Preparation and Characterization of Nitrendipine-loaded Eudragit RL 100 Microspheres Prepared by an Emulsion-Solvent Evaporation Method

Purpose: The aim of the work was to prepare nitrendipne-loaded Eudragit RL 100 microspheres to achieve sustained release nitrendipine. Method: Nitrendipne-loaded Eudragit RL 100 microspheres were prepared by an emulsion-solvent evaporation method using ethanol/liquid paraffin system. The resultant microspheres were evaluated for average particle size, drug loading, in vitro drug release and release kinetics. FTIR spectrometry, scanning electron microscopy, differential scanning calorimetry and x-ray powder diffractometry were used to investigate the physical state of the drug in the microspheres. Result: The mean particle size of the microspheres was influenced by varying drug:polymer ratio and emulsifier concentration while drug loading was dependent on drug:polymer ratio. The results of FTIR spectrometry, differential scanning calorimetry and x-ray diffractometry indicated the stable character of nitrendipne in drug-loaded microspheres and also revealed absence of drug-polymer interaction. The drug release profiles of the microspheres at pH 1.2 showed poor drug release characteristics while at pH 6.8, drug release was extended over a period of 8 h; release was influenced by polymer concentration and particle size. Drug release followed the Higuchi model. Conclusion: The nitrendipine-loaded Eudragit RL 100 microspheres prepared under optimized conditions showed a good sustained release characteristics and were stable under the conditions studied Keywords: Nitrendipine, Eudragit RL 100, Microspheres, Physicochemical characterization, Sustained release. Tropical Journal of Pharmaceutical Research Vol. 7 (3) 2008: pp. 1033-104

Airflow and Thermal Behavior within Peaches Packaging Box Using Computational Fluid Dynamics - A Preliminary Study

Post-harvest cold storage of peaches is an essential element to maintain the quality of the fruits without any loss. This work aims to present a CFD model, to predict airflow patterns and temperature profiles in ventilated packaging systems, during the forced-air cooling of Peaches stored in a cold chamber. Transient CFD simulations are performed for the chamber containing four ventilated boxes and the evaluation of the results show that the temperature removal near the vent holes and the hand holes is relatively high when compared to other regions of the packaging box. This preliminary study reveals the airflow behavior develop an uneven temperature distribution within the box. To overcome the flaws, future work is focused on modifying the vent hole design to improve the airflow phenomenon to maintain the temperature homogeneity throughout the box. Keywords: Peach, Computational fluid dynamics, Airflow, Heat transfer, Packagin

PREPERATION AND IN VITRO EVALUATION OF SOLID DISPERSIONS OF NIMODIPINE USING PEG 4000 AND PVP K3

Solid dispersions in water-soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability, of a range of hydrophobic drugs. The aim of the present study was to improve the solubility and dissolution rate of a poorly water-soluble drug, nimodipine, by a solid dispersion technique. Solid dispersions were prepared by using polyethylene glycol 4000 (PEG- 4000) and polyvinylpyrrolidone K30 (PVPK30) in different drug-to-carrier ratios. The solid dispersions were prepared by melting method. Morphology of solid dispersions was characterised by scanning electron microscope. The pure drug, physical mixtures and solid dispersions were characterized by in vitro dissolution study. Dissolution characteristics were determined by using pH 4.5 acetate buffer containing 0.3% SDS. The very slow dissolution rate was observed for pure nimodipine and the dispersion of the drug in the polymers considerably enhanced the dissolution rate. This can be attributed to improved wettability and dispersibility, as well as decrease of the crystalline and increase of the amorphous fraction of the drug. Solid dispersions prepared with PEG-4000 and PVPK30 showed the highest improvement in wettability and dissolution rate of nimodipine. Even physical mixtures of nimodipine prepared with both polymers also showed better dissolution profile than that of pure nimodipine. In conclusion, dissolution of nimodipine can be enhanced by the use of hydrophilic carriers PEG-4000 and PVPK30

Formulation of Sodium Alginate Nanospheres Containing Amphotericin B for the Treatment of Systemic Candidiasis

Purpose: The aim of this work was to formulate sodium alginate nanospheres of amphotericin B by controlled gellification method and to evaluate the role of the nanospheres as a “passive carrier” in targeted antifungal therapy. Methods: Sodium alginate nanospheres of amphotericin B were prepared by controlled gellification method, and the particle size analysis was carried out by scanning electron microscopy. The carrier capacity of sodium alginate was evaluated in terms of drug to polymer ratio. In vitro release study was carried out on all drug loaded nanospheres by the dialysis method. Release kinetics of drug from different drug loaded nanospheres was also determined. The in vivo antifungal efficacy of nanospheres bound drug vis-à-vis the free drug was evaluated in candidiasis- induced mice models. Results: Preparation of nanospheres through controlled gellification method yielded particles with a size range of 419.6 ± 0.28 nm. Studies on drug to polymer ratio showed a linear relationship between concentration of drug and drug loading capacity. In vitro release kinetic study revealed that the release of drug from the nanospheres followed Fickian diffusion. In vivo studies showed that the nanosphere-bound drug produced a higher antifungal efficacy than the free drug. Conclusion: The formulated sodium alginate nanospheres containing amphotericin B was found to have better antifungal activity when compared to the free drug and also yielded sustained in vitro release. Keywords: Nanospheres, sodium alginate, amphotericin B, controlled gellification method, in vitro & in vivo release > Tropical Journal of Pharmaceutical Research Vol. 6 (1) 2007: pp. 653-65

Implementation of ERP in an Automobile Manufacturing Shop Floor

The implementation of enterprise resource planning (ERP) systems has been known to be much more difficult than the development of a computer application supporting a single business function. This paper addresses the implementation of an ERP system in an automobile manufacture shop floor. This paper examines step by step procedure for implementing an ERP system within the shop floor and also looks improve business process and operations through good business communication system. The Development of a planning module by visual basic programming language were also discussed

CFD parametric study of thermal performance of different fruit packaging box designs

Air temperature and relative humidity values of cold storage conditions are the major factor affecting the perishability of fresh fruits. The sooner the field heat is extracted from the products and the proper temperature is maintained consistency throughout the cold chain, larger it will be shelf life of these products. Forced air cooling is the most commonly used technique to remove the field heat in post-harvest storage. Energy-efficient and quality-oriented cold storage mainly depends on the time to remove the heat. This time can be reduced by optimizing the configuration of the vent holes of the packaging box, namely it dimension (area), it shape, alignment and position. This paper shows the numerical predictions of air temperature and velocity by a CFD parametric study of eight different vent hole configurations. These configurations consider a packaging box with double wall. The vent holes of each wall have different dimension and shape. The vent holes of both walls can be also aligned or unaligned. The analysis of results aims to determine the best configurations that improve the cooling rate, the airflow and temperature uniformity. The numerical predictions of the air temperature show close values, but three configurations can be identified as predicting the lowest air temperature values with lowest standard deviation. These results may help on the development of new configuration for fruit boxes that promote the extension of the fruits shelflife.(undefined

Numerical Study of the Impact on Cooling Behaviour of Vent-Holes Design of Fruit Packaging Boxes

Fruit packaging is highly impactful in temperature and humidity distribution for post-harvest fresh fruit cooling and conservation. It is also the most flexible part on fruit production and should be able to increase shelf-life by deterring adverse conditions. However, packaging thermal performance during cold storage where it is displayed to the internal airflow is influenced by the size and position of vent-holes. In this study airflow inside the fruit box and fruits thermal behaviour are evaluated in order to determine differences between three prototype package models. Models differ from each other by the holes' configuration and size. Furthermore, models' performance is compared to a commercially available box of similar dimensions. Experimental tests were carried out in three stacked boxes, equipped with temperature and humidity sensors, and placed inside a refrigeration chamber with forced air cooling. Packaging box CFD models of each prototype wall were developed to predict the airflow and heat transfer during storage in a refrigeration chamber. Models predictions were validated by experiments results. According with simulation results, all prototypes have better thermal performance than the commercial model. However, significant performance differences between prototype walls were found. Fewer, larger and strategically distributed vent-holes allow a better result in terms of temperature homogeneity inside the box and significant reduction in fruit cooling times

CFD Modelling of the Thermal Performance of Fruit Packaging Boxes - Influence of Vent-Holes Design

The shelf life of perishable products depends mainly on the conservation of air temperature. Packaging boxes are usually used to accommodate food products during cold storage and transport and/or display. The design of the vent-holes of the packaging box must promote cold airflow and remove the field heat of the produce after harvest at a short time. This study describes the influence of the vent-holes design and its performance during cold storage. The cooling performance of the different packaging boxes is evaluated experimentally and numerically using Computational Fluid Dynamics (CFD). Three new packaging box configurations with the same size but different vent-holes design (size, shape and position) and a reference box are modelled. The transient three-dimensional CFD model predicts the airflow pattern and temperature distribution within the different packaging boxes. The best thermal performance packaging achieved a fruit model temperature 1.5 K to 5 K lower than the other configurations at the end of 8 h of cooling. These predictions allow the development of new packaging box designs that promote the shelf-life extension of perishable products.info:eu-repo/semantics/publishedVersio

Kristalne modifikacije i profil oslobađanja piroksikama

Piroxicam is a nonsteroidal anti-inflammatory drug with low aqueous solubility which exhibits polymorphism. The present study was carried out to develop polymorphs of piroxicam with enhanced solubility and dissolution rate by the crystal modification technique using different solvent mixtures prepared with PEG 4000 and PVP K30. Physicochemical characteristics of the modified crystal forms of piroxicam were investigated by X-ray powder diffractometry, FT-IR spectrophotometry and differential scanning calorimetry. Dissolution and solubility profiles of each modified crystal form were studied and compared with pure piroxicam. Solvent evaporation method (method I) produced bothneedle and cubic shaped crystals. Slow crystallization from ethanol with addition of PEG 4000 or PVP K30 at room temperature (method II) produced cubic crystal forms. Needle forms produced by method I improved dissolution but not solubility. Cubic crystals produced by method I had a dissolution profile similar to that of untreated piroxicam but showed better solubility than untreated piroxicam. Cubic shaped crystals produced by method II showed improved dissolution, without a significant change in solubility. Based on the XRPD results, modified piroxicam crystals obtained by method I from acetone/benzene were cube shaped, which correlates well with the FTIR spectrum; modified needle forms obtained from ethanol/methanol and ethanol/acetone showed a slight shift of FTIR peak that may be attributed to differences in the internal structure or conformation.Piroksikam je nesteroidni protuupalni lijek male topljivosti u vodi koji ima svojstvo polimorfije. Cilj rada bio je priprema polimorfa piroksikama povećane topljivosti i brzine oslobađanja koristeći smjese različitih otapala i PEG 4000, odnosno PVP K30. Fizikokemijska svojstva modificiranih kristalnih oblika piroksikama ispitivana su difrakcijom X-zraka na praškastom uzorku FT-IR spektrofotometrijom i diferencijalnom pretražnom kalorimetrijom. Profili oslobađanja i topljivosti modificiranih kristalnih oblika proučavani su i uspoređivani sa čistim piroksikamom. Metodom uparavanja otapala (metoda I) dobiveni su igličasti i kubični kristali. Polaganom kristalizacijom iz etanola uz dodatak PEG 4000 ili PVP K30 na sobnoj temperaturi (metoda II) dobiveni su kubični kristali. Igličasti kristali dobiveni metodom I poboljšali su oslobađanje, ali ne i topljivost. Kubični kristali dobiveni metodom I imali su poboljšanu topljivost, ali sličan profil oslobađanja kao i netretirani piroksikam. Kubični kristali dobiveni metodom II imali su poboljšani profil oslobađanja, bez značajne promjene u topljivosti. Na temelju XRPD rezultata, modificirani kristali piroksikama dobiveni metodom I iz smjese acetona i benzena bili su kubični, što dobro korelira s FTIR spektrom; modificirani igličasti kristali dobiveni iz smjese etanol/metanol i etanol/aceton imali su lagani pomak FTIR signala što bi se moglo pripisati razlikama u internoj strukturi ili konformacijama