3 research outputs found
Vancomycin Pharmacokinetics Throughout Life: Results from a Pooled Population Analysis and Evaluation of Current Dosing Recommendations
Abstract
Background and Objectives
Uncertainty exists regarding the optimal dosing regimen for vancomycin in diferent patient
populations, leading to a plethora of subgroup-specifc pharmacokinetic models and derived dosing regimens. We aimed to
investigate whether a single model for vancomycin could be developed based on a broad dataset covering the extremes of
patient characteristics. Furthermore, as a benchmark for current dosing recommendations, we evaluated and optimised the
expected vancomycin exposure throughout life and for specifc patient subgroups.
Methods
A pooled population-pharmacokinetic model was built in NONMEM based on data from 14 diferent studies in
diferent patient populations. Steady-state exposure was simulated and compared across patient subgr
Scholarly publishing depends on peer reviewers
The peer-review crisis is posing a risk to the scholarly peer-reviewed journal system. Journals have to ask many potential peer reviewers to obtain a minimum acceptable number of peers accepting reviewing a manuscript. Several solutions have been suggested to overcome this shortage. From reimbursing for the job, to eliminating pre-publication reviews, one cannot predict which is more dangerous for the future of scholarly publishing. And, why not acknowledging their contribution to the final version of the article published? PubMed created two categories of contributors: authors [AU] and collaborators [IR]. Why not a third category for the peer-reviewer?Scopu