Régi magyar kéziratok kiadásra való előkészítése és kiadása = Publishing old Hungarian manuscripts

A pályázat a kitűzött céloknak megfelelően zárult le. A kutatások három témakörben a következő eredményekkel jártak: 1. Régi Magyar Kódexek - Megjelent két 16. századi kódex (Kazinczy-kódex. 1526-41., Pozsonyi Kódex 1520.) hasonmást és betűhű átiratot, valamint szakmai bevezetőt és jegyzeteket tartalmazó kiadása 2003-ban, ill. 2004-ben. Elkészült és nyomdába került a Tihanyi Kódex (1532.) hasonló módon felszerelt kézirata. 2. A magyar nyelvtörténet forrásai - Megjelent Szenczi Molnár Albert 1610-es latin nyelvű magyar grammatikájának hasonmást, magyar fordítást, bevezető tanulmányt és szakmai jegyzeteket tartalmazó kiadása (2004.) Elkészült egy másik, ugyancsak nagyon jelentős 17. századi magyar grammatika (Pereszlényi Pál: Grammatica Lingvae Vngaricae, 1682.) hasonló módon kialakított kézirata. 3. Régi Magyar Levelestár - A sorozat 2. köteteként elkészült a "25 levél a 16. századból" című levélgyűjtemény betűhű átírást, bevezetőt és jegyzeteket tartalmazó kézirata. A kiadványban az eredeti levelek méretpontos hasonmásai kivehető mellékletként lesznek megtalálhatók. | By the end of the period 2002?2005, research work was completed according to the schedule in 3 given topics. 1. Old Hungarian Codices - The volumes of two 16th century codices were published in 2003 (Kazinczy-kódex, 1526-1541.) and in 2004 (Pozsonyi Kódex, 1520). The manuscript of Tihanyi Kódex (1532.), containing the facsimile and the letter-perfect transcription of the original, with notes and an introductory essay, has been also completed and sent to the printing office. 2. Sources of Hungarian Historical Linguistics - A volume containing the facsimile and the Hungarian translation of the grammar of Albert Szenczi Molnár (1610.) was published in 2004. The manuscript of another 17th century grammar by Pál Pereszlényi (1682.) has been completed and sent to the printing office. (It contains the facsimile of the original, written in Latin, a complete Hungarian translation, notes and an introductory essay.) 3. Old Hungarian Archives ? A volume of a collection of 16th century letters containing their letter-perfect transcription and the scale facimile of the letters enclosed as a loose appendix, has been completed and sent to the printing office

Perspectivization and modes of quoting in Hungarian

This paper examines modes of quoting with special regard to the organization of perspective. Due to the pragmatic interest of the study, our focus is on the functioning of two context-dependent vantage points, the subject of consciousness and the referential centre. Our key question about the former is to whom speaking as a sign of active consciousness is attributed and how this is linguistically marked. As regards the latter, the central issue is from where and how the spatio-temporal and interpersonal relations of the quoted discourse are represented.Further problems to be discussed include the questions of how and to what extent quoting is associated with pragmatic or metapragmatic awareness, and how various quoting modes may differ along this dimension.Although the paper is mostly concerned with a ‘universal pragmatic’ characterization of the functioning of perspective in quotations, it also highlights some language-particular features of Hungarian quoting strategies and touches on their evolution in the history of the language

The location of olfactory receptors within olfactory epithelium is independent of odorant volatility and solubility

<p>Abstract</p> <p>Background</p> <p>Our objective was to study the pattern of olfactory receptor expression within the dorsal and ventral regions of the mouse olfactory epithelium. We hypothesized that olfactory receptors were distributed based on the chemical properties of their ligands: e.g. receptors for polar, hydrophilic and weakly volatile odorants would be present in the dorsal region of olfactory epithelium; while receptors for non-polar, more volatile odorants would be distributed to the ventral region. To test our hypothesis, we used micro-transplantation of cilia-enriched plasma membranes derived from dorsal or ventral regions of the olfactory epithelium into Xenopus oocytes for electrophysiological characterization against a panel of 100 odorants.</p> <p>Findings</p> <p>Odorants detected by ORs from the dorsal and ventral regions showed overlap in volatility and water solubility. We did not find evidence for a correlation between the solubility and volatility of odorants and the functional expression of olfactory receptors in the dorsal or ventral region of the olfactory epithelia.</p> <p>Conclusions</p> <p>No simple clustering or relationship between chemical properties of odorants could be associated with the different regions of the olfactory epithelium. These results suggest that the location of ORs within the epithelium is not organized based on the physico-chemical properties of their ligands.</p

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery

Profiles of Volatile Biomarkers Detect Tuberculosis from Skin

Tuberculosis (TB) is an infectious disease that threatens >10 million people annually. Despite advances in TB diagnostics, patients continue to receive an insufficient diagnosis as TB symptoms are not specific. Many existing biodiagnostic tests are slow, have low clinical performance, and can be unsuitable for resource-limited settings. According to the World Health Organization (WHO), a rapid, sputum-free, and cost-effective triage test for real-time detection of TB is urgently needed. This article reports on a new diagnostic pathway enabling a noninvasive, fast, and highly accurate way of detecting TB. The approach relies on TB-specific volatile organic compounds (VOCs) that are detected and quantified from the skin headspace. A specifically designed nanomaterial-based sensors array translates these findings into a point-of-care diagnosis by discriminating between active pulmonary TB patients and controls with sensitivity above 90%. This fulfills the WHO's triage test requirements and poses the potential to become a TB triage test