Coupling CAD and CFD codes within a virtual integration platform

The Virtual Integration Platform (VIP) is an essential component of the VIRTUE project. It provides a system for combining disparate numerical analysis methods into a simulation environment. The platform allows for defining process chains, allocating of which tools to be used, and assigning users to perform the individual tasks. The platform also manages the data that are imported into or generated within a process, so that a version history of input and output can be evaluated. Within the VIP, a re-usable template for a given process chain can be created. A process chain is composed of one or more smaller tasks. For each of these tasks, a selection of available tools can be allocated. The advanced scripting methods in the VIP use wrappers for managing the individual tools. A wrapper allows communication between the platform and the tool, and passes input and output data as necessary, in most cases without modifying the tool in any way. In this way, third-party tools may also be used without the need for access to source code or special modifications. The included case study demonstrates several advantages of using the integration platform. A parametric propeller design process couples CAD and CFD codes to adapt the propeller to given operating constraints. The VIP template helped eliminate common user errors, and captured enough expert knowledge so that the casual user could perform the given tasks with minimal guidance. Areas of improvements to in-house codes and to the overall process were identified while using the integration platform. Additionally, the process chain was designed to facilitate formal optimisation methods

Individualisation of time-motion analysis : a method comparison and case report series

© Georg Thieme Verlag KG. This study compared the intensity distribution of time-motion analysis data, when speed zones were categorized by different methods. 12 U18 players undertook a routine battery of laboratory- and field-based assessments to determine their running speed corresponding to the respiratory compensation threshold (RCT), maximal aerobic speed (MAS), maximal oxygen consumption (vVO 2max ) and maximal sprint speed (MSS). Players match-demands were tracked using 5 Hz GPS units in 22 fixtures (50 eligible match observations). The percentage of total distance covered running at high-speed (%HSR), very-high speed (%VHSR) and sprinting were determined using the following speed thresholds: 1) arbitrary; 2) individualised (IND) using RCT, vVO 2max and MSS; 3) individualised via MAS per se; 4) individualised via MSS per se; and 5) individualised using MAS and MSS as measures of locomotor capacities (LOCO). Using MSS in isolation resulted in 61 % and 39 % of player's % HSR and % VHSR, respectively, being incorrectly interpreted, when compared to the IND technique. Estimating the RCT from fractional values of MAS resulted in erroneous interpretations of % HSR in 50 % of cases. The present results suggest that practitioners and researchers should avoid using singular fitness characteristics to individualise the intensity distribution of time-motion analysis data. A combination of players' anaerobic threshold, MAS, and MSS characteristics are recommended to individualise player-tracking data

HUNK Phosphorylates Rubicon to Support Autophagy

Background: Autophagy is a catabolic cellular recycling pathway that is essential for maintaining intracellular homeostasis. Autophagosome formation is achieved via the coordination of the Beclin-1 protein complex. Rubicon is a Beclin-1 associated protein that suppresses autophagy by impairing the activity of the class III PI3K, Vps34. However, very little is known about the molecular mechanisms that regulate Rubicon function. Methods: In this study, co-immunoprecipitation and kinase assays were used to investigate the ability of Hormonally Upregulated Neu-associated Kinase (HUNK) to bind to and phosphorylate Rubicon. LC3B was monitored by immunofluorescence and immunoblotting to determine whether phosphorylation of Rubicon by HUNK controls the autophagy suppressive function of Rubicon. Results: Findings from this study identify Rubicon as a novel substrate of HUNK and show that phosphorylation of Rubicon inhibits its function, promoting autophagy

The MAJORANA 76Ge neutrino less double-beta decay project: A brief update

At present, MAJORANA is a research and development (R&D) project to investigate the feasibility and cost of constructing and operating a one ton decay experiment with ~1000 kg of Ge detectors fabricated from germanium enriched to 86% in . The study will include three separate cryostats with various types of detectors: un-segmented, un-segmented point-contact, minimally segmented, and highly segmented. One cryostat will contain at least 30 kg of enriched (preferably point-contact) detectors. The performance of the cryostats and detectors as well as background levels will be investigated. The goal of the demonstrator project is to reach a discovery sensitivity of ~ 1026 y.Comment: 3 pages, no figure

Understanding Bottom Production

We describe calculations of b b-bar production to next-to-next-to-leading order (NNLO) and next-to-next-to-leading logarithm (NNLL) near threshold in pp interactions. Our calculations are in good agreement with the b b-bar total cross section measured by HERA-B.Comment: contribution to the proceedings of Quark Matter'02, 4 pages, 1 .eps figure, uses special included style fil

The GALATEA Test-Facility for High Purity Germanium Detectors

GALATEA is a test facility designed to investigate bulk and surface effects in high purity germanium detectors. A vacuum tank houses an infrared screened volume with a cooled detector inside. A system of three stages allows an almost complete scan of the detector. The main feature of GALATEA is that there is no material between source and detector. This allows the usage of alpha and beta sources as well as of a laser beam to study surface effects. A 19-fold segmented true-coaxial germanium detector was used for commissioning

Physical Performance Differences in Sea, Air and Land (SEAL) Operator Cohorts Separated by Demographics

Please refer to the pdf version of the abstract located adjacent to the title

Background reduction and sensitivity for germanium double beta decay experiments

Germanium detectors have very good capabilities for the investigation of rare phenomena like the neutrinoless double beta decay. Rejection of the background entangling the expected signal is one primary goal in this kind of experiments. Here, the attainable background reduction in the energy region where the neutrinoless double beta decay signal of 76Ge is expected to appear has been evaluated for experiments using germanium detectors, taking into consideration different strategies like the granularity of the detector system, the segmentation of each individual germanium detector and the application of Pulse Shape Analysis techniques to discriminate signal from background events. Detection efficiency to the signal is affected by background rejection techniques, and therefore it has been estimated for each of the background rejection scenarios considered. Finally, conditions regarding crystal mass, radiopurity, exposure to cosmic rays, shielding and rejection capabilities are discussed with the aim to achieve a background level of 10-3 c keV-1 kg-1 y-1 in the region of interest, which would allow to explore neutrino effective masses around 40 meV.Comment: 13 pages, 19 figures. Accepted by Astroparticle Physic