A practical framework and online tool for mutational signature analyses show inter-tissue variation and driver dependencies

Mutational signatures are patterns of mutations that arise during tumorigenesis. We present an enhanced, practical framework for mutational signature analyses. Applying these methods on 3,107 whole genome sequenced (WGS) primary cancers of 21 organs reveals known signatures and nine previously undescribed rearrangement signatures. We highlight inter-organ variability of signatures and present a way of visualizing that diversity, reinforcing our findings in an independent analysis of 3,096 WGS metastatic cancers. Signatures with a high level of genomic instability are dependent on TP53 dysregulation. We illustrate how uncertainty in mutational signature identification and assignment to samples affects tumor classification, reinforcing that using multiple orthogonal mutational signature data is not only beneficial, it is essential for accurate tumor stratification. Finally, we present a reference web-based tool for cancer and experimentally-generated mutational signatures, called Signal (https://signal.mutationalsignatures.com), that also supports performing mutational signature analyses.This work was funded by a Cancer Research UK (CRUK) Pioneer Award (grant no. C60100/A23433), Wellcome-Beit Prize, CRUK Advanced Clinician Scientist Fellowship (grant no. C60100/A23916), Wellcome Trust Strategic Award (WT100126/B/13/Z) and CRUK PRECISION Grand Challenge awar

Salient beliefs and intention to shop online

This paper examines the relationships between salient beliefs and intention to shop online based on TRA model.Over 140 students of a Malaysian university completed a 4-page questionnaire consisting of 26-items measuring salient beliefs(convenience, information, product perception, shopping experience, customer service and customer risk) and 4-items measuring intention to shop online for 18 product categories.Regression analysis of factor scores (resulting from factor analysis of salient beliefs) shows that convenience, information and product perception jointly explain 43.5 percent variance in intention to shop online.The finding implies that online shopping is becoming more popular amongst students due to its convenience, ease of getting information and positive product perceptions.This implies that E-commerce operators should continue to make their presence known on the web. Limitations and practical implications of the findings are also discussed in the paper

Denyut Voltan Tinggi

Permintaan pengguna ke atas makanan sentiasa berubah. Pada hari ini pengguna menuntut makanan yang segar dan asli. Pempasteuran terma bukan sahaja boleh membunuh mikroorganisma tetapi boleh memberi kesan kepada rasa, warna dan kualiti makanan yang digunakan. Kaedah pempasteuran sejuk dibangunkan untuk membunuh mikroorganisma tanpa penggunaan haba. Salah satu kaedah ialah dengan menggunakan medan denyut elektrik untuk pempasteuran makanan cecair. Kajian adalah melibatkan penggunaan medan denyut elektrik keatas makanan cecair seperti susu. Sampel susu dimasukkan ke dalam bekas rawatan dan dirawat menggunakan medan denyut elektrik. Maksimum voltan yang mampu dibekalkan ialah 17 kV. Parameter seperti kekuatan medan elektrik, bilangan denyut, lebar denyut diubah-ubah untuk mengkaji kesannya terhadap kadar ketidakaktifan mikroorganisma

Characterizing Product Performance as Visual Imaging in Influencing Designer Design Thinking in Product Development

The main purpose of this research is to explore Product Design Images influencing factors to designers prior to Visual Methods to be presented within the Design Research context at the stage of Design Activity. The researcher has chosen the Sequential Explanatory Design to easily communicate the procedures for this mixed-method study. The significance of this project enables researchers to discover the underlying relationship and potential of Research Photography in the product development process for product performance analysis. Qualitative data through the Verbal Protocol Analysis model will potentially be supporting the researcher to investigate within the activity of designers understanding product performances and user needs.  Keywords: Product Design; Visual Methods; Photography; Design Activity eISSN: 2398-4287 © 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v6iSI6.304

Alkaline treatments on EFB fibre: the effect on mechanical-physical properties and fibre-cement hydration rate

The natural fibres commonly used to enhance the brittleness of the cement matrix but appropriate fibre should be used for a particular purpose depending upon the type of fibre and characteristics. The Oil Palm Empty Fruit Bunch (EFB) fibre is one of the major crops in Malaysia, which contribute large scale of waste that is durable and make it reasonable for utilization in cement-based product. However, the presence of hemicellulose, lignin and extractive (oil, sugar and starch) affect the performance of EFB fibre and causes an incompatibility of EFB fibre and cement. Hence, this research is been conducted to explore the suitable proportion of Sodium Hydroxide (NaOH) treatment for EFB fibre to increase the compatibility of cement with EFB fibre. The NaOH concentration of 0.2%, 0.4%, 0.6%, 0.8%, 1%, 2%, 3% and 4% were used in this study as a chemical pre-treatment of EFB fibre for surface morphology observation and hydration rate test. Meanwhile for only untreated fibre, fibre treated with 0.4% (low concentration), 1% (medium concentration) and 4% (high concentration) of alkali treatment were tested for tensile strength of single EFB fibre. The fibre treated with NaOH has shown a significant different on the hydration temperature for EFB fibre- cement mixed compared with the untreated fibre. The higher NaOH concentration, the greater hydration temperatures obtain. The Scanning Electron Microscopy (SEM) image show that the increment NaOH concentration applied, the rougher EFB fibre surface is observed with lesser silica body remain. The tensile properties of individual fibre treated with NaOH (0.4%, 1% and 4%) has shown significant increment as compare to the untreated fibre with the highest tensile properties mean value 422.90 N/mm2 at 4% NaOH concentration

The basic of self-management in Asian Folklore

Without management, human lives will face with a lot of risk. For example, self-management has become a basic thing that has been exposed since childhood by adults as well as individuals nearby. Such exposure is also applied in children’s books from an early age as a useful initial input. In this case, the management aspect is knowledge-based that has been widely introduced in Asia for a long time. This can be seen in the Koleksi Cerita Rakyat Asia Untuk Kanak-kanak (Buku 1) which has been published by the Dewan Bahasa dan Pustaka as a result of the Asian Copublication Programme, organized by the Asian Cultural Centre for Unesco / Tokyo Book Development Centre, in collaboration with Unesco and the countries of UNESCO members in Asia. The findings also showed that the dominant basis of selfmanagement which covers basic things such as time management, emotions, conflict and hygiene

A Hybrid Method of Least Square Support Vector Machine and Bacterial Foraging Optimization Algorithm for Medium Term Electricity Price Forecasting

Predicting electricity price has now become an important task for planning and maintenance of power system. In medium term forecast, electricity price can be predicted for several weeks ahead up to a year or few months ahead. It is useful for resources reallocation where the market players have to manage the price risk on the expected market scenario. However, researches on medium term price forecast have also exhibit low forecast accuracy. This is due to the limited historical data for training and testing purposes. Therefore, an optimization technique of Bacterial Foraging Optimization Algorithm (BFOA) for Least Square Support Vector Machine (LSSVM) was developed in this study to provide an accurate electricity price forecast with optimized LSSVM parameters and input features. So far, no literature has been found on feature and parameter selections using the LSSVM-BFOA method for medium term price prediction. The model was examined on the Ontario power market; which is reported as among the most volatile market worldwide. Monthly average of Hourly Ontario Electricity Price (HOEP) for the past 12 months and month index are selected as the input features. The developed LSSVM-BFOA shows higher forecast accuracy with lower complexity than the existing models

E-Commerce Logistic and Supply Chain Management: Evidence from Indonesian Perspectives

The web is essentially affecting how firms cooperate with one another and their clienteles. Past interruptions for supply chain incorporation, for example, high exchange prices between allies, weak info accessibility, with encounters of overseeing multifaceted borders between utilitarian affiliations have been on the whole dissolving on the web. In this study, it is examined how the web has been altering SCM. 100 Questionnaire has been used to acquire the response from the employees of Indonesia companies having E-Commerce business. Smart PLS software has been used to get data examination. ponder presented a study of developing on the consequence of e-business on SCM with descriptive frameworks, e-procurement, e-collaboration and e-commerce

Expressing the Prolonged Grief Disorder through Face Expression by using Silk Screen

The purpose of the project is to express prolonged grief through facial expressions. Grief is a natural response to loss because it is a universal and singular experience. Art students and academics frequently employed art-based study as a technique and research strategy. This study's methodology includes the processes of artwork analysis, visual data collection, and artwork making. According to the researcher, this study will significantly impact the art scene, especially among printmakers. The outcomes will be implemented in producing artworks incorporating silk screen printing techniques. Keywords: Grief, Face expression, Silk Screen, Printmaking eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA CE-Bs by E-International Publishing House, Ltd., UK. This is an open-access article under the CC  BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer-review under responsibility of AMER (Association of Malaysian Environment-Behavior Researchers), ABRA (Association of Behavioral Researchers on Asians), and cE-Bs (Centre for Environment-Behavior Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v7iSI9.393

Motion estimation on homogenous surface for around view monitoring system

Around View Monitoring (AVM) system uses multiple input cameras mounted on different positions of a vehicle to display 360° bird-eye-view around the vehicle that is not readily visible to the driver. The development of this system will contribute to the reduction of parking accidents by monitoring its surroundings, detecting lanes and identifying obstacles. With AVM, we can significantly decrease the number of minor accidents. AVM will not only be used for parking assistance but can also assist navigation in the narrow path area. Conventional AVM systems developed in the market using four or six cameras and requires an additional sensor for detection in order to minimise stitching error or to reduce the time to calibrate the output display image. The procedure is time-consuming and increases the cost of development. We propose to develop two ultra-wide-angle cameras located on the front and rear vehicle integrated with the motion estimation (ME) algorithm to produce a parking bird eye view and forward/backward trajectory lines. From our ablative analysis, optical flow is not suitable to be used for real-time ADAS systems as it fails at least 25.5% of the time. However, block matching algorithm based on normalized cross-correlation (CCORR NORMED) and normalised correlation coefficient (CCOEFF NORMED) were able to detect all templates correctly with 0% of false detection on our dataset