Международное и национальное правовое регулирование социальных гарантий и труда лиц, отвечающих за управление воздушным движением в гражданской авиации

This article is devoted to the study of the peculiarities of the legal regulation of labor of workers engaged in the field of air traffic control of civil aviation. The work is intended for students, legal advisers and civil aviation workers. Also, this work is addressed directly to members of civil aviation flight crews, air traffic controllers. Analyzed the most important points of the features of labor regulation of aviation workers of their labor rights and social security.Данная статья посвящена исследованию особенностей правового регулирования труда работников, осуществляющих деятельность в сфере управления воздушным движением гражданской авиации. Работа предназначена для студентов, юрисконсультов и работников гражданской авиации. Также данная работа адресована непосредственно членам летных экипажей гражданской авиации, авиадиспетчерам. Проанализированы важнейшие моменты особенностей регулирования труда авиационных работников, их трудовых прав и социального обеспечения

Using acoustic emission signal categorization for reconstruction of wear development timeline in tribosystems: Case studies and application examples

The purpose of this work is to demonstrate how a new acoustic emission (AE) technique can be used to monitor friction surface degradation in a four-ball tribosystem under different types of lubrication. The AE method is based on a novel signal spectral categorization technique, and it was used to identify concurrent degradation processes in bearing steel. The correlation of AE features with the development of specific microstructural features on the contact surfaces has been used to identify the AE "signature" of specific damage mechanisms, and thus to monitor the progression of wear. The proposed approach enables the construction of a chronology of lubricant and/or contacting material degradation during tribological testing with a high degree of confidence. Furthermore, it provides an efficient means for automated wear monitoring and for real-time, non-supervised interpretation of the state of wear in a given tribosystem

Analysis of microvascular thrombus mechanobiology with a novel particle-based model

Platelet accumulation at the site of a vascular injury is regulated by soluble platelet agonists, which induce various types of platelet responses, including integrin activation and granule secretion. The interplay between local biochemical cues, mechanical interactions between platelets and macroscopic thrombus dynamics is poorly understood. Here we describe a novel computational model of microvascular clot formation for the detailed analysis of thrombus mechanics. We adopt a previously developed two-dimensional particle-based model focused on the thrombus shell formation and revise it to introduce the platelet agonists. Blood flow is simulated via a computational fluid dynamics approach. In order to model soluble platelet activators, we apply Langevin dynamics to a large number of non-dimensional virtual particles. Taking advantage of the available data on platelet dense granule secretion kinetics, we model platelet degranulation as a stochastic agonist-dependent process. The new model qualitatively reproduces the enhanced thrombus formation due to dense granule secretion, in line with in vivo findings, and provides a mechanism for the thrombin confinement at the early stages of clot formation. Our calculations also predict that the release of platelet dense granules results in the additional mechanical stabilization of the inner layers of thrombus. Distribution of the inter-platelet forces throughout the aggregate reveals multiple weak spots in the outer regions of a thrombus, which are expected to result in the mechanical disruptions at the later stages of clot formation. © 2021 Elsevier Lt

Anomalous fluctuations in the dynamics of complex systems: from DNA and physiology to econophysics

We discuss examples of complex systems composed of many interacting subsystems. We focus on those systems displaying nontrivial long-range correlations. These include the one-dimensional sequence of base pairs in DNA, the sequence of flight times of the large seabird Wandering Albatross, and the annual fluctuations in the growth rate of business firms. We review formal analogies in the models that describe the observed long-range correlations, and conclude by discussing the possibility that behavior of large numbers of humans (as measured, e.g., by economic indices) might conform to analogs of the scaling laws that have proved useful in describing systems composed of large numbers of inanimate objects

Association of Second Allogeneic Hematopoietic Cell Transplant vs Donor Lymphocyte Infusion With Overall Survival in Patients With Acute Myeloid Leukemia Relapse

Contains fulltext : 196443.pdf (publisher's version ) (Closed access)Importance: The optimal treatment approach to patients with acute myeloid leukemia (AML) who relapse after an allogeneic hematopoietic cell transplant (allo-HCT) remains elusive. No randomized clinical trial comparing survival outcomes of a second allo-HCT (allo-HCT2) vs donor lymphocyte infusion (DLI) has been conducted to date. Objective: To compare overall survival (OS) after an allo-HCT2 or DLI in relapsed AML after a first allo-HCT. Design, Setting, and Participants: A retrospective registry study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation involving 418 adults who received an allo-HCT2 (n = 137) or DLI (n = 281) for postallograft-relapsed AML. Analysis was assessed on the principle of intent-to-first received intervention. The data were collected from November 21, 2015, to May 15, 2017, and analysis was performed June 1, 2017. Main Outcomes and Measures: Number of patients with relapsed AML who are alive after 2 years and 5 years from receiving an allo-HCT2 or DLI. Results: Of the 418 patients, 228 (54.5%) were men; mean age was 46.2 years (interquartile range, 36.5-56.9 years). There was no apparent difference in OS whether an allo-HCT2 or DLI was prescribed (2-year OS with allo-HCT2, 26%; 5-year OS with allo-HCT2, 19%; 2-year OS with DLI, 25%; 5-year OS with DLI, 15%; P = .86). Overall survival was better if either of these procedures was offered when the patient was in complete remission (hazard ratio, 0.55; 95% CI, 0.41-0.74; P < .001). Conversely, OS was low for patients relapsing within less than 6 months after an allo-HCT1, regardless of the treatment prescribed (5-year OS: allo-HCT2, 9%; 95% CI, 1%-17% vs DLI, 4%; 95% CI, 1%-8%; P = .86). Conclusion and Relevance: Heterogeneity of the patient-, disease-, and treatment-related characteristics limit the ability to recommend one approach over another. Findings of this study highlight that best outcomes seem to be achieved in patients relapsing 6 or more months from an allo-HCT1 or those in complete remission at the time of either allo-HCT2 or DLI