Pengaruh Iradiasi Ultraviolet Terhadap Multiplikasi Tunas Aksiler Dan Kadar Klorofil Anyelir (Dianthus Caryophyllus L.)

Ultraviolet (UV) is one of the lights spectrum that causes plant cell to damage. The use of ultraviolet irradiation in combination with tissue culture techniques has not been widely used in somaclonal variation method for carnation breeding, whereas the source of ultraviolet irradiation is more easily obtained compared to other sources of irradiation such as gamma rays, x-rays and neutron rays. The purpose of this study was to determine effect of ultraviolet irradiation on the multiplication of axillary shoot in carnation. Explants of internode stem of carnation were grown in multiplication medium Murashige Skoog (MS) consisted of 10-7 M NAA and 5.10-6 M BAP. After four times subculture, the culture bottles were exposed to ultraviolet light C with some variation of irradiation time in combination with storage in light or dark. The results showed that ultraviolet light can reduce the number of shoots formed, shoot length and chlorophyll content of carnation. Based on the results obtained, ultraviolet radiation affected the organs of plants that were formed, but did not cause meristem activity to a standstil

{2-[(3-Bromo­benzyl­idene)amino]-5-chloro­phen­yl}(phen­yl)methanone

In the title compound, C20H13BrClNO, the azomethine double bond [C=N = 1.246 (4) Å] adopts an E conformation. The bromo- and chlorophenyl rings are inclined to one another by 13.70 (11)°, and form dihedral angles of 76.68 (10) and 74.24 (7)°, respectively, with the phenyl ring. In the crystal, mol­ecules are linked by C—H⋯O hydrogen bonds to form double stranded chains propagating along the b-axis direction

Evaluasi Plasma Nutfah Padi Gogo Berdasarkan Karakter Kuantitatif Perakaran Tanaman

Produktivitas padi gogo umumnya lebih rendah dibanding dengan padi sawah disebabkan oleh sifat fisik dan terbatasnya air dalam tanah serta karakteristik perakaran tanaman. Varietas padi gogo yang adaptif pada lingkungan lahan marginal dapat diperoleh melalui pemuliaan tanaman. Tujuan penelitian ini adalah mengevaluasi sistem perakaran plasma nutfah padi gogo melalui kemampuan perakarannya menembus lapisan keras dan untuk mengukur perakaran yang diduga berkaitan dengan adaptabilitasnya terhadap lingkungan kekeringan dan kepadatan tanah. Penelitian dilakukan di rumah kaca BB Biogen Bogor pada bulan Juli–Agustus 2015. Benih plasma nutfah 100 aksesi (varietas lokal) yang berasal dari provinsi Sumatra Utara, Sumatra Selatan, Sulawesi Utara, Jambi, Kalimantan Tengah, Kalimantan Timur, NTT, Jawa Tengah, Jawa Timur, Jawa Barat, DIY, dan Banten ditanam pada pot dengan bagian dasar dilapisi dengan kombinasi campuran 60% parafin dan 40% vaselin yang setara dengan kekerasan 12 bar. Hasil penelitian menunjukkan pengelompokan plasma nutfah 100 varietas padi gogo dapat dikelompokkan berdasarkan varietas yang karakteristiknya jauh berbeda dengan yang lain, yaitu varietas Si Gambiri Etek asal Sumatra Utara, varietas Cikapundeng asal Banten, dan varietas Ketan Kasumba B asal Banten. Plasma nutfah yang memiliki karakteristik perakaran baik (bobot akar dan rasio akar tajuk yang tinggi) dapat digunakan sebagai tetua dalam program pemuliaan tanaman

17-(Pyrimidin-2-yl)-8,16-dioxa-17-aza­tetra­cyclo­[7.7.1.02,7.010,15]hepta­deca-2,4,6,10,12,14-hexa­ene

In the title compound, C18H13N3O2, the benzene rings form a dihedral angle of 78.49 (9)°. The dihedral angles between the benzene rings and the pyrimidine ring are 76.53 (10) and 27.73 (11)°. The two cis-fused six-membered heterocyclic rings adopt half-chair confirmations. In the crystal, mol­ecules are linked by C—H⋯O hydrogen bonds, forming chains parallel to the b axis

{5-Chloro-2-[(2-hy­droxy­benzyl­idene)amino]­phen­yl}(phen­yl)methanone

The title Schiff base compound, C20H14ClNO2, adopts an E configuration about the azomethine bond. The phenol and chloro­benzene rings form dihedral angles of 84.71 (9) and 80.70 (8)°, respectively, with the phenyl ring and are twisted by 15.32 (8)° with respect to one another. The mol­ecular conformation is stabilized by an intra­molecular O—H⋯N hydrogen bond, which forms an S(6) ring motif. In the crystal, mol­ecules are linked by C—H⋯O hydrogen bonds, forming columns parallel to the a axis

MICALs in control of the cytoskeleton, exocytosis, and cell death

MICALs form an evolutionary conserved family of multidomain signal transduction proteins characterized by a flavoprotein monooxygenase domain. MICALs are being implicated in the regulation of an increasing number of molecular and cellular processes including cytoskeletal dynamics and intracellular trafficking. Intriguingly, some of these effects are dependent on the MICAL monooxygenase enzyme and redox signaling, while other functions rely on other parts of the MICAL protein. Recent breakthroughs in our understanding of MICAL signaling identify the ability of MICALs to bind and directly modify the actin cytoskeleton, link MICALs to the docking and fusion of exocytotic vesicles, and uncover MICALs as anti-apoptotic proteins. These discoveries could lead to therapeutic advances in neural regeneration, cancer, and other diseases

PANC Study (Pancreatitis: A National Cohort Study): national cohort study examining the first 30 days from presentation of acute pancreatitis in the UK

Background Acute pancreatitis is a common, yet complex, emergency surgical presentation. Multiple guidelines exist and management can vary significantly. The aim of this first UK, multicentre, prospective cohort study was to assess the variation in management of acute pancreatitis to guide resource planning and optimize treatment. Methods All patients aged greater than or equal to 18 years presenting with acute pancreatitis, as per the Atlanta criteria, from March to April 2021 were eligible for inclusion and followed up for 30 days. Anonymized data were uploaded to a secure electronic database in line with local governance approvals. Results A total of 113 hospitals contributed data on 2580 patients, with an equal sex distribution and a mean age of 57 years. The aetiology was gallstones in 50.6 per cent, with idiopathic the next most common (22.4 per cent). In addition to the 7.6 per cent with a diagnosis of chronic pancreatitis, 20.1 per cent of patients had a previous episode of acute pancreatitis. One in 20 patients were classed as having severe pancreatitis, as per the Atlanta criteria. The overall mortality rate was 2.3 per cent at 30 days, but rose to one in three in the severe group. Predictors of death included male sex, increased age, and frailty; previous acute pancreatitis and gallstones as aetiologies were protective. Smoking status and body mass index did not affect death. Conclusion Most patients presenting with acute pancreatitis have a mild, self-limiting disease. Rates of patients with idiopathic pancreatitis are high. Recurrent attacks of pancreatitis are common, but are likely to have reduced risk of death on subsequent admissions

PANC Study (Pancreatitis: A National Cohort Study): national cohort study examining the first 30 days from presentation of acute pancreatitis in the UK

Abstract Background Acute pancreatitis is a common, yet complex, emergency surgical presentation. Multiple guidelines exist and management can vary significantly. The aim of this first UK, multicentre, prospective cohort study was to assess the variation in management of acute pancreatitis to guide resource planning and optimize treatment. Methods All patients aged greater than or equal to 18 years presenting with acute pancreatitis, as per the Atlanta criteria, from March to April 2021 were eligible for inclusion and followed up for 30 days. Anonymized data were uploaded to a secure electronic database in line with local governance approvals. Results A total of 113 hospitals contributed data on 2580 patients, with an equal sex distribution and a mean age of 57 years. The aetiology was gallstones in 50.6 per cent, with idiopathic the next most common (22.4 per cent). In addition to the 7.6 per cent with a diagnosis of chronic pancreatitis, 20.1 per cent of patients had a previous episode of acute pancreatitis. One in 20 patients were classed as having severe pancreatitis, as per the Atlanta criteria. The overall mortality rate was 2.3 per cent at 30 days, but rose to one in three in the severe group. Predictors of death included male sex, increased age, and frailty; previous acute pancreatitis and gallstones as aetiologies were protective. Smoking status and body mass index did not affect death. Conclusion Most patients presenting with acute pancreatitis have a mild, self-limiting disease. Rates of patients with idiopathic pancreatitis are high. Recurrent attacks of pancreatitis are common, but are likely to have reduced risk of death on subsequent admissions. </jats:sec

Nutzung der Möglichkeiten künstlicher Intelligenz und Robotik zur Erzielung von Wettbewerbsvorteilen für eine nachhaltige Entwicklung in Krankenhäusern mit Ableitung künftiger Forschungsansätze

Artificial intelligence (AI) and robotics have emerged as game-changing technologies with the potential to revolutionize the healthcare industry. In the context of hospitals, their integration holds the promise of not only improving patient care but also driving competitive advantage and fostering sustainable development. This review paper aims to explore and evaluate the impact of AI and robotics applications on attaining competitive advantage and promoting sustainable development in hospitals, examines the current landscape of AI and robotics adoption in healthcare settings and delve into their specific applications within hospitals, including AI-assisted diagnosis, robotic surgery, patient monitoring, and data analytics. A key finding is the insufficient use of KI to date in terms of promoting sustainable development in hospitals. Furthermore, attempts to analyze the potential benefits and challenges associated with these technologies in terms of enhancing patient outcomes, operational efficiency, cost savings, and differentiation from competitors. Drawing upon a comprehensive review of the existing literature and case studies, this paper provides valuable insights into the transformative potential of AI and robotics in hospitals.Künstliche Intelligenz (KI) und Robotik haben sich als bahnbrechende Technologien erwiesen, die das Potenzial haben, die Gesundheitsbranche zu revolutionieren. Im Kontext von Krankenhäusern verspricht ihre Integration nicht nur eine Verbesserung der Patientenversorgung, sondern auch einen Wettbewerbsvorteil und eine nachhaltige Entwicklung. Diese Übersichtsarbeit zielt darauf ab, die Auswirkungen von KI- und Robotikanwendungen auf die Erzielung von Wettbewerbsvorteilen und die Förderung einer nachhaltigen Entwicklung in Krankenhäusern zu untersuchen und zu bewerten. Das Review untersucht die KI- und Robotikanwendungen im Gesundheitswesen und befasst sich mit deren spezifischen Anwendungen in Krankenhäusern einschließlich KI-gestützter Diagnose, Roboterchirurgie, Patientenüberwachung und Datenanalyse. Ein wichtiges Ergebnis ist die bisher ungenügende Nutzung von KI in Hinblick auf die Förderung der nachhaltigen Entwicklung in Krankenhäusern. Darüber hinaus wird versucht, die potenziellen Vorteile und Herausforderungen zu analysieren, die mit diesen Technologien in Bezug auf die Verbesserung der Patientenergebnisse, der betrieblichen Effizienz, der Kosteneinsparungen und der Differenzierung von der Konkurrenz verbunden sind. Auf der Grundlage einer umfassenden Überprüfung der vorhandenen Literatur und von Fallstudien bietet das Review weiterführende Einblicke in das transformative Potenzial von KI und Robotik in Krankenhäusern