Hypothalamic actions of neuromedin U.

The central nervous system and gut peptide neuromedin U (NMU) inhibits feeding after intracerebroventricular injection. This study explored the hypothalamic actions of NMU on feeding and the hypothalamo-pituitary-adrenal axis. Intraparaventricular nucleus (intra-PVN) NMU dose-dependently inhibited food intake, with a minimum effective dose of 0.1 nmol and a robust effect at 0.3 nmol. Feeding inhibition was mapped by NMU injection into eight hypothalamic areas. NMU (0.3 nmol) inhibited food intake in the PVN (0-1 h, 59 ± 6.9% of the control value; P < 0.001) and arcuate nucleus (0-1 h, 76 ± 10.4% of the control value; P < 0.05). Intra-PVN NMU markedly increased grooming and locomotor behavior and dose-dependently increased plasma ACTH (0.3 nmol NMU, 24.8 ± 1.9 pg/ml; saline, 11.4 ± 1.0; P < 0.001) and corticosterone (0.3 nmol NMU, 275.4 ± 40.5 ng/ml; saline, 129.4 ± 25.0; P < 0.01). Using hypothalamic explants in vitro, NMU stimulated CRH (100 nM NMU, 5.9 ± 0.95 pmol/explant; basal, 3.8 ± 0.39; P < 0.01) and arginine vasopressin release (100 nM NMU, 124.5 ± 21.8 fmol/explant; basal, 74.5 ± 7.6; P < 0.01). Leptin stimulated NMU release (141.9 ± 20.4 fmol/explant; basal, 92.9 ± 9.4; P < 0.01). Thus, we describe a novel role for NMU in the PVN to stimulate the hypothalamo-pituitary-adrenal axis and locomotor and grooming behavior and to inhibit feeding

Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat.

Intracerebroventricular (ICV) administration of the hypothalamic neuropeptide neuromedin U (NMU) or the adipostat hormone leptin increases plasma ACTH and corticosterone. The relationship between leptin and NMU in the regulation of the hypothalamo-pituitary adrenal (HPA) axis is currently unknown. In this study, leptin (1 nM) significantly increased the release of CRH from ex vivo hypothalamic explants by 207 ± 8.4% (P < 0.05 vs. basal), an effect blocked by the administration of anti-NMU IgG. The ICV administration of leptin (10 μg, 0.625 nmol) increased plasma ACTH and corticosterone 20 min after injection [plasma ACTH (picograms per milliliter): vehicle, 63 ± 20, leptin, 135 ± 36, P < 0.05; plasma corticosterone (nanograms per milliliter): vehicle, 285 ± 39, leptin, 452 ± 44, P < 0.01]. These effects were partially attenuated by the prior administration of anti-NMU IgG. Peripheral leptin also stimulated ACTH release, an effect attenuated by prior ICV administration of anti-NMU IgG. We examined the diurnal pattern of hypothalamic NMU mRNA expression and peptide content, plasma leptin, and plasma corticosterone. The diurnal changes in hypothalamic NMU mRNA expression were positively correlated with hypothalamic NMU peptide content, plasma corticosterone, and plasma leptin. The ICV administration of anti-NMU IgG significantly attenuated the dark phase rise in corticosterone [corticosterone (nanograms per milliliter): vehicle, 493 ± 38; NMU IgG, 342 ± 47 (P < 0.05)]. These studies suggest that NMU may play a role in the regulation of the HPA axis and partially mediate leptin-induced HPA stimulation. Copyright © 2006 by The Endocrine Society

Three-loop matching coefficients for hot QCD: Reduction and gauge independence

We perform an integral reduction for the 3-loop effective gauge coupling and screening mass of QCD at high temperatures, defined as matching coefficients appearing in the dimensionally reduced effective field theory (EQCD). Expressing both parameters in terms of a set master (sum-) integrals, we show explicit gauge parameter independence. The lack of suitable methods for solving the comparatively large number of master integrals forbids the complete evaluation at the moment. Taking one generic class of masters as an example, we highlight the calculational techniques involved. The full result would allow to improve on one of the classic probes for the convergence of the weak-coupling expansion at high temperatures, namely the comparison of full and effective theory determinations of the spatial string tension. Furthermore, the full result would also allow to determine one new contribution of order O(g**7) to the pressure of hot QCD.Comment: 19 pages, 2 figures. v2: new Section 6 discussing applications, to match journal versio

A multi-wavelength census of star formation activity in the young embedded cluster around Serpens/G3-G6

Aims. The aim of this paper is to characterise the star formation activity in the poorly studied embedded cluster Serpens/G3-G6, located ~ 45' (3 pc) to the south of the Serpens Cloud Core, and to determine the luminosity and mass functions of its population of Young Stellar Objects (YSOs). Methods. Multi-wavelength broadband photometry was obtained to sample the near and mid-IR spectral energy distributions to separate YSOs from field stars and classify the YSO evolutionary stage. ISOCAM mapping in the two filters LW2 (5-8.5 um) and LW3 (12-18 um) of a 19' x 16' field was combined with JHKs data from 2MASS, Ks data from Arnica/NOT, and L' data from SIRCA/NOT. Continuum emission at 1.3 mm (IRAM) and 3.6 cm (VLA) was mapped to study the cloud structure and the coldest/youngest sources. Deep narrow band imaging at the 2.12 um S(1) line of H2 from NOTCam/NOT was obtained to search for signs of bipolar outflows. Results. We have strong evidence for a stellar population of 31 Class II sources, 5 flat-spectrum sources, 5 Class I sources, and two Class 0 sources. Our method does not sample the Class III sources. The cloud is composed of two main dense clumps aligned along a ridge over ~ 0.5 pc plus a starless core coinciding with absorption features seen in the ISOCAM maps. We find two S-shaped bipolar collimated flows embedded in the NE clump, and propose the two driving sources to be a Class 0 candidate (MMS3) and a double Class I (MMS2). For the Class II population we find a best age of ~ 2 Myr and compatibility with recent Initial Mass Functions (IMFs) by comparing the observed Class II luminosity function (LF), which is complete to 0.08 L_sun, to various model LFs with different star formation scenarios and input IMFs.Comment: 18 pages, 16 figures, 3 online tables, accepted by A&

Gravitational waves from intermediate-mass black holes in young clusters

Massive young clusters (YCs) are expected to host intermediate-mass black holes (IMBHs) born via runaway collapse. These IMBHs are likely in binaries and can undergo mergers with other compact objects, such as stellar mass black holes (BHs) and neutron stars (NSs). We derive the frequency of such mergers starting from information available in the Local Universe. Mergers of IMBH-NS and IMBH-BH binaries are sources of gravitational waves (GWs), which might allow us to reveal the presence of IMBHs. We thus examine their detectability by current and future GW observatories, both ground- and space-based. In particular, as representative of different classes of instruments we consider Initial and Advanced LIGO, the Einstein gravitational-wave Telescope (ET) and the Laser Interferometer Space Antenna (LISA). We find that IMBH mergers are unlikely to be detected with instruments operating at the current sensitivity (Initial LIGO). LISA detections are disfavored by the mass range of IMBH-NS and IMBH-BH binaries: less than one event per year is expected to be observed by such instrument. Advanced LIGO is expected to observe a few merger events involving IMBH binaries in a 1-year long observation. Advanced LIGO is particularly suited for mergers of relatively light IMBHs (~100 Msun) with stellar mass BHs. The number of mergers detectable with ET is much larger: tens (hundreds) of IMBH-NS (IMBH-BH) mergers might be observed per year, according to the runaway collapse scenario for the formation of IMBHs. We note that our results are affected by large uncertainties, produced by poor observational constraints on many of the physical processes involved in this study, such as the evolution of the YC density with redshift.[abridged]Comment: 29 pages, 4 figures, accepted for publication in Ap

On creating mass/matter by extra dimensions in the Einstein-Gauss-Bonnet gravity

Kaluza-Klein (KK) black hole solutions in the Einstein-Gauss-Bonnet (EGB) gravity in $D$ dimensions obtained in the current series of the works by Maeda, Dadhich and Molina are examined. Interpreting their solutions, the authors claim that the mass/matter is created by the extra dimensions. To support this claim, one needs to show that such objects have classically defined masses. We calculate the mass and mass flux for 3D KK black holes in 6D EGB gravity whose properties are sufficiently physically interesting. Superpotentials for arbitrary types of perturbations on arbitrary curved backgrounds, recently obtained by the author, are used, and acceptable mass and mass flux are obtained. A possibility of considering the KK created matter as dark matter in the Universe is discussed.Comment: 15 pages, no figures, minor changes related to the Journal publication with adding two references in footnote

Heavy fermions and two loop electroweak corrections to b→s+γb\rightarrow s+\gamma

Applying effective Lagrangian method and on-shell scheme, we analyze the electroweak corrections to the rare decay $b\rightarrow s+\gamma$ from some special two loop diagrams in which a closed heavy fermion loop is attached to the virtual charged gauge bosons or Higgs. At the decoupling limit where the virtual fermions in inner loop are much heavier than the electroweak scale, we verify the final results satisfying the decoupling theorem explicitly when the interactions among Higgs and heavy fermions do not contain the nondecoupling couplings. Adopting the universal assumptions on the relevant couplings and mass spectrum of new physics, we find that the relative corrections from those two loop diagrams to the SM theoretical prediction on the branching ratio of $B\rightarrow X_{_s}\gamma$ can reach 5% as the energy scale of new physics $\Lambda_{_{\rm NP}}=200$ GeV.Comment: 30 pages,4 figure

Evidence for Colour-Octet Mechanism from CERN LEP2 gamma gamma -> J/psi + X Data

We present theoretical predictions for the transverse-momentum distribution of J/psi mesons promptly produced in gamma gamma collisions within the factorization formalism of nonrelativistic quantum chromodynamics, including the contributions from both direct and resolved photons, and we perform a conservative error analysis. The fraction of J/psi mesons from decays of bottom-flavoured hadrons is estimated to be negligibly small. New data taken by the DELPHI Collaboration at LEP2 nicely confirm these predictions, while they disfavour those obtained within the traditional colour-singlet model.Comment: 11 pages (Latex), 3 figures (Postscript); updated experimental data included, references added, accepted for publication in Phys. Rev. Let

Associated Production of Bottomonia and Higgs Bosons at Hadron Colliders

We study the associated production of bottomonia and Higgs bosons at hadron colliders within the factorization formalism of nonrelativistic quantum chromodynamics providing all contributing partonic cross sections in analytic form. While such processes tend to be suppressed in the standard model, they may have interesting cross sections in its minimal supersymmetric extension, especially at large values of tan(beta), where the bottom Yukawa couplings are enhanced. We present numerical results for the processes involving the lighter CP-even h^0 boson and the CP-odd A^0 boson appropriate for the Fermilab Tevatron and the CERN LHC.Comment: 33 pages, 7 figures, Latex, to appear in Phys. Rev.

Dynamical Boson Stars

The idea of stable, localized bundles of energy has strong appeal as a model for particles. In the 1950s John Wheeler envisioned such bundles as smooth configurations of electromagnetic energy that he called {\em geons}, but none were found. Instead, particle-like solutions were found in the late 1960s with the addition of a scalar field, and these were given the name {\em boson stars}. Since then, boson stars find use in a wide variety of models as sources of dark matter, as black hole mimickers, in simple models of binary systems, and as a tool in finding black holes in higher dimensions with only a single killing vector. We discuss important varieties of boson stars, their dynamic properties, and some of their uses, concentrating on recent efforts.Comment: 79 pages, 25 figures, invited review for Living Reviews in Relativity; major revision in 201