The Pierre Auger Observatory: Results on Ultra-High Energy Cosmic Rays

The focus of this article is on recent results on ultra-high energy cosmic rays obtained with the Pierre Auger Observatory. The world's largest instrument of this type and its performance are described. The observations presented here include the energy spectrum, the primary particle composition, limits on the fluxes of photons and neutrinos and a discussion of the anisotropic distribution of the arrival directions of the most energetic particles. Finally, plans for the construction of a Northern Auger Observatory in Colorado, USA, are discussed.Comment: Proceedings of the International Workshop on Advances in Cosmic Ray Science, Waseda University, Shinjuku, Tokyo, Japan, March 2008; to be published in the Journal of the Physical Society of Japan (JPSJ) supplemen

Janis-Newman-Winicour and Wyman solutions are the same

We show that the well-known most general static and spherically symmetric exact solution to the Einstein-massless scalar equations given by Wyman is the same as one found by Janis, Newman and Winicour several years ago. We obtain the energy associated with this spacetime and find that the total energy for the case of the purely scalar field is zero.Comment: 9 pages, LaTex, no figures, misprints corrected, to appear in Int. J. Mod. Phys.

Understanding the role of estrogen in the development of benign prostatic hyperplasia

Introduction: Benign prostatic hyperplasia (BPH) is a non-malignant enlargement of the prostate that affects ageing men. As the number of men affected by this condition will only continue to grow with the aging population, finding new strategies and new therapeutic options for its treatment is crucial. Androgenic hormones have been known to play an important role in the development of BPH and they have been a target in its medical treatment. Estrogens have also been implicated in BPH but in contrast to androgens, the functions of estrogens in the prostate are still obscure.Objective: This review aims to highlight the roles of estrogen in the development of BPH.Methods: Authors reviewed the literature covering the past forty years to highlight the roles of estrogen in the prostate and BPH. Data from authors’ experimental work in this field was also referenced.Results: The effects of estrogen in the prostate are mediated by estrogen receptors alpha and beta (ERα and ERβ). These two receptors have different expression and functions in the prostate, thereby presenting a window of opportunity to selectively target them for therapeutic purposes in BPH. The actions of estrogens, as mediated by estrogen receptors, appear to contribute to the development of BPH in men through an intricate molecular process that is yet to be fully elucidated. Although surgery remains the gold standard in the treatment of BPH, understanding the elusive role of estrogen in BPH, in addition to the established role of androgens, would enhance the current therapeutic options and perhaps lead to the development of new therapies. There are indications that phytoestrogens might be beneficial in the management of BPH.Conclusion: This review highlights the roles of estrogen as well as the therapeutic use of phytoestrogens in the prevention and management of BPH.Keywords: Benign prostatic hyperplasia (BPH); Estrogen; Estrogen receptors; Phytoestrogen; Androgen

The Visibility of Galactic Bars and Spiral Structure At High Redshifts

We investigate the visibility of galactic bars and spiral structure in the distant Universe by artificially redshifting 101 B-band CCD images of local spiral galaxies from the Ohio State University Bright Spiral Galaxy Survey. Our artificially redshifted images correspond to Hubble Space Telescope I-band observations of the local galaxy sample seen at z=0.7, with integration times matching those of both the very deep Northern Hubble Deep Field data, and the much shallower Flanking Field observations. The expected visibility of galactic bars is probed in two ways: (1) using traditional visual classification, and (2) by charting the changing shape of the galaxy distribution in "Hubble space", a quantitative two-parameter description of galactic structure that maps closely on to Hubble's original tuning fork. Both analyses suggest that over 2/3 of strongly barred luminous local spirals i.e. objects classified as SB in the Third Reference Catalog) would still be classified as strongly barred at z=0.7 in the Hubble Deep Field data. Under the same conditions, most weakly barred spirals (classified SAB in the Third Reference Catalog) would be classified as regular spirals. The corresponding visibility of spiral structure is assessed visually, by comparing luminosity classifications for the artificially redshifted sample with the corresponding luminosity classifications from the Revised Shapley Ames Catalog. We find that for exposures times similar to that of the Hubble Deep Field spiral structure should be detectable in most luminous low-inclination spiral galaxies at z=0.7 in which it is present. [ABRIDGED]Comment: Accepted for publication in The Astronomical Journa

Collective Effects in Linear Spectroscopy of Dipole-Coupled Molecular Arrays

We present a consistent analysis of linear spectroscopy for arrays of nearest neighbor dipole-coupled two-level molecules that reveals distinct signatures of weak and strong coupling regimes separated for infinite size arrays by a quantum critical point. In the weak coupling regime, the ground state of the molecular array is disordered, but in the strong coupling regime it has (anti)ferroelectric ordering. We show that multiple molecular excitations (odd/even in weak/strong coupling regime) can be accessed directly from the ground state. We analyze the scaling of absorption and emission with system size and find that the oscillator strengths show enhanced superradiant behavior in both ordered and disordered phases. As the coupling increases, the single excitation oscillator strength rapidly exceeds the well known Heitler-London value. In the strong coupling regime we show the existence of a unique spectral transition with excitation energy that can be tuned by varying the system size and that asymptotically approaches zero for large systems. The oscillator strength for this transition scales quadratically with system size, showing an anomalous one-photon superradiance. For systems of infinite size, we find a novel, singular spectroscopic signature of the quantum phase transition between disordered and ordered ground states. We outline how arrays of ultra cold dipolar molecules trapped in an optical lattice can be used to access the strong coupling regime and observe the anomalous superradiant effects associated with this regime.Comment: 12 pages, 7 figures main tex

The Star Formation History of the Hubble Sequence: Spatially Resolved Colour Distributions of Intermediate Redshift Galaxies in the Hubble Deep Field

We analyse the spatially resolved colours of distant galaxies of known redshift in the Hubble Deep Field, using a new technique based on matching resolved four-band internal colour data to the predictions of evolutionary synthesis models. We quantify the relative age, dispersion in age, ongoing star-formation rate, star-formation history, and dust content of these galaxies. To demonstrate the potential of the method, we study the near-complete sample of 32 I ~ 0.5 studied by Bouwens et al (1997). The dispersion of the internal colours of a sample of 0.4<z<1 early-type field galaxies in the HDF indicates that ~40% [4/11] show evidence of star formation which must have occurred within the past third of their ages at the epoch of observation. For a sample of well-defined spirals, we similarly exploit the dispersion in colour to analyse the relative histories of bulge and disc stars, in order to resolve the current controversy regarding the ages of galactic bulges. Dust and metallicity gradients are ruled out as major contributors to the colour dispersions we observe in these systems. The median ages of bulge stars are found to be signicantly older than those in galactic discs, and exhibit markedly different star-formation histories. This result is inconsistent with a secular growth of bulges from disc instabilities, but consistent with gradual disc formation by accretion of gas onto bulges, as predicted by hierarchical theories. We extend our technique in order to discuss the star formation history of the entire Bouwens et al sample in the context of earlier studies concerned with global star formation histories.Comment: 8 colour postscript figures plus LaTeX source; submitted to MNRAS. Uses the mnras.sty LaTeX style fil

Non-LTE, Relativistic Accretion Disk Fits to 3C~273 and the Origin of the Lyman Limit Spectral Break

We fit general relativistic, geometrically thin accretion disk models with non-LTE atmospheres to near simultaneous multiwavelength data of 3C~273, extending from the optical to the far ultraviolet. Our model fits show no flux discontinuity associated with a hydrogen Lyman edge, but they do exhibit a spectral break which qualitatively resembles that seen in the data. This break arises from relativistic smearing of Lyman emission edges which are produced locally at tens of gravitational radii in the disk. We discuss the possible effects of metal line blanketing on the model spectra, as well as the substantial Comptonization required to explain the observed soft X-ray excess. Our best fit accretion disk model underpredicts the near ultraviolet emission in this source, and also has an optical spectrum which is too red. We discuss some of the remaining physical uncertainties, and suggest in particular that an extension of our models to the slim disk regime and/or including nonzero magnetic torques across the innermost stable circular orbit may help resolve these discrepancies.Comment: Accepted for publication in Ap

Directional solidification of aluminum-nickel eutectic alloys using electroslag remelting

Attempts were made to produce directionally solidified, specifically grain aligned Al-6 wt pct Ni eutectic alloy using a laboratory scale ESR unit. For this purpose sand cast alloy electrodes were electroslag remelted under different mold conditions. The grain structure of the ingots obtained from these meltings showed that insulated silica molds gave the best vertical alignment of grains along the length of the ingot. The NiAl3 fibers within the grains tended to fan out and there was only a preferred alignment of fibers along the growth direction under the conditions of our experiments. The ESR parameters most suitable for vertical alignment of eutectic grains have been identified. In some electroslag remelting trials ingots were grown on a seed ingot. This resulted in a fewer vertical grains compared to the case when no seed ingot was used. The sand cast specimen of the eutectic exhibited a maximum tensile strength of around 88.2 MN/m2 (9.0 kg/mm2) whereas conventional ESR using water cooled mold gave strength value of 98.0 MN/m2 (10 kg/mm2). The directionally solidified ESR material showed longitudinal tensile strength as high as 213.7 MN/m2 (21.8 kg/mm2) which could be further increased to 220.6 MN/m2 (22.5 kg/mm2) by using the seed ingot. The average growth rate was varied between 5 to 25 mm/min during electroslag remelting in this study. The flow stresses, tangent modulus and ultimate tensile strength of directionally solidified eutectic increased with increasing growth rates

Rank Maximal Matchings -- Structure and Algorithms

Let G = (A U P, E) be a bipartite graph where A denotes a set of agents, P denotes a set of posts and ranks on the edges denote preferences of the agents over posts. A matching M in G is rank-maximal if it matches the maximum number of applicants to their top-rank post, subject to this, the maximum number of applicants to their second rank post and so on. In this paper, we develop a switching graph characterization of rank-maximal matchings, which is a useful tool that encodes all rank-maximal matchings in an instance. The characterization leads to simple and efficient algorithms for several interesting problems. In particular, we give an efficient algorithm to compute the set of rank-maximal pairs in an instance. We show that the problem of counting the number of rank-maximal matchings is #P-Complete and also give an FPRAS for the problem. Finally, we consider the problem of deciding whether a rank-maximal matching is popular among all the rank-maximal matchings in a given instance, and give an efficient algorithm for the problem

Dimensionality reduction, and function approximation of poly (lactic-co-glycolic acid) micro-and nanoparticle dissolution rate

Prediction of poly(lactic-co-glycolic acid) (PLGA) micro- and nanoparticles’ dissolution rates plays a significant role in pharmaceutical and medical industries. The prediction of PLGA dissolution rate is crucial for drug manufacturing. Therefore, a model that predicts the PLGA dissolution rate could be beneficial. PLGA dissolution is influenced by numerous factors (features), and counting the known features leads to a dataset with 300 features. This large number of features and high redundancy within the dataset makes the prediction task very difficult and inaccurate. In this study, dimensionality reduction techniques were applied in order to simplify the task and eliminate irrelevant and redundant features. A heterogeneous pool of several regression algorithms were independently tested and evaluated. In addition, several ensemble methods were tested in order to improve the accuracy of prediction. The empirical results revealed that the proposed evolutionary weighted ensemble method offered the lowest margin of error and significantly outperformed the individual algorithms and the other ensemble techniques