A Data-Driven Approach for Enhancing the Efficiency in Chiller Plants: A Hospital Case Study

This article belongs to the Special Issue Energy Performance and Indoor Climate Analysis in Buildings)[EN] Large buildings cause more than 20% of the global energy consumption in advanced countries. In buildings such as hospitals, cooling loads represent an important percentage of the overall energy demand (up to 44%) due to the intensive use of heating, ventilation and air conditioning (HVAC) systems among other key factors, so their study should be considered. In this paper, we propose a data-driven analysis for improving the efficiency in multiple-chiller plants. Coefficient of performance (COP) is used as energy efficiency indicator. Data analysis, based on aggregation operations, filtering and data projection, allows us to obtain knowledge from chillers and the whole plant, in order to define and tune management rules. The plant manager software (PMS) that implements those rules establishes when a chiller should be staged up/down and which chiller should be started/stopped according different efficiency criteria. This approach has been applied on the chiller plant at the Hospital of León.SIThis research was funded by the Spanish Ministerio de Ciencia e Innovación and the European FEDER under project CICYT DPI2015-69891-C2-1-R/2-R

Study of hifi polymorphisms of the Pit-1 gene and their associations with type traits, milk yield and days open in holstein cows from Antioquia, Colombia

ABSTRACT: The aim of this study was to determine allele and phenotypic frequencies for single nucleotide polymorphism (SNP) of exon VI in the Pit-1 gene and their associations with type traits, milk yield, and days open. A total of 390 Holstein cows from Antioquia (Colombia) were genotyped for the Pit-1 Hin polymorphism by PCR-RFLP. We found AA, AB, and BB genotypes with a frequency of 0.03, 0.43, and 0.53, respectively. The A allele frequency was 0.35 and its presence in the genotype was associated with higher milk production, udder depth and body depth; the absence of the A allele in the genotype was associated with fewer days open. This study indicates that it is possible to develop breeding programs using the Pit-1 gene in Holstein cattle in the department of Antioquia.RESUMEN: El objetivo de este estudio fue determinar las frecuencias alélicas y fenotípicas del polimorfismo de nucleótido simple (SNP) del exón VI del gen Pit-1 y su asociación con características de tipo, producción de leche y días abiertos. Se muestrearon un total de 390 vacas Holstein del departamento de Antioquia (Colombia), genotipificadas para el polimorfismo Hin de Pit-1 por PCR-RFLP. Se encontraron los genotipos AA, AB y BB con frecuencia de 0,03, 0,43 y 0,53, respectivamente. El alelo A tuvo frecuencia de 0,35 y su presencia en el genotipo se asoció con mayor producción de leche, profundidad de la ubre y del cuerpo; la ausencia del alelo A en el genotipo se asoció con menores días abiertos. Este estudio indica que es posible desarrollar programas de selección usando el gen Pit-1 en bovinos Holstein del departamento de Antioquia

Desarrollo de un programa de educación acuática en la escuela indígena de la comunidad seri

Antecedentes: Las prácticas acuáticas contribuyen al desarrollo motriz y disminuyen la probabilidad de ahogamientos. Su implementación es particularmente importante en comunidades costeras, dada la relación de sus integrantes con el entorno marino. Objetivos: Por lo que se llevó a cabo una escuela de verano que tuvo como objetivo la adaptación, de la comunidad indígena Seri de Punta Checa, norte de México, al medio acuático en un entorno natural. Método: Las actividades fueron retos motores para desarrollar habilidades y destrezas de supervivencia en el ambiente acuático; estaciones de habilidades de juego grupal; y enseñanza de técnica. Resultados: Participaron 48 niños en total, con un promedio de asistencia de dos días por semana. Ninguno de los participantes sabía nadar antes del programa y todos adquirieron habilidades de supervivencia básicas. Los niños mayores de 8 años desarrollaron habilidades motrices y lograron completar circuitos con estaciones cuyas distintas los obligaban a poner en práctica estas habilidades. Los niños de 6 a 8 años alcanzaron una fase preliminar de desarrollo, puesto que fueron capaces de realizar algunas actividades en lugares poco profundos. Por medio de dibujos, los niños expresaron sus intereses, y la natación estuvo entre sus actividades preferidas. Conclusiones: Los niños, las familias, los docentes y las autoridades educativas consideraron que el programa había tenido resultados positivos, lo cual resalta la importancia de incluir la adaptación al medio acuático en el plan de estudios. Esto, contribuiría a la seguridad acuática y el desarrollo de la competencia motriz de los niños, sino también a una mayor disposición al aprendizaje curricular

Genetic diversity of HLA system in four populations from Baja California, Mexico: Mexicali, La Paz, Tijuana and rural Baja California

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 250 Mexicans from the states of Baja California Norte and Baja California Sur living in Mexicali (N = 100), La Paz (N = 75), Tijuana (N = 25) and rural communities (N = 50) to obtain information regarding allelic and haplotypic frequencies. The most frequent haplotypes for the Baja California region include nine Native American and five European haplotypes. Admixture estimates revealed that the main genetic components are European (50.45 ± 1.84% by ML; 42.03% of European haplotypes) and Native American (43.72 ± 2.36% by ML; 40.24% of Native American haplotypes), while the African genetic component was less apparent (5.83 ± 0.98% by ML; 9.36% of African haplotypes)

Memoria cultural del nordeste antioqueño

Presentación, 1. La identidad antioqueña y su tratamiento literario, 2. Modernización de la provincia de Antioquia e inmigración. Carlos Segismundo De Greiff, 3. El poema “Bárbara Jaramillo” del humorista liberal Manuel Uribe Velásquez, 4. Federico Velásquez Caballero: Exploración literaria del Nordeste (1860 - 1870), 5. “El machete” de Julio Posada Rodríguez: un cuento ilustrado y heterogéneo, 6. León Zafir: el rosal salvaje y el parterre citadino, 7. La herencia literaria hispánica en la obra de Tomás Carrasquilla: presencia de “La cueva de Montesinos” de Cervantes en Frutos de mi tierra, 8. Trayectoria de Tomás Carrasquilla en El Espectador (Medellín 1913-1915), 9. Francisco de Paula Rendón editado por Alpha, 10. Isabel Carrasquilla: ‘el estigma de la mancha de tinta’ en la literatura antioqueña de los siglos XIX y XX, 11. Aproximación a las músicas y los compositores del nordeste antioqueñ

Associated factors for mortality in a COVID-19 colombian cohort : is the third wave relevant when Mu variant was predominant epidemiologically?

Q1Q1Pacientes con COVID-19Objectives: To evaluate the association between Colombia's third wave when the Mu variant was predominant epidemiologically (until 75%) in Colombia and COVID-19 all-cause in-hospital mortality. Methods: In this retrospective cohort, we included hospitalized patients ≥18 years with SARS-CoV-2 infection between March 2020 to September 2021 in ten hospitals from three cities in Colombia. Description analysis, survival, and multivariate Cox regression analyses were performed to evaluate the association between the third epidemic wave and in-hospital mortality. Results: A total of 25,371 patients were included. The age-stratified time-to-mortality curves showed differences according to epidemic waves in patients ≥75 years (log-rank test p = 0.012). In the multivariate Cox analysis, the third wave was not associated with increased mortality relative to the first wave (aHR 0.95; 95%CI 0.84–1.08), but there was an interaction between age ≥75 years and the third wave finding a lower HR for mortality (aHR 0.56, 95%CI 0.36–0.86). Conclusions: We did not find an increase in in-hospital mortality during the third epidemic wave in which the Mu variant was predominant in Colombia. The reduced hazard in mortality in patients ≥75 years hospitalized in the third wave could be explained by the high coverage of SARS-CoV-2 vaccination in this population and patients with underlying conditions.https://orcid.org/0000-0003-1833-1599https://orcid.org/0000-0001-5363-5729https://orcid.org/0000-0001-6964-2229https://orcid.org/0000-0003-3975-2835https://orcid.org/0000-0001-9441-4375Revista Internacional - IndexadaA1N

RPAS (Remotely Piloted Aircraft Systems) para la elaboración de salidas de campo virtuales como recursos docentes “flipped classroom” para Grados relacionados con Ciencias de la Tierra

El principal objetivo del Proyecto es continuar con el desarrollo de material docente geológico y de recorridos de interés geológico virtuales además del uso de RPAS (Remotely Piloted Aircraft System) aeronaves no tripuladas que permiten acercarse a zonas de difícil accesibilidad. Este proyecto pretende desarrollar prácticas de campo virtuales mediante el manejo de nuevas tecnologías, tanto usando métodos de adquisición y elaboración de datos geológicos (RPAS: Remotely Piloted Aircraft System) como para su presentación y uso de la información y comunicación (TICs)

Uso de RPAS (Remotely Piloted Aircraft System) para la docencia y divulgación de las Ciencias de la Tierra

Proyecto de Innovación docente enfocado a la elaboración de material audiovisual digital modular basado en las imágenes obtenidas con dron y enfocado a la enseñanza a nivel de grado y master, así como a la divulgación científica.Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasFALSEsubmitte

Association of a single nucleotide polymorphism combination pattern of the Klotho gene with non-cardiovascular death in patients with chronic kidney disease

Chronic kidney disease (CKD) is associated with an elevated risk of all-cause mortality, with cardiovascular death being extensively investigated. However, non-cardiovascular mortality represents the biggest percentage, showing an evident increase in recent years. Klotho is a gene highly expressed in the kidney, with a clear influence on lifespan. Low levels of Klotho have been linked to CKD progression and adverse outcomes. Single nucleotide polymorphisms (SNPs) of the Klotho gene have been associated with several diseases, but studies investigating the association of Klotho SNPs with noncardiovascular death in CKD populations are lacking. The main aim of this study was to assess whether 11 Klotho SNPs were associated with non-cardiovascular death in a subpopulation of the National Observatory of Atherosclerosis in Nephrology (NEFRONA) study (n ¼ 2185 CKD patients). After 48 months of follow-up, 62 cardiovascular deaths and 108 non-cardiovascular deaths were recorded. We identified a high non-cardiovascular death risk combination of SNPs corresponding to individuals carrying the most frequent allele (G) at rs562020, the rare allele (C) at rs2283368 and homozygotes for the rare allele (G) at rs2320762 (rs562020 GG/AG þ rs2283368 CC/CT þ rs2320762 GG). Among the patients with the three SNPs genotyped (n ¼ 1016), 75 (7.4%) showed this combination. Furthermore, 95 (9.3%) patients showed a low-risk combination carrying all the opposite genotypes (rs562020 AA þ rs2283368 TT þ rs2320762 GT/TT). All the other combinations [n ¼ 846 (83.3%)] were considered as normal risk. Using competing risk regression analysis, we confirmed that the proposed combinations are independently associated with a higher fhazard ratio [HR] 3.28 [confidence interval (CI) 1.51-7.12]g and lower [HR 6 × 10- (95% CI 3.3 × 10--1.1 × 10-)] risk of suffering a non-cardiovascular death in the CKD population of the NEFRONA cohort compared with patients with the normal-risk combination. Determination of three SNPs of the Klotho gene could help in the prediction of non-cardiovascular death in CKD