Ecological, Biological and Hematological Index of the Blood Analysis of Sturgeons (Acipenser) in the Caspian Sea

The Caspian is a unique drainless water body with no connection to the ocean. This study of the peculiarities of blood cell composition of the Russian sturgeon (Acipenser güldenstädtii) and sevruga (Acipenser stellatus) revealed minor destructive disorders of the blood cells. The number of blood cells also deviated from conditional norms. The study of the leukocyte profile of sturgeons showed the granular forms of leukocytes, band neutrophils and eosinophils, and segmentonuclear neutrophils and eosinophils. The total number of granulocytes in the blood of the Russian sturgeon was increased, which indicated the activation of the body’s protective systems in response to the anthropogenic load. In cytomorphological terms, the destructive disorders were revealed. Such phenomena are associated with the ever-increasing anthropogenic load on the biocenoses of natural reservoirs. Summarizing the results, it can be concluded that the quantitative indicators of red blood in the Russian sturgeon (Acipenser gueldenstaedtii) and sevruga (Acipenser stellatus) caught off of the Dagestan coast of the Caspian Sea were reduced in the spring of 2018 compared to 2016, but were in the normal range given in the literature. The concentration of hemoglobin in the Russian sturgeon and sevruga in 2016 was 13% and 15% higher than in 2014, respectively. This phenomenon could be a measure to compensate for the lack of oxygen in various fish tissues and organs. Keywords: Russian sturgeon, red blood cells, lymphocytes, eosinophils, neutrophils, anisocytosis, cytolysis of red blood cell

The role of complement system and other inflammatory factors in the development of age-related macular degeneration

The article is a review of literature on the role of complement system and inflammatory factors in the development of age-related macular degeneration. The review uses materials of domestic and foreign researchers. The clinical characteristics of age-related macular degeneration are presented, the role of genetic factors, complement factors, biomarkers of inflammation and alternative pathway of complement activation in the pathogenesis and risk of age-related macular degeneration is determined. Age-related macular degeneration is a chronic progressive multifactorial disease that affects macular area of the retina and is the main cause of loss of central vision in patients of older age group. The most important genetic factors are chromosome 1 (1q32) including complement factor H and complement factor H related genes and chromosome 10 (10q31). Variants associated with a moderate effect on developmental risk were identified in C3, complement factor I and complement factor B genes. In the pathogenesis of age-related macular degeneration, the key role is played by the damaged regulation of the alternative complement pathway. Single nucleotide polymorphisms in complement genes that affect the risk of development of age-related macular degeneration are predominantly involved in the alternative pathway of activation of the complement system. In pathomorphological studies, the initial localization of the pathological process of this pathology was established to be a complex of retinal pigment epithelium, Bruch’s membrane, and choriocapillaries followed by loss of photoreceptor function. The review of studies of systemic inflammatory biomarkers, cytokines, vascular endothelial growth factors in peripheral blood, blood serum, aqueous humour at various stages and forms of age-related macular degeneration is presented

Использование АБИС для мониторинга данных об обеспеченности учебного процесса в вузе

The author describes the functional features of “Book availability” module (based on the example of Ruslan ILS) providing library information support of education process in the higher education institutions according to effective education standards and regulations of the learning aids collection development/ She examines the benefits of the digital book sufficiency catalog as compared to its printed version. Due to IT application, the labor time expenditures decrease, less efforts of library staff are required, information delivery is more time-efficient and accurate, errors on the output reports are eliminated. The functionality of the “Book availability” module enables to generate reports with defined characteristics. The list of additional reports that can be efficiently used to monitor data on curriculum support at the higher education institutions is given. The author concludes that the digital book availability catalog is an important and flexible instrument to add, edit and deliver data on the availability of learning aids to support basic curricula; in user services it functions as a reference aid, as it comprises reference books on curriculum and education processes.Раскрыто функциональное назначение модуля «Книгообеспеченность» (на базе АБИС «Руслан») в организации библиотечно-информационной поддержки учебного процесса в вузе (на примере Воронежского государственного аграрного университета им. императора Петра I) согласно действующим образовательным стандартам и нормативным требованиям к комплектованию фонда учебной и учебно-методической литературой. Представлены преимущества использования автоматизированной картотеки книгообеспеченности в сравнении с её печатным вариантом, благодаря которым снижаются затраты рабочего времени, облегчается труд библиотекаря, возрастает оперативность получения информации, уменьшается вероятность ошибки при получении выходных форм отчётов. Охарактеризованы ресурсы модуля АРМ «Книгообеспеченность» для создания дополнительных отчётов с заданными характеристиками. Приведён перечень дополнительных форм отчётности, которые служат активным инструментом для мониторинга данных об обеспеченности учебного процесса в вузе. Сделан вывод: автоматизированная картотека книгообеспеченности - это важный и гибкий инструмент, предназначенный для наполнения, редактирования и предоставления сведений об обеспеченности учебной и учебно-методической литературой основных образовательных программ в вузе; в процессе обслуживания пользователей вузовской библиотеки эта картотека может выполнять функции справочного аппарата, так как содержит в своей структуре справочники, отражающие информацию об учебном процессе

Socio-cultural Transformations in Traditional Societies in the Context of Globalization

The paper presents a study of socio-cultural transformations in traditional societies in the context of globalization. The authors emphasize that global changes have affected all aspects of traditional societies using the socio-cultural approach. Postmodern culture, the problems of self-identification at different levels of the human community are the main consequences of globalization. The differences between the social strata are leveled through the introduction of a mass unified consumerism culture, desubjectivation of the individual and public institutions takes place. The social space has changed, the forms of human interaction with the external environment and interpersonal communications have changed. Previously existing models of communications, which were direct interpersonal relations, were replaced in the modern world by forms of mediated communication. They bring new patterns of behavior and understanding of sociocultural reality. Changing the traditional family as an important subject of socialization and translation of spiritual values leads to further transformations in society.     Keywords: sociocultural transformations; values; globalization; society; traditions

Youth Extremist Attitudes Driven By Destabilization of Traditional Culture

The paper considers a relevant and burning issue of youth extremism. The authors analyze the reasons for radical and extreme attitudes of the youth and state that extremism among youth is caused by destabilization of the traditional culture. The core of the traditional culture is purposefully destabilized by creating some pseudo-scientific problems and assigning heroic features to minor people in history. Many young people are conscious in their choice of traditionalism with different archaic violence practices which try to openly challenge the modern civility standardized under liberal capitalism and a consumerist society. Mass culture extensively contributes into the development and expansion of the youth extremism patterns. The paper underlines that overall social psychological attitude and confidence of young people in their future, a developed self-consciousness and tradition succession play a huge role in combatting extremism among the youth. Traditional behavioral aspects could oppose extremist manifestations which are rejected at a deep ethnical level of culture, because they contradict its nature and search for development in the today’s world.     Keywords: youth; extremism; traditions; destabilization; culture

Клинический случай предоперационной лучевой терапии с последующей операцией у больного гигантской первичной G1 забрюшинной липосаркомой

Despite the development of contemporary surgical management of retroperitoneal liposarcomas, local recurrence remains the major challenge in the treatment of these tumors. Currently, surgery is the main treatment option for liposarcoma. The international cancer community faces a global goal — the development of new combined treatment options for the treatment of retroperitoneal liposarcoma to reduce the postoperative recurrence rate and increase the overall survival. This article presents the world literature data on the treatment of retroperitoneal liposarcomas and demonstrates a case report describing treatment of a patient with this disease in the N. N. Blokhin NMRC of Oncology.Несмотря на развитие современных технологий хирургических методов лечения, основной проблемой лечения забрюшинных липосарком является их местнорецидивирующий характер. В настоящее время ведущим методом лечения этого заболевания является хирургический. Перед мировым онкологическим сообществом стоит глобальная цель — разработка новых подходов в комбинированном лечении больных забрюшинными липосаркомами, что позволит снизить частоту рецидивов в послеоперационном периоде и повысить общую выживаемость пациентов с данной нозологией. В представленной статье представлены данные мировой литературы по методам лечения больных с забрюшинными липосаркомами, а также демонстрируется клинический случай лечения пациента с указанной нозологией в НМИЦ онкологии им. Н.Н. Блохина

Сопряженные процессы на основе реакции окисления оксида углерода (II).

The catalytic systems are proposed to oxidize CO: solutions PdX2-organic solvent, where solvent is 1,4- dioxan or tetrahydrofuran, X – Br, I. It was shown that a number of conjugated processes proceed in these systems.Предложены новые каталитические системы для окисления СО: растворы PdX2- органический растворитель, где Х – галоид (лучше бром или иод), органический растворитель – 1.4-диоксан или тетрагидрофуран. Показано, что в этих системах протекает ряд сопряженных процессов

Выбор режимов фракционирования при стереотаксической лучевой терапии больных ранними стадиями рака легкого

Stereotactic body radiotherapy for early stage non-small-cell lung cancer was, is, and will remain the key subject of discussions between radiation oncologists and surgeons. Despite the positive treatment outcomes reported in some large studies on efficacy of the stereotactic radiotherapy, its use instead of surgery may not always be an unconditional decision. However, stereotactic radiotherapy opens new treatment options in patients who are inoperable or refused surgery. This is possibly due to the high accuracy of modern linear accelerators, which allow to reduce the toxicity of radiotherapy and achieve an almost identical overall survival rate compared to surgery.Стереотаксическая лучевая терапия больных ранними стадиями немелкоклеточного рака легкого была, есть и останется основной темой для дискуссии между радиотерапевтами и хирургами. Несмотря на представленные положительные результаты лечения в отдельных крупных исследованиях по эффективности стереотаксической лучевой терапии (Stereotactic Body Radiotherapy — SBRT), ее назначение вместо хирургического лечения не всегда может быть безоговорочным решением. Однако стереотаксическая радиотерапия открывает новые возможности лечения в случае отказа пациента от хирургического лечения или невозможности проведения операции. Это стало возможно благодаря высокой точности современных линейных ускорителей, которые позволяют снизить токсичность лучевой терапии, добиться примерно равных показателей общей выживаемости в сравнении с хирургическим лечением