A Comparative Study of the Mechanics of Flying and Swimming in Some Common Brown Bats

Author Institution: Central State College, Wilberforce, Ohi

Abiotic and Biotic Soil Characteristics in Old Growth Forests and Thinned or Unthinned Mature Stands in Three Regions of Oregon

We compared forest floor depth, soil organic matter, soil moisture, anaerobic mineralizable nitrogen (a measure of microbial biomass), denitrification potential, and soil/litter arthropod communities among old growth, unthinned mature stands, and thinned mature stands at nine sites (each with all three stand types) distributed among three regions of Oregon. Mineral soil measurements were restricted to the top 10 cm. Data were analyzed with both multivariate and univariate analyses of variance. Multivariate analyses were conducted with and without soil mesofauna or forest floor mesofauna, as data for those taxa were not collected on some sites. In multivariate analysis with soil mesofauna, the model giving the strongest separation among stand types (P = 0.019) included abundance and richness of soil mesofauna and anaerobic mineralizable nitrogen. The best model with forest floor mesofauna (P = 0.010) included anaerobic mineralizable nitrogen, soil moisture content, and richness of forest floor mesofauna. Old growth had the highest mean values for all variables, and in both models differed significantly from mature stands, while the latter did not differ. Old growth also averaged higher percent soil organic matter, and analysis including that variable was significant but not as strong as without it. Results of the multivariate analyses were mostly supported by univariate analyses, but there were some differences. In univariate analysis, the difference in percent soil organic matter between old growth and thinned mature was due to a single site in which the old growth had exceptionally high soil organic matter; without that site, percent soil organic matter did not differ between old growth and thinned mature, and a multivariate model containing soil organic matter was not statistically significant. In univariate analyses soil mesofauna had to be compared nonparametrically (because of heavy left-tails) and differed only in the Siskiyou Mountains, where they were most abundant and species rich in old growth forests. Species richness of mineral soil mesofauna correlated significantly (+) with percent soil organic matter and soil moisture, while richness of forest floor mesofauna correlated (+) with depth of the forest floor. Composition of forest floor and soil mesofauna suggest the two groups represent a single community. Soil moisture correlated highly with percent soil organic matter, with no evidence for drying in sites that were sampled relatively late in the summer drought, suggesting losses of surface soil moisture were at least partially replaced by hydraulic lift (which has been demonstrated in other forests of the region)

Allergic reaction to protamine: A late complication of elective vasectomy?,

Nucleoprotamines are a normal component of human sperm cells. Antibodies against these protamines develop in 22 to 33 per cent of patients undergoing elective vasectomy. These antibodies, in turn, have been shown to cross-react with medicinal protamines, which are extracted commercially from the testes of salmon and certain other fish. This cross-reactivity against protamines raises the possibility that patients who have undergone elective vasectomy may be at increased risk of an allergic reaction developing if they are later exposed to protamine as a medication. Since medicinal protamines currently enjoy widespread clinical use, this information should be borne in mind by those clinicians using protamine and by urologists when counselling patients concerning elective vasectomy for sterilization.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25078/1/0000509.pd

The University of Salford Sound of Laughter project

What follows is a report of the University of Salford’s Sound of Laughter Project (2018). This pilot study was set up as an initial attempt to ascertain whether it is possible to discern any meaning from the different laughter sounds that audiences might make during a stand-up comedy show. The experiment also aimed to discover whether comedians can recognise variations in the properties of laughter responses made during the act of public joking. Further, the study aimed to establish whether performers can discern these different audience laughter sounds in real time and use them as identifiable ‘cues’ to check the efficacy (or otherwise) of their comic communication. This combined report on the pilot study has been prepared by a group of researchers at the University of Salford, all of which were involved in different stages of the experiment and whose initials are appended to each relevant section of the report. Keywords: Audience laughter; stand-up comedy; joking; psychoacoustics, audience respons

Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

Publisher Copyright: © 2022, The Author(s).We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half the PGI’s magnitude of association with EA and other phenotypes. The correlation between mate-pair PGIs is far too large to be consistent with phenotypic assortment alone, implying additional assortment on PGI-associated factors. In an additional GWAS of dominance deviations from the additive model, we identify no genome-wide-significant SNPs, and a separate X-chromosome additive GWAS identifies 57.Peer reviewe

Through a Glass, Darkly:The CIA and Oral History

This article broaches the thorny issue of how we may study the history of the CIA by utilizing oral history interviews. This article argues that while oral history interviews impose particular demands upon the researcher, they are particularly pronounced in relation to studying the history of intelligence services. This article, nevertheless, also argues that while intelligence history and oral history each harbour their own epistemological perils and biases, pitfalls which may in fact be pronounced when they are conjoined, the relationship between them may nevertheless be a productive one. Indeed, each field may enrich the other provided we have thought carefully about the linkages between them: this article's point of departure. The first part of this article outlines some of the problems encountered in studying the CIA by relating them to the author's own work. This involved researching the CIA's role in US foreign policy towards Afghanistan since a landmark year in the history of the late Cold War, 1979 (i.e. the year the Soviet Union invaded that country). The second part of this article then considers some of the issues historians must confront when applying oral history to the study of the CIA. To bring this within the sphere of cognition of the reader the author recounts some of his own experiences interviewing CIA officers in and around Washington DC. The third part then looks at some of the contributions oral history in particular can make towards a better understanding of the history of intelligence services and the CIA

Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis

Abstract: Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity and high economic burden. Here we conduct a GWAS meta-analysis in 35,474 cases and 267,505 female controls of European ancestry, identifying eight novel genome-wide significant (P < 5 × 10−8) loci, in addition to confirming 21 previously reported loci, including multiple independent signals at 10 loci. Phenotypic stratification of UL by heavy menstrual bleeding in 3409 cases and 199,171 female controls reveals genome-wide significant associations at three of the 29 UL loci: 5p15.33 (TERT), 5q35.2 (FGFR4) and 11q22.3 (ATM). Four loci identified in the meta-analysis are also associated with endometriosis risk; an epidemiological meta-analysis across 402,868 women suggests at least a doubling of risk for UL diagnosis among those with a history of endometriosis. These findings increase our understanding of genetic contribution and biology underlying UL development, and suggest overlapping genetic origins with endometriosis

Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity

The bacteriophage population is large, dynamic, ancient, and genetically diverse. Limited genomic information shows that phage genomes are mosaic, and the genetic architecture of phage populations remains ill-defined. To understand the population structure of phages infecting a single host strain, we isolated, sequenced, and compared 627 phages of Mycobacterium smegmatis. Their genetic diversity is considerable, and there are 28 distinct genomic types (clusters) with related nucleotide sequences. However, amino acid sequence comparisons show pervasive genomic mosaicism, and quantification of inter-cluster and intra-cluster relatedness reveals a continuum of genetic diversity, albeit with uneven representation of different phages. Furthermore, rarefaction analysis shows that the mycobacteriophage population is not closed, and there is a constant influx of genes from other sources. Phage isolation and analysis was performed by a large consortium of academic institutions, illustrating the substantial benefits of a disseminated, structured program involving large numbers of freshman undergraduates in scientific discovery

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders 1 . They are heritable 2,3 and etiologically related 4,5 behaviors that have been resistant to gene discovery efforts 6–11 . In sample sizes up to 1.2 million individuals, we discovered 566 genetic variants in 406 loci associated with multiple stages of tobacco use (initiation, cessation, and heaviness) as well as alcohol use, with 150 loci evidencing pleiotropic association. Smoking phenotypes were positively genetically correlated with many health conditions, whereas alcohol use was negatively correlated with these conditions, such that increased genetic risk for alcohol use is associated with lower disease risk. We report evidence for the involvement of many systems in tobacco and alcohol use, including genes involved in nicotinic, dopaminergic, and glutamatergic neurotransmission. The results provide a solid starting point to evaluate the effects of these loci in model organisms and more precise substance use measures