251 research outputs found
Anatomic outcomes after retinal detachment surgery in patients with retinal detachment associated with choroidal detachment
PURPOSE: To investigate relationships between preoperative and intraoperative characteristics with outcome variables in patients suffering from primary rhegmatogenous retinal detachment (RRD) or traction retinal detachment (TRD) complicated by serous choroidal detachment (CD). Choroidal detachment is a rare complication of retinal detachment and the current literature cites generally poor visual outcome variables. By investigating a retrospective case series, we hope to elucidate new relationships and embolden existing ones so that future physicians can make more educated decisions regarding the care for these complicated patients.
METHODS: A retrospective case series analyzed 18 patient’s medical records (18 eyes) who had been diagnosed and surgically treated for RRD or TRD associated with a CD at the Longwood Medical Eye Center at Beth Israel Deaconess Medical Center. Patients with RDCD who had undergone 23-gauge pars plana vitrectomy with silicone oil tamponade were selected. Exclusionary criteria included ocular complications such as phthisis bulbi and open globe trauma. Patients experienced a variety of surgical procedures including by not limited to relaxing retinotomy (n=12 eyes), choroidal drainage (n=10 eyes), endoscopy-assisted PPV (n=10 eyes), and ERM peeling (n=8 eyes). Primary outcome variables tabulated were primary and final anatomic success, defined as successful reattachment of the retina to the underlying choroid, and final visual acuity.
RESULTS: The mean age of the sample group was 69 with 8 patients (44%) diagnosed with preoperative hypotony (IOP <= 6 mmHg). A total of 12 patients were pseudophakic (67%). With a mean follow-up of 21.6 months, patients exhibited expected visual outcomes with 6 patients (33%) improving visual acuity and 7 patients (39%) decreasing visual acuity. Final anatomic success was seen in 17 cases (94%). A significant correlation was found between decreased number of previous surgeries and better visual outcomes (change in BCVA). Another significant relationship correlates choroidal drainage with worse visual outcomes (change in BCVA). Finally, patients who received ERM peeling had better rates of primary anatomic success.
CONCLUSION: The advanced age of the sample lends itself to increased risk for cataracts and thus pseudophakia. In addition, high rates of diabetes and macular degeneration follow. The pathophysiology of RDCD in relation to the risk factors of hypotony and macular holes is possibly based on the Starling forces and favorable fluid transudation into the suprachoroidal space. Although the outcomes of this study were similar to previous literature, the visual outcomes are still poor at best. Reducing the number of previous, invasive, ocular surgeries was seen to be correlated with better visual outcomes. In addition, performing ERM peels is seen to be correlated with improved rates of primary anatomic success. More research is required on the etiology of the disease process and a case-controlled longitudinal study may be helpful in determining more relationships with outcome variables
Longitudinal Associations Between School Connectedness and Adjustment Problems During Adolescence
Given that adolescents spend majority of their lives in school, nearly seven hours every day, it is crucial to investigate how their relationship with their school impacts developmental outcomes. Key features of school connectedness, such as support and acceptance from the community, serve as protective factors against development of depression and anxiety symptoms during adolescence (Waters et al., 2009; Joyce & Early, 2014). Further, longitudinal research suggests that school connectedness is negatively correlated with behavioral problems and psychopathology during the adolescent period (Lester et al., 2013; Loukaset al., 2009). Although these relationships have been established, extant research has yet to investigate potential developmental pathways among these constructs. Therefore, the current study sought to examine depressive and anxiety symptoms as mediators of the relationship between school connectedness and later problem behavior.Data were drawn from the Predictors of Anxiety and Depression During Adolescence (PANDA) Project(Ohannessian & Vannucci, 2018), which surveyed adolescents from five Northeastern State middle schools in fall 2016 (T1; Mage=12.75; SD=.71; 51% female), spring 2017 (T2), and fall 2017 (T3).Adolescents reported on depressive and social anxiety symptoms, feeling of school connectedness, and problem behaviors. The Center for Epidemiological Studies Depression Scale for Children (Weissman etal., 1980) was used to measure adolescent depressive symptoms (αT1=.91); the Screen for Child Anxiety Related Emotional Disorders (Birmaher et al., 1999) was used to assess social anxiety (αT1=.87); and a school connectedness scale measured school connectedness (αT1=.71). Adolescent also reported on the frequency in which they engaged in a variety of risk behaviors (e.g., start physical fights; αT1=.95)(American Psychiatric Association, 2013).Structural equation modeling was used to examine whether depressive and anxiety symptoms (T2)mediated the relationship between school connectedness (T1) and later problem behavior (T3). Age,gender, and previous time points of all endogenous variables were controlled (Figure 1). Model results indicated that school connectedness negatively predicted later depressive and anxiety symptoms.However, only depressive symptoms in turn positively predicted later problem behavior. The direct effectof school connectedness to problem behavior 1.5 years later remained significant after accounting for the mediated pathways, suggesting that depressive symptoms partially mediated this effect.These findings highlight a developmental pathway from school connectedness to later problem behavior through adolescents’ depressive symptoms. Findings may aid schools in identifying at-risk youth for developing later emotional and behavioral problems and point to the importance of promoting school connectedness among young adolescents.https://ir.library.illinoisstate.edu/urspsych/1001/thumbnail.jp
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Deer mouse hemoglobin exhibits a lowered oxygen affinity owing to mobility of the E helix
The deer mouse, Peromyscus maniculatus, exhibits altitude-associated variation in hemoglobin oxygen affinity. To examine the structural basis of this functional variation, the structure of the hemoglobin was solved. Recombinant hemoglobin was expressed in Escherichia coli and was purified by ion-exchange chromatography. Recombinant hemoglobin was crystallized by the hangingdrop vapor-diffusion method using polyethylene glycol as a precipitant. The obtained orthorhombic crystal contained two subunits in the asymmetric unit. The refined structure was interpreted as the aquo-met form. Structural comparisons were performed among hemoglobins from deer mouse, house mouse and human. In contrast to human hemoglobin, deer mouse hemoglobin lacks the hydrogen bond between α1Trp14 in the A helix and α1Thr67 in the E helix owing to the Thr67Ala substitution. In addition, deer mouse hemoglobin has a unique hydrogen bond at the α1β1 interface between residues α1Cys34 and β1Ser128
EPOCHS VII: Discovery of high redshift () AGN candidates in JWST ERO and PEARLS data
We present an analysis of a sample of robust high redshift galaxies selected
photometrically from the `blank' fields of the Prime Extragalactic Areas for
Reionization Science (PEARLS) survey and Early Release Observations (ERO) data
of the James Webb Space Telescope (JWST) with the aim of selecting candidate
high redshift active galactic nuclei (AGN). Sources were identified from the
parent sample using a threefold selection procedure, which includes spectral
energy distribution (SED) fitting to identify sources that are best fitted by
AGN SED templates, a further selection based on the relative performance of AGN
and non-AGN models, and finally morphological fitting to identify compact
sources of emission, resulting in a purity-oriented procedure. Using this
procedure, we identify a sample of nine AGN candidates at , from
which we constrain their physical properties as well as measure a lower bound
on the AGN fraction in this redshift range of \%. As this is an
extreme lower limit due to our focus on purity and our SEDs being calibrated
for unobscured Type 1 AGN, this demonstrates that AGN are perhaps quite common
at this early epoch. The rest-frame UV colors of our candidate objects suggest
that these systems are potentially candidate obese black hole galaxies (OBG),
or AGN with very little galaxy component. We also investigate emission from our
sample sources from fields overlapping with Chandra and VLA surveys, allowing
us to place X-ray and 3 GHz radio detection limits on our candidates. Of note
is a candidate source exhibiting an abrupt morphological shift in
the reddest band as compared to the bluer bands, indicating a potential merger
or an unusually strong outflow.Comment: Submitted to MNRAS, 12 pages, 11 figures, typos correcte
Magellanic System Stars Identified in the SMACS J0723.3-7327 JWST ERO Images
We identify 68 distant stars in JWST/NIRCam ERO images of the field of galaxy
cluster SMACS J0723.3-7327 (SMACS 0723). Given the relatively small
() angular separation between SMACS 0723 and the Large
Magellanic Cloud, it is likely that these stars are associated with the LMC
outskirts or Leading Arm. This is further bolstered by a spectral energy
distribution analysis, which suggests an excess of stars at a physical distance
of kpc, consistent with being associated with or located behind the
Magellanic system. In particular, we find that the overall surface density of
stars brighter than 27.0 mag in the field of SMACS 0723 is 2.3 times that
of stars in a blank field with similar galactic latitude (the North Ecliptic
Pole Time Domain Field), and that the density of stars in the SMACS 0723 field
with SED-derived distances consistent with the Magellanic system is 7.3
times larger than that of the blank field. The candidate stars at these
distances are consistent with a stellar population at the same distance modulus
with [Fe/H] and an age of Gyr. On the assumption that all
of the 68 stars are associated with the LMC, then the stellar density of the
LMC at the location of the SMACS 0723 field is stars kpc,
which helps trace the density of stars in the LMC outskirts.Comment: Submitted to ApJ, comments welcom
JWST's PEARLS: TN J1338-1942 -- I. Extreme jet triggered star-formation in a z=4.11 luminous radio galaxy
We present the first JWST observations of the z = 4.11 luminous radio galaxy TN J1338–1942, obtained as part of the ‘Prime Extragalactic Areas for Reionization and Lensing Science’ (‘PEARLS’) project. Our NIRCam observations, designed to probe the key rest-frame optical continuum and emission line features at this redshift, enable resolved spectral energy distribution modelling that incorporates both a range of stellar population assumptions and radiative shock models. With an estimated stellar mass of log10(M/M) ∼ 10.9, TN J1338–1942 is confirmed to be one of the most massive galaxies known at this epoch. Our observations also reveal extremely high equivalent-width nebular emission coincident with the luminous AGN jets that is best fit by radiative shocks surrounded by extensive recent star formation. We estimate the total star-formation rate (SFR) could be as high as ∼ 1600 M yr−1 , with the SFR that we attribute to the jet induced burst conservatively 500 M yr−1. The mass-weighted age of the star-formation, tmass < 4 Myr, is consistent with the likely age of the jets responsible for the triggered activity and significantly younger than that measured in the core of the host galaxy. The extreme scale of the potential jet-triggered star-formation activity indicates the potential importance of positive AGN feedback in the earliest stages of massive galaxy formation, with our observations also illustrating the extraordinary prospects for detailed studies of high-redshift galaxies with JWST.KJD acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement number 892117 (HIZRAD) and support from the STFC through an Ernest Rutherford Fellowship (grant number ST/W003120/1). RAW, SHC, and RAJ acknowledge support from NASA JWST Interdisciplinary Scientist grants NAG5-12460, NNX14AN10G, and 80NSSC18K0200 from GSFC. Work by CJC acknowledges support from the European Research Council (ERC) Advanced Investigator Grant EPOCHS (788113). BLF thanks the Berkeley Center for Theoretical Physics for their hospitality during the writing of this paper. MAM acknowledges the support of a National Research Council of Canada Plaskett Fellowship, and the Australian Research Council center of Excellence for All Sky Astrophysics in 3 Dimensions (ASTRO 3D), through project number CE17010001. CNAW acknowledges funding from the JWST/NIRCam contract NASS-0215 to the University of Arizona. TAH is supported by an appointment to the NASA Postdoctoral Program (NPP) at NASA Goddard Space Flight Center, administered by Oak Ridge Associated Universities under contract with NASA.Peer reviewe
JWST's PEARLS: a new lens model for ACT-CL J01024915, "EL Gordo'', and the first red supergiant star at cosmological distances discovered by JWST
The first JWST data on the massive colliding cluster El Gordo confirm 23
known families of multiply lensed images and identify 8 new members of these
families. Based on these families, which have been confirmed spectroscopically
by MUSE, we derived an initial lens model. This model guided the identification
of 37 additional families of multiply lensed galaxies, among which 28 are
entirely new systems, and 9 were previously known. The initial lens model
determined geometric redshifts for the 37 new systems. The geometric redshifts
agree reasonably well with spectroscopic or photometric redshifts when those
are available. The geometric redshifts enable two additional models that
include all 60 families of multiply lensed galaxies spanning a redshift range
. The derived dark-matter distribution confirms the double-peak
configuration of mass found by earlier work with the southern and northern
clumps having similar masses. We confirm that El Gordo is the most massive
known cluster at and has an estimated virial mass close the maximum
mass allowed by standard cosmological models. The JWST images also reveal the
presence of small-mass perturbers that produce small lensing distortions. The
smallest of these is consistent with being a dwarf galaxy at and has
an estimated mass of ~\Msol, making it the smallest substructure
found at . The JWST images also show several candidate caustic-crossing
events. One of them is detected at high significance at the expected position
of the critical curve and is likely a red supergiant star at . This
would be the first red supergiant found at cosmological distances. The cluster
lensing should magnify background objects at , making more of them visible
than in blank fields of similar size, but there appears to be a deficiency of
such objects.Comment: 27 pages, 21 figure
Plasmodium falciparum Merozoite Invasion Is Inhibited by Antibodies that Target the PfRh2a and b Binding Domains
Plasmodium falciparum, the causative agent of the most severe form of malaria in humans invades erythrocytes using multiple ligand-receptor interactions. The P. falciparum reticulocyte binding-like homologue proteins (PfRh or PfRBL) are important for entry of the invasive merozoite form of the parasite into red blood cells. We have analysed two members of this protein family, PfRh2a and PfRh2b, and show they undergo a complex series of proteolytic cleavage events before and during merozoite invasion. We show that PfRh2a undergoes a cleavage event in the transmembrane region during invasion consistent with activity of the membrane associated PfROM4 protease that would result in release of the ectodomain into the supernatant. We also show that PfRh2a and PfRh2b bind to red blood cells and have defined the erythrocyte-binding domain to a 15 kDa region at the N-terminus of each protein. Antibodies to this receptor-binding region block merozoite invasion demonstrating the important function of this domain. This region of PfRh2a and PfRh2b has potential in a combination vaccine with other erythrocyte binding ligands for induction of antibodies that would block a broad range of invasion pathways for P. falciparum into human erythrocytes
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