Space Transportation System Availability Requirement and Its Influencing Attributes Relationships

It is important that engineering and management accept the need for an availability requirement that is derived with its influencing attributes. It is the intent of this paper to provide the visibility of relationships of these major attribute drivers (variables) to each other and the resultant system inherent availability. Also important to provide bounds of the variables providing engineering the insight required to control the system's engineering solution, e.g., these influencing attributes become design requirements also. These variables will drive the need to provide integration of similar discipline functions or technology selection to allow control of the total parts count. The relationship of selecting a reliability requirement will place a constraint on parts count to achieve a given availability requirement or if allowed to increase the parts count will drive the system reliability requirement higher. They also provide the understanding for the relationship of mean repair time (or mean down time) to maintainability, e.g., accessibility for repair, and both the mean time between failure, e.g., reliability of hardware and availability. The concerns and importance of achieving a strong availability requirement is driven by the need for affordability, the choice of using the two launch solution for the single space application, or the need to control the spare parts count needed to support the long stay in either orbit or on the surface of the moon. Understanding the requirements before starting the architectural design concept will avoid considerable time and money required to iterate the design to meet the redesign and assessment process required to achieve the results required of the customer's space transportation system. In fact the impact to the schedule to being able to deliver the system that meets the customer's needs, goals, and objectives may cause the customer to compromise his desired operational goal and objectives resulting in considerable increased life cycle cost of the fielded space transportation system

Space Transportation System Availability Requirements and Its Influencing Attributes Relationships

It is important that engineering and management accept the need for an availability requirement that is derived with its influencing attributes. It is the intent of this paper to provide the visibility of relationships of these major attribute drivers (variables) to each other and the resultant system inherent availability. Also important to provide bounds of the variables providing engineering the insight required to control the system's engineering solution, e.g., these influencing attributes become design requirements also. These variables will drive the need to provide integration of similar discipline functions or technology selection to allow control of the total parts count. The relationship of selecting a reliability requirement will place a constraint on parts count to achieve a given availability requirement or if allowed to increase the parts count will drive the system reliability requirement higher. They also provide the understanding for the relationship of mean repair time (or mean down time) to maintainability, e.g., accessibility for repair, and both the mean time between failure, e.g., reliability of hardware and availability. The concerns and importance of achieving a strong availability requirement is driven by the need for affordability, the choice of using the two launch solution for the single space application, or the need to control the spare parts count needed to support the long stay in either orbit or on the surface of the moon. Understanding the requirements before starting the architectural design concept will avoid considerable time and money required to iterate the design to meet the redesign and assessment process required to achieve the results required of the customer's space transportation system. In fact the impact to the schedule to being able to deliver the system that meets the customer's needs, goals, and objectives may cause the customer to compromise his desired operational goal and objectives resulting in considerable increased life cycle cost of the fielded space transportation system

Digging Digitally: Creating a More Dynamic Archaeological Field Journal Archive

As the daily record of observations, the field journal always has been central to the archaeological process. Yet in recent decades, these important texts have been ignored in the rush to create digital artifact archives. This project, which builds upon software designed to manage the field books at the Ohio State University Excavations at Isthmia, will correct this oversight by enabling a community of scholars to use scans of the hand written texts to link electronically the disparate forms of evidence that make up the archaeological record. Also, this project will determine the best equipment and practices to allow archaeologists to utilize a digital notebook archive in their research. The result will be an inexpensive, multi-platform, and open source system that can be adapted by other scholars to simplify and enhance research in any field of humanities research that depends upon hand written documents as a primary source of evidence

Space Transportation System Availability Requirements and Its Influencing Attributes Relationships

It is essential that management and engineering understand the need for an availability requirement for the customer's space transportation system as it enables the meeting of his needs, goal, and objectives. There are three types of availability, e.g., operational availability, achieved availability, or inherent availability. The basic definition of availability is equal to the mean uptime divided by the sum of the mean uptime plus the mean downtime. The major difference is the inclusiveness of the functions within the mean downtime and the mean uptime. This paper will address tIe inherent availability which only addresses the mean downtime as that mean time to repair or the time to determine the failed article, remove it, install a replacement article and verify the functionality of the repaired system. The definitions of operational availability include the replacement hardware supply or maintenance delays and other non-design factors in the mean downtime. Also with inherent availability the mean uptime will only consider the mean time between failures (other availability definitions consider this as mean time between maintenance - preventive and corrective maintenance) that requires the repair of the system to be functional. It is also essential that management and engineering understand all influencing attributes relationships to each other and to the resultant inherent availability requirement. This visibility will provide the decision makers with the understanding necessary to place constraints on the design definition for the major drivers that will determine the inherent availability, safety, reliability, maintainability, and the life cycle cost of the fielded system provided the customer. This inherent availability requirement may be driven by the need to use a multiple launch approach to placing humans on the moon or the desire to control the number of spare parts required to support long stays in either orbit or on the surface of the moon or mars. It is the intent of this paper to provide the visibility of relationships of these major attribute drivers (variables) to each other and the resultant system inherent availability, but also provide the capability to bound the variables providing engineering the insight required to control the system's engineering solution. An example of this visibility will be the need to provide integration of similar discipline functions to allow control of the total parts count of the space transportation system. Also the relationship visibility of selecting a reliability requirement will place a constraint on parts count to achieve a given inherent availability requirement or accepting a larger parts count with the resulting higher reliability requirement. This paper will provide an understanding for the relationship of mean repair time (mean downtime) to maintainability, e.g., accessibility for repair, and both mean time between failure, e.g., reliability of hardware and the system inherent availability. Having an understanding of these relationships and resulting requirements before starting the architectural design concept definition will avoid considerable time and money required to iterate the design to meet the redesign and assessment process required to achieve the results required of the customer's space transportation system. In fact the impact to the schedule to being able to deliver the system that meets the customer's needs, goals, and objectives may cause the customer to compromise his desired operational goal and objectives resulting in considerable increased life cycle cost of the fielded space transportation system

Development of an efficient glucosinolate extraction method

Background: Glucosinolates, anionic sulfur rich secondary metabolites, have been extensively studied because of their occurrence in the agriculturally important brassicaceae and their impact on human and animal health. There is also increasing interest in the biofumigant properties of toxic glucosinolate hydrolysis products as a method to control agricultural pests. Evaluating biofumigation potential requires rapid and accurate quantification of glucosinolates, but current commonly used methods of extraction prior to analysis involve a number of time consuming and hazardous steps; this study aimed to develop an improved method for glucosinolate extraction. Results: Three methods previously used to extract glucosinolates from brassicaceae tissues, namely extraction in cold methanol, extraction in boiling methanol, and extraction in boiling water were compared across tissue type (root, stem leaf ) and four brassicaceae species (B. juncea, S. alba, R. sativus, and E. sativa). Cold methanol extraction was shown to perform as well or better than all other tested methods for extraction of glucosinolates with the exception of glucoraphasatin in R. sativus shoots. It was also demonstrated that lyophilisation methods, routinely used during extraction to allow tissue disruption, can reduce final glucosinolate concentrations and that extracting from frozen wet tissue samples in cold 80% methanol is more effective. Conclusions: We present a simplified method for extracting glucosinolates from plant tissues which does not require the use of a freeze drier or boiling methanol, and is therefore less hazardous, and more time and cost effective. The presented method has been shown to have comparable or improved glucosinolate extraction efficiency relative to the commonly used ISO method for major glucosinolates in the Brassicaceae species studied: sinigrin and gluconasturtiin in B. juncea; sinalbin, glucotropaeolin, and gluconasturtiin in S. alba; glucoraphenin and glucoraphasatin in R. sativus; and glucosatavin, glucoerucin and glucoraphanin in E. sativa

The Feasibility of the Use of Video Capture, Feedback Process in the Obstetrics and Gynecology Residents

The Feasibility of the use of Video Capture, Feedback Process in the Obstetrics and Gynecology Residents Sean Adams Martin A. Martino, MD; Joseph E. Patruno, MD; Timothy M. Pellini, MD Abstract Educating a resident and proving that he is capable of consistently performing a procedure is a difficult task. This is vastly important for the patients safety. One of the key parts of becoming a quality surgeon is technical skill. To assess the technical skills of the obstetrics and gynecology residents, myself and four other students performed a video capture, feedback process using a product called SimCapture. This process involved us video recording four different types of surgeries performed by residents. After each case, the resident and attending participated in a feedback process to review the strengths and weaknesses of the resident for that particular case. The feasibility of the process is very significant in helping determine if this method is effective and if it should be used in the future. Often times, we planned on recording a case for our data in which something went wrong such as a resident who didn’t operate at all or a change in the operating room (OR) schedule we were not made aware of. This caused us to miss quite a few cases that we planned on recording. Nurses, attendings, and residents were slightly skeptical about our study initially, but over time they became more comfortable with us recording the surgeries. The consistent issues and obstacles forced us to be very proactive and flexible. Ultimately, we were successful in collecting the research we wanted. Background Becoming an expert surgeon is a long and difficult process including many years of medical school and residency. This calls for thousands of hours of learning information, practicing on simulators, and performing surgeries with an attending surgeon. It is important that the attending surgeon mentors and assists the resident(1). The education of these residents must be maximized for the purpose of patient safety. While there are many factors in determining a surgeons abilities, technical skill is the most related to the outcome of the patient (2). Evaluating the technical skill of residents is an especially challenging subject. An educational program called FLS (The Fundamentals of Laproscopic Surgery) was developed to improve the knowledge and technical skills of residents (3). A study done by three Washington D.C hospitals compared the FLS examination scores of residents to their objective OR skill evaluations (3). The results showed a clear relationship as residents with higher FLS scores also received better evaluations in the OR (3). The FLS test includes a written section to express knowledge of laproscopic surgery as well as skills tests on box trainers (3). Another way to evaluate the technical skill of surgeons is through video analysis. A study done by the Michigan Bariatric Surgery Collaborative (MBSC) had 20 surgeons submit a video of themselves performing a laproscopic gastric bypass (2). The skills of these surgeons were then evaluated by blinded surgeons and rated on a 1 to 5 scale. These scores were then compared to the outcomes of surgeries done by the same 20 surgeons on around 10,000 patients (2). The results showed that the top quartile of scores were related to lower complication rates (2). The bottom quartile were related to higher complication rates (2). The use of videotape assessment is a very effective way for residency programs to improve the technical skill of residents through feedback. It is also a way to determine whether or not their residents are competent performing certain surgical procedures. If hospitals are considering a form of video taping and feedback process, it is important that they know the feasibility of the process. How accepting were the residents and attending surgeons to the process? Were participating in the debriefing after? Was the process overcrowding the OR? Was it difficult to record the cases? A type of video recording technology called SimCapture was purchased by the Lehigh Valley Hospital for the purpose of recording residents. The technology includes a software programmed into a laptop computer that then allows you to record surgeries from a webcam. The data recorded on the webcam and through connection to the endoscopic tower is then stored on the software for further analysis. Purpose The purpose of my project is to determine the feasibility of a video capture, feedback process that will be used to improve and calculate the technical skill of obstetrics and gynecology residents at the Lehigh Valley Hospital. The video capture, feedback process involves recording the surgeries performed by a number of different residents. The attending surgeons will provide feedback based on their real time analysis of the residents performance. The videotapes of each case will be sent out to blinded experts for analysis using the same evaluation forms that were completed by the attending surgeon and resident that were present at the case. In the future, the recorded surgeries could also be used to build a portfolio for each resident to show their competency performing certain procedures. My complete focus will be on determining the degree of how convenient a video capture, feedback process can be done. Methods For our data collection, we recorded the obstetrics and gynecology residents performing four different types of surgeries. These different surgeries included C section, Hysteroscopy, Robotic Hysterectomy, and Laparoscopic tubal ligation (BTL). Our exact methods for recording the surgeries varied slightly depending on the case. The residents varied in experience from first through fourth year. The fourth year residents would often do large portions of the cases while the less experienced residents did less. The night before the cases, we would look at the OR schedule and plan out the cases we were going to record the next day. A group of two scholars would show up about a half hour before the first surgery. At this time they would find the resident and attending for the case to introduce themselves, tell them about the project, and ask them to participate in a debrief session following the case. The scholars would then enter into the OR to set up the technology. The computer with the Sim Capture program is connected to the endoscopic tower using the appropriate adaptors. This allows us to get an internal view of the patient. A camera attached to an extension chord is mounted on top of an IV pole using a clamp and then angled toward the incision made on the patient. For C sections, there is no endoscopic tower used. For robotic hysterectomy cases, we record the resident’s hands when using the robot instead of the incisions. One scholar then logs into the SimCapture program and runs a new session. To run the session, they have to input information such as the resident number, name of scholar operating the system, and the type of surgery. Once everything is set up, both scholars leave the OR until the patient is all ready to be operated on. Upon re-entering the OR, the scholar working the laptop then starts recording once time out is called. Every time the resident stops or starts operating, an annotation is made in the video tape. The scholar who is not working the SimCapture program fills out the form which keeps track of each time the attending teaches the resident. That scholar also completes the feasibility form which notes if the resident, attending, and other staff were understanding of our study as well as any problems that occurred. Once the surgery is completed, recording is stopped and both scholars disassemble the equipment. After leaving the OR; both scholars, the resident, and the attending participate in a short debriefing session. In this debriefing session, the attending and resident each complete the appropriate OPRS and milestone forms. The resident then discusses what he thought he did well and also what could be improved. The attending follows up with his feedback. Once the debriefing is completed, the scholars then plug all the forms into the SimCapture program and discuss the case. Results Figure 1: Number of cases recorded for each procedure Procedure Number of cases recorded Hysteroscopy 11 Robotic Hysterectomy 8 C section 17 BTL 3 Total 39 Figure 2: Percentage of cases recorded Percentage of Cases Recorded Recorded Missed Total Percent Recorded 39 25 64 61% Figure 4: Summary of feasibility form Average time to set up equipment 5.7 min Average time to disassemble equipment 3.2 min Average time to debrief 3.6 min Percent of cases where debrief occurred 61% Percent of cases where resident was receptive to process 97% Percent of cases where attending was receptive to process 95% Percent of cases where OR staff was receptive to process 97% Conclusion / discussion After about six weeks of collecting data, we were able to record 39 cases as shown in figure 1. You can see in figure 2 that we did miss quite a few of the cases that we had planned on recording. Our 61% success rate had to do with the number of issues and obstacles that occurred throughout the process. Some of the obstacles included technology issues, resident not operating, changes in the OR schedule, surgeon preference, and patient preference. Figure 3 allows you to see the breakdown of how often certain issues occurred in the 25 cases we missed. As we became more comfortable with our video capture feedback process, the issues became less and less frequent. Some of the initial technology issues included delays in the camera feed, one camera not working at all, SimCaptu re not picking up the camera and tower feeds, and not having the correct adaptor to connect the program into the tower. We sorted out almost all of these issues in the first few weeks. Experience also allowed us to perform the process more efficiently, including setting up the equipment. Over time, we had developed a consistent system to record cases and stay out of the way of the staff. This allowed our process to gain acceptance by attendings, residents, and OR staff. After performing a number of cases, they became more comfortable with us recording the cases in the OR. Figure 4 shows a summary of the results for the feasibility forms we completed for each case. One of the other key difficulties of our process was getting the resident and attendings to participate in the debriefing after the case. This is shown by the fact that only 61% of the cases had debriefings. The attendings, residents, or both of them were often needed elsewhere and had little time after the cases.Throughout the 6 weeks, we were forced to make quite and few innovations and be flexible with our process. For example, we needed to purchase an adaptor that would allow us to connect the SimCapture program into the endoscopic tower. Often times, the nurses and OR staff got very nervous about all the wires that we were bringing into the OR. We often had to be innovative by attaching the camera to the IV pole to get a good angle and laying a mat over all the wires. Even with all these issues, we were able to record a very good amount of cases over the 6 week period. This shows that a video capture, feedback process using a system such as SimCapture can be very effective in evaluating the technical skills of residents. References Levy, B. (2012). Experience Counts. American College of Obstetricians and Gynecologists, 119(4), 693-694. Birkmeyer, J. (2013, October 10). Surgical Skill and Complication Rates after Bariatric Surgery. www.nejm.org. 3. Antosh, D. (2012, December 8). Blinded Assessment of Operative Performance After Fundamentals of Laparoscopic Surgery in Gynecology Training. www.jmig.org

Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12.

Innate lymphoid cells (ILCs) are tissue-resident sentinels that are essential for early host protection from pathogens at initial sites of infection. However, whether pathogen-derived antigens directly modulate the responses of tissue-resident ILCs has remained unclear. In the present study, it was found that liver-resident type 1 ILCs (ILC1s) expanded locally and persisted after the resolution of infection with mouse cytomegalovirus (MCMV). ILC1s acquired stable transcriptional, epigenetic and phenotypic changes a month after the resolution of MCMV infection, and showed an enhanced protective effector response to secondary challenge with MCMV consistent with a memory lymphocyte response. Memory ILC1 responses were dependent on the MCMV-encoded glycoprotein m12, and were independent of bystander activation by proinflammatory cytokines after heterologous infection. Thus, liver ILC1s acquire adaptive features in an MCMV-specific manner

Avoidant Coping and Self-efficacy Mediate Relationships between Perceived Social Constraints and Symptoms among Long-term Breast Cancer Survivors

Objective Many breast cancer survivors feel constrained in discussing their cancer experience with others. Limited evidence suggests that social constraints (e.g., avoidance and criticism) from loved ones may negatively impact breast cancer survivors' global health, but research has yet to examine relationships between social constraints and common physical symptoms. Informed by social cognitive processing theory, this study examined whether perceived social constraints from partners and healthcare providers (HCPs) were associated with fatigue, sleep disturbance, and attentional functioning among long-term breast cancer survivors (N = 1052). In addition, avoidant coping and self-efficacy for symptom management were examined as potential mediators of these relationships. Methods Long-term breast cancer survivors (mean years since diagnosis = 6) completed questionnaires assessing social constraints from partners and HCPs, avoidant coping, self-efficacy for symptom management, and symptoms (i.e., fatigue, sleep disturbance, and attentional functioning). Structural equation modeling was used to evaluate the hypothesized relationships among variables in two models: one focused on social constraints from partners and one focused on social constraints from HCPs. Results Both models demonstrated good fit. Consistent with theory and prior research, greater social constraints from both partners and HCPs were associated with greater symptom burden (i.e., greater fatigue and sleep disturbance, poorer attentional functioning). In addition, all relationships were mediated by avoidant coping and self-efficacy for symptom management. Conclusions Findings are consistent with social cognitive processing theory and suggest that symptom management interventions may be enhanced by addressing the impact of social constraints from survivors' partners and HCPs on their coping and self-efficacy