A Novel Features-Based Multivariate Gaussian Distribution Method for the Fraudulent Consumers Detection in the Power Utilities of Developing Countries

According to statistics, developing countries all over the world have suffered significant non-technical losses (NTLs) both in natural gas and electricity distribution. NTLs are thought of as energy that is consumed but not billed e.g., theft, meter tampering, meter reversing, etc. The adaptation of smart metering technology has enabled much of the developed world to significantly reduce their NTLs. Also, the recent advancements in machine learning and data analytics have enabled a further reduction in these losses. However, these solutions are not directly applicable to developing countries because of their infrastructure and manual data collection. This paper proposes a tailored solution based on machine learning to mitigate NTLs in developing countries. The proposed method is based on a multivariate Gaussian distribution framework to identify fraudulent consumers. It integrates novel features like social class stratification and the weather profile of an area. Thus, achieving a significant improvement in fraudulent consumer detection. This study has been done on a real dataset of consumers provided by the local power distribution companies that have been cross-validated by onsite inspection. The obtained results successfully identify fraudulent consumers with a maximum success rate of 75%. 2013 IEEE.This work was supported by the Qatar National Library.Scopus2-s2.0-8510734936

Key Features of SARS-CoV-2 and Available Therapies for COVID-19

The disease caused by severe acute respiratory syndrome (SARS-CoV2) is highly pathogenic and communicable infection, progressed in Wuhan city of China and then goes viral around the globe. The Genomic investigations exposed that Phylogenetically SARS-CoV2 resembles the other SARS-like bat viruses, therefore bats were also considered as the possible potential reservoir for SARS-CoV2. There are 2 prevalent types of SARS-CoV2, L type (~70%) and S type (~30%).The L strains are considered more infectious and virulent than the ancestral S strain. The positive sense single-stranded RNA genetic material contains 29891 nucleotides which codes for 9860 amino acids. The ORF1a/b is involved in carrying the translation of two (2) polyproteins, pp1a and pp1ab as well as the encoding of 16 NSPs (Non-structural proteins), and the leftover ORFS can bring about the encoding of non-essential and structural proteins. The origination source and transmission to humankinds is still not clear, but the intermediate hosts are supposed to have a significant role in the transfer and emergence of SARS-CoV2 from bats to humans. There is still no approved drug or vaccine available for Covid-19. In the current review, we condense and fairly evaluate the emergence and pathogenicity of SARS-CoV2, SARS-CoV and MERS-CoV. Moreover, we also discuss the treatment and vaccine developments strategies for Covid-19

Cholangiocarcinoma in a Resected Biliary Cyst: Importance of Follow-up

Biliary cysts are rare cystic dilatations of the biliary tree. Biliary cysts are positively associated with several significant complications, amongst them, cholangiocarcinoma befalls the most dreadful one. The elevated incidence is 20-30% in the unresected cyst and 0.7% in resected cysts. Magnetic resonance imaging (MRI) scan, magnetic resonance cholangiopancreatography (MRCP) or a contrast-enhanced computed tomography (CECT) is applied for the initial diagnostic study but the ultimate diagnosis ordinarily requires the tissue biopsy. Currently, the sole curative option involves the complete surgical resection of the lesion, with standard chemotherapy and active radiation applied as an alternative for the unresectable tumors. Despite the curative surgery the percentage of eternal recurrence of the tumor indefinitely persists, and effective post-surgical surveillance is reasonably demanded. We report a case of 29-year-old female with local recurrence of cholangiocarcinoma in a previously resected biliary cyst type I. The curative resection of the choledochal cyst only minimizes the considerable risk of the possible development of future cholangiocarcinoma but it does not completely prevent it. The appropriate follow-up for potential patients who have been typically treated for a biliary cyst is unclear. The lethal course of cholangiocarcinoma is believed due to its slow asymptomatic growing phase. Therefore, to adequately screen for malignancy, periodic imaging along with annual liver tests represents a reasonable approach to prevent the possible development of this appalling complication.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Calpastatin (CAST) gene polymorphism in Kajli, Lohi and Thalli sheep breeds

Calpastatin-encoding gene (<i>CAST</i>) is located on the fifth chromosome of sheep and it plays an  important role in the development of muscles and in meat tenderness. The present study was conducted to  investigate a calpastatin (CAST) gene polymorphism in Pakistani Thalli, Lohi and Kajli sheep breed. Random blood samples were collected from 300 animals (100 samples from each Thalli, Lohi and Kajli breeds).  Genomic DNA was extracted using phenol-chloroform extraction method. A 622 bp CAST gene segment (exon 1C/1D region) was amplified by polymerase chain reaction (PCR) using ovine specific primers. Restriction  fragment length polymorphisms (RFLPs) in the amplified fragments were studied using Msp1 restriction  enzyme. Frequencies of MM, MN and NN genotypes were found to be 77, 20 and 3% in Lohi breed and 68, 26 and 6% in Kajli breed respectively. In Thalli sheep, only the MM (80%) and MN (20%) genotypes were  detected. Chi-Square test (p < 0.05) showed that all the three populations used in this study were in Hardy-Weinberg equilibrium. By comparing the results of this study with those of previous studies, it seems that the MM genotype is the dominant genotype and the M allele is the dominant allele in small ruminant breeds belonging to different geographical locations.Key words: Thalli, Lohi, CAST gene, Kajli, polymorphism, Msp1, PCR-RFLP

Neurological involvement associated with plasmodium vivax malaria from Pakistan

Plasmodium vivax is the most common specie causing malaria outside Africa with approximately 13.8 million reported cases worldwide. We report case of P. vivax infection with cerebral involvement. A nine year old boy presented with high grade fever accompanied by projectile vomiting and abnormal behavior later he developed seizures, shock, and unconsciousness. P. vivax monoinfection was diagnosed based on peripheral smears and PCR. After antimalarial therapy, patient made full recovery. Current case highlights increasing trend of cerebral complications caused by P. vivax

Hybrid and Composite Crystalline Materials

A facile approach for developing an interfacial solar evaporator by heat localization of solar-thermal energy conversion at water-air liquid composed by in-situ polymerization of Fe2O3 nanoparticles (Fe2O3@PPy) deposited over a facial sponge is proposed. The demonstrated system consists of a floating solar receiver having a vertically cross-linked microchannel for wicking up saline water. The in situ polymerized Fe2O3@PPy interfacial layer promotes diffuse reflection and its rough black surface allows Omni-directional solar absorption (94%) and facilitates efficient thermal localization at the water/air interface and offers a defect-rich surface to promote heat localization (41.9 °C) and excellent thermal management due to cellulosic content. The self-floating composite foam reveals continuous vapors generation at a rate of 1.52 kg m−2 h−1 under one 1 kW m−2 and profound evaporating efficiency (95%) without heat losses that dissipates in its surroundings. Indeed, long-term evaporation experiments reveal the negligible disparity in continuous evaporation rate (33.84 kg m−2/8.3 h) receiving two sun solar intensity, and ensures the stability of the device under intense seawater conditions synchronized with excellent salt rejection potential. More importantly, Raman spectroscopy investigation validates the orange dye rejection via Fe2O3@PPy solar evaporator. The combined advantages of high efficiency, self-floating capability, multimedia rejection, low cost, and this configuration are promising for producing large-scale solar steam generating systems appropriate for commercial clean water yield due to their scalable fabrication

Characterization and differentiation potential of mesenchymal stem cells isolated from multiple canine adipose tissue sources

Background Mesenchymal stem cells (MSCs) are undifferentiated cells that can give rise to a mesoderm lineage. Adipose-derived MSCs are an easy and accessible source for MSCs isolation, although each source of MSC has its own advantages and disadvantages. Our study identifies a promising source for the isolation and differentiation of canines MSCs. For this purpose, adipose tissue from inguinal subcutaneous (SC), perirenal (PR), omental (OM), and infrapatellar fat pad (IPFP) was isolated and processed for MSCs isolation. In the third passage, MSCs proliferation/metabolism, surface markers expression, in vitro differentiation potential and quantitative reverse transcription PCR (CD73, CD90, CD105, PPARγ, FabP4, FAS, SP7, Osteopontin, and Osteocalcin) were evaluated. Results Our results showed that MSCs derived from IPFP have a higher proliferation rate, while OM-derived MSCs have higher cell metabolism. In addition, MSCs from all adipose tissue sources showed positive expression of CD73 (NT5E), CD90 (THY1), CD105 (ENDOGLIN), and very low expression of CD45. The isolated canine MSCs were successfully differentiated into adipogenic and osteogenic lineages. The oil-red-O quantification and adipogenic gene expression (FAS, FabP4, and PPARγ) were higher in OM-derived cells, followed by IPFP-MSCs. Similarly, in osteogenic differentiation, alkaline phosphatase activity and osteogenic gene (SP7 and Osteocalcin) expression were higher in OM-derived MSCs, while osteopontin expression was higher in PR-derived MSCs. Conclusion In summary, among all four adipose tissue sources, OM-derived MSCs have better differentiation potential toward adipo- and osteogenic lineages, followed by IPFP-MSCs. Interestingly, among all adipose tissue sources, MSCs derived from IPFP have the maximum proliferation potential. The characterization and differentiation potential of canine MSCs isolated from four different adipose tissue sources are useful to assess their potential for application in regenerative medicine

Beyond climate change : Examining the role of environmental justice, agricultural mechanization, and social expenditures in alleviating rural poverty

Extreme weather events and extreme poverty are two sides of the same coin, with far-reaching consequences for emerging nations like Pakistan. Rural people are more likely to experience poverty and inequality as climate change worsens. This research aspires to close the gap between environmental ethics and justice by investigating how climate change issues contribute to poverty in Pakistan. The study used Robust Least Squares (RLS) regression to analyze the impact of water scarcity, extreme temperatures, and excessive rainfall on rural poverty in Pakistan from 1990Q1 to 2022Q4. Further, the study examines the effect of environmental justice in�terventions, access to healthcare and education, agricultural value-added and agricultural mechanization on the country’s rural poverty. Results reveal that climate change contributes to rural poverty in Pakistan, while environmental justice initiatives, healthcare access, and agricultural automation alleviate poverty incidence. The Impulse Response Function (IRF) estimates suggested that rural poverty will be exacerbated over the next decade by water scarcity, high temperatures, and low agricultural value added but alleviated by excessive rainfall, environmental justice intervention, healthcare access, and agricultural mechanization. According to Variance Decomposition Analysis (VDA) projections, agricultural value added will substantially impact rural poverty by 2032, increasing it by 11.431%. Addressing these problems requires policymakers to prioritize the interests of the most marginalized groups by fostering fair results. Policies should cut GHG emissions and encourage sus�tainable development to combat climate change. Modernizing farming techniques and expanding access to healthcare are also necessary for increasing efficiency and production. It is essential to execute environmental justice interventions so that all communities have access to environmental resources and protections equitably. Promoting equitable outcomes and reducing poverty in Pakistan’s climate change context may be achieved by closing the gap between environmental ethics and justice

Fossil Energy Demand and Economic Development in BRICS Countries

Energy is considered the oxygen of an economy fueling all economic activities. Energy utilization and its type have an intertemporal and size-based effect on economic development. Therefore, this study empirically analyzes the relationship of fossil energy consumption with economic development in the case of BRICS countries between 1990 and 2019. Fully modified ordinary least squares is used with the quadratic function of coal, oil, and gas consumption to assess the size-based effect across time. This study shows that coal and natural gas consumption follows the inverted U-shaped relationship with HDI, while coal consumption shows a negative relationship with HDI. Hence, coal and gas energy assists in development when its share is small, while over-consumption hampers development. The BRICS countries should optimize coal and gas consumption with respect to economic development. Reducing fossil energy should be substituted with alternative clean energy resources by using advanced technology such as the gasification process

Genetic Investigation of Consanguineous Pakistani Families Segregating Rare Spinocerebellar Disorders

Spinocerebellar disorders are a vast group of rare neurogenetic conditions, generally characterized by overlapping clinical symptoms including progressive cerebellar ataxia, spastic paraparesis, cognitive deficiencies, skeletal/muscular and ocular abnormalities. The objective of the present study is to identify the underlying genetic causes of the rare spinocerebellar disorders in the Pakistani population. Herein, nine consanguineous families presenting different spinocerebellar phenotypes have been investigated using whole exome sequencing. Sanger sequencing was performed for segregation analysis in all the available individuals of each family. The molecular analysis of these families identified six novel pathogenic/likely pathogenic variants; ZFYVE26: c.1093del, SACS: c.1201C>T, BICD2: c.2156A>T, ALS2: c.2171-3T>G, ALS2: c.3145T>A, and B4GALNT1: c.334_335dup, and three already reported pathogenic variants; FA2H: c.159_176del, APTX: c.689T>G, and SETX: c.5308_5311del. The clinical features of all patients in each family are concurrent with the already reported cases. Hence, the current study expands the mutation spectrum of rare spinocerebellar disorders and implies the usefulness of next-generation sequencing in combination with clinical investigation for better diagnosis of these overlapping phenotypes