The L-shaped method for large-scale mixed-integer waste management decision making problems

It is without a doubt that deciding upon strategic issues requires us to somehow anticipate and consider possible variations of the future. Unfortunately, when it comes to the actual modelling, the sheer size of the problems that accurately describe the uncertainty is often extremely hard to work with. This paper aims to describe a possible way of dealing with the issue of large-scale mixed integer models (in term of the number of possible future scenarios it can handle) for the studied waste management decision making problem. The algorithm is based on the idea of decomposing the overall problem alongside the different scenarios and solving these smaller problems instead. The use of the algorithm is demonstrated on a strategic waste management problem of choosing the optimal sites to build new incineration plants, while minimizing the expected cost of waste transport and processing. The uncertainty was modelled by 5,000 scenarios and the problem was solved to high accuracy using relatively modest means (in terms of computational power and needed software)

Design and Simulation of High Performance Parallel Architectures Using the ISAC Language

Most of modern embedded systems for multimediaand network applications are based on parallel data streamprocessing. The data processing can be done using very longinstruction word processors (VLIW), or using more than onehigh performance application-specific instruction set processor(ASIPs), or even by their combination on single chip.Design and testing of these complex systems is time-consumingand iterative process. Architecture description languages (ADLs)are one of the most effective solutions for single processor design.However, support for description of parallel architectures andmulti-processor systems is very low or completely missing innowadays ADLs. This article presents utilization of newextensions for existing architecture description language ISAC.These extensions are used for easy and fast prototyping andtesting of parallel based systems and processors

Dead or Alive: Drivers of Wind Mortality Initiate Multiple Disturbance Regime in a Temperate Primeval Mountain Forest

The driving forces of tree mortality following wind disturbances of mountain mixed European temperate forests belongs among issues not comprehensively resolved. Hence, we aimed to elucidate the key factors of tree resistance to historical severe disturbance events in the Boubínský Primeval Forest, one of the oldest forest reserves in the Czech Republic. By using spatially explicit tree census, dendrochronological and soil data, we study spatial and temporal patterns of past disturbances and mathematically compared selected characteristics of neighboring trees that were killed by a severe storm in 2017 and those that remained undisturbed. The tendency of trees toward falling was primarily driven edaphically, limiting severe events non-randomly to previously disturbed sites occupied by hydromorphic soils and promoting the existence of two spatially-separated disturbance regimes. While disturbed trees usually recruited in gaps and experienced only one severe release event, surviving trees characteristically regenerated under the canopy and were repeatedly released. Despite the fact that disturbed trees tended to reach both lower ages and dimensions than survivors, they experienced significantly higher growth rates. Our study indicates that slow growth with several suppression periods emerged as the most effective tree strategy for withstanding severe windstorms, dying of senescence in overaged life stage. Despite the selective impact of the Herwart storm on conifer population, we did not find any difference in species sensitivity for most characteristics studied. We conclude that the presence of such ancient, high-density wood trees contributes significantly to the resistance of an entire stand to severe storms

ANALYSIS OF NEUTRON FIELDS GENERATED IN SPALLATION TARGETS OF B-URAN EXPERIMENTAL ASSEMBLY USING MONTE CARLO METHOD

The aim of this paper is to introduce experimental assembly B-URAN and the results of Monte Carlo simulations of neutron fields, which will be generated by using various spallation targets. This experimental assembly was constructed in Joint Institute of Nuclear Research in Dubna, Russian Federation, in order to study accelerator driven systems fundamental characteristics. Beam of 660 MeV protons should be used for that purpose. The MCNP model of such set-up has been developed at Brno University of Technology, Czech Republic. The goal is to get data needed for prediction of reaction rates in detectors placed in B-URAN experimental channels. Such data will be experimentally validated later. Furthermore, simulations of radiation exposure around this xperimental assembly were performed

Usporedba vrijednosti vlastitih frekvencija lista kružne pile određenih različitim metodama

In most cases high cutting speed is used when cutting wood by circular saw. This results in oscillating of circular saw blade, which may lead to destroying the tool, machine or hurting the operator. The aim of this paper is to show that it is possible to apply any of the methods used in the research as an equivalent method for obtaining the values of natural frequencies of circular saw blade. The article deals with three methods for obtaining the values of natural frequencies. The first method is modal analysis, the second method is the determination of values measured experimentally and the last method calculates the values by Bessel functions. A circular saw blade was used with the diameter of 350 mm and 36 teeth on the blade.Tijekom rezanja drva kružnim pilama vrlo se često primijenjuje velika brzina rezanja, što uzrokuje oscilacije lista kružne pila te katkad može rezultirati uništavanjem alata odnosno stroja ili dovesti do ozljede radnika. Cilj je ovoga rada prikazati mogućnosti primjene različitih metoda za određivanje vrijednosti vlastitih frekvencija lista kružne pile. U članku se prikazuje primjena triju metoda za određivanje vrijednosti vlastitih frekvencija lista kružne pile. Prva je metoda modalna analiza, druga je metoda eksperimentalno određivanje vlastitih frekvencija uz pomoć mjernog uređaja, a treća je metoda izračunavanje vrijednosti frekvencija s pomoću Besselovih funkcija. U eksperimentu je upotrijebljen list kružne pila promjera 350 mm s 36 zubi

Dual LSD1 and HDAC6 Inhibition Induces Doxorubicin Sensitivity in Acute Myeloid Leukemia Cells

Defects in epigenetic pathways are key drivers of oncogenic cell proliferation. We developed a LSD1/HDAC6 multitargeting inhibitor (iDual), a hydroxamic acid analogue of the clinical candidate LSD1 inhibitor GSK2879552. iDual inhibits both targets with IC50 values of 540, 110, and 290 nM, respectively, against LSD1, HDAC6, and HDAC8. We compared its activity to structurally similar control probes that act by HDAC or LSD1 inhibition alone, as well as an inactive null compound. iDual inhibited the growth of leukemia cell lines at a higher level than GSK2879552 with micromolar IC50 values. Dual engagement with LSD1 and HDAC6 was supported by dose dependent increases in substrate levels, biomarkers, and cellular thermal shift assay. Both histone methylation and acetylation of tubulin were increased, while acetylated histone levels were only mildly affected, indicating selectivity for HDAC6. Downstream gene expression (CD11b, CD86, p21) was also elevated in response to iDual treatment. Remarkably, iDual synergized with doxorubicin, triggering significant levels of apoptosis with a sublethal concentration of the drug. While mechanistic studies did not reveal changes in DNA repair or drug efflux pathways, the expression of AGPAT9, ALOX5, BTG1, HIPK2, IFI44L, and LRP1, previously implicated in doxorubicin sensitivity, was significantly elevated

BioTIME: A Database of Biodiversity Time Series for the Anthropocene

Motivation: The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community-led open-source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns of biodiversity in the Anthropocene. Main types of variables included: The database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, the database contains metadata relating to sampling methodology and contextual information about each record. Spatial location and grain: BioTIME is a global database of 547,161 unique sampling locations spanning the marine, freshwater and terrestrial realms. Grain size varies across datasets from 0.0000000158 km(2) (158 cm(2)) to 100 km(2) (1,000,000,000,000 cm(2)). Time period and grainBio: TIME records span from 1874 to 2016. The minimal temporal grain across all datasets in BioTIME is a year. Major taxa and level of measurement: BioTIME includes data from 44,440 species across the plant and animal kingdoms, ranging from plants, plankton and terrestrial invertebrates to small and large vertebrates

Multitargeting epi-epi drugs for multidrug reistance

Epigenetic therapy is now a clinical reality with eight approved drugs that target DNA methyltransferases, histone deacetylases (HDACs) and lysine methyltransferases. A further recent development is the concept of epigenetic multitargeting through the rational design of novel agents that combine the inhibition of an epigenetic pathway with a second non-epigenetic target and five such compounds have advanced to clinical development. We are investigating the even newer concept of „epi-epi‟ drugs that inhibit two separate epigenetic pathways. Such dual targeting agents have the potential to achieve higher efficacy against proliferating cancer cells while reducing tunor resistance. In this presentation, we report a selective dual histone deacetylase and demethylase inhibitor with an IC50 LSD1 respectively. The compound was biologically profiled together with control compounds that were either single inhibitors or inactive against either enzyme. The dua inhibitor was active against a panel of leukemia cell lines at a micromolar level and induced apoptosis. Target engagement asays such as CETSA were employed to confirm the inhibition of HDAC6 and LSD1 in cells. Further experiments were carried out to identify synergistic effects with clinically approved agents and promising results were observed with doxorubicin

Generated heat by different targets irradiated by 660 MeV protons

Calorimetric experiments have been performed to analyze different thick targets of natU, C, Pb material, irradiated by 660 MeV protons at the Phasotron accelerator facility, Joint Institute for Nuclear Research (JINR) in Dubna, Russia. The method of online temperature measurement has been compared with MCNPX 2.7.0 simulation and selected with Ansys Transient Thermal Simulation to compare measured temperature with the simulated one. Thermocouples type T and E have been used as a temperature probe. Many different positions have been measured for each target. Temperature results are following very well the processes inside of the cylinders. Changes of heat deposition caused by drops of the proton beam intensity are displayed very well as a jagged line shown in almost every chart. Accurate temperature changing measurement is a very modest variation of how to observe inner macroscopic behavior online

BioTIME: A database of biodiversity time series for the Anthropocene.

MotivationThe BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community-led open-source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns of biodiversity in the Anthropocene.Main types of variables includedThe database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, the database contains metadata relating to sampling methodology and contextual information about each record.Spatial location and grainBioTIME is a global database of 547,161 unique sampling locations spanning the marine, freshwater and terrestrial realms. Grain size varies across datasets from 0.0000000158 km2 (158 cm2) to 100 km2 (1,000,000,000,000 cm2).Time period and grainBioTIME records span from 1874 to 2016. The minimal temporal grain across all datasets in BioTIME is a year.Major taxa and level of measurementBioTIME includes data from 44,440 species across the plant and animal kingdoms, ranging from plants, plankton and terrestrial invertebrates to small and large vertebrates.Software format.csv and .SQL