642 research outputs found
The first measurement of meson semi-leptonic decay contribution to non-photonic electrons at RHIC
We present the first measurement for the meson semi-leptonic decay
contribution to non-photonic electrons at RHIC using non-photonic electron
azimuthal correlations with charged hadrons in p+p collisions at GeV from STAR.Comment: 4 pages, 3 figures, Quark Matter 2006 Proceedings, to appear in J.
Phys.
Ab initio Calculations of Multilayer Relaxations of Stepped Cu Surfaces
We present trends in the multilayer relaxations of several vicinals of
Cu(100) and Cu(111) of varying terrace widths and geometry. The electronic
structure calculations are based on density functional theory in the local
density approximation with norm-conserving, non-local pseudopotentials in the
mixed basis representation. While relaxations continue for several layers, the
major effect concentrates near the step and corner atoms. On all surfaces the
step atoms contract inwards, in agreement with experimental findings.
Additionally, the corner atoms move outwards and the atoms in the adjacent
chain undergo large inward relaxation. Correspondingly, the largest contraction
(4%) is in the bond length between the step atom and its bulk nearest neighbor
(BNN), while that between the corner atom and BNN is somewhat enlarged. The
surface atoms also display changes in registry of upto 1.5%. Our results are in
general in good agreement with LEED data including the controversial case of
Cu(511). Subtle differences are found with results obtained from semi-empirical
potentials.Comment: 21 pages and 3 figure
Baseline Q-Wave Surpasses Time From Symptom Onset as a Prognostic Marker in ST-Segment Elevation Myocardial Infarction Patients Treated With Primary Percutaneous Coronary Intervention
ObjectivesWe assessed the incremental value of baseline Q waves over time from symptom onset as a marker of clinical outcome in ST-segment elevation myocardial infarction (STEMI).BackgroundTime from symptom onset is a central focus in STEMI patients. The presence of Q waves on the baseline electrocardiogram (ECG) has been suggested to be of incremental value to time from symptom onset in evaluating clinical outcomes.MethodsWe evaluated baseline Q waves and ST-segment resolution 30 min after primary percutaneous intervention (PCI) ECGs in 4,530 STEMI patients without prior infarction. Additionally, peak biomarkers; 90-day mortality; and the composite of death, congestive heart failure (CHF), or cardiogenic shock were assessed.ResultsFifty-six percent of patients had baseline Q waves: they were older, more frequently male and diabetic, and had a more advanced Killip class. Patients with baseline Q waves had greater mortality and a higher composite rate of death, CHF, and shock versus patients without baseline Q waves at 90 days (5.3% vs. 2.1% and 12.1% vs. 4.8%, respectively, both p < 0.001). Complete ST-segment resolution was highest, whereas 90-day mortality and the composite outcome were lowest among those randomized ≤3 h without baseline Q waves. After multivariable adjustment, baseline Q-wave but not time from symptom onset was significantly associated with a 78% relative increase in the hazard of 90-day mortality and a 90% relative increase in the hazard of death, shock, and CHF.ConclusionsBaseline Q waves in STEMI patients treated with primary PCI provide an independent prognostic marker of clinical outcome. These data might be useful in designing future clinical trials as well as in evaluating patients for triage and potential transfer for planned primary PCI. (Pexelizumab in Conjunction With Angioplasty in Acute Myocardial Infarction [APEX-AMI]; NCT00091637
Strongly Correlated Quantum Fluids: Ultracold Quantum Gases, Quantum Chromodynamic Plasmas, and Holographic Duality
Strongly correlated quantum fluids are phases of matter that are
intrinsically quantum mechanical, and that do not have a simple description in
terms of weakly interacting quasi-particles. Two systems that have recently
attracted a great deal of interest are the quark-gluon plasma, a plasma of
strongly interacting quarks and gluons produced in relativistic heavy ion
collisions, and ultracold atomic Fermi gases, very dilute clouds of atomic
gases confined in optical or magnetic traps. These systems differ by more than
20 orders of magnitude in temperature, but they were shown to exhibit very
similar hydrodynamic flow. In particular, both fluids exhibit a robustly low
shear viscosity to entropy density ratio which is characteristic of quantum
fluids described by holographic duality, a mapping from strongly correlated
quantum field theories to weakly curved higher dimensional classical gravity.
This review explores the connection between these fields, and it also serves as
an introduction to the Focus Issue of New Journal of Physics on Strongly
Correlated Quantum Fluids: from Ultracold Quantum Gases to QCD Plasmas. The
presentation is made accessible to the general physics reader and includes
discussions of the latest research developments in all three areas.Comment: 138 pages, 25 figures, review associated with New Journal of Physics
special issue "Focus on Strongly Correlated Quantum Fluids: from Ultracold
Quantum Gases to QCD Plasmas"
(http://iopscience.iop.org/1367-2630/focus/Focus%20on%20Strongly%20Correlated%20Quantum%20Fluids%20-%20from%20Ultracold%20Quantum%20Gases%20to%20QCD%20Plasmas
Heat Stress Enhances the Accumulation of Polyadenylated Mitochondrial Transcripts in Arabidopsis thaliana
Background: Polyadenylation of RNA has a decisive influence on RNA stability. Depending on the organisms or subcellular compartment, it either enhances transcript stability or targets RNAs for degradation. In plant mitochondria, polyadenylation promotes RNA degradation, and polyadenylated mitochondrial transcripts are therefore widely considered to be rare and unstable. We followed up a surprising observation that a large number of mitochondrial transcripts are detectable in microarray experiments that used poly(A)-specific RNA probes, and that these transcript levels are significantly enhanced after heat treatment. Methodology/Principal Findings: As the Columbia genome contains a complete set of mitochondrial genes, we had to identify polymorphisms to differentiate between nuclear and mitochondrial copies of a mitochondrial transcript. We found that the affected transcripts were uncapped transcripts of mitochondrial origin, which were polyadenylated at multiple sites within their 39region. Heat-induced enhancement of these transcripts was quickly restored during a short recovery period. Conclusions/Significance: Our results show that polyadenylated transcripts of mitochondrial origin are more stable than previously suggested, and that their steady-state levels can even be significantly enhanced under certain conditions. As many microarrays contain mitochondrial probes, due to the frequent transfer of mitochondrial genes into the genome
The nuclear receptors of Biomphalaria glabrata and Lottia gigantea: Implications for developing new model organisms
© 2015 Kaur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedNuclear receptors (NRs) are transcription regulators involved in an array of diverse physiological functions including key roles in endocrine and metabolic function. The aim of this study was to identify nuclear receptors in the fully sequenced genome of the gastropod snail, Biomphalaria glabrata, intermediate host for Schistosoma mansoni and compare these to known vertebrate NRs, with a view to assessing the snail's potential as a invertebrate model organism for endocrine function, both as a prospective new test organism and to elucidate the fundamental genetic and mechanistic causes of disease. For comparative purposes, the genome of a second gastropod, the owl limpet, Lottia gigantea was also investigated for nuclear receptors. Thirty-nine and thirty-three putative NRs were identified from the B. glabrata and L. gigantea genomes respectively, based on the presence of a conserved DNA-binding domain and/or ligand-binding domain. Nuclear receptor transcript expression was confirmed and sequences were subjected to a comparative phylogenetic analysis, which demonstrated that these molluscs have representatives of all the major NR subfamilies (1-6). Many of the identified NRs are conserved between vertebrates and invertebrates, however differences exist, most notably, the absence of receptors of Group 3C, which includes some of the vertebrate endocrine hormone targets. The mollusc genomes also contain NR homologues that are present in insects and nematodes but not in vertebrates, such as Group 1J (HR48/DAF12/HR96). The identification of many shared receptors between humans and molluscs indicates the potential for molluscs as model organisms; however the absence of several steroid hormone receptors indicates snail endocrine systems are fundamentally different.The National Centre for the Replacement, Refinement and Reduction of Animals in Research, Grant Ref:G0900802 to CSJ, LRN, SJ & EJR [www.nc3rs.org.uk]
First Demonstration of Electrostatic Damping of Parametric Instability at Advanced LIGO
Interferometric gravitational wave detectors operate with high optical power in their arms in order to achieve high shot-noise limited strain sensitivity. A significant limitation to increasing the optical power is the phenomenon of three-mode parametric instabilities, in which the laser field in the arm cavities is scattered into higher-order optical modes by acoustic modes of the cavity mirrors. The optical modes can further drive the acoustic modes via radiation pressure, potentially producing an exponential buildup. One proposed technique to stabilize parametric instability is active damping of acoustic modes. We report here the first demonstration of damping a parametrically unstable mode using active feedback forces on the cavity mirror. A 15 538 Hz mode that grew exponentially with a time constant of 182 sec was damped using electrostatic actuation, with a resulting decay time constant of 23 sec. An average control force of 0.03 nN was required to maintain the acoustic mode at its minimum amplitude
25-Hydroxyvitamin D levels and chronic kidney disease in the AusDiab (Australian Diabetes, Obesity and Lifestyle) study
<p>Abstract</p> <p>Background</p> <p>Low 25-hydroxy vitamin D (25(OH)D) levels have been associated with an increased risk of albuminuria, however an association with glomerular filtration rate (GFR) is not clear. We explored the relationship between 25(OH)D levels and prevalent chronic kidney disease (CKD), albuminuria and impaired GFR, in a national, population-based cohort of Australian adults (AusDiab Study).</p> <p>Methods</p> <p>10,732 adults ≥25 years of age participating in the baseline survey of the AusDiab study (1999–2000) were included. The GFR was estimated using an enzymatic creatinine assay and the CKD-EPI equation, with CKD defined as eGFR <60 ml/min/1.73 m<sup>2</sup>. Albuminuria was defined as a spot urine albumin to creatinine ratio (ACR) of ≥2.5 mg/mmol for men and ≥3.5 for women. Serum 25(OH)D levels of <50 nmol/L were considered vitamin D deficient. The associations between 25(OH)D level, albuminuria and impaired eGFR were estimated using multivariate regression models.</p> <p>Results</p> <p>30.7% of the study population had a 25(OH)D level <50 nmol/L (95% CI 25.6-35.8). 25(OH)D deficiency was significantly associated with an impaired eGFR in the univariate model (OR 1.52, 95% CI 1.07-2.17), but not in the multivariate model (OR 0.95, 95% CI 0.67-1.35). 25(OH)D deficiency was significantly associated with albuminuria in the univariate (OR 2.05, 95% CI 1.58-2.67) and multivariate models (OR 1.54, 95% CI 1.14-2.07).</p> <p>Conclusions</p> <p>Vitamin D deficiency is common in this population, and 25(OH)D levels of <50 nmol/L were independently associated with albuminuria, but not with impaired eGFR. These associations warrant further exploration in prospective and interventional studies.</p
All-sky search for time-integrated neutrino emission from astrophysical sources with 7 years of IceCube data
Since the recent detection of an astrophysical flux of high energy neutrinos,
the question of its origin has not yet fully been answered. Much of what is
known about this flux comes from a small event sample of high neutrino purity,
good energy resolution, but large angular uncertainties. In searches for
point-like sources, on the other hand, the best performance is given by using
large statistics and good angular reconstructions. Track-like muon events
produced in neutrino interactions satisfy these requirements. We present here
the results of searches for point-like sources with neutrinos using data
acquired by the IceCube detector over seven years from 2008--2015. The
discovery potential of the analysis in the northern sky is now significantly
below , on average
lower than the sensitivity of the previously published analysis of four
years exposure. No significant clustering of neutrinos above background
expectation was observed, and implications for prominent neutrino source
candidates are discussed.Comment: 19 pages, 17 figures, 3 tables; ; submitted to The Astrophysical
Journa
The contribution of Fermi-2LAC blazars to the diffuse TeV-PeV neutrino flux
The recent discovery of a diffuse cosmic neutrino flux extending up to PeV
energies raises the question of which astrophysical sources generate this
signal. One class of extragalactic sources which may produce such high-energy
neutrinos are blazars. We present a likelihood analysis searching for
cumulative neutrino emission from blazars in the 2nd Fermi-LAT AGN catalogue
(2LAC) using an IceCube neutrino dataset 2009-12 which was optimised for the
detection of individual sources. In contrast to previous searches with IceCube,
the populations investigated contain up to hundreds of sources, the largest one
being the entire blazar sample in the 2LAC catalogue. No significant excess is
observed and upper limits for the cumulative flux from these populations are
obtained. These constrain the maximum contribution of the 2LAC blazars to the
observed astrophysical neutrino flux to be or less between around 10
TeV and 2 PeV, assuming equipartition of flavours at Earth and a single
power-law spectrum with a spectral index of . We can still exclude that
the 2LAC blazars (and sub-populations) emit more than of the observed
neutrinos up to a spectral index as hard as in the same energy range.
Our result takes into account that the neutrino source count distribution is
unknown, and it does not assume strict proportionality of the neutrino flux to
the measured 2LAC -ray signal for each source. Additionally, we
constrain recent models for neutrino emission by blazars.Comment: 18 pages, 22 figure
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