The Creative Laboratory: Embracing Childlike Imagination to Develop Lifelong Creativity and Cognitive Ability Through Worldplay

There is a decline in creativity that occurs in children around the sixth grade. Although it is commonly agreed that creativity is a valuable skill, the playful activities of childhood that naturally develop creativity are often discouraged once the child reaches middle school age. This thesis investigates methods of generating creativity that can be introduced to children as a way to combat the slump. Specifically, it analyzes worldplay, the act of creating an imaginary world, as a potential tool for building creativity. To test the viability of worldplay as a creative tool, the thesis used a literature review to establish existing methods of generating creativity, particularly exploratory play, constructive play, and roleplay. Then, case studies and content analysis were employed to examine the worldplay activities of known worldbuilders. The results showed that many of the common activities involved in worldplay naturally incorporate the methods of generating creativity, supporting the idea that worldplay can function as a laboratory in which children can practice and hone their creative abilities. Therefore, the thesis visual deliverable was the construction of a worldplay guidebook for middle school age children, demonstrating the process of worldplay through the creation of an imaginary world, with a focus on teaching and implementing the methods of play that foster creativity

The Investigation of Geologically Relevant Metal Phosphites as a Plausible Source of Phosphorus in Prebiotic Chemistry

To understand the origin of life, the abiotic incorporation of phosphorus in energy-promoting molecules like adenosine triphosphate (ATP) need to be identified. However, a consensus has not been reached on the source of phosphorus for prebiotic chemistry on Archaean Earth. One hypothesis is that metal phosphites were an important source of phosphorus for prebiotic chemistry. The primary issue with this hypothesis is the lack of phosphites in the geological rock record, where different phosphorus compounds (mostly inorganic phosphates) are observed instead. Two geologically relevant metal phosphites with varying waters of hydration, CaHPO3 and MgHPO3, were synthesized, structurally characterized, and thermally processed to determine if the conditions on early Earth could explain the lack of phosphite in the geological record. The phosphites were characterized using Thermogravimetic Analysis, X-Ray Diffraction, and phosphorus Nuclear Magnetic Resonance. From these experiments, interstitial waters associated with the metal phosphites are dehydrated from the compounds, which influences their reactivity. From Thermogravimetric Analysis, and phosphorus Nuclear Magentic Resonance data, simultaneous polymerization and oxidation is observed defining reactivity. Also, X-Ray Diffraction data validated the synthesis of metal phosphites in the lab. Since they are subject to polymerize and oxidize at higher temperatures in different environments, metal phopshites may not easily preserved in the geological rock record. Preliminary data to support this investigation will be presented here

How Baccalaureate Nursing Students Value an Interprofessional Patient Safety Course for Professional Development

Nursing students need foundation knowledge and skills to keep patients safe in continuously changing health care environments. A gap exists in our knowledge of the value students place on interprofessional patient safety education. The purpose of this exploratory, mixed methods study was to understand nursing students' attitudes about the value of an interprofessional patient safety course to their professional development and its role in health professions curricula. Qualitative and quantitative data were collected from formative course performance measures, course evaluations, and interviews with six nursing students. The qualitative themes of awareness, ownership, and action emerged and triangulated with the descriptive quantitative results from student performance and course evaluations. Students placed high value on the course and essential nature of interprofessional patient safety content. These findings provide a first step toward integration of interprofessional patient safety education into nursing curricula and in meeting the Institute of Medicine's goals for the nursing profession

What memory representation is acquired during nonword speech production learning? The influence of stimulus features and training modality on nonword encoding

The purpose of this research was to investigate memory representations related to speech processing. Psycholinguistic and speech motor control theorists have hypothesized a variety of fundamental memory representations, such as syllables or phonemes, which may be learned during speech acquisition tasks. Yet, it remains unclear which fundamental representations are encoded and retrieved during learning and generalization tasks. Two experiments were conducted using a motor learning paradigm to investigate if representations for syllables and phonemes were acquired during a nonword repetition task. Additionally, different training modalities were implemented across studies to examine if training modality influenced memory encoding for nonword stimuli. Results suggest multiple representations may be acquired during training regardless of training modality; however, the underlying memory representations learned during training may be less abstract than current models hypothesize

The Tularosa Study: An Experimental Design and Implementation to Quantify the Effectiveness of Cyber Deception

The Tularosa study was designed to understand how defensive deception--including both cyber and psychological--affects cyber attackers. Over 130 red teamers participated in a network penetration task over two days in which we controlled both the presence of and explicit mention of deceptive defensive techniques. To our knowledge, this represents the largest study of its kind ever conducted on a professional red team population. The design was conducted with a battery of questionnaires (e.g., experience, personality, etc.) and cognitive tasks (e.g., fluid intelligence, working memory, etc.), allowing for the characterization of a ``typical\u27\u27 red teamer, as well as physiological measures (e.g., galvanic skin response, heart rate, etc.) to be correlated with the cyber events. This paper focuses on the design, implementation, data, population characteristics, and begins to examine preliminary results

Digital volunteer networks and humanitarian crisis reporting

Digital technologies and big data are rapidly transforming humanitarian crisis response and changing the traditional roles and powers of its actors. This article looks at a particular aspect of this transformation – the appearance of digital volunteer networks – and explores their potential to act as a new source for media coverage, in addition to their already established role as emergency response supporters. I argue that digital humanitarians can offer a unique combination of speed and safe access, while escaping some of the traditional constraints of the aid-media relationship and exceeding the conventional conceptualizations of citizen journalism. Journalists can find both challenges and opportunities in the environment where multiple crisis actors are assuming some of the media roles. The article draws on interviews with humanitarian organizations, journalists, and digital volunteer networks about their understanding of digital humanitarian communication and its significance for media coverage of crises

The Imprint of Gravitational Waves in Models Dominated by a Dynamical Cosmic Scalar Field

An alternative to the standard cold dark matter model has been recently proposed in which a significant fraction of the energy density of the universe is due to a dynamical scalar field ($Q$) whose effective equation-of-state differs from that of matter, radiation or cosmological constant ($\Lambda$). In this paper, we determine how the Q-component modifies the primordial inflation gravitational wave (tensor metric) contribution to the cosmic microwave background anisotropy and, thereby, one of the key tests of inflation.Comment: 15 pages, 14 figures, revtex, submitted to Phys. Rev.

Using DNA Methylation Patterns to Infer Tumor Ancestry

Background: Exactly how human tumors grow is uncertain because serial observations are impractical. One approach to reconstruct the histories of individual human cancers is to analyze the current genomic variation between its cells. The greater the variations, on average, the greater the time since the last clonal evolution cycle (‘‘a molecular clock hypothesis’’). Here we analyze passenger DNA methylation patterns from opposite sides of 12 primary human colorectal cancers (CRCs) to evaluate whether the variation (pairwise distances between epialleles) is consistent with a single clonal expansion after transformation. Methodology/Principal Findings: Data from 12 primary CRCs are compared to epigenomic data simulated under a single clonal expansion for a variety of possible growth scenarios. We find that for many different growth rates, a single clonal expansion can explain the population variation in 11 out of 12 CRCs. In eight CRCs, the cells from different glands are all equally distantly related, and cells sampled from the same tumor half appear no more closely related than cells sampled from opposite tumor halves. In these tumors, growth appears consistent with a single ‘‘symmetric’ ’ clonal expansion. In three CRCs, the variation in epigenetic distances was different between sides, but this asymmetry could be explained by a single clonal expansion with one region of a tumor having undergone more cell division than the other. The variation in one CRC was complex and inconsistent with a simple single clonal expansion

Research on the Premotor Symptoms of Parkinson’s Disease: Clinical and Etiological Implications

Background: The etiology and natural history of Parkinson’s disease (PD) are not well understood. Some non-motor symptoms such as hyposmia, rapid eye movement sleep behavior disorder, and constipation may develop during the prodromal stage of PD and precede PD diagnosis by years. Objectives: We examined the promise and pitfalls of research on premotor symptoms of PD and developed priorities and strategies to understand their clinical and etiological implications. Methods: This review was based on a workshop, Parkinson’s Disease Premotor Symptom Symposium, held 7–8 June 2012 at the National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina. Discussion: Research on premotor symptoms of PD may offer an excellent opportunity to characterize high-risk populations and to better understand PD etiology. Such research may lead to evaluation of novel etiological hypotheses such as the possibility that environmental toxicants or viruses may initiate PD pathogenesis in the gastrointestinal tract or olfactory bulb. At present, our understanding of premotor symptoms of PD is in its infancy and faces many obstacles. These symptoms are often not specific to PD and have low positive predictive value for early PD diagnosis. Further, the pathological bases and biological mechanisms of these premotor symptoms and their relevance to PD pathogenesis are poorly understood. Conclusion: This is an emerging research area with important data gaps to be filled. Future research is needed to understand the prevalence of multiple premotor symptoms and their etiological relevance to PD. Animal experiments and mechanistic studies will further understanding of the biology of these premotor symptoms and test novel etiological hypothesis. Citation: Chen H, Burton EA, Ross GW, Huang X, Savica R, Abbott RD, Ascherio A, Caviness JN, Gao X, Gray KA, Hong JS, Kamel F, Jennings D, Kirshner A, Lawler C, Liu R, Miller GW, Nussbaum R, Peddada SD, Comstock Rick A, Ritz B, Siderowf AD, Tanner CM, Tröster AI, Zhang J. 2013. Research on the premotor symptoms of Parkinson’s Disease: clinical and etiological implications. Environ Health Perspect 121:1245–1252; http://dx.doi.org/10.1289/ehp.130696