ADENOCARCINOMA PAPILAR DEL CUELLO UTERINO: COMUNICACIÓN DE UN CASO Y REVISIÓN DE LA LITERATURA

Se presenta el caso clínico de una paciente de 42 años con diagnóstico de adenocarcinoma seroso papilar del cuello uterino etapa Ib1 tratada mediante histerectomía radical más linfadenectomía pélvica bilateral. El estudio anatomopatológico demostró bordes quirúrgicos libres y ausencia de enfermedad metastásica ganglionar por lo que se consideró a la paciente tratada. Este es el primer caso de adenocarcinoma seroso papilar del cuello uterino reportado en el país. Hay que descartar el compromiso cervical secundario por tumores serosos de endometrio, ovario o trompa antes de plantear el origen primario de cuello uterino. No se conoce el real comportamiento, pronóstico y óptimo tratamiento en este tipo de tumores. La determinación de los niveles de CA-125 basal y seriados durante el seguimiento pudiese ser de utilidad en la evaluación del tratamiento realizado y en la sospecha de enfermedad persistente o reciPad

ADENOCARCINOMA PAPILAR DEL CUELLO UTERINO: COMUNICACIÓN DE UN CASO Y REVISIÓN DE LA LITERATURA

Se presenta el caso clínico de una paciente de 42 años con diagnóstico de adenocarcinoma seroso papilar del cuello uterino etapa Ib1 tratada mediante histerectomía radical más linfadenectomía pélvica bilateral. El estudio anatomopatológico demostró bordes quirúrgicos libres y ausencia de enfermedad metastásica ganglionar por lo que se consideró a la paciente tratada. Este es el primer caso de adenocarcinoma seroso papilar del cuello uterino reportado en el país. Hay que descartar el compromiso cervical secundario por tumores serosos de endometrio, ovario o trompa antes de plantear el origen primario de cuello uterino. No se conoce el real comportamiento, pronóstico y óptimo tratamiento en este tipo de tumores. La determinación de los niveles de CA-125 basal y seriados durante el seguimiento pudiese ser de utilidad en la evaluación del tratamiento realizado y en la sospecha de enfermedad persistente o reciPadaA 42 year old patient with a diagnosis of serous papillary adenocarcinoma of the cervix stage Ib1 treated by radical hysterectomy and bilateral lymphadenectomy is reported. The patient was considered treated because the pathology study did not demonstrate tumor outside the cervix or lymphatic nodes. The serous papillary adenocarcinoma of the uterine cervix is an extremely infrequent tumor and therefore compels to discard a secondary cervical involvement by serous tumors derived from the endometrium, ovary or tube. This is the first chilean case reported. The prognosis and optimum treatment of these tumors is still uncertain. Basal Ca-125 and then during the follow-up could help in evaluation of treatment as well as in the suspicion of persistent illness or reciPe

TUMOR DE LOS CORDONES SEXUALES CON TÚBULOS ANULARES DEL OVARIO NO ASOCIADO A SÍNDROME DE PEUTZ-JEGHERS: REPORTE DE UN CASO

Se presenta el raro caso de una mujer de 20 años con un tumor del estroma gonadal específico del ovario, variedad tumor de los cordones sexuales, con túbulos anulares no asociado a síndrome de Peutz-Jeghers. Se revisa la literatura sobre el manejo de esta entidadA twenty years-old woman with an unusual variant of ovarian sex cord-stromal tumor, a sex cord tumor with annular tubules non-associated to Peutz-Jeghers syndrome, is reported. A review of the literature in the management of this unfrequent entity is also presente

Genomic survey of pathogenicity determinants and VNTR markers in the cassava bacterial pathogen <em>Xanthomonas axonopodis</em> pv. <em>manihotis</em> strain CIO151

Xanthomonas axonopodis pv. manihotis (Xam) is the causal agent of bacterial blight of cassava, which is among the main components of human diet in Africa and South America. Current information about the molecular pathogenicity factors involved in the infection process of this organism is limited. Previous studies in other bacteria in this genus suggest that advanced draft genome sequences are valuable resources for molecular studies on their interaction with plants and could provide valuable tools for diagnostics and detection. Here we have generated the first manually annotated high-quality draft genome sequence of Xam strain CIO151. Its genomic structure is similar to that of other xanthomonads, especially Xanthomonas euvesicatoria and Xanthomonas citri pv. citri species. Several putative pathogenicity factors were identified, including type III effectors, cell wall-degrading enzymes and clusters encoding protein secretion systems. Specific characteristics in this genome include changes in the xanthomonadin cluster that could explain the lack of typical yellow color in all strains of this pathovar and the presence of 50 regions in the genome with atypical nucleotide composition. The genome sequence was used to predict and evaluate 22 variable number of tandem repeat (VNTR) loci that were subsequently demonstrated as polymorphic in representative Xam strains. Our results demonstrate that Xanthomonas axonopodis pv. manihotis strain CIO151 possesses ten clusters of pathogenicity factors conserved within the genus Xanthomonas. We report 126 genes that are potentially unique to Xam, as well as potential horizontal transfer events in the history of the genome. The relation of these regions with virulence and pathogenicity could explain several aspects of the biology of this pathogen, including its ability to colonize both vascular and non-vascular tissues of cassava plants. A set of 16 robust, polymorphic VNTR loci will be useful to develop a multi-locus VNTR analysis scheme for epidemiological surveillance of this disease. (Résumé d'auteur