Apport des systèmes d'informations [sic] et nouvelles technologies dans le monde du sport

De nos jours, l’informatique ainsi que les nouvelles technologies sont présents dans tous les domaines de la société. Par conséquent, il est intéressant de se poser la question de ce qu’apportent ces nouvelles technologies ? Ce travail va, ainsi, permettre de répondre à cette question par rapport à l’informatique et aux nouvelles technologies dans le domaine du sport. En effet, après avoir fait un contexte général des applications informatiques existantes ainsi que des sports les utilisant, une analyse va être faite sur l’apport de ces outils par rapport aux performances des sportifs

Speed of Light in Non--Trivial Vacua

We unify all existing results on the change of the speed of low--energy photons due to modifications of the vacuum, finding that it is given by a universal constant times the quotient of the difference of energy densities between the usual and modified vacua over the mass of the electron to the fourth power. Whether photons move faster or slower than $c$ depends only on the lower or higher energy density of the modified vacuum, respectively. Physically, a higher energy density is characterized by the presence of additional particles (real or virtual) in the vacuum whereas a lower one stems from the absence of some virtual modes. We then carry out a systematic study of the speed of propagation of massless particles for several field theories up to two loops on a thermal vacuum. Only low--energy massless particles corresponding to a massive theory show genuine modifications of their speed while remaining massless. All other modifications are mass-related, or running mass-related. We also develop a formalism for the Casimir vacuum which parallels the thermal one and check that photons travel faster than $c$ between plates.Comment: 24 p., plain te

Monitoring mountains in a changing world: new horizons for the Global Network for Observations and Information on Mountain Environments (GEO-GNOME)

Mountains are globally distributed environments that provide significant societal benefits, a function that is increasingly compromised by climatic change, environmental stress, political and socioeconomic transformations, and unsustainable use of natural resources. Gaps in our understanding of these processes and their interactions limit our capacity to inform decisions, where both generalities of mountain regions (eg climate processes) and specificities (eg context-specific manifestations of climate risks) matter. The Global Network for Observations and Information on Mountain Environments (GEO-GNOME), a Group on Earth Observations initiative, aims to fill these gaps through accessible Earth Observation (EO) as well as in-situ data and information on global change drivers, conditions, and trends. A workshop convened by the Mountain Research Initiative (MRI) revised GEO-GNOME's work plan, galvanizing a network that promotes relevant monitoring of global change in mountains and is responsive to the integrated knowledge needs of policy, research, and management

MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration

Background: MicroRNA (miRNA) expression in the brain is altered in neurodegenerative diseases. Recent studies demonstrated that selected miRNAs conventionally regulating gene expression at the post-transcriptional level can act extracellularly as signaling molecules. The identity of miRNA species serving as membrane receptor ligands involved in neuronal apoptosis in the central nervous system (CNS), as well as the miRNAs' sequence and structure required for this mode of action remained largely unresolved. Methods. Using a microarray-based screening approach we analyzed apoptotic cortical neurons of C56BL/6 mice and their supernatant with respect to alterations in miRNA expression/presence. HEK-Blue Toll-like receptor (TLR) 7/8 reporter cells, primary microglia and macrophages derived from human and mouse were employed to test the potential of the identified miRNAs released from apoptotic neurons to serve as signaling molecules for the RNA-sensing receptors. Biophysical and bioinformatical approaches, as well as immunoassays and sequential microscopy were used to analyze the interaction between candidate miRNA and TLR. Immunocytochemical and -histochemical analyses of murine CNS cultures and adult mice intrathecally injected with miRNAs, respectively, were performed to evaluate the impact of miRNA-induced TLR activation on neuronal survival and microglial activation. Results: We identified a specific pattern of miRNAs released from apoptotic cortical neurons that activate TLR7 and/or TLR8, depending on sequence and species. Exposure of microglia and macrophages to certain miRNA classes released from apoptotic neurons resulted in the sequence-specific production of distinct cytokines/chemokines and increased phagocytic activity. Out of those miRNAs miR-100-5p and miR-298-5p, which have consistently been linked to neurodegenerative diseases, entered microglia, located to their endosomes, and directly bound to human TLR8. The miRNA-TLR interaction required novel sequence features, but no specific structure formation of mature miRNA. As a consequence of miR-100-5p- and miR-298-5p-induced TLR activation, cortical neurons underwent cell-autonomous apoptosis. Presence of miR-100-5p and miR-298-5p in cerebrospinal fluid led to neurodegeneration and microglial accumulation in the murine cerebral cortex through TLR7 signaling. Conclusion: Our data demonstrate that specific miRNAs are released from apoptotic cortical neurons, serve as endogenous TLR7/8 ligands, and thereby trigger further neuronal apoptosis in the CNS. Our findings underline the recently discovered role of miRNAs as extracellular signaling molecules, particularly in the context of neurodegeneration

Ecological characteristics of Simulium breeding sites in West Africa

Twenty-nine taxa of Simulium were identified amongst 527 collections of larvae and pupae from untreated rivers and streams in Liberia (362 collections in 1967–71 & 1989), Togo (125 in 1979–81), Benin (35 in1979–81) and Ghana (5 in 1980–81). Presence or absence of associations between different taxa were usedto group them into six clusters using Ward agglomerative hierarchical cluster analysis. Environmental data associated with the pre-imaginal habitats were then analysed in relation to the six clusters by oneway ANOVA. The results revealed significant effects in determining the clusters of maximum river width (all P < 0.001 unless stated otherwise), water temperature, dry bulb air temperature, relative humidity,altitude, type of water (on a range from trickle to large river), water level, slope, current, vegetation,light conditions, discharge, length of breeding area, environs, terrain, river bed type (P < 0.01), and the supports to which the insects were attached (P < 0.01). When four non-significant contributors (wet bulb temperature, river features, height of waterfall and depth) were excluded and the reduced data-set analysed by principal components analysis (PCA), the first two principal components (PCs) accounted for 87% of the variance, with geographical features dominant in PC1 and hydrological characteristics in PC2. The analyses also revealed the ecological characteristics of each taxon’s pre-imaginal habitats, which are discussed with particular reference to members of the Simulium damnosum species complex, whose breeding site distributions were further analysed by canonical correspondence analysis (CCA), a method also applied to the data on non-vector species

PuraStat in gastrointestinal bleeding: results of a prospective multicentre observational pilot study

Background: A recently developed haemostatic peptide gel for endoscopic application has been introduced to improve the management of gastrointestinal bleeding. The aim of this pilot study was to evaluate the feasibility, safety, efficacy and indication profiles of PuraStat in a clinical setting. Methods: In this prospective observational multicentre pilot study, patients with acute non-variceal gastrointestinal bleeding (upper and lower) were included. Primary and secondary application of PuraStat was evaluated. Haemoglobin, prothrombin time, platelets and transfusion behaviour were documented before and after haemostasis. The efficacy of PuraStat was assessed during the procedure, at 3 days and 1 week after application. Results: 111 patients with acute gastrointestinal bleeding were recruited into the study. 70 percent (78/111) of the patients had upper gastrointestinal bleeding and 30% (33/111) had lower gastrointestinal bleeding. After primary application of PuraStat, initial haemostatic success was achieved in 94% of patients (74/79, 95% CI 88-99%), and in 75% of the patients when used as a secondary haemostatic product, following failure of established techniques (24/32, 95% CI 59-91%). The therapeutic success rates (absence of rebleeding) after 3 and 7 days were 91% and 87% after primary use, and 87% and 81% in all study patients. Overall rebleeding rate at 30 day follow-up was 16% (18/111). In the 5 patients who finally required surgery (4.5%), PuraStat allowed temporary haemostasis and stabilisation. Conclusions: PuraStat expanded the therapeutic toolbox available for an effective treatment of gastrointestinal bleeding sources. It could be safely applied and administered without complications as a primary or secondary therapy. PuraStat may additionally serve as a bridge to surgery in order to achieve temporary haemostasis in case of refractory severe bleeding, possibly playing a role in preventing immediate emergency surgery