Berberine, a popular dietary supplement for human and animal health: Quantitative research literature analysis a review

Berberine is an alkaloid with a wide range of reported beneficial health effects. The current work provides an extensive literature analysis on berberine. Bibliometric data were identified by means of the search string TOPIC=(berberin* OR umbellatine*), which yielded 5,547 publications indexed in the Web of Science Core Collection electronic database. The VOSviewer software generated bubble maps to visualize semantic terms with citation results. The ratio of original articles to reviews was 13.6:1. The literature has been growing more quickly since the 2010s. Major contributing countries were China, the United States, India, Japan, and South Korea. Most of the publications appeared in journals specialized in pharmacology pharmacy, biochemistry molecular biology, chemistry, and plant science. Some of the frequently mentioned chemicals/chemical classes were alkaloid, palmatine, jatrorrhizine, coptisine, isoquinoline, and sanguinarine. The prevalent medical conditions under investigation included Alzheimers disease, cancer, diabetes, and obesity.Acknowledge the support by the Polish KNOW (LeadingNational Research Centre) Scientific Consortium “Healthy Animal-Safe Food,” decision of Ministry of Science and Higher Education No. 05-1/KNOW2/2015 and the European Union under the European Regional Development Fund (Homing/2017-4/41). Antoni Sureda has been supported by the Institute of Health Carlos III (Project CIBEROBN CB12/03/30038). Joanna Feder-Kubis was financed by the Polish Ministry of Science and Higher Education for the Faculty of Chemistry of Wrocław University of Science and Technology.info:eu-repo/semantics/publishedVersio

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Not AvailableThe formation of adventitious roots (ARs) is primarily considered as a most crucial developmental phase for the vegetative propagation of plants. AR either originates naturally in whole plants, as a programmed developmental process, or develops in response to any stress or injury, for example, in cuttings. AR formation in plants is a complex and multistep process, regulated by several factors such as environmental stimuli and endogenous hormones. Availability of energy sources and supply of nitrogen and amino acid affect the pace and intensity of AR formation. Furthermore, significant alterations in enzyme activities and metabolite accumulation observed in plant cuttings suggest that the activity of specific enzymes and metabolites governs AR formation. Profiling of metabolites displays a significant increase in organic acids and several essential amino acids. There are major metabolic stages in AR formation: (1) sink establishment phase, (2) recovery phase, and (3) maintenance phase. However, available information regarding the molecular and physiological basis of AR formation is scarce and requires further investigations to unfold the precise mechanism of AR formation. Therefore, the present article is an attempt to provide a better understanding of AR formation in plant cuttings. Furthermore, the focus is also given to equate the corelation between varied actions of the aforementioned factors during AR formation.Not Availabl

Copper Complexes of Henna-sulforaphane Conjugates as Potent Antiproliferative Agents Against Human Myeloma KBM-5 Cells Through Blockade of Transcription Factor NF-κB

The semi-thiosemicarbazone and N4-substituted thiosemicarbazone derivatives and their metal complexes of the active principle of Henna were structurally characterized along with single crystal X-ray studies. The compounds were evaluated for their antiproliferative activity against human leukemia KBM-5 cells, where [Cu(3)] was the most active compound with IC 50 of 0.3 μM attributed to down regulation of NF-κB activation. © 2007 Bentham Science Publishers Ltd

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Not AvailableThe membrane lipids serve as the first line of defence to protect the cells from stress. The membrane glycerophospholipids and the associated enzymes have an important role in membrane stability, fluidity, and function. One of the key regulators in membrane dynamics is phospholipase D (PLD) which produces phosphatidic acid for dual working as a producer of membrane lipid diversity and as a secondary messenger. Phosphatidic acid has a binding affinity for many effector proteins including NADPH oxidase, MAP kinases etc. which actively participate in signalling pathways. Under various abiotic stresses, the role of various isoforms of PLD has been documented. The different isoforms behave differently. Two isoforms PLDα and PLDδ have been studied well and through the mutant analyses, their role under specific stress conditions has been highlighted. There is a cross-talk among PA, Ca2+, and NO through integrated signalling pathways which needs further investigation for dissecting the role of individual species.Not AvailableNot Availabl

Dietary natural products and their potential to influence health and disease including animal model studies

Although biological and pharmacological effects of dietary natural products have been intensively studied, there has been no bibliometric analysis performed on this research field up to now. The current study has aimed to identify and analyze the manuscripts on dietary natural products and their potential to influence health and disease including studies using animal models. Data, including words from titles and abstracts, publication and citation data, have been extracted from Web of Science database and analyzed by the VOSviewer software. Our search has yielded 1,014 manuscripts. The ratio of original articles to reviews was identified to be 1.5:1. Over half of the manuscripts have been published since 2010. The manuscripts have been contributed by 4,301 authors from 1,445 organizations in 76 countries/territories and published in 499 journals. The results from the current study point out that scientific research focusing on the potential of dietary natural products to affect health and disease status (including animal model studies) is expanding, and suggests an increasing significance of this scientific area. With the progressive development and improvement of animal studies, it should be expected that animal models of different human diseases (especially civilization ones) would be an integral part of the research for the evaluation of pharmaceuticals originated from dietary natural products like plants or plant materials. Moreover, natural products can also be fed to animals to improve the quality of animal products, with numerous resulting functional effects.</p

Resveratrol, a popular dietary supplement for human and animal health: Quantitative research literature analysis -a review

Resveratrol is a stilbene-type bioactive molecule with a broad spectrum of reported biological effects. In this sense, the current work provides a comprehensive literature analysis on resveratrol, representing a highly-researched commercially available dietary ingredient. Bibliometric data were identified by means of the search string TOPIC=(“resveratrol*”) and analyzed with the VOSviewer software, which yielded 17,561 publications extracted from the Web of Science Core Collection electronic database. The ratio of original articles to reviews was 9.5:1. More than half of the overall manuscripts have been published since 2013. Major contributing countries were USA, China, Italy, South Korea, and Spain. Most of the publications appeared in journals specialized in biochemistry and molecular biology, pharmacology and pharmacy, food science technology, cell biology, or oncology. The phytochemicals or phytochemical classes that were frequently mentioned in the keywords of analyzed publications included, in descending order: resveratrol, trans-resveratrol, polyphenols, flavonoids, quercetin, stilbenes, curcumin, piceatannol, cis-resveratrol, and anthocyanins