14 research outputs found

    TEXTE ET IMAGE COMME SUPPORTS DE COMPREHENSION -VERS UNE ANALYSE SEMIOTIQUE DU VETEMENT TRADITIONNEL ALGERIEN FEMININ

    Get PDF
    Autour de la théorie du signe prennent forme des réflexions sur les significations profondes et systématisées que véhiculent des textes et des images. Dans ce sens, notre étude a pour objectif de mettre en exergue la nature sémiotique des textes et des images à travers une application ancrée dans notre culture : le vêtement traditionnel algérien féminin. En effet, le texte et l’image sont des supports qui nous permettent de comprendre la structuration et la codification du vêtement et, en définitif, d’avoir une vision cohérente sur les rapports interdisciplinaires de la sémiotique

    Smart greenhouses as the path towards precision agriculture in the food-energy and water nexus: case study of Qatar

    Get PDF
    Greenhouse farming is essential in increasing domestic crop production in countries with limited resources and a harsh climate like Qatar. Smart greenhouse development is even more important to overcome these limitations and achieve high levels of food security. While the main aim of greenhouses is to offer an appropriate environment for high-yield production while protecting crops from adverse climate conditions, smart greenhouses provide precise regulation and control of the microclimate variables by utilizing the latest control techniques, advanced metering and communication infrastructures, and smart management systems thus providing the optimal environment for crop development. However, due to the development of information technology, greenhouses are undergoing a big transformation. In fact, the new generation of greenhouses has gone from simple constructions to sophisticated factories that drive agricultural production at the minimum possible cost. The main objective of this paper is to present a comprehensive understanding framework of the actual greenhouse development in Qatar, so as to be able to support the transition to sustainable precision agriculture. Qatar’s greenhouse market is a dynamic sector, and it is expected to mark double-digit growth by 2025. Thus, this study may offer effective supporting information to decision and policy makers, professionals, and end-users in introducing new technologies and taking advantage of monitoring techniques, artificial intelligence, and communication infrastructure in the agriculture sector by adopting smart greenhouses, consequently enhancing the Food-Energy-Water Nexus resilience and sustainable development. Furthermore, an analysis of the actual agriculture situation in Qatar is provided by examining its potential development regarding the existing drivers and barriers. Finally, the study presents the policy measures already implemented in Qatar and analyses the future development of the local greenhouse sector in terms of sustainability and resource-saving perspective and its penetration into Qatar’s economy.Open Access funding provided by the Qatar National Library. The authors are grateful to Qatar National Research Fund (QNRF) for funding and supporting the M-NEX Project (Grant No. BFSUGI01-1120-170005) in Qatar. The M-NEX is a project of the Collaborative Research Area Belmont Forum (Grant No. 11314551)

    Toward systems-informed models for biologics disposition: covariates of the abundance of the neonatal Fc Receptor (FcRn) in human tissues and implications for pharmacokinetic modelling

    Get PDF
    Biologics are a fast-growing therapeutic class, with intertwined pharmacokinetics and pharmacodynamics, affected by the abundance and function of the FcRn receptor. While many investigators assume adequacy of classical models, such as allometry, for pharmacokinetic characterization of biologics, advocates of physiologically-based pharmacokinetics (PBPK) propose consideration of known systems parameters that affect the fate of biologics to enable a priori predictions, which go beyond allometry. The aim of this study was to deploy a systems-informed modelling approach to predict the disposition of Fc-containing biologics. We used global proteomics to quantify the FcRn receptor [p51 and β2-microglobulin (B2M) subunits] in 167 samples of human tissue (liver, intestine, kidney and skin) and assessed covariates of its expression. FcRn p51 subunit was highest in liver relative to other tissues, and B2M was 1–2 orders of magnitude more abundant than FcRn p51 across all sets. There were no sex-related differences, while higher expression was confirmed in neonate liver compared with adult liver. Trends of expression in liver and kidney indicated a moderate effect of body mass index, which should be confirmed in a larger sample size. Expression of FcRn p51 subunit was approximately 2-fold lower in histologically normal liver tissue adjacent to cancer compared with healthy liver. FcRn mRNA in plasma-derived exosomes correlated moderately with protein abundance in matching liver tissue, opening the possibility of use as a potential clinical tool. Predicted effects of trends in FcRn abundance in healthy and disease (cancer and psoriasis) populations using trastuzumab and efalizumab PBPK models were in line with clinical observations, and global sensitivity analysis revealed endogenous IgG plasma concentration and tissue FcRn abundance as key systems parameters influencing exposure to Fc-conjugated biologics

    Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

    Get PDF
    Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

    Agro-industrial byproducts in rabbit food: Case of the complex of detoxified apricot kernel cake and dehydrated tomato pulp

    Get PDF
    Background and Aim: The use of agro-industrial byproducts as an unconventional source of raw materials for monogastric feed is one possible solution. This study aimed to determine the effects of incorporating detoxified apricot kernel meal (DAKM) as a substitute for soybean meal and dehydrated tomato pulp (DTP) as a substitute for alfalfa hay on the local rabbit fattening. Materials and Methods: A total of 120 white strain rabbits, weaned at 33 days, were randomly assigned to four groups of 30. The rabbits in each group were ringed, placed in cages at 6 rabbits/cage, and fed according to DAKM and DTP incorporation rates (0%, 30%, 40%, and 60%). Results: The weights at 77 days were improved (p<0.05) with unchanged mean daily intakes. The vast majority of slaughter parameters and carcass characteristics improved. The chemical composition of the meat constituents improved significantly, with a 60% increase in the protein content of the batch (26.55% vs. 28.53%), 38% reduction in the total feed cost, and 40 DA saved for each kilogram of feed consumed per rabbit. The relative economic efficiency improved in proportion to the substitution rates of soybean meal by DAKM and alfalfa hay by DTP. Conclusion: Substituting DAKM and DTP, as byproducts of agro-industrial processing, for up to 60% induced satisfactory results in rabbit fattening. Therefore, it would be more insightful to increase the incorporation rates to determine the optimal threshold

    Smart greenhouses as the path towards precision agriculture in the food-energy and water nexus: case study of Qatar

    Get PDF
    Greenhouse farming is essential in increasing domestic crop production in countries with limited resources and a harsh climate like Qatar. Smart greenhouse development is even more important to overcome these limitations and achieve high levels of food security. While the main aim of greenhouses is to offer an appropriate environment for high-yield production while protecting crops from adverse climate conditions, smart greenhouses provide precise regulation and control of the microclimate variables by utilizing the latest control techniques, advanced metering and communication infrastructures, and smart management systems thus providing the optimal environment for crop development. However, due to the development of information technology, greenhouses are undergoing a big transformation. In fact, the new generation of greenhouses has gone from simple constructions to sophisticated factories that drive agricultural production at the minimum possible cost. The main objective of this paper is to present a comprehensive understanding framework of the actual greenhouse development in Qatar, so as to be able to support the transition to sustainable precision agriculture. Qatar’s greenhouse market is a dynamic sector, and it is expected to mark double-digit growth by 2025. Thus, this study may offer effective supporting information to decision and policy makers, professionals, and end-users in introducing new technologies and taking advantage of monitoring techniques, artificial intelligence, and communication infrastructure in the agriculture sector by adopting smart greenhouses, consequently enhancing the Food-Energy-Water Nexus resilience and sustainable development. Furthermore, an analysis of the actual agriculture situation in Qatar is provided by examining its potential development regarding the existing drivers and barriers. Finally, the study presents the policy measures already implemented in Qatar and analyses the future development of the local greenhouse sector in terms of sustainability and resource-saving perspective and its penetration into Qatar’s economy.Other Information Published in: Environment Systems and Decisions License: https://creativecommons.org/licenses/by/4.0See article on publisher's website: http://dx.doi.org/10.1007/s10669-022-09862-2</p

    Effects of incorporating agro-industrial by-products into diet of New Zealand rabbits: case of rebus of date and apricot kernel meal

    No full text
    The aim of this study was to determine the effects of incorporating the by-products complex of date and apricot on the fattening performance of the New Zealand breed of rabbits, to reduce the economic costs of the food formula. The change in weight from day 35 to 77 and the average daily gain are not significantly different, regardless of the diet. The pH and water content are proportional to the substitution rates (6.4-6.6% and 66.5-68.8%). Meat protein levels increased significantly, in particular for the 10% and 30% groups (+8.1% and 6%) while the fat and mineral content levels decreased significantly, in particular for the 30% group displaying −16% and −17%, respectively. Incorporation of dates and apricot kernel meal into the ration of rabbits reduces the cost of the kilogram of food produced of −9%, with an opportunity cost of  165 Algerian dinars (DZD). The date rebus/apricot kernel meal complex can be used as an alternative to the corn/soybean meal complex at substitution rates of up to 30% without adverse effects on growth rates, feed contribution, or slaughter yield. It improves the chemical composition of the meat and reduces the cost price of the quintal of feed produced
    corecore