Virtualization of pliocene sites in the Huelva province: valuating the paleontological heritage in differentiate educative settings I

El patrimonio paleontológico del Plioceno de la provincia de Huelva es uno de los más importantes de España y referente europeo de moluscos de este período. Sin embargo, no existe un inventario de catalogación básica de los principales yacimientos ni de los principales grupos fósiles presentes, así como de su importancia como patrimonio natural. El presente trabajo pretende rellenar este notable vacío con una proyección tanto hacia materias preuniversitarias como universitarias, así como hacia posibles instituciones y corporaciones públicas susceptibles de utilizarlo en sus planes de ordenación. Por otro lado, se pretende que actúe como mecanismo de interconexión entre titulaciones con bajo número de alumnos de nuevo ingreso y los centros de Bachillerato, de forma que incentive una posible elección de estos Grados por los alumnos de las opciones científico-tecnológicas. También puede ser interesante para captar egresados hacia Másteres Oficiales en Patrimonio Histórico y Natural. En este sentido, se ha realizado un DVD documental sobre el patrimonio paleontológico del Plioceno de la provincia de Huelva, concretamente de las formaciones “Arenas de Huelva” y “Arenas de Bonares” desarrolladas en ambientes marinos someros y costeros durante la última etapa de evolución neógena de la cuenca. Este documental incluye una visión de conjunto de los principales yacimientos fósiles de esta edad, así como una explicación de la evolución paleogeográfica de nuestra provincia y los organismos que la han caracterizado en los últimos millones de años. Esta aportación es aplicable en el trabajo de campo de varios Grados y Posgrados universitarios y de fácil uso como material didáctico en diversas asignaturas de E.S.O. y Bachillerato. Este trabajo se ha realizado en el marco del proyecto de innovación docente (PID nº 10050) de la Universidad de Huelva.The paleontological heritage from the Neogene in the province of Huelva is one of the most important in Spain and it is considered a European reference site for the mollusk fossil record from this period. However, there are not basic inventories neither for the main sites nor the major fossil groups. Furthermore, no inventories exist about their natural heritage importance. This work aims to fill this significant gap for both pre-university and university levels, as well as to public institutions and corporations that may use it in their management plans. In addition, it is intended to act as an linking mechanism between university degrees with low number of first-year students and high school centres, in order to encourage a possible choice of these Bachelor’s degrees by scientific and technological students. It may also be interesting to catch the attention of graduates for Official Masters in Historical and Natural Heritage. In this sense, a DVD-documentary has been made about the paleontological heritage from the Pliocene in the province of Huelva, specifically from the “Arenas de Huelva” and “Arenas de Bonares” formations. These units were developed in shallow marine and coastal environments during the last stage of the Neogene evolution in the Guadalquivir Basin. This documental includes an overview of main marine fossil sites from this age and a brief explanation of the palaeogeographic evolution of the Huelva province during the last million of years. This contribution is useful for the fieldwork at Bachelor and Master Degree level and it is easy to use as teaching materials in different ESO (Obligatory Secondary Teaching) and High School subjects. This work has been support for an Innovation in Teaching Project (PID No. 10050) of the Huelva University

Virtualization of niebla formation sites (upper miocene) in the Huelva province: valuating the paleontological heritage in differentiate educative settings II

El patrimonio paleontológico del Neógeno de la provincia de Huelva es uno de los más importantes de España y referente europeo de moluscos de este período. Sin embargo, no existe un inventario de catalogación básica de los principales yacimientos ni de los principales grupos fósiles presentes, así como de su importancia como patrimonio natural. El presente trabajo pretende rellenar este notable vacío con una proyección tanto hacia materias preuniversitarias como universitarias, así como hacia posibles instituciones y corporaciones públicas susceptibles de utilizarlo en sus planes de ordenación. Por otro lado, se pretende que actúe como mecanismo de interconexión entre titulaciones con bajo número de alumnos de nuevo ingreso y los centros de Bachillerato, de forma que incentive una posible elección de estos Grados por los alumnos de las opciones científico-tecnológicas. También puede ser interesante para captar egresados hacia Másteres Oficiales en Patrimonio Histórico y Natural. En este sentido, se ha realizado un DVD documental sobre el patrimonio paleontológico del Mioceno superior de la provincia de Huelva. Este documental incluye una visión de conjunto de los principales yacimientos de fósiles marinos de la Fm. Niebla, desarrollada en un marco transgresivo bajo unas condiciones más húmedas y cálidas que las actuales. Esta aportación es aplicable al trabajo de campo de varios Grados y Posgrados universitarios y de fácil uso como material didáctico en diversas asignaturas de E.S.O. y Bachillerato. Este trabajo se ha realizado en el marco del proyecto de innovación docente (PID nº 11003) de la Universidad de Huelva.The paleontological heritage from the Neogene in the province of Huelva is one of the most important in Spain and it is considered a European reference site for the mollusk fossil record from this period. However, there are not basic inventories neither for the main sites nor the major fossil groups. Furthermore, no inventories exist about their natural heritage importance. This work aims to fill this significant gap for both pre-university and university levels, as well as to public institutions and corporations that may use it in their management plans. In addition, it is intended to act as an linking mechanism between university degrees with low number of first-year students and high school centres, in order to encourage a possible choice of these Bachelor’s degrees by scientific and technological students. It may also be interesting to catch the attention of graduates for Official Masters in Historical and Natural Heritage. In this sense, a DVD-documentary has been made about the paleontological heritage from the Upper Miocene in the province of Huelva. This documental includes an overview of the main marine fossil sites from the Niebla Formation developed in a transgressive setting under more humid and warmer conditions than today. This contribution is useful for the fieldwork at Bachelor and Master Degree level and it is easy to use as teaching materials in different ESO (Obligatory Secondary Teaching) and High School subjects. This work has been funded for an Innovation in Teaching Project (PID No. 10050) of the Huelva University

Developments in pharmacogenetics, pharmacogenomics, and personalized medicine

The development of Pharmacogenetics and Pharmacogenomics in Western Europe is highly relevant in the worldwide scenario. Despite the usually low institutional support, many research groups, composed of basic and clinical researchers, have been actively working for decades in this field. Their contributions made an international impact and paved the way for further studies and pharmacogenomics implementation in clinical practice. In this manuscript, that makes part of the Special Issue entitled Spanish Pharmacology, we present an analysis of the state of the art of Pharmacogenetics and Pharmacogenomics research in Europe, we compare it with the developments in Spain, and we summarize the most salient contributions since 1988 to the present, as well as recent developments in the clinical application of pharmacogenomics knowledge. Finally, we present some considerations on how we could improve translation to clinical practice in this specific scenari

The effect of CYP2D6 variation on antipsychotic-induced hyperprolactinaemia: a systematic review and meta-analysis

Hyperprolactinemia is a known adverse drug reaction to antipsychotic treatment. Antipsychotic blood levels are influenced by cytochrome P450 enzymes, primarily CYP2D6. Variation in CYP450 genes may affect the risk of antipsychotic-induced hyperprolactinemia. We undertook a systematic review and meta-analysis to assess whether CYP2D6 functional genetic variants are associated with antipsychotic-induced hyperprolactinemia. The systematic review identified 16 relevant papers, seven of which were suitable for the meta-analysis (n = 303 participants including 134 extreme metabolisers). Participants were classified into four phenotype groups as poor, intermediate, extensive, and ultra-rapid metabolisers. A random effects meta-analysis was used and Cohen’s d calculated as the effect size for each primary study. We found no significant differences in prolactin levels between CYP2D6 metabolic groups. Current evidence does not support using CYP2D6 genotyping to reduce risk of antipsychotic-induced hyperprolactinemia. However, statistical power is limited. Future studies with larger samples and including a range of prolactin-elevating drugs are needed

Association of common genetic variants with risperidone adverse events in a Spanish schizophrenic population

Risperidone non-compliance is often high due to undesirable side effects, whose development is in part genetically determined. Studies with genetic variants involved in the pharmacokinetics and pharmacodynamics of risperidone have yielded inconsistent results. Thus, the aim of this study was to investigate the putative association of genetic markers with the occurrence of four frequently observed adverse events secondary to risperidone treatment: sleepiness, weight gain, extrapyramidal symptoms and sexual adverse events. A series of 111 schizophrenia inpatients were genotyped for genetic variants previously associated with or potentially involved in risperidone response. Presence of adverse events was the main variable and potential confounding factors were considered. Allele 16Gly of ADRB2 was significantly associated with a higher risk of sexual adverse events. There were other non-significant trends for DRD3 9Gly and SLC6A4 S alleles. Our results, although preliminary, provide new candidate variants of potential use in risperidone safety prediction

Variable pulmonary manifestations in Chitayat syndrome: Six additional affected individuals

Hand hyperphalangism leading to shortened index fingers with ulnar deviation, hallux valgus, mild facial dysmorphism and respiratory compromise requiring assisted ventilation are the key features of Chitayat syndrome. This condition results from the recurrent heterozygous missense variant NM_006494.2:c.266A>G; p.(Tyr89Cys) in ERF on chromosome 19q13.2, encoding the ETS2 repressor factor (ERF) protein. The pathomechanism of Chitayat syndrome is unknown. To date, seven individuals with Chitayat syndrome and the recurrent pathogenic ERF variant have been reported in the literature. Here, we describe six additional individuals, among them only one presenting with a history of assisted ventilation, and the remaining presenting with variable pulmonary phenotypes, including one individual without any obvious pulmonary manifestations. Our findings widen the phenotype spectrum caused by the recurrent pathogenic variant in ERF, underline Chitayat syndrome as a cause of isolated skeletal malformations and therefore contribute to the improvement of diagnostic strategies in individuals with hand hyperphalangism

High prevalence of methicillin resistance and PVL genes among <i>Staphylococcus aureus</i> isolates from the nares and skin lesions of pediatric patients with atopic dermatitis

Staphylococcus aureus is highly prevalent among patients with atopic dermatitis (AD), and this pathogen may trigger and aggravate AD lesions. The aim of this study was to determine the prevalence of S. aureus in the nares of pediatric subjects and verify the phenotypic and molecular characteristics of the isolates in pediatric patients with AD. Isolates were tested for antimicrobial susceptibility, SCCmec typing, and Panton-Valentine Leukocidin (PVL) genes. Lineages were determined by pulsed-field gel electrophoresis and multilocus sequence typing (MLST). AD severity was assessed with the Scoring Atopic Dermatitis (SCORAD) index. Among 106 patients, 90 (85%) presented S. aureus isolates in their nares, and 8 also presented the pathogen in their skin infections. Two patients had two positive lesions, making a total of 10 S. aureus isolates from skin infections. Methicillin-resistant S. aureus (MRSA) was detected in 24 (26.6%) patients, and PVL genes were identified in 21 (23.3%), including 6 (75%) of the 8 patients with skin lesions but mainly in patients with severe and moderate SCORAD values (P=0.0095). All 24 MRSA isolates were susceptible to trimethoprim/sulfamethoxazole, while 8 isolates had a minimum inhibitory concentration (MIC) to mupirocin >1024 μg/mL. High lineage diversity was found among the isolates including USA1100/ST30, USA400/ST1, USA800/ST5, ST83, ST188, ST718, ST1635, and ST2791. There was a high prevalence of MRSA and PVL genes among the isolates recovered in this study. PVL genes were found mostly among patients with severe and moderate SCORAD values. These findings can help clinicians improve the therapies and strategies for the management of pediatric patients with AD

On a novel iterative method to compute polynomial approximations to Bessel functions of the first kind and its connection to the solution of fractional diffusion/diffusion-wave problems

We present an iterative method to obtain approximations to Bessel functions of the first kind $J_p(x)$ ($p>-1$) via the repeated application of an integral operator to an initial seed function $f_0(x)$. The class of seed functions $f_0(x)$ leading to sets of increasingly accurate approximations $f_n(x)$ is considerably large and includes any polynomial. When the operator is applied once to a polynomial of degree $s$, it yields a polynomial of degree $s+2$, and so the iteration of this operator generates sets of increasingly better polynomial approximations of increasing degree. We focus on the set of polynomial approximations generated from the seed function $f_0(x)=1$. This set of polynomials is not only useful for the computation of $J_p(x)$, but also from a physical point of view, as it describes the long-time decay modes of certain fractional diffusion and diffusion-wave problems.Comment: 14 pages, 4 figures. To be published in J. Phys. A: Math. Theo

Comparative descriptions of eggs from three species of Rhodnius (Hemiptera: Reduviidae: Triatominae)

The authors describe and compare the morphological and ultrastructural characteristics of eggs from the three most recent described species of the genus Rhodnius Stål, 1859, which have not previously been studied. These species are Rhodnius colombiensis (Mejia, Galvão & Jurberg 1999), Rhodnius milesi (Carcavallo, Rocha, Galvão & Jurberg 2001) and Rhodnius stali (Lent, Jurberg & Galvão 1993). The results revealed that there are similarities in the exochorial architecture of optical microscopy and scanning electron microscopy; these include the predominance of hexagonal cells that are common to all Rhodnius species and variable degrees of lateral flattening, which is common not only to species of this genus, but also to the Rhodniini tribe. Differences in overall colour, the presence of a collar in R. milesi, a longitudinal bevel in R. stali and the precise length of R. colombiensis can be useful distinguishing features. As a result of this study, the key for egg identification proposed by Barata in 1981 can be updated.European Community - Chagas Disease Intervention ActivitiesCNPqCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES