37 research outputs found
Production in Two-Photon Processes at TRISTAN
We have carried out an inclusive measurement of production
in two-photon processes at TRISTAN. The mean was 58 GeV and the
integrated luminosity was 199 pb. High-statistics samples were
obtained under such conditions as no-, anti-electron, and remnant-jet tags. The
remnant-jet tag, in particular, allowed us, for the first time, to measure the
cross sections separately for the resolved-photon and direct processes.Comment: 20 pages, Latex format, 4 figures and KEK-mark included. Table 1
revised. To be published in Phys. Lett.
Measurement of inclusive electron cross section in collisions at TRISTAN
We have studied open charm production in collisions with the
TOPAZ detector at the TRISTAN collider. In this study, charm
quarks were identified by electrons (and positrons) from semi-leptonic decays
of charmed hadrons. The data corresponded to an integrated luminosity of 95.3
pb at a center-of-mass energy of 58 GeV. The results are presented as
the cross sections of inclusive electron production in
collisions with an anti-tag condition, as well as the subprocess cross
sections, which correspond to resolved-photon processes. The latter were
measured by using a sub-sample with remnant jets. A comparison with various
theoretical predictions based on direct and resolved-photon processes showed
that our data prefer that with relatively large gluon contents in a photon at
small , with the next-to-leading order correction, and with a
charm-quark mass of 1.3 GeV.Comment: 26 pages, Latex format (article), 5 figures included, to be published
in Phys. Lett.
Measurement of the forward-backward asymmetries for charm- and bottom-quark pair productions at =58GeV with electron tagging
We have measured, with electron tagging, the forward-backward asymmetries of
charm- and bottom-quark pair productions at =58.01GeV, based on
23,783 hadronic events selected from a data sample of 197pb taken with
the TOPAZ detector at TRISTAN. The measured forward-backward asymmetries are
and , which are consistent with the standard model
predictions.Comment: 19 pages, Latex format (article), 5 figures included. to be published
in Phys. Lett.
Measurement of the cross-section and forward-backward charge asymmetry for the b and c-quark in e+e- annihilation with inclusive muons at sqrt(s) = 58 GeV
We have studied inclusive muon events using all the data collected by the
TOPAZ detector at sqrt(s)=58 GeV with an integrated luminosity of 273pb-1. From
1328 inclusive muon events, we measured the ratio R_qq of the cross section for
qq-bar production to the total hadronic cross section and forward-backward
asymmetry A^q_FB for b and c quarks. The obtained results are R_bb =
0.13+-0.02(stat)+-0.01(syst), R_cc = 0.36+-0.05(stat)+-0.05(syst), A^b_FB =
-0.20+-0.16(stat)+-0.01(syst) and A^c_FB = -0.17+-0.14(stat)+-0.02(syst), in
fair agreement with a prediction of the standard model.Comment: To be published in EPJ C. 24 pages, 12 figure
A Measurement of the Cross Section in Two-Photon Processes
We have measured the inclusive production cross section in a
two-photon collision at the TRISTAN collider. The mean of
the collider was 57.16 GeV and the integrated luminosity was 150 . The
differential cross section () was obtained in the
range between 1.6 and 6.6 GeV and compared with theoretical predictions, such
as those involving direct and resolved photon processes.Comment: 8 pages, Latex format (article), figures corrected, published in
Phys. Rev. D 50 (1994) 187
Observation of Highly Virtual Photon-Photon Collisions to Hadrons at TRISTAN
We have observed highly virtual () photon-photon collisions
to hadronic final states at . The integrated
luminosity of the data sample was 241pb. Both scattered beam-electrons
and scattered beam-positrons were detected using low-angle calorimeters (i.e.,
both photons were highly virtual, "double-tag"); we obtained 115 hadronic
events with an estimated background of . The cross section obtained
was pb in the GeV and GeV region, while the lowest order quark-parton model predicted 3.00pb.Comment: 14 pages, latex (revtex), 2 figures, available at
http://topsun1.kek.jp/~enomoto/dtag.p
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force
「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection
DOCK2 is involved in the host genetics and biology of severe COVID-19
「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target