Handbook of Research on Advancing Teaching and Teacher Education in the Context of a Virtual Age

Nicole Fletcher (with Audrey Meador) is a contributing author, Preparing for an Effective Mathematics Teaching Practice Online: The Case for Virtual Number Talks, Chapter 10 pp. 203-228. The possibilities of the virtual age can provide many valuable resources and opportunities for teachers, preservice teachers, and teacher educators. However, in order to utilize these resources responsibly and productively, the researchers and practitioners of teaching and teacher education must better understand the new potentials and pitfalls related to teaching and learning that are present within the virtual age. The Handbook of Research on Advancing Teaching and Teacher Education in the Context of a Virtual Age focuses on the recent innovations in teaching and teacher educations as well as innovations in the curriculum and pedagogy of teacher education. It deepens discussions related to how teacher education can address educational possibilities within this digital age. Covering topics such as learning material adaptation, teacher talent pipelines, and metaverse, this major reference work is a comprehensive resource for administrators and educators of both K-12 and higher education, teacher educators, pre-service teachers, government officials, librarians, researchers, and academicians.https://digitalcommons.fairfield.edu/education-books/1072/thumbnail.jp

Childhood Obesity, Cortical Structure, and Executive Function in Healthy Children.

The development of executive function is linked to maturation of prefrontal cortex (PFC) in childhood. Childhood obesity has been associated with changes in brain structure, particularly in PFC, as well as deficits in executive functions. We aimed to determine whether differences in cortical structure mediate the relationship between executive function and childhood obesity. We analyzed MR-derived measures of cortical thickness for 2700 children between the ages of 9 and 11 years, recruited as part of the NIH Adolescent Brain and Cognitive Development (ABCD) study. We related our findings to measures of executive function and body mass index (BMI). In our analysis, increased BMI was associated with significantly reduced mean cortical thickness, as well as specific bilateral reduced cortical thickness in prefrontal cortical regions. This relationship remained after accounting for age, sex, race, parental education, household income, birth-weight, and in-scanner motion. Increased BMI was also associated with lower executive function. Reduced thickness in the rostral medial and superior frontal cortex, the inferior frontal gyrus, and the lateral orbitofrontal cortex partially accounted for reductions in executive function. These results suggest that childhood obesity is associated with compromised executive function. This relationship may be partly explained by BMI-associated reduced cortical thickness in the PFC.Wellcome Trust Bernard Wolfe Health Neuroscience Fun

Longitudinal analysis of the developing rhesus monkey brain using magnetic resonance imaging: birth to adulthood.

We have longitudinally assessed normative brain growth patterns in naturalistically reared Macaca mulatta monkeys. Postnatal to early adulthood brain development in two cohorts of rhesus monkeys was analyzed using magnetic resonance imaging. Cohort A consisted of 24 rhesus monkeys (12 male, 12 female) and cohort B of 21 monkeys (11 male, 10 female). All subjects were scanned at 1, 4, 8, 13, 26, 39, and 52 weeks; cohort A had additional scans at 156 weeks (3 years) and 260 weeks (5 years). Age-specific segmentation templates were developed for automated volumetric analyses of the T1-weighted magnetic resonance imaging scans. Trajectories of total brain size as well as cerebral and subcortical subdivisions were evaluated over this period. Total brain volume was about 64 % of adult estimates in the 1-week-old monkey. Brain volume of the male subjects was always, on average, larger than the female subjects. While brain volume generally increased between any two imaging time points, there was a transient plateau of brain growth between 26 and 39 weeks in both cohorts of monkeys. The trajectory of enlargement differed across cortical regions with the occipital cortex demonstrating the most idiosyncratic pattern of maturation and the frontal and temporal lobes showing the greatest and most protracted growth. A variety of allometric measurements were also acquired and body weight gain was most closely associated with the rate of brain growth. These findings provide a valuable baseline for the effects of fetal and early postnatal manipulations on the pattern of abnormal brain growth related to neurodevelopmental disorders

A Prospective Study of Medical Student Mental Health and Attitudes of Mental Illness Disclosure

BACKGROUND: Little is known about whether students would disclose a history of mental illness on a residency or state medical licensure applications if disclosure were required. This study uses preliminary data to explore the burden of perceived mental illness among medical students, whether or not medical students would be willing to disclose this information on a residency or licensure application if prompted, and reasons for disclosure hesitance. METHODS: We electronically invited all University of New Mexico School of Medicine (UNM SOM) students enrolled in the Classes of 2019-2022 to participate in a REDCap survey about the diagnosis and treatment of mental illness. Four e-mails were sent to these students over a one-month period. This process was then repeated the following year targeting all medical students in the Classes of 2020-2023 at the UNM SOM. RESULTS: The average response rate for the two years of analysis was 49.3% (391 respondents). There was no significant effect due to difference in the two cohorts (p-value= 0.51). There was a significant effect of year in school and odds of perceived worsening of mental health (p-value= \u3c 0.001). The odds ratio of worsening mental health when compared to 1st-year students for the pooled cohorts was highest in 3rd year students at 11.8 (95% CI: 6.09-22.88). 45% of polled students perceived that their mental health worsened during medical school. 62% of students would not disclose their mental condition to ERAS and 51% of respondents would not disclose this information on a licensure application to the New Mexico Board of Medical Education if prompted. CONCLUSION: Students who perceive themselves to have mental health conditions are unlikely to disclose their mental health status on residency applications or state medical board applications when asked to do so. Furthermore there appears to be an association between year in school and mental health status, although more data is required

The First Brown Dwarf Discovered by the Backyard Worlds: Planet 9 Citizen Science Project

The Wide-field Infrared Survey Explorer (WISE) is a powerful tool for finding nearby brown dwarfs and searching for new planets in the outer solar system, especially with the incorporation of NEOWISE and NEOWISE-Reactivation data. So far, searches for brown dwarfs in WISE data have yet to take advantage of the full depth of the WISE images. To efficiently search this unexplored space via visual inspection, we have launched a new citizen science project, called "Backyard Worlds: Planet 9," which asks volunteers to examine short animations composed of difference images constructed from time-resolved WISE coadds. We report the discovery of the first new substellar object found by this project, WISEA J110125.95+540052.8, a T5.5 brown dwarf located approximately 34 pc from the Sun with a total proper motion of $\sim$0.7 as yr$^{-1}$. WISEA J110125.95+540052.8 has a WISE $W2$ magnitude of $W2=15.37 \pm 0.09$, this discovery demonstrates the ability of citizen scientists to identify moving objects via visual inspection that are 0.9 magnitudes fainter than the $W2$ single-exposure sensitivity, a threshold that has limited prior motion-based brown dwarf searches with WISE.Comment: 9 pages, 4 figures, 1 table. Accepted for publication in the Astrophysical Journal Letter

The Vanity of Small Differences: Empirical Studies of Artistic Value and Extrinsic Factors

To what extent are factors that are extrinsic to the artwork relevant to judgments of artistic value? One might approach this question using traditional philosophical methods, but one can also approach it using empirical methods; that is, by doing experimental philosophical aesthetics. This paper provides an example of the latter approach. We report two empirical studies that examine the significance of three sorts of extrinsic factors for judgments of artistic value: the causal-historical factor of contagion, the ontological factor of uniqueness, and the contextual factor of appreciative environment. We explore the context of appreciation by performing studies in a museum as well as the lab. We found that contagion made a difference to judgments of artistic value in both settings. These results are congruent with previous empirical research as well as recent philosophical work that defends the artistic significance of authenticity. However, uniqueness only made a difference in the lab setting, but not in the museum. This suggests that the context of appreciation may make a difference to judgments of artistic value. Of broader significance, these studies show the value of experimental philosophical aesthetics and the value of doing in situ empirical research on art

Decoy peptide targeted to Toll-IL-1R domain inhibits LPS and TLR4-active metabolite morphine-3 glucuronide sensitization of sensory neurons

Accumulating evidence indicates that Toll-like receptor (TLR) signaling adapter protein interactions with Toll/Interleukin-1 Receptor (TIR) domains present in sensory neurons may modulate neuropathic pain states. Following ligand interaction with TLRs, TIR serves to both initiate intracellular signaling and facilitate recruitment of signaling adapter proteins to the intracytoplasmic domain. Although TLR TIR is central to a number of TLR signaling cascades, its role in sensory neurons is poorly understood. In this study we investigated the degree to which TLR TIR decoy peptide modified to include a TAT sequence (Trans-Activator of Transcription gene in HIV; TAT-4BB) affected LPS-induced intracellular calcium flux and excitation in sensory neurons, and behavioral changes due to TLR4 active metabolite, morphine-3-glucuronide (M3G) exposure in vivo. TAT-4BB inhibited LPS-induced calcium changes in a majority of sensory neurons and decreased LPS-dependent neuronal excitability in small diameter neurons. Acute systemic administration of the TAT-4BB reversed M3G-induced tactile allodynia in a dose-dependent manner but did not affect motor activity, anxiety or responses to noxious thermal stimulus. These data suggest that targeting TLR TIR domains may provide novel pharmacological targets to reduce or reverse TLR4-dependent pain behavior in the rodent

Obesity associated with increased brain age from midlife.

Common mechanisms in aging and obesity are hypothesized to increase susceptibility to neurodegeneration, however, direct evidence in support of this hypothesis is lacking. We therefore performed a cross-sectional analysis of magnetic resonance image-based brain structure on a population-based cohort of healthy adults. Study participants were originally part of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) and included 527 individuals aged 20-87 years. Cortical reconstruction techniques were used to generate measures of whole-brain cerebral white-matter volume, cortical thickness, and surface area. Results indicated that cerebral white-matter volume in overweight and obese individuals was associated with a greater degree of atrophy, with maximal effects in middle-age corresponding to an estimated increase of brain age of 10 years. There were no similar body mass index-related changes in cortical parameters. This study suggests that at a population level, obesity may increase the risk of neurodegeneration.This work was supported by the Bernard Wolfe Health Neuroscience Fund and the Wellcome Trust (grant number RNAG/259). The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) research was supported by the Biotechnology and Biological Sciences Research Council (grant number BB/H008217/1).This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.neurobiolaging.2016.07.01

The F-CHROMA grid of 1D RADYN flare models

Context: Solar flares are the result of the sudden release of magnetic energy in the corona. Much of this energy goes into accelerating charged particles to high velocity. These particles travel along the magnetic field and the energy is dissipated when the density gets high enough, primarily in the solar chromosphere. Modelling this region is difficult because the radiation energy balance is dominated by strong, optically thick spectral lines. Aims: Our aim is to provide the community with realistic simulations of a flaring loop with an emphasis on the detailed treatment of the chromospheric energy balance. This will enable a detailed comparison of existing and upcoming observations with synthetic observables from the simulations, thereby elucidating the complex interactions in a flaring chromosphere. Methods: We used the 1D radiation hydrodynamics code RADYN to perform simulations of the effect of a beam of electrons injected at the apex of a solar coronal loop. A grid of models was produced, varying the total energy input, the steepness, and low-energy cutoff of the beam energy spectrum. Results: The full simulation results for a grid of models are made available online. Some general properties of the simulations are discussed.Comment: 11 pages, 9 figures. Accepted for publication in Astronomy & Astrophysic

Randomized Phase III Trial of Pegfilgrastim versus Filgrastim after Autologus Peripheral Blood Stem Cell Transplantation

Nonrandomized trials suggest that pegfilgrastim, a pegylated granulocyte colony-stimulating factor, could be used in lieu of filgrastim after autologus peripheral blood stem cell transplantation. This phase III, randomized, double-blinded, placebo-controlled trial compared the efficacy, costs, and safety of single-dose pegfilgrastim (single 6mg dose) versus daily filgrastim (5μg/kg/day) for this indication. Seventy-eight patients, matched for age, sex, underlying disease, stage, and CD34/kg transplant dose were enrolled. Cytokines were started on day +1 posttransplant and continued to an absolute neutrophil count (ANC) of 5×109/L for 3 days or 10×109/L for 1 day. The median time to neutrophil engraftment (ANC >1.5×109/L for 3 days or 5×109/L for 1 day) was the same in both groups (12 days). No differences in platelet engraftment (11 versus 13 days), number of platelet transfusions (5 versus 4), percent with positive cultures for bacterial pathogens (23% versus 15%), days of fever (1 versus 2), deaths prior to engraftment (1 versus 1), or duration of hospital stay (19 versus 19 days) were seen between the pegfilgrastim and filgrastim groups, respectively. Using the average wholesale price for doses used in this trial, there was a per-patient savings of $961 for the pegfilgrastim group (P < .001). This phase III study failed to demonstrate a difference in time to neutrophil engraftment or any clinical sequelae between pegfilgrastim and filgrastim when given post-APBSCT, with pegfilgrastim achieving a cost savings over filgrastim