Выбор хирургической тактики при распространенном гнойном перитоните

Summary. The article adduces the advantages and disadvantages of the traditional way of the treatment of the widespread festering peritonitis and programmed relaparotomy. The studies have shown that programmed relaparotomy is an efficient method in warning the development of the festering complications to abdominal cavity and hereunder, promotes the reduction of the complications and death-rate.Key words: widespread purulent peritonitis, programmed relaparotomy.РЕЗЮМЕ. В статье сопоставляются преимущества и недостатки традиционного способа лечения распространенного гнойного перитонита и программированных релапаротомий. Исследования показали, что программированная релапаротомия является эффективным методом в предупреждении развития гнойных осложнений брюшной полости и тем самым способствует снижению количества осложнений и летальности.Ключевые слова: распространенный гнойный перитонит, программированная релапаротомия

Неотложная эндовидеохирургия при острых заболеваниях органов брюшной полости

Summary. The basis of research included results of diagnostics and treatment by videoendoscopic interventions of 1812 patients with urgent surgical diseases of abdominal cavity and also the videolaparoscopy was done for patients with diagnostic purpose. During the carried-out researches it was established that the video laparoscopy is highly effective, safe, less traumatic way of surgical treatment. The quantity of the open laparotomies and their complications as eventration, postoperative hernias and suppurations of wounds was reduced.Key words:РЕЗЮМЕ. В основу исследования вошли результаты диагностики и лечения 1812 больных, которым были выполнены видеоэндоскопические вмешательства по поводу неотложных хирургических заболеваний брюшной полости, а также видеолапароскопия с диагностической целью. В ходе проведенных исследований установлено, что видеолапароскопия является высокоэффективным, безопасным, малотравматичным способом хирургического лечения. Сокращается количество напрасных лапаротомий и их осложнений в виде эвентраций, послеоперационных грыж и нагноений ран.Ключові слова:

Neutronic model of a fusion neutron source

The MCNPX numerical code has been used to model a fusion neutron source based on a combined stellaratormirror trap. Calculation results for the neutron spectrum near the inner wall and radial leakage of neutrons through the mantle surface of the fusion neutron source are presented.С помощью программы MCNPX разработана концепция термоядерного источника нейтронов на основе открытой ловушки. Представлены спектры нейтронов вблизи первой стенки, а также результаты расчетов радиальной утечки нейтронных потоков за пределы моделируемой системы.За допомогою програми MCNPX розроблена концепція термоядерного джерела нейтронів на основі відкритої пастки. Представлені спектри нейтронів поблизу першої стінки, а також результати розрахунків радіального витоку нейтронних потоків за межі модельованої системи

Neutronic model of a stellarator-mirror fusion-fission hybrid

The MCNPX numerical code has been used to model a compact concept for a fusion-fission reactor based on a combined stellarator-mirror trap. Calculation results for the radial leakage of neutrons through the mantle surface of the fission reactor are presented.С помощью программы MCNPX разработана концепция контролированного гибридного реактора не больших размеров на основе открытой ловушки. В работе представлены результаты радиальной утечки нейтронных потоков за пределы моделируемой системы.За допомогою програми MCNPX розроблена концепція контрольованого гібридного реактора не великих розмірів на основі відкритої пастки. В роботі представлено результати розрахунків виходу нейтронних потоків за межі модельованої системи

Selectively Modified Lactose and N-Acetyllactosamine Analogs at Three Key Positions to Afford Effective Galectin-3 Ligands †

Galectins constitute a family of galactose-binding lectins overly expressed in the tumor microenvironment as well as in innate and adaptive immune cells, in inflammatory diseases. Lactose ((β-D-galactopyranosyl)-(1→4)-β-D-glucopyranose, Lac) and N-Acetyllactosamine (2-acetamido-2-deoxy-4-O-β-D-galactopyranosyl-D-glucopyranose, LacNAc) have been widely exploited as ligands for a wide range of galectins, sometimes with modest selectivity. Even though several chemical modifications at single positions of the sugar rings have been applied to these ligands, very few examples combined the simultaneous modifications at key positions known to increase both affinity and selectivity. We report herein combined modifications at the anomeric position, C-2, and O-3′ of each of the two sugars, resulting in a 3′-O-sulfated LacNAc analog having a Kd of 14.7 µM against human Gal-3 as measured by isothermal titration calorimetry (ITC). This represents a six-fold increase in affinity when compared to methyl β-D-lactoside having a Kd of 91 µM. The three best compounds contained sulfate groups at the O-3′ position of the galactoside moieties, which were perfectly in line with the observed highly cationic character of the human Gal-3 binding site shown by the co-crystal of one of the best candidates of the LacNAc series

Palaeo-environmental evolution of Central Asia during the Cenozoic: new insights from the continental sedimentary archive of the Valley of Lakes (Mongolia)

The Valley of Lakes basin (Mongolia) contains a unique continental sedimentary archive, suitable for constraining the influence of tectonics and climate change on the aridification of Central Asia in the Cenozoic. We identify the sedimentary provenance, the (post)depositional environment and the palaeo-climate based on sedimentological, petrographical, mineralogical, and (isotope) geochemical signatures recorded in authigenic and detrital silicates as well as soil carbonates in a sedimentary succession spanning from ~34 to 21 Ma. The depositional setting was characterized by an ephemeral braided river system draining prograding alluvial fans, with episodes of lake, playa or open-steppe sedimentation. Metamorphics from the northern adjacent Neoarchean to late Proterozoic hinterlands provided a continuous influx of silicate detritus to the basin, as indicated by K-Ar ages of detrital muscovite (~798-728 Ma) and discrimination function analysis. The authigenic clay fraction is dominated by illite-smectite and “hairy” illite (K-Ar ages of ~34-25 Ma), which formed during coupled petrogenesis and precipitation from hydrothermal fluids originating from major basalt flow events (~32-29 and ~29-25 Ma). Changes in hydroclimate are recorded in [delta]18O and [delta]13C profiles of soil carbonates and in silicate mineral weathering patterns, indicating that comparatively humid to semi-arid conditions prevailed in the late(st) Eocene, changing into arid conditions in the Oligocene and back to humid to semi-arid conditions in the early Miocene. Aridification steps are indicated at ~34-33, ~31, ~28 and ~23 Ma and coincide with some episodes of high-latitude ice-sheet expansion inferred from marine deep-sea sedimentary records. This suggests that long-term variations in the ocean-atmosphere circulation patterns due to pCO2 fall, reconfiguration of ocean gateways and ice-sheet expansion in Antarctica could have impacted the hydroclimate and weathering regime in the basin. We conclude that the aridification in Central Asia was triggered by reduced moisture influx by westerly winds driven by Cenozoic climate forcing and the exhumation of the Tian Shan and Altai Mountains and modulated by global climate events

Reconstructions of deltaic environments from Holocene palynological records in the Volga delta, northern Caspian Sea

This article was made available through open access by the Brunel Open Access Publishing Fund.New palynological and ostracod data are presented from the Holocene Volga delta, obtained from short cores and surface samples collected in the Damchik region, near Astrakhan, Russian Federation in the northern Caspian Sea. Four phases of delta deposition are recognized and constrained by accelerated mass spectrometry (AMS) radiocarbon ages. Palynological records show that erosive channels, dunes (Baer hills) and inter-dune lakes were present during the period 11,500–8900 cal. BP at the time of the Mangyshlak Caspian lowstand. The period 8900–3770 cal. BP was characterized regionally by extensive steppe vegetation, with forest present at times with warmer, more humid climates, and with halophytic and xerophytic vegetation present at times of drought. The period 3770–2080 cal. BP was a time of active delta deposition, with forest or woodland close to the delta, indicating relatively warm and humid climates and variable Caspian Sea levels. From 2080 cal. BP to the present-day, aquatic pollen is frequent in highstand intervals and herbaceous pollen and fungal hyphae frequent in lowstand intervals. Soils and incised valley sediments are associated with the regional Derbent regression and may be time-equivalent with the ‘Medieval Warm Period’. Fungal spores are an indicator of erosional or aeolian processes, whereas fungal hyphae are associated with soil formation. Freshwater algae, ostracods and dinocysts indicate mainly freshwater conditions during the Holocene with minor brackish influences. Dinocysts present include Spiniferites cruciformis, Caspidinium rugosum, Impagidinium caspienense and Pterocysta cruciformis, the latter a new record for the Caspian Sea. The Holocene Volga delta is a partial analogue for the much larger oil and gas bearing Mio-Pliocene palaeo-Volga delta.Funding for the data collection and field work was provided from the following sources: 1 – IGCP-UNESCO 2003–2008 (Project 481 CASPAGE, Dating Caspian Sea Level Change); 2 – NWO, Netherlands Science Foundation and RFFI, Russian Science Foundation 2005–2008 (Programme: ‘VHR Seismic Stratigraphy and Paleoecology of the Holocene Volga Delta’); and 3 – BP Exploration (Caspian Sea) Sea Ltd. (Azeri-Chirag-Gunashli) 2005–2008 (‘Unravelling the Small-Scale Stratigraphy and Sediment Dynamics of the Modern Volga Delta Using VHR Marine Geophysics’). The palynological work was funded jointly by BP Exploration (Caspian Sea) Ltd., Delft University of Technology and KrA Stratigraphic Ltd. Ostracod analyses were funded by StrataData Ltd. and funding for two additional radiocarbon dates provided by Deltares

Inheritance of cleistogamy in interspecific hybridization of Gossypium barbadense L.

Studies of the inheritance and and variability of chasmo- and cleistogamous types of cotton flower on the base of intraspecies hybridization of Gossypium barbadense L. are an urgent genetical task, whose applications involve plant breeding and seed industry. The purpose of our study was to determine the genetic control of this trait on the base of the regularity of alternative chasmo- and cleistogamous types of flowers in intraspecific hybrids of G. barbadense species. It is of theoretical and practical significance in the development of isogenic forms, lines, and varieties with the fully closed cleistogamous type of flowers, possessing important commercial traits. A pioneering method was elaborated for determining the genetic control of chasmo- and cleistogamous types of flowers in inrtaspecific hybridization of Gossypium barbadense L., which was a continuation of our studies on interspecific cotton hybridization. Two strategies were applied to the genetic analysis of hybrids: (1) paired reciprocal hybrids F1, F2 and (2) backcrossed hybrids Fb. On the grounds of these strategies, we determined the inheritance mode of flower types in reciprocal hybrids F1, which possessed the c1cg1Cg2cg2 genotype with chasmogamous flowers without reciprocal difference. The classes segregated in F2 as follows: 1 (cg1cg1Cg2Cg2) : 2 (cg1cg1Cg2cg2) : 1 (cg1cg1cg2cg2), where cleistogamy was double recessive (This trait shows the complete dominance inheritance pattern.) Segregation into two phenotypic classes occurs in the 3:1 ratio, i.e., three plants with chasmogamous flowers per one cleistogamous. The segregation Fb is 1:1; i.e., 1 chasmogamous : 1 cleistogamous. Thus, cotton chasmogamy is inherited in F2 according to the Mendelian law in a completely dominant manner: 3:1, which is proven by the Fb cross

Теплопроводность водных растворов хлоридов металлов подгруппы бериллия

The paper presents experimental data on thermal conductivity of BeCl2 and SrCl2 salt aqueous solutions in the temperature range from 20 to 300 °С  and at various electrolyte concentrations  in mass percent. For the first time thermal conductivity of the system Н2О + BeCl2 has been investigated at high temperatures.The experimental results are described with the help of an empirical equation in the form of: λs = λo (1+ Am + Bm3/2 + Cm2),where λs  and λo – thermal conductivity coefficients of solution and water; A, B and C – coefficients depending on electrolyte nature; m – molality in units mol/kg.The formula error is less than  ±1 %.Приведены  экспериментальные данные по теплопроводности водных растворов солей BeCl2 и SrCl2 в области температур от 20 до 300 °С и при различных концентрациях электролита в массовых процентах. Впервые изучена теплопроводность системы Н2О + BeCl2 при высоких температурах.Экспериментальные результаты настоящей работы описываются эмпирическим уравнением в видеλp = λo (1+ Am + Bm3/2 + Cm2),где λp и λo – коэффициенты теплопроводности раствора и воды; А, В и С – коэффициенты, зависящие от природы электролита; m – моляльность в единицах моль/кг.Погрешность формулы меньше ±1 %