130 research outputs found
Development of a Mesoamerican intra-genepool genetic map for quantitative trait loci detection in a drought tolerant Ă susceptible common bean (Phaseolus vulgaris L.) cross
- Author
- A Frei
- Alejandro Velasco CastrillĂłn
- B Tarâan
- BN Sponchiado
- CA Wortmann
- Carlos H. Galeano
- CG Muñoz Perea
- CJ Basten
- E GaitĂĄn
- E Lander
- Eduardo Tovar
- F Funk
- GA Churchill
- GV Subbarao
- H TerĂĄn
- I MĂ©tais
- Idupulapati M. Rao
- IE Ochoa
- IM Rao
- J Lynch
- JA Acosta-Gallegos
- JW White
- JW White
- JW White
- JW White
- JW White
- KA Cichy
- KA Schneider
- KA Schneider
- L Afanador
- LC Muñoz
- M Thung
- MA Frahm
- MA Hannah
- Matthew W. Blair
- MI Vales
- Monica C. Muñoz Torres
- MW Blair
- MW Blair
- MW Blair
- MW Blair
- MW Blair
- MW Blair
- NC Collins
- OE Checa
- P RamĂrez-Vallejo
- S Beebe
- S Beebe
- SE Beebe
- SE Beebe
- SO Park
- SP Singh
- SP Singh
- Steve E. Beebe
- WJ Broughton
- Publication venue
- Springer Netherlands
- Publication date
- 01/01/2010
- Field of study
Drought is a major constraint to common bean (Phaseolus vulgaris L.) production, especially in developing countries where irrigation for the crop is infrequent. The Mesoamerican genepool is the most widely grown subdivision of common beans that include small red, small cream and black seeded varieties. The objective of this study was to develop a reliable genetic map for a Mesoamerican Ă Mesoamerican drought tolerant Ă susceptible cross and to use this map to analyze the inheritance of yield traits under drought and fully irrigated conditions over 3 years of experiments. The source of drought tolerance used in the cross was the cream-seeded advanced line BAT477 crossed with the small red variety DOR364 and the population was made up of recombinant inbred lines in the F5 generation. Quantitative trait loci were detected by composite interval mapping for the traits of overall seed yield, yield per day, 100 seed weight, days to flowering and days to maturity for each field environment consisting of two treatments (irrigated and rainfed) and lattice design experiments with three repetitions for a total of six environments. The genetic map based on amplified fragment length polymorphism and random amplified polymorphic DNA markers was anchored with 60 simple sequence repeat (SSR) markers and had a total map length of 1,087.5 cM across 11 linkage groups covering the whole common bean genome with saturation of one marker every 5.9 cM. Gaps for the genetic map existed on linkage groups b03, b09 and b11 but overall there were only nine gaps larger than 15 cM. All traits were inherited quantitatively, with the greatest number for seed weight followed by yield per day, yield per se, days to flowering and days to maturity. The relevance of these results for breeding common beans is discussed in particular in the light of crop improvement for drought tolerance in the Mesoamerican genepool
A Gap Analysis Methodology for Collecting Crop Genepools: A Case Study with Phaseolus Beans
- Author
- A Delgado-Salinas
- A Delgado-Salinas
- A Delgado-Salinas
- A Jarvis
- A Jarvis
- A Jarvis
- A Jimenez-Valverde
- AJ Challinor
- Andy Jarvis
- B Hawkins
- BA Loiselle
- BA Meilleur
- C Graham
- C Graham
- C Khoury
- C Liu
- C Prescott-Allen
- C Schinkel
- CF Dormann
- CJ Salcedo
- CJ Salcedo
- Colin Khoury
- Daniel Gabriel Debouck
- DG Debouck
- DG Debouck
- DG Debouck
- DG Debouck
- Dorian Q. Fuller
- FD Garvin
- GC Costa
- GF Freytag
- GP Nabhan
- J Elith
- J Kornegay
- J Smartt
- J VanDerWal
- JA Acosta-Gallegos
- JA Kipe-Nolt
- JM Lobo
- JM Lobo
- JR Busby
- JR Harlan
- JuliĂĄn RamĂrez-Villegas
- KC Shelley-Dessert
- LC Munoz
- Luigi Guarino
- M Lobo Burle
- M Termansen
- MB Burke
- MC Fitzpatrick
- MG Smolik
- MS Wisz
- N Maxted
- N Maxted
- N Maxted
- N Maxted
- P Gepts
- P McClean
- PA Hernandez
- PB Jones
- R Hajjar
- RJ Hijmans
- RJ Hijmans
- RJ Hijmans
- RJ Hijmans
- RJ Hijmans
- RJ Hijmans
- RJ Singh
- RP Guralnick
- SD Tanksley
- SD Veloz
- SJ Phillips
- SJ Phillips
- SJ Phillips
- SP Singh
- TM Brooks
- U Parthasarathy
- W Thuiller
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Background The wild relatives of crops represent a major source of valuable traits for crop improvement. These resources are threatened by habitat destruction, land use changes, and other factors, requiring their urgent collection and long-term availability for research and breeding from ex situ collections. We propose a method to identify gaps in ex situ collections (i.e. gap analysis) of crop wild relatives as a means to guide efficient and effective collecting activities. Methodology/Principal Findings The methodology prioritizes among taxa based on a combination of sampling, geographic, and environmental gaps. We apply the gap analysis methodology to wild taxa of the Phaseolus genepool. Of 85 taxa, 48 (56.5%) are assigned high priority for collecting due to lack of, or under-representation, in genebanks, 17 taxa are given medium priority for collecting, 15 low priority, and 5 species are assessed as adequately represented in ex situ collections. Gap âhotspotsâ, representing priority target areas for collecting, are concentrated in central Mexico, although the narrow endemic nature of a suite of priority species adds a number of specific additional regions to spatial collecting priorities. Conclusions/Significance Results of the gap analysis method mostly align very well with expert opinion of gaps in ex situ collections, with only a few exceptions. A more detailed prioritization of taxa and geographic areas for collection can be achieved by including in the analysis predictive threat factors, such as climate change or habitat destruction, or by adding additional prioritization filters, such as the degree of relatedness to cultivated species (i.e. ease of use in crop breeding). Furthermore, results for multiple crop genepools may be overlaid, which would allow a global analysis of gaps in ex situ collections of the world's plant genetic resource
American palm ethnomedicine: A meta-analysis
- Author
- A Andrade-Cetto
- A Arévalo
- A Barfod
- A Barfod
- A Byg
- A D'Alessandro
- A Gutiérrez
- A Henderson
- AD AlanĂs
- AF May
- AH Haines
- AL Agero
- APM Rocha
- APS Azevedo
- APS Azevedo
- AR Wallace
- BC Bennett
- BE Grimwood
- BG Marinho
- BM Boom
- BP Silva
- BW Beckert
- C Desmarchelier
- C La Rotta
- C Lans
- C Ulbricht
- CE CerĂłn
- CE CerĂłn
- CG Silva
- CG Silva
- CK MejĂa
- CP Batista
- D Carbajal
- D Esquenazi
- D Fanshawe
- D Lee
- DS Alviano
- E Amorim
- E Deharo
- E Deharo
- E Perez Arbelaez
- E Perez Arbelaez
- EB Russo
- EM Gong
- ES Ayensu
- F Abad-Franch
- F Calzada
- F Comhaire
- F Cook
- F Hizli
- F Kahn
- F Kahn
- F Samudio
- FC Hoehne
- FK Habib
- FK Habib
- FRF Nascimento
- G Bourdy
- G Galeano
- G Usher
- GJ Martinez
- GS PĂ©rez
- GS PĂ©rez
- GT Prance
- H Balslev
- H Balslev
- H GarcĂa Barriga
- H GarcĂa Barriga
- H Lorenzi
- H Pereira
- H Pittier
- H Quero
- Henrik Balslev
- I Vandebroek
- J Dransfield
- J Gertsch
- J Mora-UprĂ
- J Sosnowska
- J Vormisto
- J Wilbert
- JA Duke
- JA Duke
- JF Jensen
- JH Cano
- Joanna Sosnowska
- JP Lescure
- K Hostanska
- L de la Torre
- L Diotaiuti
- LI Belostotskaia
- M Acosta-Solis
- M Cardenas
- M Heinrich
- M Leonti
- M Noa
- M Pio Correa
- M ToursarkissiĂĄn
- MA Miles
- MD Feliciangeli
- ME Bar
- ME Matheus
- ME Matheus
- MIA DĂaz
- MJ Balick
- MJ Balick
- MJ Balick
- MJ Balick
- MJ Balick
- MJ MacĂa
- MJ Plotkin
- MJ Sanchez-Martin
- ML Arruzazabala
- ML Arruzazabala
- ML Arruzazabala
- ML Arruzazabala
- MN Colares
- MT Campos
- N Baurin
- N Bletter
- N Lopatkin
- NLP Martins
- NY Paniagua-Zambrana
- O Sarquis
- P LeCointe
- PR Koschek
- R Braga
- R Gamez
- R Govaerts
- R Gurgel-Gonçalves
- R Gurgel-Gonçalves
- R Menéndez
- RA Gallegos
- RE Schultes
- RE Schultes
- RM Moraes
- RN Baldez
- RR Mendonca-Filho
- S Broseghini
- SG Marques
- SJ DeWalt
- SJ Moore
- T Andel
- T Andel
- T CĂłrdova-Fraga
- T Johnson
- T Ticktin
- TL Wadsworth
- UMSA CIPTA, IRD, FONAMA, EIA
- V Tene
- W Milliken
- WS Alviano
- Y Hirose
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
<p>Abstract</p> <p>Background</p> <p>Many recent papers have documented the phytochemical and pharmacological bases for the use of palms (<it>Arecaceae</it>) in ethnomedicine. Early publications were based almost entirely on interviews that solicited local knowledge. More recently, ethnobotanically guided searches for new medicinal plants have proven more successful than random sampling for identifying plants that contain biodynamic ingredients. However, limited laboratory time and the high cost of clinical trials make it difficult to test all potential medicinal plants in the search for new drug candidates. The purpose of this study was to summarize and analyze previous studies on the medicinal uses of American palms in order to narrow down the search for new palm-derived medicines.</p> <p>Methods</p> <p>Relevant literature was surveyed and data was extracted and organized into medicinal use categories. We focused on more recent literature than that considered in a review published 25 years ago. We included phytochemical and pharmacological research that explored the importance of American palms in ethnomedicine.</p> <p>Results</p> <p>Of 730 species of American palms, we found evidence that 106 species had known medicinal uses, ranging from treatments for diabetes and leishmaniasis to prostatic hyperplasia. Thus, the number of American palm species with known uses had increased from 48 to 106 over the last quarter of a century. Furthermore, the pharmacological bases for many of the effects are now understood.</p> <p>Conclusions</p> <p>Palms are important in American ethnomedicine. Some, like <it>Serenoa repens </it>and <it>Roystonea regia</it>, are the sources of drugs that have been approved for medicinal uses. In contrast, recent ethnopharmacological studies suggested that many of the reported uses of several other palms do not appear to have a strong physiological basis. This study has provided a useful assessment of the ethnobotanical and pharmacological data available on palms.</p
Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial
- Author
- Abdelmalek M
- Abdelmalek MF
- Abrams G
- Aguilar H
- Ahmed A
- Aigner E
- Aithal G
- Al-Shamma S
- Ala A
- Alazawi W
- Albillos A
- Allison M
- Andrade R
- Andreone P
- Angelico M
- Ankoma-Sey V
- Anstee Q
- Anstee QM
- Anty R
- Araya V
- Arenas Ruiz JI
- Arkkila P
- Arora M
- Asselah T
- Au J
- Ayonrinde O
- Bailey RJ
- Balakrishnan M
- Bambha K
- Bansal M
- Barritt S
- Bate J
- Beato J
- Beckebaum S
- Beckebaum S
- Bedossa P
- Behari J
- Bellot P
- Ben Ari Z
- Bennett M
- Berenguer M
- Beretta-Piccoli BT
- Berg T
- Bonacini M
- Bonet L
- Borg B
- Bourliere M
- Boursier J
- Boursier J
- Bowman W
- Bradley D
- Brankovic M
- Braun M
- Bronowicki J-P
- Bruno S
- Bugianesi E
- Bugianesi E
- Cai C
- Calleja Panero JL
- Campagna J
- Carey E
- Carmiel M
- CarriĂłn JA
- Cave M
- Chagas C
- Chami T
- Chang A
- Coates A
- Cobbold J
- Corey K
- Corless L
- Cortez-Pinto H
- Cortez-Pinto H
- Crespo J
- Cruz Pereira O
- de Ledinghen V
- deLemos A
- Diago M
- Dufour J-F
- Dufour J-F
- Dugalic P
- Dunn W
- Elkhashab M
- Epstein M
- Escudero-Garcia MD
- Etzion O
- Evans L
- Falcone R
- Fernandez C
- Ferreira J
- Fink S
- Finnegan K
- Firpi-Morell R
- Floreani A
- Fontanges T
- Ford R
- Forrest E
- Fowell A
- Fracanzani AL
- Francque S
- Freilich B
- Frias J
- Fuchs M
- Fuentes J
- Galambos M
- Gallegos J
- Geerts A
- Geier A
- Geier A
- George J
- Ghali M
- Ghalib R
- Gholam P
- Gines P
- Gitlin N
- Gluud LL
- Gluud LL
- Goeser T
- Goff J
- Goodman Z
- Gordon F
- Gordon S
- Goria O
- Graupera I
- Greer S
- Grigorian A
- Gronbaek H
- Guillaume M
- Gunaratnam N
- Halegoua-De Marzio D
- Hameed B
- Hametner S
- Hamilton J
- Harrison S
- Harrison S
- Hartleb M
- Hassanein T
- Hellstern P
- Herring R
- Heurich E
- Hezode C
- Hinrichsen H
- Holland Fischer P
- Horsmans Y
- Huang J
- HĂ€ussinger D
- Jakiche A
- Jeffers L
- Jones B
- Jorge R
- Jorquera F
- Kahraman A
- Kaita K
- Karyotakis N
- Kayali Z
- Kechagias S
- Kepczyk T
- Khalili M
- Khallafi H
- Kluwe J
- Knapple W
- Knapple W
- Kohli A
- Korenblat K
- Kowdley K
- Kowdley KV
- Krag A
- Krause R
- Kremer A
- Krok K
- Krstic M
- Kugelmas M
- Kumar S
- Labarriere D
- Lai M
- Lampertico P
- Lawitz E
- Lawitz E
- Lee A
- Leroy V
- Lidofsky S
- Lim J
- Lim TH
- Lipkis D
- Little E
- Lonardo A
- Long M
- Loomba R
- Loomba R
- Lurie Y
- MacConell L
- Macedo G
- Makara M
- Maliakkal B
- Manns M
- Manousou P
- Mantry P
- Marchesini G
- Marinho C
- Marotta P
- Marschall H-U
- Mathurin P
- Mathurin P
- Mayo M
- Mazzella G
- Mazzella G
- McCullen M
- McLaughlin W
- Merriman R
- Modi A
- Molina E
- Montano-Loza A
- Montano-Loza AJ
- Monteverde C
- Moreea S
- Moreno C
- Morisco F
- Mubarak A
- Muellhaupt B
- Mukherjee S
- Muller K
- MĂŒller T
- Nagorni A
- Naik J
- Neff G
- Nevah M
- Newsome P
- Newsome PN
- Nguyen-Khac E
- Noureddin M
- Oben J
- Olveira A
- Olveira A
- Orlent H
- Orr D
- Orr D
- Orr J
- Ortiz-Lasanta G
- Ozenne V
- Pandya P
- Paredes A
- Park J
- Patel J
- Patel K
- Patton H
- Peck-Radosavljevic M
- Petta S
- Pianko S
- Piekarska A
- Pimstone N
- Pockros P
- Pol S
- Porayko M
- Poulos J
- Pound D
- Pouzar J
- Presa Ramos J
- Pyrsopoulos N
- Rafiq N
- Ramji A
- Ratziu V
- Ratziu V
- Ravinuthala R
- Reddy K G G
- Reddy K R KR
- Reddy C
- Regenstein F
- Reindollar R
- Riera A
- Rinella M
- Rinella M
- Rivera Acosta J
- Robaeys G
- Roberts S
- Rodriguez-Perez F
- Romero-Gomez M
- Rubin R
- Rumi M
- Rushbrook S
- Rust C
- Ryan M
- Safadi R
- Said A
- Salminen K
- Samuel D
- Santoro J
- Sanyal A
- Sanyal AJ
- Sarkar S
- Schaeffer C
- Schattenberg J
- Schiefke I
- Schiff E
- Schmidt W
- Schneider J
- Schouten J
- Schultz M
- Sebastiani G
- Semela D
- Sepe T
- Shapiro D
- Sheikh A
- Sheikh M
- Sheikh MY
- Sheridan D
- Sheridan D
- Sherman K
- Shibolet O
- Shiffman M
- Shringarpure R
- Siddique A
- Sieberhagen C
- Sigal S
- Sikorska K
- Simon K
- Sinclair M
- Skoien R
- Solis J
- Sood S
- Souder B
- Spivey J
- Stal P
- Stinton L
- Strasser S
- Svorcan P
- Szabo G
- Talal A
- Tam E
- Tetri B
- Thuluvath P
- Tobias H
- Tomasiewicz K
- Torres D
- Trauner M
- Trautwein C
- Trotter J
- Trotter J
- Tsochatzis E
- Unitt E
- Uta M
- Vargas V
- Varkonyi I
- Veitsman E
- Vespasiani Gentilucci U
- Victor D
- Vierling J
- Vincent C
- Vincze A
- von der Ohe M
- Von Roenn N
- Vuppalanchi R
- Waters M
- Watt K
- Weltman M
- Wieland A
- Wiener G
- Williams A A
- Williams J J
- Wilson J
- Yataco M
- Yoshida E
- Younes Z
- Younossi ZM
- Yuan L
- Zaru L
- Zivony A
- Zogg D
- Zoller H
- Zoulim F
- Zuckerman E
- Zuin M
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND
Non-alcoholic steatohepatitis (NASH) is a common type of chronic liver disease that can lead to cirrhosis. Obeticholic acid, a farnesoid X receptor agonist, has been shown to improve the histological features of NASH. Here we report results from a planned interim analysis of an ongoing, phase 3 study of obeticholic acid for NASH.
METHODS
In this multicentre, randomised, double-blind, placebo-controlled study, adult patients with definite NASH, non-alcoholic fatty liver disease (NAFLD) activity score of at least 4, and fibrosis stages F2-F3, or F1 with at least one accompanying comorbidity, were randomly assigned using an interactive web response system in a 1:1:1 ratio to receive oral placebo, obeticholic acid 10 mg, or obeticholic acid 25 mg daily. Patients were excluded if cirrhosis, other chronic liver disease, elevated alcohol consumption, or confounding conditions were present. The primary endpoints for the month-18 interim analysis were fibrosis improvement (â„1 stage) with no worsening of NASH, or NASH resolution with no worsening of fibrosis, with the study considered successful if either primary endpoint was met. Primary analyses were done by intention to treat, in patients with fibrosis stage F2-F3 who received at least one dose of treatment and reached, or would have reached, the month 18 visit by the prespecified interim analysis cutoff date. The study also evaluated other histological and biochemical markers of NASH and fibrosis, and safety. This study is ongoing, and registered with ClinicalTrials.gov, NCT02548351, and EudraCT, 20150-025601-6.
FINDINGS
Between Dec 9, 2015, and Oct 26, 2018, 1968 patients with stage F1-F3 fibrosis were enrolled and received at least one dose of study treatment; 931 patients with stage F2-F3 fibrosis were included in the primary analysis (311 in the placebo group, 312 in the obeticholic acid 10 mg group, and 308 in the obeticholic acid 25 mg group). The fibrosis improvement endpoint was achieved by 37 (12%) patients in the placebo group, 55 (18%) in the obeticholic acid 10 mg group (p=0·045), and 71 (23%) in the obeticholic acid 25 mg group (p=0·0002). The NASH resolution endpoint was not met (25 [8%] patients in the placebo group, 35 [11%] in the obeticholic acid 10 mg group [p=0·18], and 36 [12%] in the obeticholic acid 25 mg group [p=0·13]). In the safety population (1968 patients with fibrosis stages F1-F3), the most common adverse event was pruritus (123 [19%] in the placebo group, 183 [28%] in the obeticholic acid 10 mg group, and 336 [51%] in the obeticholic acid 25 mg group); incidence was generally mild to moderate in severity. The overall safety profile was similar to that in previous studies, and incidence of serious adverse events was similar across treatment groups (75 [11%] patients in the placebo group, 72 [11%] in the obeticholic acid 10 mg group, and 93 [14%] in the obeticholic acid 25 mg group).
INTERPRETATION
Obeticholic acid 25 mg significantly improved fibrosis and key components of NASH disease activity among patients with NASH. The results from this planned interim analysis show clinically significant histological improvement that is reasonably likely to predict clinical benefit. This study is ongoing to assess clinical outcomes.
FUNDING
Intercept Pharmaceuticals
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Measurement of the Higgs boson production via vector boson fusion and its decay into bottom quarks in proton-proton collisions at sâ = 13 TeV
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbott S
- Abbrescia M
- Abdalla H
- Abdullah Al-Mashad M
- Abdullin S
- Abreu A
- Abu Zeid S
- Acharya H
- Acosta D
- Adam W
- Adamidis K
- Adams E
- Adams MR
- Adams T
- Addesa FM
- Adloff C
- Adzic P
- Afanasiev S
- Agapitos A
- Agarwal G
- Agram J-L
- Aguilar-Benitez M
- Agyel D
- Ahmad A
- Ahmad M
- Ahmed A
- AimĂš C
- Ajmal S
- Akchurin N
- Akgun B
- Akpinar A
- Al Kadhim A
- Albert A
- Albrecht A
- Albrecht S
- Albrow M
- Alcaraz Maestre J
- Alcerro Alcerro LF
- Aldaya Martin M
- AldĂĄ JĂșnior WL
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Allmond B
- Almond J
- Alpana A
- Alsufyani B
- Alvarez Gonzalez B
- Alverson G
- Alves Gallo Pereira M
- Alves GA
- Aly R
- Alyari M
- Amapane N
- Ambrozas M
- Amendola C
- Amoroso S
- Amram O
- Amsler C
- An S
- An Y
- Anagnostou G
- Andrea J
- Andreev V
- Andreev Y
- Andrejkovic JW
- Andrews MB
- Androsov K
- Anguiano J
- Antchev G
- Anthony D
- Antonello M
- Apollinari G
- Apparu D
- Appelt E
- Apresyan A
- Araujo M
- Aravind A
- Arcaro D
- Arcidiacono R
- Ardino R
- Argiro S
- Arneodo M
- Aruta C
- Asawatangtrakuldee C
- Asenov P
- Asghar MI
- Asilar E
- Askew A
- Assiouras P
- Assran Y
- Atakisi IO
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
- Awais A
- Awan MIM
- Ayala E
- Ayala G
- Aydilek O
- Azarkin M
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babaev A
- Babbar J
- Bacchetta N
- Bachtis M
- Backhaus M
- Baden A
- Baechler J
- Bagliesi G
- Bahinipati S
- Bainbridge R
- Bak G
- Bakas G
- Bakhshiansohi H
- Bakshi AS
- Bala A
- Baldenegro Barrera C
- Ball AH
- Ban Y
- Band R
- Bandyopadhyay H
- Banerjee S
- Banerjee S
- Bansal S
- Baradia S
- Barbagli G
- Barberis E
- Barbosa Trujillo DA
- Bardelli G
- Bargassa P
- Baringer P
- Barman S
- Barnes VE
- Barney D
- Baron O
- Barria P
- Barrio Luna M
- Barroso Ferreira Filho M
- Bartek R
- Bartosik N
- BartĂłk M
- Bastos D
- Battilana C
- Baty A
- Bauer G
- Bauerdick LAT
- Bautista I
- Baxter S
- Bayatmakou M
- Bean A
- Beauceron S
- Beaudette F
- Becerril Gonzalez H
- Bedoya CF
- Behera PK
- Behera SC
- Behnke O
- Bein S
- BeirĂŁo Da Cruz E Silva C
- Belforte S
- Bell KW
- Bellan R
- Belloni A
- Bellora A
- Belyaev A
- Belyaev A
- Benaglia A
- Benato L
- Bencze G
- Bendavid J
- Benecke A
- Benelli G
- Benitez JF
- Bennett C
- Benussi L
- Bergauer T
- Beri SB
- BermĂșdez MartĂnez A
- Bernardes CA
- Berry D
- Berryhill J
- Besancon M
- Bestintzanos I
- Bethani A
- Bevilacqua T
- Beyrouthy T
- Bhardwaj A
- Bharthuar S
- Bhat PC
- Bhatnagar V
- Bhattacharya R
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- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 30/01/2024
- Field of study
A preprint version of the article is available at arXiv:2308.01253v2 [hep-ex], https://arxiv.org/abs/2308.01253v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/HIG-22-009 (CMS Public Pages). Report number: CMS-HIG-22-009, CERN-EP-2023-110.A measurement of the Higgs boson (H) production via vector boson fusion (VBF) and its decay into a bottom quark-antiquark pair (bbÂŻ) is presented using proton-proton collision data recorded by the CMS experiment at sâ = 13 TeV and corresponding to an integrated luminosity of 90.8 fbâ1. Treating the gluon-gluon fusion process as a background and constraining its rate to the value expected in the standard model (SM) within uncertainties, the signal strength of the VBF process, defined as the ratio of the observed signal rate to that predicted by the SM, is measured to be ÎŒqqHHbbÂŻ = 1.01 +0.55â0.46. The VBF signal is observed with a significance of 2.4 standard deviations relative to the background prediction, while the expected significance is 2.7 standard deviations. Considering inclusive Higgs boson production and decay into bottom quarks, the signal strength is measured to be ÎŒincl.HbbÂŻ = 0.99 +0.48â0.41, corresponding to an observed (expected) significance of 2.6 (2.9) standard deviations.SCOAP3, STFC; Marie-Curie program and the European Research Council and Horizon 2020 Gran
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Evidence for tWZ production in proton-proton collisions at âs=13 TeV in multilepton final states
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- Aarup Petersen H
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- Yockey H
- Yohay R
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- Yoo J
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- Yoon I
- You Z
- Yu D
- Yu I
- Yu SS
- Yuan L
- Yuan S
- Yuldashev BS
- Yusuff I
- Zabi A
- Zabolotny W
- Zacharopoulou A
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
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- Zaza A
- Zecchinelli AG
- Zehetner P
- Zeinali M
- Zejdl P
- Zeuner WD
- Zghiche A
- Zhang F
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- Zhizhin I
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- Zhu RY
- Ziemons T
- Zilizi G
- Zimermmane Castro Santos A
- Zipper N
- Zisopoulos I
- Zoi I
- Zolkapli Z
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- Zorbilmez C
- Zotto P
- Zotz A
- Zou R
- Zucchetta A
- Zuo X
- Zuolo D
- Zygala L
- Publication venue
- Elsevier BV
- Publication date
- 21/06/2024
- Field of study
Data availability - https://www.sciencedirect.com/science/article/pii/S0370269324003733?via%3Dihub#dav0001 [Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS data preservation, re-use and open access policy (https://cms-docdb.cern.ch/cgi-bin/PublicDocDB/RetrieveFile?docid=6032&filename=CMSDataPolicyV1.2.pdf&version=2)]The first evidence for the standard model production of a top quark in association with a W boson and a Z boson is reported. The measurement is performed in multilepton final states, where the Z boson is reconstructed via its decays to electron or muon pairs. At least one W boson, associated or from top quark decay, decays leptonically, too. The analysed data were recorded by the CMS experiment at the CERN LHC in 2016â2018 in proton-proton collisions at âs=13 TeV, and correspond to an integrated luminosity of 138 fbâ1. The measured cross section is 354±54(stat)±95(syst) fb, and corresponds to a statistical significance of 3.4 standard deviations.SCOAP
Recommended from our members
Search for new Higgs bosons via same-sign top quark pair production in association with a jet in proton-proton collisions at âs = 13 TeV
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbott S
- Abbrescia M
- Abdalla H
- Abdullin S
- Abreu A
- Abu Zeid S
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- Yuldashev BS
- Yusuff I
- Zabi A
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- Zacharopoulou A
- Zaleski S
- Zalewski P
- Zanetti M
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- Zghiche A
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- Zhizhin I
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- Ziemons T
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- Zorbakir IS
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- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Publication venue
- Elsevier
- Publication date
- 02/02/2024
- Field of study
Data availability:
Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in âCMS data preservation, re-use and open access policyâ available online at: https://cms-docdb.cern.ch/cgi-bin/PublicDocDB/RetrieveFile?docid=6032&filename=CMSDataPolicyV1.2.pdf&version=2 .A preprint of this article is available online at arXiv:2311.03261v2 [hep-ex] https://arxiv.org/abs/2311.03261v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/TOP-22-010 (CMS Public Pages)A search is presented for new Higgs bosons in proton-proton (pp) collision events in which a same-sign top quark pair is produced in association with a jet, via the pp â tH/A â ttÂŻc and pp â tH/A â ttÂŻu processes. Here, H and A represent the extra scalar and pseudoscalar boson, respectively, of the second Higgs doublet in the generalized two-Higgs-doublet model (g2HDM). The search is based on pp collision data collected at a center-of-mass energy of 13 TeV with the CMS detector at the LHC, corresponding to an integrated luminosity of 138 fbâ1. Final states with a same-sign lepton pair in association with jets and missing transverse momentum are considered. New Higgs bosons in the 200-1000 GeV mass range and new Yukawa couplings between 0.1 and 1.0 are targeted in the search, for scenarios in which either H or A appear alone, or in which they coexist and interfere. No significant excess above the standard model prediction is observed. Exclusion limits are derived in the context of the g2HDM.SCOAP3
Recommended from our members
Search for direct production of GeV-scale resonances decaying to a pair of muons in proton-proton collisions at sâ = 13 TeV
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbott S
- Abbrescia M
- Abdullah Al-Mashad M
- Abdullin S
- Abreu A
- Abu Zeid S
- Acharya H
- Acosta D
- Adam W
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- Adzic P
- Aebi D
- Afanasiev S
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- Aldaya Martin M
- AldĂĄ JĂșnior WL
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- Zuolo D
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- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 30/11/2023
- Field of study
A preprint version of the article is available at arXiv:2309.16003v2 [hep-ex], https://arxiv.org/abs/2309.16003v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables, including additional supplementary figures, can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/EXO-21-005 (CMS Public Pages). Report number: CMS-EXO-21-005, CERN-EP-2023-165.A search for direct production of low-mass dimuon resonances is performed using sâ = 13 TeV proton-proton collision data collected by the CMS experiment during the 2017-2018 operation of the CERN LHC with an integrated luminosity of 96.6 fbâ1. The search exploits a dedicated high-rate trigger stream that records events with two muons with transverse momenta as low as 3 GeV but does not include the full event information. The search is performed by looking for narrow peaks in the dimuon mass spectrum in the ranges of 1.1-2.6 GeV and 4.2-7.9 GeV. No significant excess of events above the expectation from the standard model background is observed. Model-independent limits on production rates of dimuon resonances within the experimental fiducial acceptance are set. Competitive or world's best limits are set at 90% confidence level for a minimal dark photon model and for a scenario with two Higgs doublets and an extra complex scalar singlet (2HDM+S). Values of the squared kinetic mixing coefficient Δ2 in the dark photon model above 10â6 are excluded over most of the mass range of the search. In the 2HDM+S, values of the mixing angle sin(ΞH) above 0.08 are excluded over most of the mass range of the search with a fixed ratio of the Higgs doublets vacuum expectation tanÎČ = 0.5.SCOAP3
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Search for WâČ bosons decaying to a top and a bottom quark in leptonic final states in proton-proton collisions at sâ = 13 TeV
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbott S
- Abbrescia M
- Abdullah Al-Mashad M
- Abdullin S
- Abreu A
- Abu Zeid S
- Acharya H
- Acosta D
- Adam W
- Adamidis K
- Adams E
- Adams MR
- Adams T
- Addesa FM
- Adloff C
- Adzic P
- Aebi D
- Afanasiev S
- Agapitos A
- Agarwal G
- Agram J-L
- Aguilar-Benitez M
- Agyel D
- Ahmad A
- Ahmad M
- Ahmed A
- AimĂš C
- Ajmal S
- Akchurin N
- Akgun B
- Akpinar A
- Al Kadhim A
- Albert A
- Albrecht A
- Albrecht S
- Albrow M
- Alcaraz Maestre J
- Alcerro Alcerro LF
- Aldaya Martin M
- AldĂĄ JĂșnior WL
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Allmond B
- Ally D
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- Alpana A
- Alsufyani B
- Alvarez Gonzalez B
- Alverson G
- Alves Gallo Pereira M
- Alves GA
- Aly R
- Alyari M
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- Amram O
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- Anagnostou G
- Andrea J
- Andreev V
- Andreev Y
- Andrejkovic JW
- Andrews MB
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- Anguiano J
- Antchev G
- Anthony D
- Antonello M
- Apollinari G
- Apparu D
- Appelt E
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- Publication venue
- Springer Nature
- Publication date
- 05/04/2024
- Field of study
A preprint version of the article is available at arXiv:2310.19893v1 [hep-ex], https://arxiv.org/abs/2310.19893v1 . Comments: Submitted to the Journal of High Energy Physics. All figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/B2G-20-012 (CMS Public Pages). Report number: CMS-B2G-20-012, CERN-EP-2023-213.A search for W' bosons decaying to a top and a bottom quark in final states including an electron or a muon is performed with the CMS detector at the LHC. The analyzed data correspond to an integrated luminosity of 138 fb^{-1} of proton-proton collisions at a center-of-mass energy of 13 Tev. Good agreement with the standard model expectation is observed and no evidence for the existence of the W' boson is found over the mass range examined. The largest observed deviation from the standard model expectation is found for a W' boson mass (mWâČ) hypothesis of 3.8 TeV with a relative decay width of 1%, with a local (global) significance of 2.6 (2.0) standard deviations. Upper limits on the production cross sections of W' bosons decaying to a top and a bottom quark are set. Left- and right-handed W' bosons with mWâČ below 3.9 and 4.3 TeV, respectively, are excluded at the 95% confidence level, under the assumption that the new particle has a narrow decay width. Limits are also set for relative decay widths up to 30%. These are the most stringent limits to date on this W' boson decay channel.SCOAP3
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