In this study we describe the pharmacokinetics of IL-1beta, administered centrally or systemically, in the serum or in peripheral tissues. IL-1beta administered i.c.v. resulted in higher peak IL-1beta concentrations, and lasted longer, than intravenous (i.v.) or intraperitoneal (i.p.) administration. Higher IL-1beta levels in the liver and heart were observed after i. c.v. administration (compared to the i.p. or i.v. route). Our data suggest that centrally injected IL-1 induces higher circulating and hepatic IL-1 levels and contributes to the fact that the i.c.v. route of administration is particularly effective in inducing a liver acute-phase response
Inducible expression of the long pentraxin PTX3 in the central nervous system
: PTX3 is a prototypic long pentraxin consisting of a C terminal 203-amino acid pentraxin-like domain coupled with an N-terminal 178-amino acid unrelated portion. PTX3 is induced by primary proinflammatory signals in various cell types, most prominently macrophages and endothelial cells. Other long pentraxins, such as murine or rat neuronal pentraxin 1 (NP1) and human neuronal pentraxin 2 (NPTX2), are expressed in the central nervous system (CNS). The present study was designed to investigate whether PTX3 is expressed in the brain and to define the structures and cells involved. Intracerebroventricular (i.c.v.), but not i.v., injection of LPS induced high levels of PTX3 mRNA in the mouse brain. In contrast NP1 is constitutively expressed in the murine CNS and is not modulated by LPS administration. I.c.v. IL-1beta was also a potent inducer of PTX3 expression in the CNS, whereas TNFalpha was substantially less effective and IL-6 induced a barely detectable signal. Central administration of LPS and IL-1 induced PTX3 also in the periphery (heart), whereas the reverse did not occur. Expression of PTX3 was also observed in the brain of mice infected with Candida albicans (C. albicans) or Cryptococcus neoformans. (C. neoformans). The kinetics of PTX3 gene induction were consistently different between C. albicans- and C. neoformans-infected mice, according to the diverse outcome of the CNS immune reaction. In situ hybridization revealed that i.c.v. injection of LPS induced a strong PTX3 expression in presumptive glial cells, in the white matter (corpus callosum, fimbria) and meningeal pia mater as well as in dentate gyrus hilus and granule cells. No constitutive expression of PTX3 was detected. Central expression of PTX3 may amplify mechanisms of innate resistance and damage in the CNS. The possibility of a direct interaction of PTX3 with neuronal cells, as suggested for NPTX2, remains to be explored
- …