1,048 research outputs found
Multiplicity Fluctuations and Bose-Einstein Correlations in DIS at HERA
Results of the recent studies of the multiplicity fluctuations and
Bose-Einstein correlations (BEC) in deep-inelastic scattering (DIS) at large
Q are reviewed. The measurements were done with the ZEUS detetor at HERA.Comment: 4 pages, 3 figures in eps, talk given at XXXI International Symposium
on Multiparticle Dynamics, Sept 1-7, 2001, Datong China. URL
http://202.114.35.18
Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of Sirt1 and Ku70
<p>Abstract</p> <p>Background</p> <p>To determine whether resveratrol, a natural plant-derived drug, has protective effects against antibody-induced apoptosis of retinal cells <it>in vitro </it>and to provide insights on the mechanism of resveratrol protection.</p> <p>Findings</p> <p>E1A.NR3 retinal cells pretreated with 40 ÎŒM resveratrol were grown in the presence of anti-recoverin (Rec-1), anti-enolase (Enol-1) antibodies, and normal purified immunoglobulins. When the cells were exposed to resveratrol before treatment with Enol-1 or Rec-1 antibodies, 30â55% more cells survived compared to the resveratrol-untreated cells. Western blotting showed a reduction in proapoptotic protein Bax in the cytoplasm and mitochondria of resveratrol-treated cells. Resveratrol-pretreated cells also showed a significant decrease in intracellular calcium and an inhibition of caspase-3 activity as compared to the untreated cells. Sirt1 expression was greatly reduced in the cells grown in the presence of Rec-1 and Enol-1, but it increased about five times in the resveratrol-pretreated cells. Immunocytochemistry revealed that Sirt1 expression in the cytoplasm and nucleus was colocalized with Ku70 expression in resveratrol-treated cells, suggesting possible interaction with each other in the cell. The pattern of the Ku70 cellular localization also overlapped with the Bax cellular localization in treated and untreated cells.</p> <p>Conclusion</p> <p><it>In vitro </it>protection of retinal cells from apoptosis by resveratrol occurred through multiple early molecular events, such as reduction of intracellular calcium levels, down-regulation of Bax, up-regulation of Sirt1 and Ku70 activities, and inhibition of caspase-3 activity. These findings will help designing future <it>in vivo </it>and pre-clinical treatments for autoimmune retinopathies.</p
Tameness of holomorphic closure dimension in a semialgebraic set
Given a semianalytic set S in a complex space and a point p in S, there is a
unique smallest complex-analytic germ at p which contains the germ of S, called
the holomorphic closure of S at p. We show that if S is semialgebraic then its
holomorphic closure is a Nash germ, for every p, and S admits a semialgebraic
filtration by the holomorphic closure dimension. As a consequence, every
semialgebraic subset of a complex vector space admits a semialgebraic
stratification into CR manifolds satisfying a strong version of the condition
of the frontier.Comment: Published versio
H-function extension of the NBD in the light of experimental data
The recently introduced H-function extension of the Negative Binomial
Distribution is investigated. The analytic form of P(n) is rederived by means
of the Mellin transform. Applications of the HNBD are provided using
experimental data for P(n) in e+e-, e+p, inelastic pp and non-diffractive
p-pbar reactions.Comment: 8 pages REVTeX, 1 eps figure embedde
Synthesis of Silver Nanoparticles Using Curcumin-Cyclodextrins Loaded into Bacterial Cellulose-Based Hydrogels for Wound Dressing Applications.
Chronic wounds are often recalcitrant to treatment because of high microbial bioburden and the problem of microbial resistance. Silver is a broad-spectrum natural antimicrobial agent with wide applications extending to proprietary wound dressings. Recently, silver nanoparticles have attracted attention in wound management. In the current study, the green synthesis of nanoparticles was accomplished using a natural reducing agent, curcumin, which is a natural polyphenolic compound that is well-known as a wound-healing agent. The hydrophobicity of curcumin was overcome by its microencapsulation in cyclodextrins. This study demonstrates the production, characterization of silver nanoparticles using aqueous curcumin:hydroxypropyl-ÎČ-cyclodextrin complex and loading them into bacterial cellulose hydrogel with moist wound-healing properties. These silver nanoparticle-loaded bacterial cellulose hydrogels were characterized for wound-management applications. In addition to high cytocompatibility, these novel dressings exhibited antimicrobial activity against three common wound-infecting pathogenic microbes , , and
Generalized Relativistic Meson Wave Function
We study the most general, relativistic, constituent meson
wave function within a new covariant framework. We find that by including a
tensor wave function component, a pure valence quark model is now capable of
reproducing not only all static pion data (, )
but also the distribution amplitude, form factor , and structure
functions. Further, our generalized spin wave function provides a much better
detailed description of meson properties than models using a simple
relativistic extension of the nonrelativistic wave function.Comment: 17 pages, REXTeX 3.0 file, (uuencoded postscript files of 8 figures
appended
Hadronic sizes and observables in high-energy scattering
The functional dependence of the high-energy observables of total cross
section and slope parameter on the sizes of the colliding hadrons predicted by
the model of the stochastic vacuum and the corresponding relations used in the
geometric model of Povh and H\"ufner are confronted with the experimental data.
The existence of a universal term in the expression for the slope, due purely
to vacuum effects, independent of the energy and of the particular hadronic
system, is investigated. Accounting for the two independent correlation
functions of the QCD vacuum, we improve the simple and consistent description
given by the model of the stochastic vacuum to the high-energy pp and pbar-p
data, with a new determination of parameters of non-perturbative QCD. The
increase of the hadronic radii with the energy accounts for the energy
dependence of the observables.Comment: Latex, using Revtex.style . 2 ps figures. To be published in Physical
Review D , July 199
Charged rho meson production in neutrino-induced reactions at E_nu = 10 GeV
The neutrinoproduction of charged mesons on nuclei and nucleons is
investigated for the first time at moderate energies ( 10
GeV), using the date obtained with SKAT bubble chamber. No strong nuclear
effects are observed in and production. The fractions of
charged and neutral pions originating from decays are obtained and
compared with higher energy data. From analysis of the obtained and available
data on and (892) neutrinoproduction, the strangeness
suppression factor in the quark string fragmentation is extracted: . Estimations are obtained for cross sections of quasiexclusive
single and coherent neutrinoproduction on nuclei. The
estimated coherent cross section = (0.29 cm is compatible with theoretical predictions.Comment: 7 pages, 6 figure
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