Longitudinal assessment of reflexive and volitional saccades in Niemann-Pick Type C disease during treatment with miglustat

Peer reviewedPublisher PD

“I don’t want to look sick skinny”: Perceptions of body image and weight loss in Hispanics living with HIV in South Texas

Objective: Obesity is rising in people with HIV (PLWH) and Hispanics. Both HIV and obesity are associated with cardiovascular disease morbidity and mortality. Our goal is to understand perceptions of body image and lifestyle in Hispanics with HIV to adapt interventions appropriately. Methods: We conducted semi-structured interviews with 22 Hispanic PLWH and 6 providers. Purposive sampling selected patient participants across weights and genders. Interviews were coded and analyzed using grounded theory, comparing perspectives between patients with and without obesity, and patients and providers. Results: Participants felt obesity and diabetes were “normal” in the community. Patients exhibited understanding of healthy diet and lifestyle but felt incapable of maintaining either. Traditionally Hispanic foods were blamed for local obesity prevalence. Five patients equated weight with health and weight loss with illness, and four expressed concerns that weight loss could lead to unintentional disclosure of HIV status. Participants with overweight or obesity expressed awareness of their weight and felt shamed by providers. Providers found weight loss interventions to be ineffective. Conclusion: Interventions in this population must address identified barriers: overweight/obesity as a normative value, lack of self-efficacy, cultural beliefs surrounding food, fear of HIV-associated weight loss and stigma, and provider perspectives on intervention futility

Enhanced conformational space sampling improves the prediction of chemical shifts in proteins.

A biased-potential molecular dynamics simulation method, accelerated molecular dynamics (AMD), was combined with the chemical shift prediction algorithm SHIFTX to calculate (1)H(N), (15)N, (13)Calpha, (13)Cbeta, and (13)C' chemical shifts of the ankyrin repeat protein IkappaBalpha (residues 67-206), the primary inhibitor of nuclear factor kappa-B (NF-kappaB). Free-energy-weighted molecular ensembles were generated over a range of acceleration levels, affording systematic enhancement of the conformational space sampling of the protein. We have found that the predicted chemical shifts, particularly for the (15)N, (13)Calpha, and (13)Cbeta nuclei, improve substantially with enhanced conformational space sampling up to an optimal acceleration level. Significant improvement in the predicted chemical shift data coincides with those regions of the protein that exhibit backbone dynamics on longer time scales. Interestingly, the optimal acceleration level for reproduction of the chemical shift data has previously been shown to best reproduce the experimental residual dipolar coupling (RDC) data for this system, as both chemical shift data and RDCs report on an ensemble and time average in the millisecond range

History at a Standstill: Agency and Gender in the Image of Civil Rights

Cet essai a pour objet de redonner une importance capitale au pouvoir et à l’influence que nous exerçons dans l’image que nous nous faisons de la barbarie et ce, en examinant des photographies de résistance passive prises durant le Mouvement des droits civiques aux États-Unis dans les années 1960. En ayant à l’esprit l’appel lancé par Walter Benjamin à “faire exploser le continuum de l’histoire”, continuum qui a tendance à légitimer la barbarie comme tremplin vers le progrès de la civilisation, je me propose de centrer mon analyse sur l’étude de la photographie iconique d’une foule blanche hostile se préparant à agresser trois manifestants attablés au comptoir d’un restaurant, lors d’un sit-in à Jackson, dans le Mississipi, en 1963. Allant à l’encontre de la façon dont les photographies des droits civiques sont traditionnellement récupérées pour construire un récit de progrès social, je choisis deux autres trajectoires. La première met en évidence la logique de répétition, plutôt que la logique de rédemption, qui est à l’œuvre dans la préfiguration de l’assassinat imminent du leader des droits civiques Medgar Evers (et de la succession d’assassinats qui suivront) telle qu’elle peut se lire dans le dos maculé de ketchup du manifestant ayant pris sa place ce jour-là. La seconde cherche à nuancer cette lecture de l’histoire en s’attardant sur le regard solidaire qu’échangent les deux femmes de races différentes assises à ce comptoir. Sans vouloir sentimentaliser la promesse de ce regard, j’avance l’hypothèse selon laquelle une analyse de photographies d’atrocités empreinte d’empathie pourrait permettre de mieux comprendre les origines de ce pouvoir et de cette influence que nous exerçons par l’image.This essay seeks to restore the centrality of agency to our picture of atrocity by examining photographs of non-violent resistance during the Civil Rights Movement of the 1960s. Heeding Walter Benjamin’s call to “blast open the continuum of history” that tends to legitimate atrocity as a stepping-stone in the march of civilization, I focus on an iconic photograph of a hostile white mob preparing to assault three seated protesters at a lunch counter sit-in in Jackson, Mississippi in 1963. Against the traditional recuperation of civil rights photographs to a narrative of social progress, I elicit two alternative trajectories. The first points toward the logic of repetition rather than redemption through the foreshadowing of the imminent murder of Civil Rights leader Medgar Evers (and the succession of assassinations that ensued) by the ketchup-smeared back of the male protestor who had taken Evers’ place. The second seeks to offset this critique by dwelling on the mutually sustaining gaze exchanged by the interracial pair of women seated at the counter. Without sentimentalizing the promise of this gaze, I propose that an analysis of affiliation in and with photographs of atrocity could illuminate and activate the origins of agency

Expression of HLA-DR Antigen in Skin from Patients with Psoriasis

Using murine monoclonal antibodies against human HLA-DR antigen and against human T cells, we investigated the indirect immunofluorescence staining pattern of involved and uninvolved skin from patients with psoriasis. The staining pattern of involved psoriatic epidermis is different from the pattern seen in uninvolved skin from the same patient and consists of scattered, single HLA-DR positive cells alternating with groups of HLA- DR positive cells. These HLA-DR positive cell clusters can be seen at any level of the epidermis. In some patients, the dermis of involved skin shows prominent accumulations of T cells which are HLA-DR positive and thus represent activated T cells

CHILD HEALTH AND SAFETY OF COMPLEMENTARY FOOD AMONG HOUSEHOLDS IN ADYEL DIVISION, LIRA DISTRICT: A CROSS-SECTIONAL STUDY.

Background Safe complementary food is food that will not cause harm to infants and children when prepared and fed as recommended. Unfortunately, children are frequently suffering from diarrhoea which is not only preventable but is also largely attributed to complementary foods hence this study.   Methodology The study was carried out in 2015 in Adyel Division, Lira District among caregiver-child pairs. The children were between the ages of 6 – 23 months. Information collected was about the children’s diarrhoeal patterns, nutritional status, and complementary food safety. Results Analyses of food samples revealed that freshly cooked food was contaminated with fecal coliforms (4.88±1.87 log cfu/g), and the levels of fecal coliforms in stored food increased with prolonged storage period (5.49b±1.86 log cfu/g).  Drinking water too was contaminated with E.coli (2.86 logs cfu/ml). Water in storage containers had total coliform counts of up to 3.14 log cfu/ml. In over half of the households (56.7%), the microbial counts in household drinking water containers (4.48E+03cfu E.coli) were more than those found at the respective water sources (4.46E+02cfu E.coli). Water treatment accounted for 25% of the variation (p=0.005) in E.coli counts in drinking water that was found in water storage containers. About 32.5% of the frequency or recurrence of diarrhea episodes in two weeks among children was explained by the presence of fecal coliforms in freshly cooked complementary food (p=0.001). Overall, diarrheal infections (p=0.030), inappropriate child-feeding practices (p=0.048), and poor hand-washing (p=0.011) played a significant role in influencing child health.  Conclusion The food safety in this study was compromised by poor complementary food handling practices. Recommendation There is a need to study specific food combinations under more controlled conditions to compare the effect of the different handling practices on the microbial load in the various foods

Leaping the language gap: strategies for preschool and head start teachers

Strategies that promote the development of language skills are recognized as important in early childhood education. For early childhood centers and care providers, there are also additional concerns that interventions which meet these developmental needs are both time and cost effective. This pilot study investigates the effect of indirect language stimulation (ILS) techniques on the receptive and expressive oral language of 4-year-olds, using techniques that can be easily taught to teachers and implemented in the classroom. Two preschool teachers in a southwest rural community in the United States were randomly assigned for instruction over a 6-month period on effective ways of integrating ILS techniques into their regular classroom instruction. Students were assessed with the PPVT-4 (receptive language) and the EVT-2 (expressive language) to determine the effect these techniques had on their English language vocabulary. Results indicate that students in classrooms where teachers received the professional development (n = 31) had significantly higher growth in expressive language scores (p = .012) than students in comparison classrooms (n = 34). This study suggests that a low-cost 2-day training intervention can be beneficial for preschool teachers and their 4-year-old students’ language acquisition

Assessment of Accelerometers for Measuring Upper-Extremity Physical Activity

Objective: The overarching goal of this study was to examine the use of triaxial accelerometers in measuring upper-extremity motions to monitor upper-extremity-exercise compliance. There were multiple questions investigated, but the primary objective was to investigate the correlation between visually observed arm motions and triaxial accelerometer activity counts to establish fundamental activity counts for the upper extremity. Study Design: Cross-sectional, basic research. Setting: Clinical laboratory. Participants: Thirty healthy individuals age 26 ± 6 y, body mass 24 ± 3 kg, and height 1.68 ± 0.09 m volunteered. Intervention: Participants performed 3 series of tasks: activities of daily living (ADLs), rehabilitation exercises, and passive shoulder range of motion at 5 specific velocities on an isokinetic dynamometer while wearing an accelerometer on each wrist. Participants performed exercises with their dominant arm to examine differences between sides. A researcher visually counted all arm motions to correlate counts with physical activity counts provided by the accelerometer. Main Outcome Measure: Physical activity counts derived from the accelerometer and visually observed activity counts recorded from a single investigator. Results: There was a strong positive correlation (r = .93, P \u3c .01) between accelerometer physical activity counts and visual activity counts for all ADLs. Accelerometers activity counts demonstrated side-to-side difference for all ADLs (P \u3c .001) and 5 of the 7 rehabilitation activities (P \u3c .003). All velocities tested on the isokinetic dynamometer were shown to be significantly different from each other (P \u3c .001). Conclusion: There is a linear relationship between arm motions counted visually and the physical activity counts generated by an accelerometer, indicating that arm motions could be potentially accounted for if monitoring arm usage. The accelerometers can detect differences in relatively slow arm-movement velocities, which is critical if attempting to evaluate exercise compliance during early phases of shoulder rehabilitation. These results provide fundamental information that indicates that triaxial accelerometers have the potential to objectively monitor and measure arm activities during rehabilitation and ADLs

Criterios de evaluación: construyendo fiabilidad y objetividad…

El presente trabajo se propone mostrar los resultados y conclusiones de un tramo del proyecto de investigación bianual llevado a cabo en el período 2016/17 en la Facultad de Lenguas, UNC que se tituló: Hacia la elaboración de criterios uniformados de evaluación que aseguren fiabilidad entre los calificadores de las pruebas escritas en las cátedras de Lengua Inglesa I, Práctica Gramatical del Inglés, Gramática Inglesa I, Práctica de la Pronunciación del Inglés, Lengua Castellana I y Lectocomprensión en Lengua Extranjera IV (Inglés). El mismo estuvo avalado por Secyt y dirigido por Mgtr. Fabián Negrelli y co dirigido por la Mgtr. Cecilia Ferreras. El proyecto plantea como objetivo general abordar la elaboración de criterios de evaluación uniformados con el objetivo de lograr fiabilidad inter evaluadora en las Cátedras de Lengua Inglesa I, Práctica Gramatical del inglés, Gramática Inglesa I, Práctica de la Pronunciación del inglés, Lengua Castellana I y Lecto comprensión en Lengua Extranjera IV (inglés) en la Facultad de Lenguas de la Universidad Nacional de Córdoba (UNC)

Instituto de educación superior tecnológico público de las Fuerzas Armadas en el distrito del Rímac, Provincia de Lima, Región Lima

La presente tesis para recibir el título profesional de Arquitecto, consiste en la investigación y desarrollo del proyecto arquitectónico “Instituto de Educación Superior Tecnológico Público de las Fuerzas Armadas”, ubicado en el Sector 2 del Fuerte Hoyos Rubio, en el Distrito del Rímac, Provincia Lima, Región Lima. El propósito principal de esta investigación es diseñar un Instituto de Educación Superior Tecnológica para los licenciados de las Fuerzas Armadas que cumplieron Servicio Militar Voluntario Acuartelado, en el cual se puedan desarrollar actividades educativas de manera adecuada, satisfaciendo las necesidades de los estudiantes e impulsando su crecimiento profesional insertándolos a la demanda laboral actual, cumpliendo con los estándares reglamentarios y tomando conceptos referentes a la vida castrense. De igual forma, se busca lograr una interrelación entre la espacialidad y funcionalidad del proyecto, jerarquizando los espacios públicos y generando una relación entre estos y los grandes bloques de equipamientos, de esta manera las actividades académicas se complementan con actividades recreativas y culturales. Por lo tanto, el proyecto se basa en el análisis de las necesidades de los usuarios, tomando en cuenta que el proyecto es de carácter nacional y abarcará los tres cuerpos de las Fuerzas Armadas, el Ejercito, la Marina de Guerra y la Fuerza Aérea, así como los requerimientos que las carreras técnicas del programa académico poseen en cuanto a infraestructura educativa.The present thesis to receive the professional title of Architect, consists of the investigation and development of the architectural project ""Institute of Public Technological Higher Education of the Armed Forces"", located in Sector 2 of Fort Hoyos Rubio, in the District of Rímac, Province Lima, Lima Region. The main purpose of this research is to design an Institute of Higher Technological Education for graduates of the Armed Forces who completed Voluntary Military Service Barracks, in which educational activities can be developed in an appropriate way, meeting the needs of students and promoting their growth. professional inserting them to the current labor demand, complying with the regulatory standards and taking concepts related to military life. Similarly, it seeks to achieve dynamism in terms of the spatiality and function of the project, prioritizing public spaces and generating an interrelation between these and the large blocks of facilities, in this way academic activities are complemented with recreational and cultural activities. Thus, the project is based on the analysis of user needs, taking into account that the project is national in nature and will encompass the three bodies of the Armed Forces, the Army, the Navy and the Air Force, as well as the requirements that the technical careers of the academic program have in terms of educational infrastructure.Tesi