Aplicación de las nuevas tecnologías en bibliotecas

El presente artículo pretende introducir y motivar algunas reflexiones sobre el desarrollo de la Biblioteca Digital y cómo las tecnologías de las Redes Sociales posibilitan una evolución de lo que se considera la Biblioteca Digital Clásica hacia una etapa superior: la Biblioteca Digital Semántica. Como complemento se hace una reflexión sobre el rol y los servicios de la biblioteca, influenciado por el desarrollo de las aplicaciones PDA —del inglés Personal Digital Assistant—, de dispositivos manuales que hacen muchas las funciones de una computadora personal, como proyectar películas, crear y leer documentos, ejecutar juegos, correo electrónico, chat, telefonía, etc, incidiendo en lo que literalmente posibilita tener “la información al alcance de la mano”

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality