Bylaag 3 tot „Koer&’’, April en Junie, 1955: Die belang van toegepaste geologie en die werk van die geoloog in ons mineral afhanklike besawing

Die toekomstigc ontwikkeling, welvaart en sekuriteit van ons land en die handhawing en verbetering van ons huidige lewenstandaard hang tot’n groot mate af van die doeltreffendste gebruik van ons oorvloedige mineraalhulpbronne, maar beperkte watervoorrade

Afrika-Seminaar: Die geologie van Afrika in oorsig

Dit is vanselfsprekend dat in ’n artikel soos hierdie die geologie van Afrika slegs in hooftrekke aangedui kan word en dat daar geen sprake van besonderhede kan wees nie. Wat hierop volg kan dus eintlik maar net as’n selektiewe uittreksel uit die publikasies van sekere skrywers oor Afrika beskou word, en met die oog hierop is dit miskien goed om eers kortliks die vernaamste bronne van inligting aan te dui

Antimicrobial Peptides and Surfactant Proteins: Potential New Factors Against Respiratory Tract Infection

Although some vaccines and antibiotics have been very effective in preventing and treating respiratory disease, they have not been fully satisfactory. Recently, components of the innate immune system have been increasingly appreciated for their role in host defense against microbial pathogens. These molecules include lysozyme and lactoferrin, but recent work in cattle, sheep, man and other species have identified new classes of peptides expressed by respiratory epithelial cells that have potent microcidal activity in nanogram quantities. These peptides, termed antimicrobial peptides (AMP), include defensins, cathelicidins and anionic peptides. Some are expressed continuously whereas expression of others is stimulated by infection/inflammation. In calves, we have found that two AMP from the defensin family, tracheal antimicrobial peptide (TAP) and lingual antimicrobial peptide (LAP), are expressed in the newborn and increased in response to Mannheimia (Pasteurella) haemolytica infection. In contrast, sheep beta defensin-1 (SBD-1) is not induced by infection and, in fact, appears decreased during viral infection with paramyxovirus-3 (Pl-3). Decreased SBD-1 by Pl-3 may increase the lung\u27s susceptibility to secondary infections or re-infections. Other innate defense molecules include proteins released with lung surfactant. Surfactant protein A and D (SAD) can opsonize and aggregate respiratory syncytial virus (RSV) and activate alveolar macrophages. Preliminary work suggests that chronic bacterial infections result in reduced SpA and SpD expression and we are currently assessing SAD expression in response to PI-3 and RSV. A long-term goal of our work is to identify ways to up-regulate expression of AMP and/or surfactant proteins in the neonate and at times of stress in older animals in order to reduce microbial colonization. Other investigators are seeking ways to utilize AMP\u27s as a new class of antibiotics

A tight lower bound instance for k-means++ in constant dimension

The k-means++ seeding algorithm is one of the most popular algorithms that is used for finding the initial $k$ centers when using the k-means heuristic. The algorithm is a simple sampling procedure and can be described as follows: Pick the first center randomly from the given points. For $i > 1$, pick a point to be the $i^{th}$ center with probability proportional to the square of the Euclidean distance of this point to the closest previously $(i-1)$ chosen centers. The k-means++ seeding algorithm is not only simple and fast but also gives an $O(\log{k})$ approximation in expectation as shown by Arthur and Vassilvitskii. There are datasets on which this seeding algorithm gives an approximation factor of $\Omega(\log{k})$ in expectation. However, it is not clear from these results if the algorithm achieves good approximation factor with reasonably high probability (say $1/poly(k)$). Brunsch and R\"{o}glin gave a dataset where the k-means++ seeding algorithm achieves an $O(\log{k})$ approximation ratio with probability that is exponentially small in $k$. However, this and all other known lower-bound examples are high dimensional. So, an open problem was to understand the behavior of the algorithm on low dimensional datasets. In this work, we give a simple two dimensional dataset on which the seeding algorithm achieves an $O(\log{k})$ approximation ratio with probability exponentially small in $k$. This solves open problems posed by Mahajan et al. and by Brunsch and R\"{o}glin.Comment: To appear in TAMC 2014. arXiv admin note: text overlap with arXiv:1306.420

Failure to meet aerobic fitness standards among urban elementary students

The aim of this study was to explore the relationship of aerobic fitness with the elementary school environment and student characteristics among 4th and 5th grade children attending urban public schools in St. Louis, MO, USA. This cross-sectional study was conducted during 2012–2015 and included 2381 children (mean age 10.5 y) who completed the FITNESSGRAM® 20-m Progressive Aerobic Cardiovascular Endurance Run. Healthy Fitness Zone (HFZ) was defined according to FITNESSGRAM® aerobic capacity criteria. Other student-level variables included age, race, National School Lunch Program eligibility, BMI z-score, weight status, and daily pedometer steps. School environment variables included playground features and playground safety, physical education and recess practices, and school census tract data on vacant houses and median household income. Bivariate analyses with sex stratification were used to identify student-level and school-level predictors of failure to achieve the aerobic HFZ; predictors were then included in a multivariable logistic regression model. Failure to meet the aerobic HFZ was observed among 33% of boys and 57% of girls. School environment was not predictive, but higher age and fewer daily steps were: each additional year of age was associated with 41% higher odds of failing to meet the aerobic HFZ among boys and 100% higher odds among girls. Conversely, each additional 1000 daily steps was associated with 15% (boys) and 13% (girls) lower odds of failure. Obesity posed a 60% higher risk of failure to meet HFZ among girls. These results highlight the importance of childhood physical activity opportunities, especially for girls residing in low-resource areas. Keywords: Aerobic fitness, School, Environment, Student, Child, Urban, Low-resourc

An adaptive-binning method for generating constant-uncertainty/constant-significance light curves with Fermi-LAT data

We present a method enabling the creation of constant-uncertainty/constant-significance light curves with the data of the Fermi-Large Area Telescope (LAT). The adaptive-binning method enables more information to be encapsulated within the light curve than with the fixed-binning method. Although primarily developed for blazar studies, it can be applied to any sources. This method allows the starting and ending times of each interval to be calculated in a simple and quick way during a first step. The reported mean flux and spectral index (assuming the spectrum is a power-law distribution) in the interval are calculated via the standard LAT analysis during a second step. The absence of major caveats associated with this method has been established by means of Monte-Carlo simulations. We present the performance of this method in determining duty cycles as well as power-density spectra relative to the traditional fixed-binning method.Comment: 17 pages, 13 figures, 5 tables. Submitted to A&

Early Epithelial Invasion by Salmonella enterica Serovar Typhimurium DT104 in the Swine Ileum

Salmonella enterica serovar Typhimurium is an important intestinal pathogen in swine. This study was performed to document the early cellular invasion of Salmonellaserovar Typhimurium in swine ileum. Ileal gut-loops were surgically prepared in ten 4- to 5-week-old mixed-breed pigs and inoculated for 0-60 minutes. Loops were harvested and prepared for both scanning and transmission electron microscopy (SEM and TEM, respectively). Preferential bacterial adherence to microfold cells (M cells) was seen within 5 minutes, and by 10 minutes bacterial invasion of the apical membrane was seen in M cells, goblet cells, and enterocytes. This multicellular invasion was observed throughout the course of infection. In addition, SEM revealed a specific affinity of Salmonella serovar Typhimurium to sites of cell extrusion. Using TEM, bacteria in these areas were focused in the crevices formed by the extruding cell and the adjacent cells and in the cytoplasm immediately beneath the extruding cell. Our results suggest that early cellular invasion by Salmonella serovar Typhimurium is nonspecific and rapid in swine. Furthermore, the combination of SEM and TEM data suggests that Salmonella serovar Typhimurium may use sites of cell extrusion as an additional mechanism for early invasion

On Existence and Properties of Approximate Pure Nash Equilibria in Bandwidth Allocation Games

In \emph{bandwidth allocation games} (BAGs), the strategy of a player consists of various demands on different resources. The player's utility is at most the sum of these demands, provided they are fully satisfied. Every resource has a limited capacity and if it is exceeded by the total demand, it has to be split between the players. Since these games generally do not have pure Nash equilibria, we consider approximate pure Nash equilibria, in which no player can improve her utility by more than some fixed factor $\alpha$ through unilateral strategy changes. There is a threshold $\alpha_\delta$ (where $\delta$ is a parameter that limits the demand of each player on a specific resource) such that $\alpha$-approximate pure Nash equilibria always exist for $\alpha \geq \alpha_\delta$, but not for $\alpha < \alpha_\delta$. We give both upper and lower bounds on this threshold $\alpha_\delta$ and show that the corresponding decision problem is ${\sf NP}$-hard. We also show that the $\alpha$-approximate price of anarchy for BAGs is $\alpha+1$. For a restricted version of the game, where demands of players only differ slightly from each other (e.g. symmetric games), we show that approximate Nash equilibria can be reached (and thus also be computed) in polynomial time using the best-response dynamic. Finally, we show that a broader class of utility-maximization games (which includes BAGs) converges quickly towards states whose social welfare is close to the optimum

Simple solutions of fireball hydrodynamics for self-similar elliptic flows

Simple, self-similar, elliptic solutions of non-relativistic fireball hydrodynamics are presented, generalizing earlier results for spherically symmetric fireballs with Hubble flows and homogeneous temperature profiles. The transition from one dimensional to three dimensional expansions is investigated in an efficient manner.Comment: 12 pages, 4 figures in 8 .eps files, references to recent data added, accepted in Physics Letters

Risk factors for low urinary citrate in calcium nephrolithiasis: low vegetable fibre intake and low urine volume to be added to the list

Risk factors for low urinary citrate excretion were assessed in 34 consecutive male recurrent idiopathic calcium stone formers (RCSF) who collected two 24-h urines while on free-choice diet. Overt hypocitraturia (hypo-cit) was defined as UCit×V<1.70 mmol/day, and ‘low' citraturia (low-cit) as UCit×V between 1.70 and 2.11 mmol/day. Twenty-three RCSF had normocitraturia (normo-cit), six low-cit and five hypo-cit. UCit×V positively correlated with urine volume (VOLUME, r=0.44, P=0.009), vegetable fibre intake (fibers, r=0.46, P=0.009) and GI-alkali absorption (alkali, r=0.47, P=0.006), and volume, fibres and alkali tended to be lower among RCSF with low-/hypo-cit. A 3-day NH4Cl loading test (0.95 mEq/kg BW daily in 3 doses) was performed in RCSF as well as in 14 age-matched healthy male controls (C). On a plot of urine pH versus serum bicarbonate, 10 of 11 RCSF with low-/hypo-cit, but only six of 23 with normo-cit (P=0.0004) fell off the normal range, indicating incomplete RTA. Two or more risk factors simultaneously occurred in only four of 23 RCSF with normo-cit, but in eight of 11 with low-/hypo-cit (P= 0.002). In conclusion, incomplete RTA is the most prevalent risk factor for low-/hypo-cit in RCSF, and decreases in vegetable fibres and urine volume emerge as two new risk factors for low urinary CI