The isolation and localization of human gene sequences and their use in the diagnosis of chromosomal abnormalities

Imperial Users onl

Motor Nerve Conduction Studies in Patients with Chronic Renal failure

Background: Detection of frequency of neuropathy in patients with chronic renal failure by utilizing nerve conduction studies (NCS) Methods: In this cross sectional comparative study, thirty patients with chronic renal failure, of at least three months duration were included. Patients were further segregated into two groups. In group I twenty patients on regular hemodialysis and in group II ten patients with end stage renal failure waiting for hemodialysis were included. Motor nerve conduction studies were done by testing median nerve and peroneal nerve, in upper and lower limbs respectively. Parameters of motor conduction studies checked were proximal and distal motor latencies, amplitudes and conduction velocities. Results: In group I, 93% of patients and in group II, 87% of patients showed altered motor nerve conduction parameters. Conclusions There is predominantly distal nerve dysfunction and peripheral nerves of lower limb are affected more than upper limb. Sub clinical neuropathies can be detected by nerve conduction studies

Marriage Provisions Polygamy in the Three Divine Books

There are provisions for marriage for each of the three religions, which we found through the revealed heavenly books. Marriage is considered an obligation in Judaism, except for some Jewish sects that forbid marriage. In Judaism, it is not permissible for a Jew to marry a non-Jew and vice versa. There is no dowry for women in Judaism, while the Lebanese Personal Status Law clearly states a dowry for Jewish women. The marriage contract in Judaism takes place in three steps, the request for the hand of the girl, the marriage contract, and the realization of the marriage. The Torah, through several texts, permitted polygamy and allowed a man to marry more than one. The origin of Christianity is the non-marriage and the call to monasticism. Although there are texts in the Bible that stipulate not to marry, there are churches that encourage marriage for procreation. The rulings on marriage differ from one church to another. In Orthodox Churches, marriage decisions are based on two steps, the engagement and the service of the wreath. The position of the Catholic Church on marriage is emerging from the decisions of the Second Vatican Council in .1965 Despite the presence of several churches that have opposed the second marriage, the Bible contains several texts that allow polygamy. Moreover, other churches consider second marriage to be a sacred divine law. The Islamic religion permitted marriage for every able-bodied man and made it revolve around three rulings: obligatory, desirable, and celibacy. Marriage in Islam is preceded by engagement and dowry, with three conditions for the completion of the marriage: consent, guardianship, and competence. Our true religion has permitted polygamy, and this is what we find clear through the texts of the Noble Qur'an. While allowing polygamy, Islamic law imposed certain conditions and justifications for that polygamy. Looking at the provisions of marriage in the three heavenly books, we found that the Torah allowed polygamy without specifying any number, and the Bible prohibited polygamy and then permitted it with only one, while the Holy Qur'an refined all of this and made it four as a maximum. Keywords: marriage, the provisions of polygamy: Judaism, Christianity, Islam

Time Course of Geometrical and Mechanical Changes in a Mouse Model of Marfan Syndrome

Ascending thoracic aortic aneurysm (ATAA) can be asymptomatic for many years, but it can also result in a patient’s death if not acted upon early. The cost to surgically act upon an ATAA has a very high risk. Thus, an accurate assessment of ATAA failure risk is a major clinical need. To find evidence of patients with ATAA risks, biomarkers may be used to predict the abnormality. These biomarkers include geometrical, genetic, microstructural, and biofluids information. To obtain this data, experimental and computational models are used. This paper reports experimental data for 3-month-old male and female mutant mice that are a model of ATAA associated with Marfan syndrome and corresponding control wild type mice. The results include the unloaded diameter and lengths of different segments of the aorta, the thickness of the aortic wall, the diameter change of the aorta with pressure, and circumferential stress versus stretch plots. From statistical analysis, we found that ascending and superior abdominal aorta are significantly different according to genotype and by sex, for the diameter increase due to pressure. However, further experiments are required to statistically analyze the descending and inferior abdominal aorta. Lastly, the stretch ratio vs. stress graphs indicates trends of a higher Young’s Modulus in mutant mice with Marfan syndrome than wild type mice. This suggests that the stresses experienced by the aorta in the mutant mice are higher than wild type mice

Automatic reactive power compensator: An open loop approach

This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.Over the last few years the sudden increase of the use of non-linear loads such as personal computers and TV sets created a Power Factor (PF) problem. Although such loads consume relatively small amount of power, however the large number of these loads resulted on huge distortion in the power quality. One major element of the power quality is the PF. This thesis proposes an automatic PF correction circuit which can generate a leading as well as lagging reactive current which can be used to improve the PF. The proposed circuit consists of two semiconductor switches and two capacitors and an inductor. Such configuration is capable of generating not only variable reactive current, but also with very low distortion compared to other techniques, which usually generate a high distortion reactive current. The proposed compensator is controlled by a microprocessor which generates the required switching pulses. The thesis also covers the protection circuits used to protect the semiconductor switches (MOSFETs) during the turn-on and turn-off times

The Effectiveness Of Handwriting Without Tears Programme In Teaching Handwriting To Students On The Autism Spectrum

Objective: This research sought to determine the effectiveness of the Handwriting without tears ® programme when used in a specialized school in Doha that caters exclusively to autistic students. Method: This was a quantitative experimental study which included two cohorts, a control group (n=18) improving their handwriting skills through traditional methods and a treatment group (n=18) that received interventions based on HWT curriculum and resources. Results: Both groups demonstrated improvements in their handwriting skills however the treatment group exhibited greater difference between pre-test and post-test scores and mastered more competency levels using the HWT® interventions and resources. Conclusion: The study supports the usage of Handwriting without tears ® with autistic students when intending to improve their handwriting skills